Method of diagnosing neoplasms - ii

ABSTRACT

The present invention relates generally to nucleic acid molecules in respect of which changes to the DNA or to the RNA or protein expression profiles are indicative of the onset, predisposition to the onset and/or progression of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules in respect of which changes to the DNA or to the RNA or protein expression profiles are indicative of the onset and/or progression of a large intestine neoplasm, such as an adenoma or an adenocarcinoma. The DNA or the expression profiles of the present invention are useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal neoplasms, such as colorectal adenocarcinomas. Accordingly, in a related aspect the present invention is directed to a method of screening a subject for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in the DNA or the RNA or protein expression profile of one or more nucleic acid molecule markers.

FIELD OF THE INVENTION

The present invention relates generally to nucleic acid molecules in respect of which changes to the DNA or to the RNA or protein expression profiles are indicative of the onset, predisposition to the onset and/or progression of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules in respect of which changes to the DNA or to the RNA or protein expression profiles are indicative of the onset and/or progression of a large intestine neoplasm, such as an adenoma or an adenocarcinoma. The DNA or the expression profiles of the present invention are useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal neoplasms, such as colorectal adenocarcinomas. Accordingly, in a related aspect the present invention is directed to a method of screening a subject for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in the DNA or the RNA or protein expression profile of one or more nucleic acid molecule markers.

BACKGROUND OF THE INVENTION

Bibliographic details of the publications referred to by author in this specification are collected alphabetically at the end of the description.

The reference in this specification to any prior publication (or information derived from it), or to any matter which is known, is not, and should not be taken as an acknowledgment or admission or any form of suggestion that that prior publication (or information derived from it) or known matter forms part of the common general knowledge in the field of endeavour to which this specification relates.

Adenomas are benign tumours, or neoplasms, of epithelial origin which are derived from glandular tissue or exhibit clearly defined glandular structures. Some adenomas show recognisable tissue elements, such as fibrous tissue (fibroadenomas) and epithelial structure, while others, such as bronchial adenomas, produce active compounds that might give rise to clinical syndromes.

Adenomas may progress to become an invasive neoplasm and are then termed adenocarcinomas. Accordingly, adenocarcinomas are defined as malignant epithelial tumours arising from glandular structures, which are constituent parts of many organs of the body. The term adenocarcinoma is also applied to tumours showing a glandular growth pattern. These tumours may be sub-classified according to the substances that they produce, for example mucus secreting and serous adenocarcinomas, or to the microscopic arrangement of their cells into patterns, for example papillary and follicular adenocarcinomas. These carcinomas may be solid or cystic (cystadenocarcinomas). Each organ may produce tumours showing a variety of histological types, for example the ovary may produce both mucinous and cystadenocarcinoma.

Adenomas in different organs behave differently. In general, the overall chance of carcinoma being present within an adenoma (i.e. a focus of cancer having developed within a benign lesion) is approximately 5%. However, this is related to size of an adenoma. For instance, in the large bowel (colon and rectum specifically) occurrence of a cancer within an adenoma is rare in adenomas of less than 1 centimetre. Such a development is estimated at 40 to 50% in adenomas which are greater than 4 centimetres and show certain histopathological change such as villous change, or high grade dysplasia. Adenomas with higher degrees of dysplasia have a higher incidence of carcinoma. In any given colorectal adenoma, the predictors of the presence of cancer now or the future occurrence of cancer in the organ include size (especially greater than 9 mm) degree of change from tubular to villous morphology, presence of high grade dysplasia and the morphological change described as “serrated adenoma”. In any given individual, the additional features of increasing age, familial occurrence of colorectal adenoma or cancer, male gender or multiplicity of adenomas, predict a future increased risk for cancer in the organ—so-called risk factors for cancer. Except for the presence of adenomas and its size, none of these is objectively defined and all those other than number and size are subject to observer error and to confusion as to precise definition of the feature in question. Because such factors can be difficult to assess and define, their value as predictors of current or future risk for cancer is imprecise.

Once a sporadic adenoma has developed, the chance of a new adenoma occurring is approximately 30% within 26 months.

Colorectal adenomas represent a class of adenomas which are exhibiting an increasing incidence, particularly in more affluent countries. The causes of adenoma, and of progression to adenocarcinoma, are still the subject of intensive research. To date it has been speculated that in addition to genetic predisposition, environmental factors (such as diet) play a role in the development of this condition. Most studies indicate that the relevant environmental factors relate to high dietary fat, low fibre, low vegetable intake, smoking, obesity, physical inactivity and high refined carbohydrates.

Colonic adenomas are localised areas of dysplastic epithelium which initially involve just one or several crypts and may not protrude from the surface, but with increased growth in size, usually resulting from an imbalance in proliferation and/or apoptosis, they may protrude. Adenomas can be classified in several ways. One is by their gross appearance and the major descriptors include degrees of protrusion: flat sessile (i.e. protruding but without a distinct stalk) or pedunculated (i.e. having a stalk). Other gross descriptors include actual size in the largest dimension and actual number in the colon/rectum. While small adenomas (less than say 5 or 10 millimetres) exhibit a smooth tan surface, pedunculated and especially larger adenomas tend to have a cobblestone or lobulated red-brown surface. Larger sessile adenomas may exhibit a more delicate villous surface. Another set of descriptors include the histopathological classification; the prime descriptors of clinical value include degree of dysplasia (low or high), whether or not a focus of invasive cancer is present, degree of change from tubular gland formation to villous gland formation (hence classification is tubular, villous or tubulovillous), presence of admixed hyperplastic change and of so-called “serrated” adenomas and its subgroups. Adenomas can be situated at any site in the colon and/or rectum although they tend to be more common in the rectum and distal colon. All of these descriptors, with the exception of number and size, are relatively subjective and subject to interobserver disagreement.

The various descriptive features of adenomas are of value not just to ascertain the neoplastic status of any given adenomas when detected, but also to predict a person's future risk of developing colorectal adenomas or cancer. Those features of an adenoma or number of adenomas in an individual that point to an increased future risk for cancer or recurrence of new adenomas include: size of the largest adenoma (especially 10 mm or larger), degree of villous change (especially at least 25% such change and particularly 100% such change), high grade dysplasia, number (3 or more of any size or histological status) or presence of serrated adenoma features. None except size or number is objective and all are relatively subjective and subject to interobserver disagreement. These predictors of risk for future neoplasia (hence “risk”) are vital in practice because they are used to determine the rate and need for and frequency of future colonoscopic surveillance. More accurate risk classification might thus reduce workload of colonoscopy, make it more cost-effective and reduce the risk of complications from unnecessary procedures.

Adenomas are generally asymptomatic, therefore rendering difficult their diagnosis and treatment at a stage prior to when they might develop invasive characteristics and so became cancer. It is technically impossible to predict the presence or absence of carcinoma based on the gross appearance of adenomas, although larger adenomas are more likely to show a region of malignant change than are smaller adenomas. Sessile adenomas exhibit a higher incidence of malignancy than pedunculated adenomas of the same size. Some adenomas result in blood loss which might be observed or detectable in the stools; while sometimes visible by eye, it is often, when it occurs, microscopic or “occult”. Larger adenomas tend to bleed more than smaller adenomas. However, since blood in the stool, whether overt or occult, can also be indicative of non-adenomatous conditions, the accurate diagnosis of adenoma is rendered difficult without the application of highly invasive procedures such as colonoscopy combined with tissue acquisition by either removal (i.e. polypectomy) or biopsy and subsequent histopathological analysis.

Accordingly, there is an on-going need to elucidate the causes of adenoma and to develop more informative diagnostic protocols or aids to diagnosis that enable one to direct colonoscopy at people more likely to have adenomas. These adenomas may be high risk, advanced or neither of these, in particular protocols which will enable the rapid, routine and accurate diagnosis of adenoma. Furthermore, it can be difficult after colonoscopy to be certain that all adenomas have been removed, especially in a person who has had multiple adenomas. An accurate screening test may minimise the need to undertake an early second colonoscopy to ensure that the colon has been cleared of neoplasms. Accordingly, the identification of molecular markers for adenomas would provide means for understanding the cause of adenomas and cancer, improving diagnosis of adenomas including development of useful screening tests, elucidating the histological stage of an adenoma, characterising a patient's future risk for colorectal neoplasia on the basis of the molecular state of an adenoma and facilitating treatment of adenomas.

To date, research has focused on the identification of gene mutations which lead to the development of colorectal neoplasms. In work leading up to the present invention, however, it has been determined that changes in the DNA or the RNA or protein expression profiles of genes which are also expressed in healthy individuals are indicative of the development of neoplasms of the large intestine, such as adenomas and adenocarcinomas. It has been further determined that in relation to neoplasms of the large intestine, diagnosis can be made based on screening for one or more of a panel of these differentially expressed genes. In a related aspect, it has still further been determined that to the extent that neoplastic tissue has been identified either by the method of the invention or by some other method, the present invention provides still further means of characterising that tissue as an adenoma or a cancer. In yet another aspect, it has been determined that a proportion of these genes are characterised by gene expression which occurs in the context of non-neoplastic tissue but not in the context of neoplastic tissue, thereby facilitating the development of qualitative analyses which do not require a relative analysis to be performed against a non-neoplastic or normal control reference level. Accordingly, the inventors have identified a panel of genes which facilitate the diagnosis of adenocarcinoma and adenoma development and/or the monitoring of conditions characterised by the development of these types of neoplasms.

SUMMARY OF THE INVENTION

Throughout this specification and the claims which follow, unless the context requires otherwise, the word “comprise”, and variations such as “comprises” and “comprising”, will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps.

As used herein, the term “derived from” shall be taken to indicate that a particular integer or group of integers has originated from the species specified, but has not necessarily been obtained directly from the specified source. Further, as used herein the singular forms of “a”, “and” and “the” include plural referents unless the context clearly dictates otherwise.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

The subject specification contains amino acid and nucleotide sequence information prepared using the programme PatentIn Version 3.4, presented herein after the bibliography. Each amino acid and nucleotide sequence is identified in the sequence listing by the numeric indicator <210> followed by the sequence identifier (eg. <210>1, <210>2, etc). The length, type of sequence (amino acid, DNA, etc.) and source organism for each sequence is indicated by information provided in the numeric indicator fields <211>m<212> and <213>, respectively. Amino acid and nucleotide sequences referred to in the specification are identified by the indicator SEQ ID NO: followed by the sequence identifier (eg. SEQ ID NO:1, SEQ ID NO: 2, etc). The sequence identifier referred to in the specification correlates to the information provided in numeric indicator field <400> in the sequence listing, which is followed by the sequence identifier (eg. <400>1, <400>2, etc). That is SEQ ID NO: 1 as detailed in the specification correlates to the sequence indicated as <400>1 in the sequence listing.

One aspect of the present invention is directed to a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:

200600_at 210133_at 227235_at 200621_at 210139_s_at 227265_at 200795_at 210298_x_at 227404_s_at 200799_at 210299_s_at 227529_s_at 200845_s_at 210302_s_at 227561_at 200859_x_at 210495_x_at 227623_at 200897_s_at 210517_s_at 227662_at 200974_at 210764_s_at 227705_at 200986_at 210809_s_at 227727_at 201041_s_at 210946_at 227826_s_at 201058_s_at 210982_s_at 227827_at 201061_s_at 211161_s_at 228202_at 201069_at 211548_s_at 228504_at 201105_at 211596_s_at 228507_at 201137_s_at 211643_x_at 228640_at 201141_at 211644_x_at 228706_s_at 201150_s_at 211645_x_at 228707_at 201289_at 211671_s_at 228750_at 201300_s_at 211696_x_at 228766_at 201324_at 211719_x_at 228846_at 201348_at 211798_x_at 228854_at 201426_s_at 211813_x_at 228885_at 201427_s_at 211848_s_at 229530_at 201438_at 211889_x_at 229839_at 201496_x_at 211896_s_at 230087_at 201497_x_at 211959_at 230264_s_at 201539_s_at 211964_at 230788_at 201540_at 211985_s_at 230830_at 201616_s_at 211990_at 231120_x_at 201617_x_at 211991_s_at 231579_s_at 201645_at 212077_at 231773_at 201667_at 212091_s_at 234764_x_at 201739_at 212097_at 234987_at 201743_at 212136_at 236300_at 201744_s_at 212158_at 236313_at 201842_s_at 212185_x_at 242317_at 201852_x_at 212192_at 200884_at 201858_s_at 212195_at 201495_x_at 201859_at 212230_at 202266_at 201865_x_at 212233_at 202350_s_at 201893_x_at 212265_at 202731_at 201920_at 212288_at 202741_at 201957_at 212386_at 202742_s_at 202007_at 212387_at 202768_at 202037_s_at 212397_at 202838_at 202069_s_at 212414_s_at 203058_s_at 202133_at 212419_at 203060_s_at 202222_s_at 212464_s_at 203240_at 202242_at 212667_at 203296_s_at 202274_at 212671_s_at 203343_at 202283_at 212713_at 203474_at 202291_s_at 212730_at 203638_s_at 202388_at 212764_at 203963_at 202555_s_at 212859_x_at 204018_x_at 202620_s_at 212956_at 204034_at 202686_s_at 213068_at 204036_at 202746_at 213071_at 204130_at 202760_s_at 213428_s_at 204388_s_at 202766_s_at 213509_x_at 204389_at 202888_s_at 213624_at 204508_s_at 202920_at 213746_s_at 204532_x_at 202953_at 213891_s_at 204607_at 202957_at 214027_x_at 204673_at 202992_at 214038_at 204818_at 202994_s_at 214091_s_at 204895_x_at 202995_s_at 214142_at 204897_at 203000_at 214414_x_at 205112_at 203001_s_at 214505_s_at 205259_at 203066_at 214677_x_at 205403_at 203131_at 214696_at 205480_s_at 203305_at 214752_x_at 205554_s_at 203382_s_at 214768_x_at 205593_s_at 203477_at 214777_at 205892_s_at 203645_s_at 215049_x_at 205929_at 203680_at 215076_s_at 206000_at 203729_at 215118_s_at 206094_x_at 203748_x_at 215176_x_at 206262_at 203766_s_at 215193_x_at 206377_at 203881_s_at 215382_x_at 206385_s_at 203908_at 215388_s_at 206664_at 203913_s_at 215657_at 207126_x_at 203914_x_at 216207_x_at 207245_at 203951_at 216401_x_at 207390_s_at 203980_at 216442_x_at 207392_x_at 204069_at 216474_x_at 207432_at 204083_s_at 216576_x_at 207761_s_at 204122_at 216834_at 208596_s_at 204135_at 216984_x_at 208920_at 204326_x_at 217148_x_at 209114_at 204438_at 217179_x_at 209374_s_at 204457_s_at 217235_x_at 209458_x_at 204570_at 217258_x_at 209791_at 204688_at 217378_x_at 210107_at 204697_s_at 217480_x_at 210524_x_at 204719_at 217546_at 210735_s_at 204745_x_at 217757_at 211372_s_at 204834_at 217762_s_at 211538_s_at 204894_s_at 217764_s_at 211549_s_at 204931_at 217767_at 211637_x_at 204938_s_at 217897_at 211699_x_at 204939_s_at 217967_s_at 211745_x_at 204940_at 218087_s_at 212224_at 204955_at 218162_at 212592_at 205097_at 218224_at 212741_at 205200_at 218312_s_at 212814_at 205267_at 218353_at 213317_at 205382_s_at 218418_s_at 213451_x_at 205412_at 218468_s_at 213629_x_at 205433_at 218469_at 213921_at 205464_at 218559_s_at 213953_at 205547_s_at 218756_s_at 214164_x_at 205683_x_at 219014_at 214433_s_at 205935_at 219087_at 214598_at 205950_s_at 219508_at 214916_x_at 206134_at 219607_s_at 215125_s_at 206143_at 219669_at 215299_x_at 206149_at 219799_s_at 215867_x_at 206198_s_at 220026_at 216336_x_at 206199_at 220037_s_at 216491_x_at 206208_at 220376_at 216510_x_at 206209_s_at 220834_at 217022_s_at 206422_at 221541_at 217109_at 206461_x_at 221667_s_at 217110_s_at 206561_s_at 221747_at 217165_x_at 206576_s_at 221748_s_at 217232_x_at 206637_at 222043_at 217414_x_at 206641_at 222162_s_at 218541_s_at 206710_s_at 222453_at 218546_at 206784_at 222513_s_at 219059_s_at 207003_at 222717_at 219543_at 207080_s_at 222722_at 219796_s_at 207134_x_at 223121_s_at 219948_x_at 207266_x_at 223122_s_at 220075_s_at 207502_at 223235_s_at 220266_s_at 207961_x_at 223343_at 220468_at 207977_s_at 223395_at 220645_at 207980_s_at 223551_at 220812_s_at 208131_s_at 223623_at 221004_s_at 208370_s_at 223952_x_at 221305_s_at 208383_s_at 224009_x_at 221584_s_at 208399_s_at 224352_s_at 221841_s_at 208450_at 224412_s_at 221896_s_at 208581_x_at 224480_s_at 223484_at 208747_s_at 224560_at 223597_at 208763_s_at 224663_s_at 223754_at 208788_at 224694_at 224342_x_at 208789_at 224823_at 224989_at 208791_at 224836_at 224990_at 208792_s_at 224840_at 225458_at 208894_at 224959_at 225728_at 209047_at 224963_at 226147_s_at 209074_s_at 224964_s_at 226302_at 209101_at 225207_at 226594_at 209116_x_at 225242_s_at 226654_at 209138_x_at 225269_s_at 226811_at 209147_s_at 225275_at 227052_at 209156_s_at 225353_s_at 227522_at 209167_at 225381_at 227682_at 209170_s_at 225442_at 227725_at 209191_at 225575_at 227735_s_at 209209_s_at 225602_at 227736_at 209210_s_at 225604_s_at 228133_s_at 209283_at 225626_at 228195_at 209301_at 225688_s_at 228232_s_at 209312_x_at 225710_at 228241_at 209335_at 225720_at 228469_at 209357_at 225721_at 228961_at 209373_at 225782_at 229070_at 209436_at 225894_at 229254_at 209457_at 225895_at 229659_s_at 209496_at 226001_at 229831_at 209498_at 226051_at 230595_at 209612_s_at 226084_at 231925_at 209613_s_at 226103_at 231975_s_at 209621_s_at 226303_at 233565_s_at 209651_at 226304_at 235146_at 209656_s_at 226333_at 235766_x_at 209667_at 226430_at 235849_at 209668_x_at 226492_at 238143_at 209687_at 226682_at 238750_at 209735_at 226694_at 238751_at 209763_at 226818_at 239272_at 209868_s_at 226834_at 241994_at 209948_at 226841_at 242447_at 210084_x_at 227006_at 242601_at 227099_s_at 227061_at 243278_at; and/or

-   -   (ii)

CLCA4 SGK MT1X ZG16 CFL2 AOC3 CA2 C1S PPAP2A CA1 SELENBP1 ZSCAN18 MS4A12 MT1E IVD AQP8 ADAMTS1 SFRP1 SLC4A4 ITM2A COL4A2 CEACAM7 POU2AF1 GPM6B TAGLN FAM55D EPB41L3 GUCA1B C6orf204 MAOA GCG AKAP12 DMD ADH1B TUBB6 MSRB3 UGT2B17 LGALS2 PLOD2 ADAMDEC1 KIAA0828 C9orf19 MT1M MGC14376 MIER3 AKR1B10 PPP1R14A XDH FN1 MUC4 CLDN23 MGP PKIB SGCE CXCL12 PIGR FOXF2 PDK4 ASPN AGR3 CA4 A2M IGLJ3 PYY LOC25845 QKI IGHA1 LGALS1 LOC399959 TPM2 BCHE ANKRD25 C6orf105 ST6GALNAC1 CRISPLD2 HPGD GJA1 ANK2 ADH1C SCNN1B LOC283666 CLCA1 FABP4 CRYAB FABP1 F13A1 ACAT1 ENAM CD36 IGL@ CFD SPARCL1 PBLD GUCA2B ZCWPW2 CCL8 FBLN1 TNC LIFR LOC63928 MT1A HLA-DRB1 ABCA8 LOC652745 UGP2 POSTN MALL IGKV1D-13 DCN GNG2 AP1S2 ITLN1 DNASE1L3 EMP3 COL6A2 EGR1 MMP28 FCGBP CMBL UGT2A3 SLC26A2 GCNT3 RGS5 PGM5 SERPING1 PTGIS DMN MEIS1 DUSP5 GPNMB EDN3 MFAP4 IGFBP5 MSN UGT1A6 CLEC3B MT1G PRKAR2B LOC253012 TPSAB1 HHLA2 DPT GPX3 LOC652128 PCK1 CDKN2B C3 CNN1 FOSB ATP2B4 HSD17B2 HSPA1A HBA1 PLAC8 CYBRD1 TCF21 TMEM47 PTGER4 PPID OGN MAG1 PPAP2B CALD1 BEST2 SPON1 ACTG2 HLA-DQA1 PHLDB2 MGC4172 PRIMA1 RARRES2 MAB21L2 MT1F ETHE1 RPL24 MAFB MMP2 ABCG2 FAM107A SRI CCDC80 PRKACB CNTN3 UGT1A1 SELM RGS2 MRC1 TYROBP COL6A1 HSD11B2 TNS1 FBN1 ANPEP MYH11 MXD1 MATN2 ITM2C PLCE1 PRNP CES2 KCNMB1 ABI3BP MS4A4A CALM1 HLA-C PDGFRA HLA-DPB1 NDE1 CA12 SMOC2 SRPX FKBP5 LOC285382 WWTR1 HSPB8 CLIC5 HMGCS2 TPSB2 APOE LOC646627 FGL2 SERPINF1 KRT20 C1QB PPP1R12B KLF4 ANGPTL1 HSPB6 FHL1 MEP1A FNBP1 ARL14 GUCY1A3 C4orf34 LUM UGDH SORBS2 SORBS1 DUSP1 GPA33 METTL7A C2orf40 GALNAC4S-6ST FAM129A PLN CFHR1 SCARA5 UGT2B15 MGC13057 SI PDLIM3 C10orf56 ACTA2 TP53INP2 SULT1A1 CD177 ATP8B1 TTRAP C10orf99 ANK3 CCL28 COL15A1 CTGF IDH3A NR3C2 MUCDHL EDG2 DHRS9 SDPR UGT1A8 LMOD1 COL14A1 RAB27A EFEMP1 DSCR1 ANTXR1 GREM1 CITED2 EMP1 IL1R2 MT1H CSRP1 LOC387763 NEXN PLEKHC1 TIMP3 MUC2 LOC572558 MYLK NID1 FOXP2 CLDN8 HBB HSPA2 RDX GCNT2 ATP1A2 TSPAN7 C20orf118 TNXB TNFRSF17 SLC20A1 FUCA1 SYNPO2 CD14 MRGPRF VIM KCTD12 HIGD1A SMPDL3A RBMS1 MFSD4 P2RY14 PTRF AXL CHGA TSPAN1 AQP1 C15orf48 UGT1A9 MAP1B COL3A1 COX7A1 PALLD CYR61 MUC12 MPEG1 TRPM6 PDCD4 KLHL5 OSTbeta CAV1 TCEAL7 IGLV1-44 FAM46C FILIP1L VSIG2 LRIG1 IQGAP2 IGHM HLA-DPA1 PRDX6 LRRC19 C1orf115 RAB31 CD163 HBA2 LOC96610 CEACAM1 EDIL3 FGFR2 TIMP2 DES PAPSS2 ENTPD5 MT2A XLKD1 DDR2 KCNMA1 SMTN CHRDL1 GAS1 C8orf4 SRGN TBC1D9 SDCBP2 PDE9A C7 CCL11 PMP22 P2RY1 ELOVL5 FLNA NR3C1 FOXF1 STMN2 STOM RELL1 MYL9 CKB PNMA1 SEMA6D CLU LOC339562 PADI2 SLC26A3 PALM2-AKAP2 SEPP1 SDC2 PAG1 TGFB1I1 SST HCLS1 SFRP2 HLA-DRA RGS1 UGT1A3 TSC22D3 FXYD6 MS4A7 IL6ST OLFML3 ALDH1A1 C1QC COL6A3 in a biological sample from said individual wherein a lower level of expression of the genes or transcripts of group (i) and/or group (ii) relative to control levels is indicative of a neoplastic large intestine cell or a cell predisposed to the onset of a neoplastic state.

Another aspect of the present invention provides a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:         -   220026_at; and/or     -   (ii) CLCA4         in a biological sample from said individual wherein a lower         level of expression of the gene or transcripts of group (i)         and/or group (ii) relative to control levels is indicative of a         neoplastic large intestine cell or a cell predisposed to the         onset of a neoplastic state.

In yet another aspect there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:         -   214142_at; and/or     -   (ii) ZG16         in a biological sample from said individual wherein a lower         level of expression of the genes or transcripts of group (i)         and/or group (ii) relative to control levels is indicative of a         neoplastic large intestine cell or a cell predisposed to the         onset of a neoplastic state.

In still another aspect there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:         -   209301_at 205950_s_at; and/or     -   (ii) CA2 CA1         in a biological sample from said individual wherein a lower         level of expression of the genes or transcripts of group (i)         and/or group (ii) relative to control levels is indicative of a         neoplastic large intestine cell or a cell predisposed to the         onset of a neoplastic state.

In still yet another aspect there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:         -   220834_at; and/or     -   (ii) MS4A12         in a biological sample from said individual wherein a lower         level of expression of the genes or transcripts of group (i)         and/or group (ii) relative to control levels is indicative of a         neoplastic large intestine cell or a cell predisposed to the         onset of a neoplastic state.

In yet still another aspect there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:         -   206784_at; and/or     -   (ii) AQP8         in a biological sample from said individual wherein a lower         level of expression of the genes or transcripts of group (i)         and/or group (ii) relative to control levels is indicative of a         neoplastic large intestine cell or a cell predisposed to the         onset of a neoplastic state.

In a further aspect there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   the gene, genes or transcripts detected by Affymetrix probeset         IDs:         -   203908_at, 206198_s_at, 205547_s_at, 207003_at, 206422_at,             209613_s_at, 207245_at; and/or     -   (ii) SLC4A4, CEACAM7, TAGLN, GUCA1B, GCG, ADH1B,         -   UGT2B17,             in a biological sample from said individual wherein a lower             level of expression of the genes or transcripts of group (i)             and/or group (ii) relative to control levels is indicative             of a neoplastic large intestine cell or a cell predisposed             to the onset of a neoplastic state.

In another further aspect there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   the gene, genes or transcripts detected by Affymetrix probeset         IDs:         -   203908_at, 206198_s_at, 205547_s_at, 207003_at, 206422_at,             209613_s_at, 207245_at; and/or     -   (ii) SLC4A4, CEACAM7, TAGLN, GUCA1B, GCG, ADH1B,         -   UGT2B17,             in a biological sample from said individual wherein a lower             level of expression of the genes or transcripts of group (i)             and/or group (ii) relative to control levels is indicative             of a neoplastic large intestine cell or a cell predisposed             to the onset of a neoplastic state.

In still another further aspect there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising screening the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:

225207_at 211548_s_at 205382_s_at 206208_at 206262_at 207502_at 207080_s_at 210107_at 202995_s_at 215118_s_at 205892_s_at 206149_at 204083_s_at 212592_at 204719_at 229070_at; and/or

-   -   (ii)

PDK4 HPGD CFD CA4 ADH1C GUCA2B PYY CLCA1 FBLN1 IGHA1 FABP1 LOC63928 TPM2 ENAM ABCA8 C6orf105 in a biological sample from said individual wherein a lower level of expression of the genes or transcripts of group (i) and/or group (ii) relative to control levels is indicative of a neoplastic large intestine cell or a cell predisposed to the onset of a neoplastic state.

In yet still yet another further aspect there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising screening the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:

210809_s_at 201617_x_at 202133_at 201893_x_at 202274_at 204607_at 223597_at 218756_s_at 238143_at 209156_s_at 210302_s_at 213953_at 203240_at 228885_at 220266_s_at 224963_at 209735_at 210299_s_at 226303_at 228504_at 220468_at 212730_at 225242_s_at 201744_s_at 201141_at 215125_s_at 218087_s_at 211959_at 204438_at 207761_s_at 205200_at 204130_at 217967_s_at 242601_at 202888_s_at 229839_at 213068_at 202350_s_at 206664_at 208383_s_at 201300_s_at 200974_at 203951_at 223395_at 219669_at 204818_at 214768_x_at 227736_at 219014_at 228133_s_at 203477_at 209656_s_at 204955_at 205259_at 222722_at; and/or

-   -   (ii)

POSTN OGN WWTR1 DCN CALD1 HMGCS2 ITLN1 ACTG2 LOC646627 COL6A2 MGC4172 KRT20 FCGBP MAB21L2 KLF4 SLC26A2 RPL24 FHL1 PGM5 ABCG2 ARL14 DMN CCDC80 LUM GPNMB UGT1A1 SORBS1 IGFBP5 MRC1 METTL7A CLEC3B HSD11B2 FAM129A LOC253012 ANPEP SCARA5 DPT MATN2 SI PCK1 PRNP ACTA2 CNN1 ABI3BP CD177 HSD17B2 HLA-C C10orf99 PLAC8 NDE1 COL15A1 TMEM47 SRPX NR3C2 in a biological sample from said individual wherein a lower level of expression of the genes or transcripts of group (i) and/or group (ii) relative to control levels is indicative of a neoplastic large intestine cell or a cell predisposed to the onset of a neoplastic state.

In a related aspect the present invention is directed to a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising screening the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:

200600_at 200665_s_at 200799_at 200845_s_at 200859_x_at 200897_s_at 200974_at 200986_at 201041_s_at 201061_s_at 201069_at 201105_at 201137_s_at 201141_at 201150_s_at 201289_at 201300_s_at 201426_s_at 201438_at 201616_s_at 201617_x_at 201645_at 201667_at 201743_at 201744_s_at 201842_s_at 201852_x_at 201858_s_at 201859_at 201865_x_at 201893_x_at 201920_at 202007_at 202069_s_at 202133_at 202283_at 202291_s_at 202403_s_at 202620_s_at 202686_s_at 202760_s_at 202766_s_at 202953_at 202957_at 202994_s_at 202995_s_at 203066_at 203131_at 203305_at 203382_s_at 203477_at 203645_s_at 203680_at 203729_at 203748_x_at 204069_at 204122_at 204135_at 204438_at 204457_s_at 204570_at 204688_at 205412_at 205683_x_at 205935_at 207134_x_at 207266_x_at 208131_s_at 208370_s_at 208747_s_at 208788_at 208789_at 208894_at 209047_at 209101_at 209138_x_at 209147_s_at 209156_s_at 209191_at 209209_s_at 209210_s_at 209312_x_at 209335_at 209436_at 209457_at 209496_at 209621_s_at 209651_at 209656_s_at 209868_s_at 210084_x_at 210133_at 210139_s_at 210495_x_at 210517_s_at 210764_s_at 210809_s_at 210982_s_at 211161_s_at 211596_s_at 211671_s_at 211719_x_at 211813_x_at 211896_s_at 211959_at 211964_at 211985_s_at 211990_at 211991_s_at 212077_at 212091_s_at 212136_at 212158_at 212185_x_at 212195_at 212230_at 212233_at 212265_at 212386_at 212387_at 212397_at 212414_s_at 212419_at 212464_s_at 212667_at 212671_s_at 212713_at 212764_at 212956_at 213428_s_at 213509_x_at 213746_s_at 213891_s_at 214038_at 214677_x_at 214752_x_at 215049_x_at 215076_s_at 215193_x_at 215382_x_at 215388_s_at 216442_x_at 216474_x_at 216834_at 217480_x_at 217757_at 217762_s_at 217764_s_at 217767_at 217897_at 218162_at 218224_at 218312_s_at 218353_at 218418_s_at 218468_s_at 218469_at 218559_s_at 219087_at 219607_s_at 221541_at 222043_at 222453_at 222513_s_at 223121_s_at 223122_s_at 223235_s_at 223343_at 224560_at 224694_at 224840_at 224964_s_at 225242_s_at 225269_s_at 225353_s_at 225381_at 225442_at 225602_at 225604_s_at 225626_at 225688_s_at 225710_at 226001_at 226051_at 226084_at 226103_at 226430_at 226682_at 226694_at 226818_at 226834_at 226841_at 227061_at 227099_s_at 227235_at 227404_s_at 227529_s_at 227561_at 227623_at 227705_at 227727_at 228507_at 228750_at 228846_at 229530_at 230264_s_at 231579_s_at 234987_at; and/or

-   -   (ii)

A2M ACAT1 ACTA2 AKAP12 ANKRD25 ANTXR1 AP1S2 APOE AQP1 ASPN ATP2B4 AXL C10orf56 C1QB C1QC C1S C20orf118 C3 C9orf19 CALD1 CALM1 CCDC80 CCL11 CCL8 CD14 CD163 CES2 CFHR1 CLU COL14A1 COL15A1 COL1A2 COL3A1 COL4A2 COL6A1 COL6A2 COL6A3 COX7A1 CRISPLD2 CTGF CYBRD1 CYR61 DCN DDR2 DSCR1 DUSP1 DUSP5 EFEMP1 EGR1 ELOVL5 EMP3 F13A1 FBLN1 FBN1 FILIP1L FKBP5 FLNA FN1 FOXF1 FXYD6 GALNAC4S-6ST GAS1 GJA1 GNG2 GPNMB GREM1 GUCY1A3 HCLS1 HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DRA HLA-DRB1 HSPA1A IDH3A IGFBP5 IGL@ IGLJ3 IL6ST KLHL5 LGALS1 LOC283666 LOC339562 LOC387763 LOC399959 LRIG1 LUM MAFB MAP1B MEIS1 MFAP4 MGP MMP2 MPEG1 MRC1 MRGPRF MS4A4A MS4A7 MSN MT2A MXD1 NEXN NID1 NR3C1 OLFML3 PAG1 PALLD PALM2-AKAP2 PDGFRA PDLIM3 PHLDB2 PLEKHC1 PLOD2 PMP22 PNMA1 POSTN PPAP2A PPAP2B PRDX6 PRKAR2B PRNP PTGIS PTRF QKI RAB31 RARRES2 RBMS1 RDX RELL1 RGS1 RGS5 SDC2 SELM SEPT6 SERPINF1 SERPING1 SFRP2 SGCE SLC20A1 SMOC2 SORBS1 SPARC SPON1 SRGN STOM TBC1D9 TCEAL7 TGFB1I1 TIMP2 TIMP3 TMEM47 TNC TPSAB1 TPSB2 TUBB6 TYROBP VIM WWTR1 ZSCAN18 in a biological sample from said individual wherein a lower level of expression of the genes or transcripts of group (i) and/or group (ii) relative to control levels is indicative of an adenoma cell or a cell predisposed to the onset of an adenoma state.

In another aspect of the present invention there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising screening the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene or genes detected by Affymetrix probeset IDs:

200884_at 201495_x_at 202266_at 202350_s_at 202731_at 202741_at 202742_s_at 202768_at 202838_at 203058_s_at 203060_s_at 203240_at 203296_s_at 203343_at 203474_at 203638_s_at 203963_at 204018_x_at 204034_at 204036_at 204130_at 204388_s_at 204389_at 204508_s_at 204532_x_at 204607_at 204673_at 204818_at 204895_x_at 204897_at 205112_at 205259_at 205403_at 205480_s_at 205554_s_at 205593_s_at 205892_s_at 205929_at 206000_at 206094_x_at 206262_at 206377_at 206385_s_at 206664_at 207126_x_at 207245_at 207390_s_at 207392_x_at 207432_at 207761_s_at 208596_s_at 208920_at 209114_at 209374_s_at 209458_x_at 209791_at 210107_at 210524_x_at 210735_s_at 211372_s_at 211538_s_at 211549_s_at 211637_x_at 211699_x_at 211745_x_at 212224_at 212592_at 212741_at 212814_at 213317_at 213451_x_at 213629_x_at 213921_at 213953_at 214164_x_at 214433_s_at 214598_at 214916_x_at 215125_s_at 215299_x_at 215867_x_at 216336_x_at 216491_x_at 216510_x_at 217022_s_at 217109_at 217110_s_at 217165_x_at 217232_x_at 217414_x_at 218541_s_at 218546_at 219059_s_at 219543_at 219796_s_at 219948_x_at 220075_s_at 220266_s_at 220468_at 220645_at 220812_s_at 221004_s_at 221305_s_at 221584_s_at 221841_s_at 221896_s_at 223484_at 223597_at 223754_at 224342_x_at 224989_at 224990_at 225458_at 225728_at 226147_s_at 226302_at 226594_at 226654_at 226811_at 227052_at 227522_at 227682_at 227725_at 227735_s_at 227736_at 228133_s_at 228195_at 228232_s_at 228241_at 228469_at 228961_at 229070_at 229254_at 229659_s_at 229831_at 230595_at 231925_at 231975_s_at 233565_s_at 235146_at 235766_x_at 235849_at 238143_at 238750_at 238751_at 239272_at 241994_at 242447_at 242601_at 243278_at; and/or

-   -   (ii)

ADH1C AGR3 ALDH1A1 ANK3 ARL14 ATP1A2 ATP8B1 BEST2 C10orf99 C15orf48 C1orf115 C4orf34 C6orf105 C8orf4 CA12 CCL28 CKB CLCA1 CLDN8 CLIC5 CMBL CNTN3 DNASE1L3 EDG2 ENAM ENTPD5 ETHE1 FABP1 FAM46C FAM55D FCGBP FGFR2 FOSB FOXF2 FOXP2 FUCA1 GPA33 HBA1 HBA2 HBB HHLA2 HIGD1A HMGCS2 HPGD HSD11B2 HSD17B2 HSPA2 IGHA1 IGHM IL1R2 IL8 IQGAP2 ITLN1 ITM2C KCNMA1 KIAA0828 KLF4 KRT20 LOC253012 LOC25845 LOC285382 LOC572558 LOC646627 LOC652128 LOC96610 MAOA MATN2 MEP1A METTL7A MFSD4 MGC13057 MIER3 MMP28 MT1A MT1F MT1M MUC12 MUC2 MUC4 MUCDHL MYH11 NDE1 NR3C2 P2RY1 PADI2 PAPSS2 PBLD PDCD4 PDE9A PIGR PLCE1 PPID PRKACB PTGER4 RAB27A SCARA5 SDCBP2 SELENBP1 SI SMTN SORBS2 SRI SST ST6GALNAC1 SULT1A1 TNXB TSPAN1 TTRAP UGDH UGP2 UGT1A1 UGT1A3 UGT1A6 UGT1A8 UGT1A9 UGT2A3 UGT2B15 UGT2B17 VSIG2 XDH XLKD1 ZCWPW2 in a biological sample from said individual wherein a lower level of expression of the genes or transcripts of group (i) and/or group (ii) relative to control levels is indicative of a cancer cell or a cell predisposed to the onset of a cancerous state.

In still another aspect there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising screening the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:

202920_at 222717_at 231120_x_at 203881_s_at 224412_s_at 231773_at 204719_at 225381_at 203296_s_at 204931_at 225575_at 206664_at 204940_at 227529_s_at 211549_s_at 205433_at 227623_at 214598_at 206637_at 227705_at 219948_x_at 207080_s_at 227827_at 220812_s_at 207980_s_at 228504_at 221305_s_at 209170_s_at 228706_s_at 229831_at 209209_s_at 228766_at 231925_at 209613_s_at 228854_at 235146_at 220037_s_at 228885_at 238751_at 220376_at 230788_at 243278_at; and/or

-   -   (ii)

ADH1B ANGPTL1 HHLA2 SORBS2 DMD SORBS2 PYY GCNT2 CLDN23 ABCA8 SDPR CNTN3 RPL24 PKIB PLEKHC1 SI CITED2 LRRC19 CLDN8 TCF21 LIFR P2RY14 P2RY1 ATP1A2 PLN ANK2 HPGD TRPM6 XLKD1 GPM6B CD36 LOC399959 UGT1A8 BCHE AKAP12 FOXP2 TCEAL7 UGT2A3 in a biological sample from said individual wherein a level of expression of the genes or transcripts of group (i) and/or group (ii) which is not substantially above background levels is indicative of a neoplastic cell or a cell predisposed to the onset of a neoplastic state.

In a further aspect there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising screening the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:         -   209209_s_at, 225381_at, 227529_s_at, 227623_at, 227705_at;             and/or     -   (ii) AKAP12, LOC399959, PLEKHC1, TCEAL7,         in a biological sample from said individual wherein a lower         level of expression of the genes or transcripts of group (i)         and/or group (ii) which is not substantially above background         levels is indicative of an adenoma cell or a cell predisposed to         the onset of an adenoma state.

In yet still another further aspect there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising screening the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:

203296_s_at 206664_at 211549_s_at 214598_at 219948_x_at 220812_s_at 221305_s_at 229831_at 231925_at 235146_at 238751_at 243278_at; and/or

-   -   (ii)

ATP1A2 CLDN8 CNTN3 FOXP2 HHLA2 HPGD P2RY1 SI SORBS2 UGT1A8 UGT2A3 in a biological sample from said individual wherein a lower level of expression of the genes or transcripts of group (i) and/or group (ii) which is not substantially above background levels is indicative of a cancer cell or a cell predisposed to the onset of a cancerous state.

In another further aspect there is provided a method of characterising a neoplastic cell or cellular population, which cell or cellular population is derived from the large intestine of an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:

200600_at 204006_s_at 213428_s_at 200665_s_at 204051_s_at 213524_s_at 200832_s_at 204122_at 213869_x_at 200974_at 204320_at 213905_x_at 200986_at 204475_at 214247_s_at 201058_s_at 204620_s_at 215049_x_at 201069_at 205479_s_at 215076_s_at 201105_at 205547_s_at 215646_s_at 201141_at 205828_at 216442_x_at 201147_s_at 207173_x_at 217430_x_at 201150_s_at 207191_s_at 217762_s_at 201162_at 208747_s_at 217763_s_at 201163_s_at 208782_at 217764_s_at 201185_at 208788_at 218468_s_at 201261_x_at 208850_s_at 218469_at 201289_at 208851_s_at 218559_s_at 201426_s_at 209101_at 218638_s_at 201438_at 209156_s_at 219087_at 201616_s_at 209218_at 221011_s_at 201645_at 209395_at 221729_at 201667_at 209396_s_at 221730_at 201744_s_at 209596_at 221731_x_at 201792_at 209875_s_at 37892_at 201842_s_at 209955_s_at 223122_s_at 201852_x_at 210095_s_at 223235_s_at 201859_at 210495_x_at 224560_at 201893_x_at 210511_s_at 224694_at 202237_at 210764_s_at 224724_at 202238_s_at 210809_s_at 225664_at 202283_at 211161_s_at 225681_at 202291_s_at 211571_s_at 225710_at 202310_s_at 211719_x_at 225799_at 202311_s_at 211813_x_at 226237_at 202403_s_at 211896_s_at 226311_at 202404_s_at 211959_at 226694_at 202450_s_at 211964_at 226777_at 202620_s_at 211966_at 226930_at 202766_s_at 211980_at 227099_s_at 202859_x_at 211981_at 227140_at 202878_s_at 212077_at 227566_at 202917_s_at 212344_at 229218_at 202998_s_at 212353_at 229802_at 203083_at 212354_at 231579_s_at 203325_s_at 212464_s_at 231766_s_at 203382_s_at 212488_at 231879_at 203477_at 212489_at 232458_at 203570_at 212667_at 233555_s_at 203645_s_at 213125_at 234994_at; and/or 203878_s_at

-   -   (ii)

COL1A2 LGALS1 SRGN CTHRC1 ELOVL5 LBH FN1 MGP CTGF POSTN MMP2 TNC SPP1 LOXL2 G0S2 MMP1 MYL9 SQLE SPARC DCN EFEMP1 LUM CALD1 APOE GREM1 FBN1 MSN IL8 MMP3 IGFBP3 IGFBP5 IGFBP7 SERPINF1 SFRP2 FSTL1 ISLR SULF1 COL4A2 HNT ASPN VCAN COL5A1 COL6A3 SMOC2 OLFML2B COL8A1 HTRA1 KIAA1913 COL12A1 CYR61 PALM2-AKAP2 COL5A2 FAP SERPING1 CDH11 VIM TYROBP THBS2 TIMP2 ACTA2 COL15A1 SCD COL3A1 COL11A1 TIMP3 PLOD2 S100A8 AEBP1 MMP11 FNDC1 GJA1 CD163 SFRP4 NNMT FCGR3B INHBA COL1A1 PLAU COL6A2 SULF2 MAFB ANTXR1 COL6A1 LOC541471 GPNMB SPON2 LOC387763 BGN CTSK CHI3L1 TAGLN MXRA5 THY1 COL4A1 C1S LOXL1 RAB31 DKK3 CD93 in said cell or cellular population wherein a lower level of expression of the genes of group (i) and/or group (ii) relative to a gastrointestinal cancer control level is indicative of an adenoma cell or a cell predisposed to the onset of an adenoma state.

In still another aspect there is provided a method of characterising a neoplastic cell or cellular population, which cell or cellular population is derived from the large intestine of an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:

200884_at 203240_at 203963_at 204508_s_at 204607_at 204811_s_at 204895_x_at 204897_at 205259_at 205765_at 205927_s_at 208063_s_at 208937_s_at 210107_at 213106_at 214234_s_at 214235_at 214433_s_at 215125_s_at 215867_x_at 217109_at 217110_s_at 218211_s_at 219543_at 219955_at 221841_s_at 221874_at 223969_s_at 223970_at 226248_s_at 226302_at 227676_at 227719_at 227725_at 228232_s_at 229070_at 231832_at 232176_at 232481_s_at 235976_at 236894_at 237521_x_at 242601_at; and/or

-   -   (ii)

CLCA1 CTSE ATP8B1 FCGBP C6orf105 CACNA2D2 HMGCS2 CKB KLF4 RETNLB ATP8A1 CYP3A5P2 L1TD1 MUC4 CAPN9 SLITRK6 UGT1A1 NR3C2 VSIG2 SELENBP1 PBLD LOC253012 PTGER4 CA12 ST6GALNAC1 MLPH WDR51B ID1 KIAA1324 FAM3D CYP3A5 in a biological sample from said individual wherein a lower level of expression of the genes or transcripts of group (i) and/or group (ii) relative to a gastrointestinal adenoma control level is indicative of a cancer or a cell predisposed to the onset of a cancerous state.

In yet another aspect there is provided a method of characterising a neoplastic cell or cellular population, which cell or cellular population is derived from the large intestine of an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene or genes detected by Affymetrix probeset IDs:         -   202404_s_at, 212464_s_at, 210809_s_at, 225681_at; and/or     -   (ii) COL1A2, FN1, POSTN, CTHRC1         in a biological sample from said individual wherein a lower         level of expression of the genes or transcripts of group (i)         and/or group (ii) relative to a gastrointestinal cancer control         level is indicative of an adenoma cell or a cell predisposed to         the onset of an adenoma state.

In yet still another aspect, there is provided a method of characterising a neoplastic cell or cellular population, which cell or cellular population is derived from the large intestine of an individual, said method comprising assessing the level of expression of one or more genes selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:         -   209875_s_at 227140_at 204475_at; and/or     -   (ii) SPP1 MMP1         in a biological sample from said individual wherein a lower         level of expression of the genes or transcripts of group (i)         and/or group (ii) relative to a gastrointestinal cancer control         level is indicative of an adenoma cell or a cell predisposed to         the onset of an adenoma state.

In still yet another aspect the present invention is directed to a method of characterising a cell or cellular population, which cell or cellular population is derived from the large intestine of an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:

200665_s_at 226237_at 226930_at 201744_s_at 225664_at 204051_s_at 218468_s_at 221730_at 210511_s_at 202859_x_at 207173_x_at 209156_s_at 211959_at 203083_at 224694_at 223122_s_at 203477_at 201141_at 212353_at 37892_at 213905_x_at 219087_at 202917_s_at 205547_s_at 201438_at; and/or

-   -   (ii)

SPARC COL8A1 SFRP4 LUM COL12A1 INHBA GREM1 COL5A2 COL6A2 IL8 CDH11 ANTXR1 IGFBP5 THBS2 GPNMB SFRP2 COL15A1 BGN SULF1 COL11A1 TAGLN ASPN S100A8 COL6A3 FNDC1 in a biological sample from said individual wherein a lower level of expression of the genes or transcripts of group (i) and/or (ii) relative to a gastrointestinal cancer control level is indicative of an adenoma or a cell predisposed to the onset of an adenoma state.

In yet another aspect the present invention is directed to a method of characterising a cell or cellular population, which cell or cellular population is derived from the large intestine of an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:         -   210107_at; and/or     -   (ii) CLCA1         in a biological sample from said individual wherein a lower         level of expression of the genes or transcripts of group (i)         and/or (ii) relative to a gastrointestinal adenoma control level         is indicative of a cancer or a cell predisposed to the onset of         a cancerous state.

In still yet another aspect the present invention is directed to a method of characterising a cell or cellular population, which cell or cellular population is derived from the large intestine of an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:

203240_at 219955_at 242601_at 204607_at 232481_s_at 227725_at 223969_s_at 228232_s_at; and/or

-   -   (ii)

FCGBP L1TD1 LOC253012 HMGCS2 SLITRK6 ST6GALNAC1 RETNLB VSIG2 in a biological sample from said individual wherein a lower level of expression of the genes or transcripts of group (i) and/or (ii) relative to a gastrointestinal adenoma control level is indicative of a cancer or a cell predisposed to the onset of a cancerous state.

A further aspect of the present invention provides a method of characterising a neoplastic cell or cellular population, which cell or cellular population is derived from the large intestine of an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene or genes detected by Affymetrix probeset IDs:         -   235976_at 236894_at 237521; and/or     -   (ii) SLITRK6 L1TD1         in a biological sample from said individual wherein expression         of the genes or transcripts of group (i) and/or (ii) at a level         which is not substantially greater than background neoplastic         tissue levels is indicative of a cancer or a cell predisposed to         the onset of a cancerous state.

A related aspect of the present invention provides a molecular array, which array comprises a plurality of

-   (i) nucleic acid molecules comprising a nucleotide sequence     corresponding to any one or more of the neoplastic marker genes     hereinbefore described or a sequence exhibiting at least 80%     identity thereto or a functional derivative, fragment, variant or     homologue of said nucleic acid molecule; or -   (ii) nucleic acid molecules comprising a nucleotide sequence capable     of hybridising to any one or more of the sequences of (i) under     medium stringency conditions or a functional derivative, fragment,     variant or homologue of said nucleic acid molecule; or -   (iii) nucleic acid probes or oligonucleotides comprising a     nucleotide sequence capable of hybridising to any one or more of the     sequences of (i) under medium stringency conditions or a functional     derivative, fragment, variant or homologue of said nucleic acid     molecule; or -   (iv) probes capable of binding to any one or more of the proteins     encoded by the nucleic acid molecules of (i) or a derivative,     fragment or, homologue thereof     wherein the level of expression of said marker genes of (i) or     proteins of (iv) is indicative of the neoplastic state of a cell or     cellular subpopulation derived from the large intestine.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a graphical representation of alcohol dehydrogenase IB (class I), beta polypeptide.

FIG. 2 is a graphical representation of the methylation of MAMDC2 and GPM6B in normal and neoplastic tissues and cell lines. Panel A shows the methylation level of the MAMDC2 gene as assessed by methylation specific PCR, using amplification of the CAGE gene to normalise for input DNA levels. Each point represents an individual tissue sample or cell line. Samples included DNAs from 18 colorectal cancer tissues, 12 colorectal adenomas, 22 matched normal colorectal tissues, 6 other normal tissues and a cell line and 6 colon cancer cell lines. Panel B shows the relative level of methylation of the GPM6B gene assessed by a COBRA assay. Levels of methylation were scored between 0 (no restriction enzyme digestion) and 5 (complete restriction enzyme digestion). Each point represents a single tissue sample. Samples included 14 colorectal cancer tissues, 11 colorectal adenomas and 22 matched normal tissues.

FIG. 3 is a schematic representation of predicted RNA variants derived from hCG_(—)1815491. cDNA clones derived from map region 8579310 to 8562303 on human chromosome 16 were used to locate exon sequences. Arrows: Oligo nucleotide primer sets were designed to allow measurement of individual RNA variants by PCR. Primers covering splice junctions are shown as spanning intron sequences which is not included in the actual oligonucleotide primer sequence.

DETAILED DESCRIPTION OF THE INVENTION

The present invention is predicated, in part, on the elucidation of gene expression profiles which characterise large intestine cellular populations in terms of their neoplastic state and, more particularly, whether they are malignant or pre-malignant. This finding has now facilitated the development of routine means of screening for the onset or predisposition to the onset of a large intestine neoplasm or characterising cellular populations derived from the large intestine based on screening for downregulation of the expression of these molecules, relative to control expression patterns and levels. To this end, in addition to assessing expression levels of the subject genes relative to normal or non-neoplastic levels, it has been determined that a proportion of these genes are not expressed in the diseased state, thereby facilitating the development of a simple qualitative test based on requiring assessment only relative to test background levels.

In accordance with the present invention, it has been determined that the genes detailed above are modulated, in terms of differential changes to their levels of expression, depending on whether the cell expressing that gene is neoplastic or not. It should be understood that reference to a gene “expression product” or “expression of a gene” is a reference to either a transcription product (such as primary RNA or mRNA) or a translation product such as protein. In this regard, one can assess changes to the level of expression of a gene either by screening for changes to the level of expression product which is produced (i.e. RNA or protein), changes to the chromatin proteins with which the gene is associated, for example the presence of histone H3 methylated on lysine at amino acid position number 9 or 27 (repressive modifications) or changes to the DNA itself which acts to downregulate expression, such as changes to the methylation of the DNA. These genes and their gene expression products, whether they be RNA transcripts, changes to the DNA which act to downregulate expression or encoded proteins, are collectively referred to as “neoplastic markers”.

Accordingly, one aspect of the present invention is directed to a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:

200600_at 210133_at 227235_at 200621_at 210139_s_at 227265_at 200795_at 210298_x_at 227404_s_at 200799_at 210299_s_at 227529_s_at 200845_s_at 210302_s_at 227561_at 200859_x_at 210495_x_at 227623_at 200897_s_at 210517_s_at 227662_at 200974_at 210764_s_at 227705_at 200986_at 210809_s_at 227727_at 201041_s_at 210946_at 227826_s_at 201058_s_at 210982_s_at 227827_at 201061_s_at 211161_s_at 228202_at 201069_at 211548_s_at 228504_at 201105_at 211596_s_at 228507_at 201137_s_at 211643_x_at 228640_at 201141_at 211644_x_at 228706_s_at 201150_s_at 211645_x_at 228707_at 201289_at 211671_s_at 228750_at 201300_s_at 211696_x_at 228766_at 201324_at 211719_x_at 228846_at 201348_at 211798_x_at 228854_at 201426_s_at 211813_x_at 228885_at 201427_s_at 211848_s_at 229530_at 201438_at 211889_x_at 229839_at 201496_x_at 211896_s_at 230087_at 201497_x_at 211959_at 230264_s_at 201539_s_at 211964_at 230788_at 201540_at 211985_s_at 230830_at 201616_s_at 211990_at 231120_x_at 201617_x_at 211991_s_at 231579_s_at 201645_at 212077_at 231773_at 201667_at 212091_s_at 234764_x_at 201739_at 212097_at 234987_at 201743_at 212136_at 236300_at 201744_s_at 212158_at 236313_at 201842_s_at 212185_x_at 242317_at 201852_x_at 212192_at 200884_at 201858_s_at 212195_at 201495_x_at 201859_at 212230_at 202266_at 201865_x_at 212233_at 202350_s_at 201893_x_at 212265_at 202731_at 201920_at 212288_at 202741_at 201957_at 212386_at 202742_s_at 202007_at 212387_at 202768_at 202037_s_at 212397_at 202838_at 202069_s_at 212414_s_at 203058_s_at 202133_at 212419_at 203060_s_at 202222_s_at 212464_s_at 203240_at 202242_at 212667_at 203296_s_at 202274_at 212671_s_at 203343_at 202283_at 212713_at 203474_at 202291_s_at 212730_at 203638_s_at 202388_at 212764_at 203963_at 202555_s_at 212859_x_at 204018_x_at 202620_s_at 212956_at 204034_at 202686_s_at 213068_at 204036_at 202746_at 213071_at 204130_at 202760_s_at 213428_s_at 204388_s_at 202766_s_at 213509_x_at 204389_at 202888_s_at 213624_at 204508_s_at 202920_at 213746_s_at 204532_x_at 202953_at 213891_s_at 204607_at 202957_at 214027_x_at 204673_at 202992_at 214038_at 204818_at 202994_s_at 214091_s_at 204895_x_at 202995_s_at 214142_at 204897_at 203000_at 214414_x_at 205112_at 203001_s_at 214505_s_at 205259_at 203066_at 214677_x_at 205403_at 203131_at 214696_at 205480_s_at 203305_at 214752_x_at 205554_s_at 203382_s_at 214768_x_at 205593_s_at 203477_at 214777_at 205892_s_at 203645_s_at 215049_x_at 205929_at 203680_at 215076_s_at 206000_at 203729_at 215118_s_at 206094_x_at 203748_x_at 215176_x_at 206262_at 203766_s_at 215193_x_at 206377_at 203881_s_at 215382_x_at 206385_s_at 203908_at 215388_s_at 206664_at 203913_s_at 215657_at 207126_x_at 203914_x_at 216207_x_at 207245_at 203951_at 216401_x_at 207390_s_at 203980_at 216442_x_at 207392_x_at 204069_at 216474_x_at 207432_at 204083_s_at 216576_x_at 207761_s_at 204122_at 216834_at 208596_s_at 204135_at 216984_x_at 208920_at 204326_x_at 217148_x_at 209114_at 204438_at 217179_x_at 209374_s_at 204457_s_at 217235_x_at 209458_x_at 204570_at 217258_x_at 209791_at 204688_at 217378_x_at 210107_at 204697_s_at 217480_x_at 210524_x_at 204719_at 217546_at 210735_s_at 204745_x_at 217757_at 211372_s_at 204834_at 217762_s_at 211538_s_at 204894_s_at 217764_s_at 211549_s_at 204931_at 217767_at 211637_x_at 204938_s_at 217897_at 211699_x_at 204939_s_at 217967_s_at 211745_x_at 204940_at 218087_s_at 212224_at 204955_at 218162_at 212592_at 205097_at 218224_at 212741_at 205200_at 218312_s_at 212814_at 205267_at 218353_at 213317_at 205382_s_at 218418_s_at 213451_x_at 205412_at 218468_s_at 213629_x_at 205433_at 218469_at 213921_at 205464_at 218559_s_at 213953_at 205547_s_at 218756_s_at 214164_x_at 205683_x_at 219014_at 214433_s_at 205935_at 219087_at 214598_at 205950_s_at 219508_at 214916_x_at 206134_at 219607_s_at 215125_s_at 206143_at 219669_at 215299_x_at 206149_at 219799_s_at 215867_x_at 206198_s_at 220026_at 216336_x_at 206199_at 220037_s_at 216491_x_at 206208_at 220376_at 216510_x_at 206209_s_at 220834_at 217022_s_at 206422_at 221541_at 217109_at 206461_x_at 221667_s_at 217110_s_at 206561_s_at 221747_at 217165_x_at 206576_s_at 221748_s_at 217232_x_at 206637_at 222043_at 217414_x_at 206641_at 222162_s_at 218541_s_at 206710_s_at 222453_at 218546_at 206784_at 222513_s_at 219059_s_at 207003_at 222717_at 219543_at 207080_s_at 222722_at 219796_s_at 207134_x_at 223121_s_at 219948_x_at 207266_x_at 223122_s_at 220075_s_at 207502_at 223235_s_at 220266_s_at 207961_x_at 223343_at 220468_at 207977_s_at 223395_at 220645_at 207980_s_at 223551_at 220812_s_at 208131_s_at 223623_at 221004_s_at 208370_s_at 223952_x_at 221305_s_at 208383_s_at 224009_x_at 221584_s_at 208399_s_at 224352_s_at 221841_s_at 208450_at 224412_s_at 221896_s_at 208581_x_at 224480_s_at 223484_at 208747_s_at 224560_at 223597_at 208763_s_at 224663_s_at 223754_at 208788_at 224694_at 224342_x_at 208789_at 224823_at 224989_at 208791_at 224836_at 224990_at 208792_s_at 224840_at 225458_at 208894_at 224959_at 225728_at 209047_at 224963_at 226147_s_at 209074_s_at 224964_s_at 226302_at 209101_at 225207_at 226594_at 209116_x_at 225242_s_at 226654_at 209138_x_at 225269_s_at 226811_at 209147_s_at 225275_at 227052_at 209156_s_at 225353_s_at 227522_at 209167_at 225381_at 227682_at 209170_s_at 225442_at 227725_at 209191_at 225575_at 227735_s_at 209209_s_at 225602_at 227736_at 209210_s_at 225604_s_at 228133_s_at 209283_at 225626_at 228195_at 209301_at 225688_s_at 228232_s_at 209312_x_at 225710_at 228241_at 209335_at 225720_at 228469_at 209357_at 225721_at 228961_at 209373_at 225782_at 229070_at 209436_at 225894_at 229254_at 209457_at 225895_at 229659_s_at 209496_at 226001_at 229831_at 209498_at 226051_at 230595_at 209612_s_at 226084_at 231925_at 209613_s_at 226103_at 231975_s_at 209621_s_at 226303_at 233565_s_at 209651_at 226304_at 235146_at 209656_s_at 226333_at 235766_x_at 209667_at 226430_at 235849_at 209668_x_at 226492_at 238143_at 209687_at 226682_at 238750_at 209735_at 226694_at 238751_at 209763_at 226818_at 239272_at 209868_s_at 226834_at 241994_at 209948_at 226841_at 242447_at 210084_x_at 227006_at 242601_at 227099_s_at 227061_at 243278_at; and/or

-   -   (ii)

CLCA4 SGK MT1X ZG16 CFL2 AOC3 CA2 C1S PPAP2A CA1 SELENBP1 ZSCAN18 MS4A12 MT1E IVD AQP8 ADAMTS1 SFRP1 SLC4A4 ITM2A COL4A2 CEACAM7 POU2AF1 GPM6B TAGLN FAM55D EPB41L3 GUCA1B C6orf204 MAOA GCG AKAP12 DMD ADH1B TUBB6 MSRB3 UGT2B17 LGALS2 PLOD2 ADAMDEC1 KIAA0828 C9orf19 MT1M MGC14376 MIER3 AKR1B10 PPP1R14A XDH FN1 MUC4 CLDN23 MGP PKIB SGCE CXCL12 PIGR FOXF2 PDK4 ASPN AGR3 CA4 A2M IGLJ3 PYY LOC25845 QKI IGHA1 LGALS1 LOC399959 TPM2 BCHE ANKRD25 C6orf105 ST6GALNAC1 CRISPLD2 HPGD GJA1 ANK2 ADH1C SCNN1B LOC283666 CLCA1 FABP4 CRYAB FABP1 F13A1 ACAT1 ENAM CD36 IGL@ CFD SPARCL1 PBLD GUCA2B ZCWPW2 CCL8 FBLN1 TNC LIFR LOC63928 MT1A HLA-DRB1 ABCA8 LOC652745 UGP2 POSTN MALL IGKV1D-13 DCN GNG2 AP1S2 ITLN1 DNASE1L3 EMP3 COL6A2 EGR1 MMP28 FCGBP CMBL UGT2A3 SLC26A2 GCNT3 RGS5 PGM5 SERPING1 PTGIS DMN MEIS1 DUSP5 GPNMB EDN3 MFAP4 IGFBP5 MSN UGT1A6 CLEC3B MT1G PRKAR2B LOC253012 TPSAB1 HHLA2 DPT GPX3 LOC652128 PCK1 CDKN2B C3 CNN1 FOSB ATP2B4 HSD17B2 HSPA1A HBA1 PLAC8 CYBRD1 TCF21 TMEM47 PTGER4 PPID OGN MAG1 PPAP2B CALD1 BEST2 SPON1 ACTG2 HLA-DQA1 PHLDB2 MGC4172 PRIMA1 RARRES2 MAB21L2 MT1F ETHE1 RPL24 MAFB MMP2 ABCG2 FAM107A SRI CCDC80 PRKACB CNTN3 UGT1A1 SELM RGS2 MRC1 TYROBP COL6A1 HSD11B2 TNS1 FBN1 ANPEP MYH11 MXD1 MATN2 ITM2C PLCE1 PRNP CES2 KCNMB1 ABI3BP MS4A4A CALM1 HLA-C PDGFRA HLA-DPB1 NDE1 CA12 SMOC2 SRPX FKBP5 LOC285382 WWTR1 HSPB8 CLIC5 HMGCS2 TPSB2 APOE LOC646627 FGL2 SERPINF1 KRT20 C1QB PPP1R12B KLF4 ANGPTL1 HSPB6 FHL1 MEP1A FNBP1 ARL14 GUCY1A3 C4orf34 LUM UGDH SORBS2 SORBS1 DUSP1 GPA33 METTL7A C2orf40 GALNAC4S-6ST FAM129A PLN CFHR1 SCARA5 UGT2B15 MGC13057 SI PDLIM3 C10orf56 ACTA2 TP53INP2 SULT1A1 CD177 ATP8B1 TTRAP C10orf99 ANK3 CCL28 COL15A1 CTGF IDH3A NR3C2 MUCDHL EDG2 DHRS9 SDPR UGT1A8 LMOD1 COL14A1 RAB27A EFEMP1 DSCR1 ANTXR1 GREM1 CITED2 EMP1 IL1R2 MT1H CSRP1 LOC387763 NEXN PLEKHC1 TIMP3 MUC2 LOC572558 MYLK NID1 FOXP2 CLDN8 HBB HSPA2 RDX GCNT2 ATP1A2 TSPAN7 C20orf118 TNXB TNFRSF17 SLC20A1 FUCA1 SYNPO2 CD14 MRGPRF VIM KCTD12 HIGD1A SMPDL3A RBMS1 MFSD4 P2RY14 PTRF AXL CHGA TSPAN1 AQP1 C15orf48 UGT1A9 MAP1B COL3A1 COX7A1 PALLD CYR61 MUC12 MPEG1 TRPM6 PDCD4 KLHL5 OSTbeta CAV1 TCEAL7 IGLV1-44 FAM46C FILIP1L VSIG2 LRIG1 IQGAP2 IGHM HLA-DPA1 PRDX6 LRRC19 C1orf115 RAB31 CD163 HBA2 LOC96610 CEACAM1 EDIL3 FGFR2 TIMP2 DES PAPSS2 ENTPD5 MT2A XLKD1 DDR2 KCNMA1 SMTN CHRDL1 GAS1 C8orf4 SRGN TBC1D9 SDCBP2 PDE9A C7 CCL11 PMP22 P2RY1 ELOVL5 FLNA NR3C1 FOXF1 STMN2 STOM RELL1 MYL9 CKB PNMA1 SEMA6D CLU LOC339562 PADI2 SLC26A3 PALM2-AKAP2 SEPP1 SDC2 PAG1 TGFB1I1 SST HCLS1 SFRP2 HLA-DRA RGS1 UGT1A3 TSC22D3 FXYD6 MS4A7 IL6ST OLFML3 ALDH1A1 C1QC COL6A3 in a biological sample from said individual wherein a lower level of expression of the genes or transcripts of group (i) and/or group (ii) relative to control levels is indicative of a neoplastic large intestine cell or a cell predisposed to the onset of a neoplastic state.

In one embodiment, said expression is assessed by screening for DNA changes which impact on methylation, in particular hypermethylation. In another embodiment expression is assessed by the association of DNA with chromatin proteins carrying repressive modifications, for example, methylation of lysines 9 or 27 of the histone H3.

Reference to “large intestine” should be understood as a reference to a cell derived from one of the six anatomical regions of the large intestine, which regions commence after the terminal region of the ileum, these being:

-   -   (i) the cecum;     -   (ii) the ascending colon;     -   (iii) the transverse colon;     -   (iv) the descending colon;     -   (v) the sigmoid colon; and     -   (vi) the rectum.

Reference to “neoplasm” should be understood as a reference to a lesion, tumour or other encapsulated or unencapsulated mass or other form of growth which comprises neoplastic cells. A “neoplastic cell” should be understood as a reference to a cell exhibiting abnormal growth. The term “growth” should be understood in its broadest sense and includes reference to proliferation. In this regard, an example of abnormal cell growth is the uncontrolled proliferation of a cell. Another example is failed apoptosis in a cell, thus prolonging its usual life span. The neoplastic cell may be a benign cell or a malignant cell. In a preferred embodiment, the subject neoplasm is an adenoma or an adenocarcinoma. Without limiting the present invention to any one theory or mode of action, an adenoma is generally a benign tumour of epithelial origin which is either derived from epithelial tissue or exhibits clearly defined epithelial structures. These structures may take on a glandular appearance. It can comprise a malignant cell population within the adenoma, such as occurs with the progression of a benign adenoma to a malignant adenocarcinoma.

Preferably, said neoplastic cell is an adenoma or adenocarcinoma and even more preferably a colorectal adenoma or adenocarcinoma.

Each of the genes and transcripts detailed in sub-paragraphs (i) and (ii), above, would be well known to the person of skill in the art, as would their encoded proteins. The identification of the expression products of these genes and transcripts as markers of neoplasia occurred by virtue of differential expression analysis using Affymetrix HGU133A or HGU133B gene chips. To this end, each gene chip is characterised by approximately 45,000 probe sets which detect the RNA transcribed from the genome. On average, approximately 11 probe pairs detect overlapping or consecutive regions of the RNA transcript. In general, the genes from which the RNA transcripts described herein are identifiable by the Affymetrix probesets are well known and characterised genes. However, to the extent that some of the probesets detect RNA transcripts which are not yet defined, these transcripts are indicated as “the gene, genes or transcripts detected by Affymetrix probe x”. In some cases a number of genes may be detectable by a single probeset. It should be understood, however, that this is not intended as a limitation as to how the expression level of the subject gene or transcript can be detected. In the first instance, it would be understood that the subject gene transcript is also detectable by other probesets which would be present on the Affymetrix gene chip. The reference to a single probeset is merely included as an identifier of the gene transcript of interest. In terms of actually screening for the transcript, however, one may utilise a probe or probeset directed to any region of the transcript and not just to the 3-terminal 600 bp transcript region to which the Affymetrix probes are often directed.

Reference to each of the genes and transcripts detailed above and their transcribed and translated expression products should therefore be understood as a reference to all forms of these molecules and to fragments or variants thereof. As would be appreciated by the person of skill in the art, some genes are known to exhibit allelic variation between individuals. Accordingly, the present invention should be understood to extend to such variants which, in terms of the present diagnostic applications, achieve the same outcome despite the fact that minor genetic variants between the actual nucleic acid sequences may exist between individuals or that within one individual there may exist 2 or more splice variants of the subject gene. The present invention should therefore be understood to extend to all forms of RNA (eg mRNA, primary RNA transcript, miRNA, etc), cDNA and peptide isoforms which arise from alternative splicing or any other mutation, polymorphic or allelic variation. It should also be understood to include reference to any subunit polypeptides such as precursor forms which may be generated, whether existing as a monomer, multimer, fusion protein or other complex.

To this end, in terms of the genes encompassed by the present invention, means for determining the existence of such variants, and characterising same, are described in Example 6. To the extent that the genes of the present invention are described by reference to an Affymetrix probeset, Table 6 provides details of the nucleic acid sequence to which each probe set is directed. Based on this information, the skilled person could, as a matter of routine procedure, identify the gene in respect of which that sequence forms part. A typical protocol for doing this is also outlined in Example 6.

It should be understood that the “individual” who is the subject of testing may be any human or non-human mammal. Examples of non-human mammals includes primates, livestock animals (e.g. horses, cattle, sheep, pigs, donkeys), laboratory test animals (e.g. mice, rats, rabbits, guinea pigs), companion animals (e.g. dogs, cats) and captive wild animals (e.g. deer, foxes). Preferably the mammal is a human.

The method of the present invention is predicated on the comparison of the level of the neoplastic markers of a biological sample with the control levels of these markers. The “control level” may be either a “normal level”, which is the level of marker expressed by a corresponding large intestine cell or cellular population which is not neoplastic.

The normal (or “non-neoplastic”) level may be determined using tissues derived from the same individual who is the subject of testing. However, it would be appreciated that this may be quite invasive for the individual concerned and it is therefore likely to be more convenient to analyse the test results relative to a standard result which reflects individual or collective results obtained from individuals other than the patient in issue. This latter form of analysis is in fact the preferred method of analysis since it enables the design of kits which require the collection and analysis of a single biological sample, being a test sample of interest. The standard results which provide the normal level may be calculated by any suitable means which would be well known to the person of skill in the art. For example, a population of normal tissues can be assessed in terms of the level of the neoplastic markers of the present invention, thereby providing a standard value or range of values against which all future test samples are analysed. It should also be understood that the normal level may be determined from the subjects of a specific cohort and for use with respect to test samples derived from that cohort. Accordingly, there may be determined a number of standard values or ranges which correspond to cohorts which differ in respect of characteristics such as age, gender, ethnicity or health status. Said “normal level” may be a discrete level or a range of levels. A decrease in the expression level of the subject genes relative to normal levels is indicative of the tissue being neoplastic.

Without limiting the present invention to any one theory or mode of action, although each of the genes or transcripts hereinbefore described is differentially expressed, either singly or in combination, as between neoplastic versus non-neoplastic cells of the large intestine, and is therefore diagnostic of the existence of a large intestine neoplasm, the expression of some of these genes was found to exhibit particularly significant levels of sensitivity, specificity and positive and negative predictive value. Accordingly, in a preferred embodiment one would screen for and assess the expression level of one or more of these genes. To this end, and without limiting the present invention to any one theory or mode of action, the following markers were determined to be expressed in neoplastic tissue at a level of 3-11 fold less than non-neoplastic tissue, when assessed by virtue of the method exemplified herein:

Gene, genes or transcripts detected by Fold Decrease Affymetrix Probe No: Gene 11 220026_at CLCA4 10 214142_at ZG16 9 209301_at CA1 205950_s_at CA2 8 220834_at MS4A12 7 206784_at AQP8 6 203908_at SLC4A4 206198_s_at CEACAM7 205547_s_at TAGLN 207003_at GUCA1B 206422_at GCG 209613_s_at ADH1B 207245_at UGT2B17 5 206134_at ADAMDEC1 217546_at MT1M 206561_s_at AKR1B10 211719_x_at FN1 202291_s_at MGP 209687_at CXCL12 4 225207_at PDK4 206208_at CA4 207080_s_at PYY 215118_s_at IGHA1 204083_s_at TPM2 229070_at C6orf105 211548_s_at HPGD 206262_at ADH1C 210107_at CLCA1 205892_s_at FABP1 212592_at ENAM 205382_s_at CFD 207502_at GUCA2B 202995_s_at FBLN1 206149_at LOC63928 204719_at ABCA8 3 210809_s_at POSTN 201893_x_at DCN 223597_at ITLN1 209156_s_at COL6A2 203240_at FCGBP 224963_at SLC26A2 226303_at PGM5 212730_at DMN 201141_at GPNMB 211959_at IGFBP5 205200_at CLEC3B 242601_at LOC253012 213068_at DPT 208383_s_at PCK1 203951_at CNN1 204818_at HSD17B2 219014_at PLAC8 209656_s_at TMEM47 222722_at OGN 201617_x_at CALD1 202274_at ACTG2 218756_s_at MGC4172 210302_s_at MAB21L2 228885_at RPL24 209735_at ABCG2 228504_at CCDC80 225242_s_at UGT1A1 215125_s_at MRC1 204438_at HSD11B2 204130_at ANPEP 202888_s_at MATN2 202350_s_at PRNP 201300_s_at ABI3BP 223395_at HLA-C 214768_x_at NDE1 228133_s_at SRPX 204955_at WWTR1 202133_at HMGCS2 204607_at LOC646627 238143_at KRT20 213953_at KLF4 220266_s_at FHL1 210299_s_at ARL14 220468_at LUM 201744_s_at SORBS1 218087_s_at METTL7A 207761_s_at FAM129A 217967_s_at SCARA5 229839_at SI 206664_at ACTA2 200974_at CD177 219669_at C10orf99 227736_at COL15A1 203477_at NR3C2 205259_at

There is therefore more particularly provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:         -   220026_at; and/or     -   (ii) CLCA4         in a biological sample from said individual wherein a lower         level of expression of the gene or transcripts of group (i)         and/or group (ii) relative to control levels is indicative of a         neoplastic large intestine cell or a cell predisposed to the         onset of a neoplastic state.

Preferably, said control level is a non-neoplastic level.

In another embodiment, there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:         -   214142_at; and/or     -   (ii) ZG16         in a biological sample from said individual wherein a lower         level of expression of the genes or transcripts of group (i)         and/or group (ii) relative to control levels is indicative of a         neoplastic large intestine cell or a cell predisposed to the         onset of a neoplastic state.

Preferably, said control level is a non-neoplastic level.

In yet another embodiment there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:         -   209301_at 205950_s_at; and/or     -   (ii) CA2 CA1         in a biological sample from said individual wherein a lower         level of expression of the genes or transcripts of group (i)         and/or group (ii) relative to control levels is indicative of a         neoplastic large intestine cell or a cell predisposed to the         onset of a neoplastic state.

Preferably, said control level is a non-neoplastic level.

In still yet another preferred embodiment, there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:         -   220834_at; and/or     -   (ii) MS4A12         in a biological sample from said individual wherein a lower         level of expression of the genes or transcripts of group (i)         and/or group (ii) relative to control levels is indicative of a         neoplastic large intestine cell or a cell predisposed to the         onset of a neoplastic state.

Preferably, said control level is a non-neoplastic level.

In yet still another preferred embodiment, there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:         -   206784_at; and/or     -   (ii) AQP8         in a biological sample from said individual wherein a lower         level of expression of the genes or transcripts of group (i)         and/or group (ii) relative to control levels is indicative of a         neoplastic large intestine cell or a cell predisposed to the         onset of a neoplastic state.

Preferably, said control level is a non-neoplastic level.

In a further embodiment, there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:         -   203908_at, 206198_s_at, 205547_s_at, 207003_at, 206422_at,             209613_s_at, 207245_at; and/or     -   (ii) SLC4A4, CEACAM7, TAGLN, GUCA1B, GCG, ADH1B, UGT2B17         in a biological sample from said individual wherein a lower         level of expression of the genes or transcripts of group (i)         and/or group (ii) relative to control levels is indicative of a         neoplastic large intestine cell or a cell predisposed to the         onset of a neoplastic state.

Preferably, said control level is a non-neoplastic level.

In another further embodiment, there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:         -   206134_at, 217546_at, 206561_s_at, 211719_x_at, 202291_s_at,             209687_at; and/or     -   (ii) ADAMDEC1, MT1M, AKR1B10, FN1, MGP, CXCL12         in a biological sample from said individual wherein a lower         level of expression of the genes or transcripts of group (i)         and/or group (ii) relative to control levels is indicative of a         neoplastic large intestine cell or a cell predisposed to the         onset of a neoplastic state.

Preferably, said control level is a non-neoplastic level.

In still another further embodiment, there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising screening the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:

225207_at 211548_s_at 205382_s_at 206208_at 206262_at 207502_at 207080_s_at 210107_at 202995_s_at 215118_s_at 205892_s_at 206149_at 204083_s_at 212592_at 204719_at 229070_at; and/or

-   -   (ii)

PDK4 HPGD CFD CA4 ADH1C GUCA2B PYY CLCA1 FBLN1 IGHA1 FABP1 LOC63928 TPM2 ENAM ABCA8 C6orf105 in a biological sample from said individual wherein a lower level of expression of the genes or transcripts of group (i) and/or group (ii) relative to control levels is indicative of a neoplastic large intestine cell or a cell predisposed to the onset of a neoplastic state.

Preferably, said control level is a non-neoplastic level.

In yet still yet another further embodiment, there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising screening the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene_(—) genes or transcripts detected by Affymetrix         probeset IDs:

210809_s_at 201617_x_at 202133_at 201893_x_at 202274_at 204607_at 223597_at 218756_s_at 238143_at 209156_s_at 210302_s_at 213953_at 203240_at 228885_at 220266_s_at 224963_at 209735_at 210299_s_at 226303_at 228504_at 220468_at 212730_at 225242_s_at 201744_s_at 201141_at 215125_s_at 218087_s_at 211959_at 204438_at 207761_s_at 205200_at 204130_at 217967_s_at 242601_at 202888_s_at 229839_at 213068_at 202350_s_at 206664_at 208383_s_at 201300_s_at 200974_at 203951_at 223395_at 219669_at 204818_at 214768_x_at 227736_at 219014_at 228133_s_at 203477_at 209656_s_at 204955_at 205259_at 222722_at; and/or

-   -   (ii)

POSTN OGN WWTR1 DCN CALD1 HMGCS2 ITLN1 ACTG2 LOC646627 COL6A2 MGC4172 KRT20 FCGBP MAB21L2 KLF4 SLC26A2 RPL24 FHL1 PGM5 ABCG2 ARL14 DMN CCDC80 LUM GPNMB UGT1A1 SORBS1 IGFBP5 MRC1 METTL7A CLEC3B HSD11B2 FAM129A LOC253012 ANPEP SCARA5 DPT MATN2 SI PCK1 PRNP ACTA2 CNN1 ABI3BP CD177 HSD17B2 HLA-C C10orf99 PLAC8 NDE1 COL15A1 TMEM47 SRPX NR3C2 in a biological sample from said individual wherein a lower level of expression of the genes or transcripts of group (i) and/or group (ii) relative to control levels is indicative of a neoplastic large intestine cell or a cell predisposed to the onset of a neoplastic state.

Preferably, said control level is a non-neoplastic level.

According to these aspects of the present invention, said large intestine tissue is preferably colorectal tissue.

In one embodiment, said expression is assessed by screening for DNA changes which impact on methylation, in particular hypermethylation. In another embodiment, expression is assessed by the association of DNA with chromatin proteins carrying repressive modifications, for example, methylation of lysines 9 or 27 of histone H3.

The detection method of the present invention can be performed on any suitable biological sample. To this end, reference to a “biological sample” should be understood as a reference to any sample of biological material derived from an animal such as, but not limited to, cellular material, biofluids (eg. blood), faeces, tissue specimens (such as biopsy specimens), surgical specimens or fluid which has been introduced into the body of an animal and subsequently removed (such as, for example, the solution retrieved from an enema wash). The biological sample which is tested according to the method of the present invention may be tested directly or may require some form of treatment prior to testing. For example, a biopsy or surgical sample may require homogenisation prior to testing or it may require sectioning for in situ testing of the qualitative expression levels of individual genes. Alternatively, a cell sample may require permeabilisation prior to testing. Further, to the extent that the biological sample is not in liquid form, (if such form is required for testing) it may require the addition of a reagent, such as a buffer, to mobilise the sample.

To the extent that the neoplastic marker gene expression product is present in a biological sample, the biological sample may be directly tested or else all or some of the nucleic acid material present in the biological sample may be isolated prior to testing. In yet another example, the sample may be partially purified or otherwise enriched prior to analysis. For example, to the extent that a biological sample comprises a very diverse cell population, it may be desirable to enrich for a sub-population of particular interest. It is within the scope of the present invention for the target cell population or molecules derived therefrom to be pretreated prior to testing, for example, inactivation of live virus or being run on a gel. It should also be understood that the biological sample may be freshly harvested or it may have been stored (for example by freezing) prior to testing or otherwise treated prior to testing (such as by undergoing culturing).

The choice of what type of sample is most suitable for testing in accordance with the method disclosed herein will be dependent on the nature of the situation. Preferably, said sample is a faecal (stool) sample, enema wash, surgical resection, tissue or blood specimen.

In a related aspect, it has been determined that certain of the markers hereinbefore defined are more indicative of adenoma development versus cancer development or vice versa. This is an extremely valuable finding since it enables one to more specifically characterise the likely nature of a neoplasm which is detected by virtue of the method of the present invention.

Accordingly, in a related aspect the present invention is directed to a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising screening the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:

200600_at 200665_s_at 200799_at 200845_s_at 200859_x_at 200897_s_at 200974_at 200986_at 201041_s_at 201061_s_at 201069_at 201105_at 201137_s_at 201141_at 201150_s_at 201289_at 201300_s_at 201426_s_at 201438_at 201616_s_at 201617_x_at 201645_at 201667_at 201743_at 201744_s_at 201842_s_at 201852_x_at 201858_s_at 201859_at 201865_x_at 201893_x_at 201920_at 202007_at 202069_s_at 202133_at 202283_at 202291_s_at 202403_s_at 202620_s_at 202686_s_at 202760_s_at 202766_s_at 202953_at 202957_at 202994_s_at 202995_s_at 203066_at 203131_at 203305_at 203382_s_at 203477_at 203645_s_at 203680_at 203729_at 203748_x_at 204069_at 204122_at 204135_at 204438_at 204457_s_at 204570_at 204688_at 205412_at 205683_x_at 205935_at 207134_x_at 207266_x_at 208131_s_at 208370_s_at 208747_s_at 208788_at 208789_at 208894_at 209047_at 209101_at 209138_x_at 209147_s_at 209156_s_at 209191_at 209209_s_at 209210_s_at 209312_x_at 209335_at 209436_at 209457_at 209496_at 209621_s_at 209651_at 209656_s_at 209868_s_at 210084_x_at 210133_at 210139_s_at 210495_x_at 210517_s_at 210764_s_at 210809_s_at 210982_s_at 211161_s_at 211596_s_at 211671_s_at 211719_x_at 211813_x_at 211896_s_at 211959_at 211964_at 211985_s_at 211990_at 211991_s_at 212077_at 212091_s_at 212136_at 212158_at 212185_x_at 212195_at 212230_at 212233_at 212265_at 212386_at 212387_at 212397_at 212414_s_at 212419_at 212464_s_at 212667_at 212671_s_at 212713_at 212764_at 212956_at 213428_s_at 213509_x_at 213746_s_at 213891_s_at 214038_at 214677_x_at 214752_x_at 215049_x_at 215076_s_at 215193_x_at 215382_x_at 215388_s_at 216442_x_at 216474_x_at 216834_at 217480_x_at 217757_at 217762_s_at 217764_s_at 217767_at 217897_at 218162_at 218224_at 218312_s_at 218353_at 218418_s_at 218468_s_at 218469_at 218559_s_at 219087_at 219607_s_at 221541_at 222043_at 222453_at 222513_s_at 223121_s_at 223122_s_at 223235_s_at 223343_at 224560_at 224694_at 224840_at 224964_s_at 225242_s_at 225269_s_at 225353_s_at 225381_at 225442_at 225602_at 225604_s_at 225626_at 225688_s_at 225710_at 226001_at 226051_at 226084_at 226103_at 226430_at 226682_at 226694_at 226818_at 226834_at 226841_at 227061_at 227099_s_at 227235_at 227404_s_at 227529_s_at 227561_at 227623_at 227705_at 227727_at 228507_at 228750_at 228846_at 229530_at 230264_s_at 231579_s_at 234987_at; and/or

-   -   (ii)

A2M ACAT1 ACTA2 AKAP12 ANKRD25 ANTXR1 AP1S2 APOE AQP1 ASPN ATP2B4 AXL C10orf56 C1QB C1QC C1S C20orf118 C3 C9orf19 CALD1 CALM1 CCDC80 CCL11 CCL8 CD14 CD163 CES2 CFHR1 CLU COL14A1 COL15A1 COL1A2 COL3A1 COL4A2 COL6A1 COL6A2 COL6A3 COX7A1 CRISPLD2 CTGF CYBRD1 CYR61 DCN DDR2 DSCR1 DUSP1 DUSP5 EFEMP1 EGR1 ELOVL5 EMP3 F13A1 FBLN1 FBN1 FILIP1L FKBP5 FLNA FN1 FOXF1 FXYD6 GALNAC4S-6ST GAS1 GJA1 GNG2 GPNMB GREM1 GUCY1A3 HCLS1 HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DRA HLA-DRB1 HSPA1A IDH3A IGFBP5 IGL@ IGLJ3 IL6ST KLHL5 LGALS1 LOC283666 LOC339562 LOC387763 LOC399959 LRIG1 LUM MAFB MAP1B MEIS1 MFAP4 MGP MMP2 MPEG1 MRC1 MRGPRF MS4A4A MS4A7 MSN MT2A MXD1 NEXN NID1 NR3C1 OLFML3 PAG1 PALLD PALM2-AKAP2 PDGFRA PDLIM3 PHLDB2 PLEKHC1 PLOD2 PMP22 PNMA1 POSTN PPAP2A PPAP2B PRDX6 PRKAR2B PRNP PTGIS PTRF QKI RAB31 RARRES2 RBMS1 RDX RELL1 RGS1 RGS5 SDC2 SELM SEPT6 SERPINF1 SERPING1 SFRP2 SGCE SLC20A1 SMOC2 SORBS1 SPARC SPON1 SRGN STOM TBC1D9 TCEAL7 TGFB1I1 TIMP2 TIMP3 TMEM47 TNC TPSAB1 TPSB2 TUBB6 TYROBP VIM WWTR1 ZSCAN18 in a biological sample from said individual wherein a lower level of expression of the genes or transcripts of group (i) and/or group (ii) relative to control levels is indicative of an adenoma cell or a cell predisposed to the onset of an adenoma state.

In another preferred embodiment of this aspect of the present invention there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising screening the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene or genes detected by Affymetrix probeset IDs:

200884_at 201495_x_at 202266_at 202350_s_at 202731_at 202741_at 202742_s_at 202768_at 202838_at 203058_s_at 203060_s_at 203240_at 203296_s_at 203343_at 203474_at 203638_s_at 203963_at 204018_x_at 204034_at 204036_at 204130_at 204388_s_at 204389_at 204508_s_at 204532_x_at 204607_at 204673_at 204818_at 204895_x_at 204897_at 205112_at 205259_at 205403_at 205480_s_at 205554_s_at 205593_s_at 205892_s_at 205929_at 206000_at 206094_x_at 206262_at 206377_at 206385_s_at 206664_at 207126_x_at 207245_at 207390_s_at 207392_x_at 207432_at 207761_s_at 208596_s_at 208920_at 209114_at 209374_s_at 209458_x_at 209791_at 210107_at 210524_x_at 210735_s_at 211372_s_at 211538_s_at 211549_s_at 211637_x_at 211699_x_at 211745_x_at 212224_at 212592_at 212741_at 212814_at 213317_at 213451_x_at 213629_x_at 213921_at 213953_at 214164_x_at 214433_s_at 214598_at 214916_x_at 215125_s_at 215299_x_at 215867_x_at 216336_x_at 216491_x_at 216510_x_at 217022_s_at 217109_at 217110_s_at 217165_x_at 217232_x_at 217414_x_at 218541_s_at 218546_at 219059_s_at 219543_at 219796_s_at 219948_x_at 220075_s_at 220266_s_at 220468_at 220645_at 220812_s_at 221004_s_at 221305_s_at 221584_s_at 221841_s_at 221896_s_at 223484_at 223597_at 223754_at 224342_x_at 224989_at 224990_at 225458_at 225728_at 226147_s_at 226302_at 226594_at 226654_at 226811_at 227052_at 227522_at 227682_at 227725_at 227735_s_at 227736_at 228133_s_at 228195_at 228232_s_at 228241_at 228469_at 228961_at 229070_at 229254_at 229659_s_at 229831_at 230595_at 231925_at 231975_s_at 233565_s_at 235146_at 235766_x_at 235849_at 238143_at 238750_at 238751_at 239272_at 241994_at 242447_at 242601_at 243278_at; and/or

-   -   (ii)

ADH1C AGR3 ALDH1A1 ANK3 ARL14 ATP1A2 ATP8B1 BEST2 C10orf99 C15orf48 C1orf115 C4orf34 C6orf105 C8orf4 CA12 CCL28 CKB CLCA1 CLDN8 CLIC5 CMBL CNTN3 DNASE1L3 EDG2 ENAM ENTPD5 ETHE1 FABP1 FAM46C FAM55D FCGBP FGFR2 FOSB FOXF2 FOXP2 FUCA1 GPA33 HBA1 HBA2 HBB HHLA2 HIGD1A HMGCS2 HPGD HSD11B2 HSD17B2 HSPA2 IGHA1 IGHM IL1R2 IL8 IQGAP2 ITLN1 ITM2C KCNMA1 KIAA0828 KLF4 KRT20 LOC253012 LOC25845 LOC285382 LOC572558 LOC646627 LOC652128 LOC96610 MAOA MATN2 MEP1A METTL7A MFSD4 MGC13057 MIER3 MMP28 MT1A MT1F MT1M MUC12 MUC2 MUC4 MUCDHL MYH11 NDE1 NR3C2 P2RY1 PADI2 PAPSS2 PBLD PDCD4 PDE9A PIGR PLCE1 PPID PRKACB PTGER4 RAB27A SCARA5 SDCBP2 SELENBP1 SI SMTN SORBS2 SRI SST ST6GALNAC1 SULT1A1 TNXB TSPAN1 TTRAP UGDH UGP2 UGT1A1 UGT1A3 UGT1A6 UGT1A8 UGT1A9 UGT2A3 UGT2B15 UGT2B17 VSIG2 XDH XLKD1 ZCWPW2 in a biological sample from said individual wherein a lower level of expression of the genes or transcripts of group (i) and/or group (ii) relative to control levels is indicative of a cancer cell or a cell predisposed to the onset of a cancerous state.

According to these aspects, said control levels are preferably non-neoplastic levels and said large intestine tissue is colorectal tissue. Even more preferably, said biological sample is a stool sample or blood sample.

In one embodiment, said expression is assessed by screening for DNA changes which impact on methylation, in particular hypermethylation. In another embodiment, expression is assessed by the association of DNA with chromatin proteins carrying repressive modifications, for example, methylation of lysines 9 or 27 of histone H3.

In a related aspect, it has been determined that a subpopulation of the markers of the present invention are not only expressed at levels lower than normal levels, their expression pattern is uniquely characterised by the fact that expression levels above that of background control levels are not detectable in neoplastic tissue. This determination has therefore enabled the development of qualitative screening systems which are simply designed to detect marker expression relative to a control background level. In accordance with this aspect of the present invention, said “control level” is therefore the “background level”.

According to this aspect, there is therefore provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising screening the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:

202920_at 222717_at 231120_x_at 203881_s_at 224412_s_at 231773_at 204719_at 225381_at 203296_s_at 204931_at 225575_at 206664_at 204940_at 227529_s_at 211549_s_at 205433_at 227623_at 214598_at 206637_at 227705_at 219948_x_at 207080_s_at 227827_at 220812_s_at 207980_s_at 228504_at 221305_s_at 209170_s_at 228706_s_at 229831_at 209209_s_at 228766_at 231925_at 209613_s_at 228854_at 235146_at 220037_s_at 228885_at 238751_at 220376_at 230788_at 243278_at; and/or

-   -   (ii)

ADH1B ANGPTL1 HHLA2 SORBS2 DMD SORBS2 PYY GCNT2 CLDN23 ABCA8 SDPR CNTN3 RPL24 PKIB PLEKHC1 SI CITED2 LRRC19 CLDN8 TCF21 LIFR P2RY14 P2RY1 ATP1A2 PLN ANK2 HPGD TRPM6 XLKD1 GPM6B CD36 LOC399959 UGT1A8 BCHE AKAP12 FOXP2 TCEAL7 UGT2A3 in a biological sample from said individual wherein a level of expression of the genes or transcripts of group (i) and/or group (ii) which is not substantially above background levels is indicative of a neoplastic cell or a cell predisposed to the onset of a neoplastic state.

In a most preferred embodiment, said genes or transcripts are selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:         -   209613_s_at, 227827_at, 204719_at, 228504_at, 228885_at,             206664_at, 207080_s_at; and/or     -   (ii) ADH1B, SORBS2, PYY, ABCA8, RPL24, SI

Preferably, said neoplasm is an adenoma or an adenocarcinoma and said gastrointestinal tissue is colorectal tissue.

In yet another embodiment, it has been determined that a further subpopulation of these markers are more characteristic of adenoma development, while others are more characteristic of cancer development. Accordingly, there is provided a convenient means of qualitatively obtaining indicative information in relation to the characteristics of the subject neoplasm.

According to this embodiment there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising screening the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:         -   209209_s_at, 225381_at, 227529_s_at, 227623_at, 227705_at;             and/or     -   (ii) AKAP12, LOC399959, PLEKHC1, TCEAL7         in a biological sample from said individual wherein a lower         level of expression of the genes or transcripts of group (i)         and/or group (ii) which is not substantially above background         levels is indicative of an adenoma cell or a cell predisposed to         the onset of an adenoma state.

In yet still another preferred embodiment there is provided a method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising screening the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:

203296_s_at 206664_at 211549_s_at 214598_at 219948_x_at 220812_s_at 221305_s_at 229831_at 231925_at 235146_at 238751_at 243278_at; and/or

-   -   (ii)

ATP1A2 CLDN8 CNTN3 FOXP2 HHLA2 HPGD P2RY1 SI SORBS2 UGT1A8 UGT2A3 in a biological sample from said individual wherein a lower level of expression of the genes or transcripts of group (i) and/or group (ii) which is not substantially above background levels is indicative of a cancer cell or a cell predisposed to the onset of a cancerous state.

Preferably, said large intestine tissue is colorectal tissue.

More preferably, said biological sample is a stool sample or a blood sample.

In one embodiment, said expression is assessed by screening for DNA changes which impact on methylation, in particular hypermethylation. In another embodiment, expression is assessed by the association of DNA with chromatin proteins carrying repressive modifications, for example, methylation of lysines 9 or 27 of histone H3.

As detailed hereinbefore, the present invention is designed to screen for a neoplastic cell or cellular population, which is located in the large intestine. Accordingly, reference to “cell or cellular population” should be understood as a reference to an individual cell or a group of cells. Said group of cells may be a diffuse population of cells, a cell suspension, an encapsulated population of cells or a population of cells which take the form of tissue.

Reference to “expression” should be understood as a reference to the transcription and/or translation of a nucleic acid molecule. In this regard, the present invention is exemplified with respect to screening for neoplastic marker expression products taking the form of RNA transcripts (eg primary RNA or mRNA). Reference to “RNA” should be understood to encompass reference to any form of RNA, such as primary RNA or mRNA. Without limiting the present invention in any way, the modulation of gene transcription leading to increased or decreased RNA synthesis will also correlate with the translation of some of these RNA transcripts (such as mRNA) to produce a protein product. Accordingly, the present invention also extends to detection methodology which is directed to screening for modulated levels or patterns of the neoplastic marker protein products as an indicator of the neoplastic state of a cell or cellular population. Although one method is to screen for mRNA transcripts and/or the corresponding protein product, it should be understood that the present invention is not limited in this regard and extends to screening for any other form of neoplastic marker expression product such as, for example, a primary RNA transcript.

In terms of screening for the downregulation of expression of a marker it would also be well known to the person of skill in the art that changes which are detectable at the DNA level are indicative of changes to gene expression activity and therefore changes to expression product levels. Such changes include but are not limited to, changes to DNA methylation. Accordingly, reference herein to “screening the level of expression” and comparison of these “levels of expression” to control “levels of expression” should be understood as a reference to assessing DNA factors which are related to transcription, such as gene/DNA methylation patterns.

It would also be known to a person skilled in the art that changes in the structure of chromatin are indicative of changes in gene expression. Silencing of gene expression is often associated with modification of chromatin proteins, methylation of lysines at either or both positions 9 and 27 of histone H3 being well studied examples, while active chromatin is marked by acetylation of lysine 9 of histone H3. Thus association of gene sequences with chromatin carrying repressive or active modifications can be used to make an assessment of the expression level of a gene.

It is well within the skill of the person of skill in the art to determine the most appropriate screening method for any given situation. To this end, the genes which are known to encode an expression product which is either secreted by the cell or membrane bound is detailed in the table below. It would be appreciated that screening for neoplastic markers which are secreted or membrane bound may provide particular advantages in terms of the design of a diagnostic screening product.

The gene or genes detected by Affymetrix probe Nos: 200600_at 205593_s_at 212185_x_at 224480_s_at 200845_s_at 205765_at 212192_at 224663_s_at 200859_x_at 205892_s_at 212224_at 224694_at 200884_at 205927_s_at 212230_at 224823_at 200897_s_at 205929_at 212233_at 224836_at 200974_at 205935_at 212265_at 224840_at 201041_s_at 205935_at 212288_at 224959_at 201058_s_at 205950_s_at 212386_at 224963_at 201061_s_at 206000_at 212387_at 224964_s_at 201069_at 206094_x_at 212397_at 224989_at 201105_at 206143_at 212414_s_at 224990_at 201137_s_at 206149_at 212419_at 225207_at 201300_s_at 206198_s_at 212671_s_at 225242_s_at 201324_at 206199_at 212730_at 225269_s_at 201426_s_at 206208_at 212741_at 225381_at 201539_s_at 206209_s_at 212764_at 225442_at 201540_at 206262_at 212814_at 225458_at 201616_s_at 206377_at 212859_x_at 225575_at 201617_x_at 206385_s_at 212956_at 225602_at 201667_at 206461_x_at 213106_at 225604_s_at 201739_at 206561_s_at 213317_at 225626_at 201743_at 206576_s_at 213509_x_at 225710_at 201865_x_at 206637_at 213629_x_at 225720_at 201920_at 206664_at 213746_s_at 225721_at 201957_at 206710_s_at 213891_s_at 225782_at 202007_at 206784_at 213953_at 225894_at 202069_s_at 207126_x_at 214027_x_at 225895_at 202133_at 207245_at 214234_s_at 226001_at 202242_at 207266_x_at 214235_at 226051_at 202266_at 207390_s_at 214414_x_at 226084_at 202274_at 207392_x_at 214433_s_at 226103_at 202388_at 207432_at 214505_s_at 226147_s_at 202555_s_at 207761_s_at 214598_at 226248_s_at 202620_s_at 207980_s_at 214677_x_at 226302_at 202686_s_at 208063_s_at 214696_at 226303_at 202731_at 208131_s_at 214752_x_at 226304_at 202741_at 208370_s_at 214768_x_at 226333_at 202742_s_at 208383_s_at 214777_at 226430_at 202746_at 208450_at 215049_x_at 226594_at 202760_s_at 208581_x_at 215118_s_at 226654_at 202768_at 208596_s_at 215125_s_at 226682_at 202888_s_at 208763_s_at 215176_x_at 226694_at 202920_at 208788_at 215193_x_at 226811_at 202957_at 208789_at 215299_x_at 226818_at 202992_at 208920_at 215657_at 226834_at 202994_s_at 208937_s_at 216207_x_at 226841_at 202995_s_at 209047_at 216336_x_at 227006_at 203000_at 209074_s_at 216401_x_at 227052_at 203001_s_at 209114_at 216491_x_at 227061_at 203058_s_at 209116_x_at 216576_x_at 227099_s_at 203060_s_at 209138_x_at 216834_at 227235_at 203066_at 209147_s_at 216984_x_at 227404_s_at 203131_at 209156_s_at 217022_s_at 227522_at 203240_at 209167_at 217148_x_at 227529_s_at 203305_at 209170_s_at 217165_x_at 227561_at 203343_at 209191_at 217232_x_at 227623_at 203382_s_at 209209_s_at 217235_x_at 227662_at 203474_at 209210_s_at 217378_x_at 227682_at 203638_s_at 209283_at 217414_x_at 227705_at 203645_s_at 209301_at 217480_x_at 227719_at 203680_at 209312_x_at 217546_at 227725_at 203729_at 209357_at 217762_s_at 227727_at 203748_x_at 209373_at 217764_s_at 227735_s_at 203766_s_at 209374_s_at 217897_at 227736_at 203908_at 209457_at 217967_s_at 228202_at 203913_s_at 209458_x_at 218087_s_at 228232_s_at 203914_x_at 209498_at 218211_s_at 228469_at 203951_at 209612_s_at 218224_at 228504_at 203980_at 209613_s_at 218312_s_at 228507_at 204018_x_at 209621_s_at 218353_at 228640_at 204034_at 209651_at 218418_s_at 228766_at 204036_at 209656_s_at 218546_at 228846_at 204069_at 209667_at 218559_s_at 228854_at 204083_s_at 209668_x_at 219014_at 228961_at 204122_at 209868_s_at 219059_s_at 229070_at 204130_at 209948_at 219508_at 229254_at 204135_at 210107_at 219543_at 229530_at 204326_x_at 210139_s_at 219607_s_at 229659_s_at 204388_s_at 210298_x_at 219796_s_at 229831_at 204389_at 210299_s_at 219948_x_at 229839_at 204438_at 210302_s_at 219955_at 230087_at 204457_s_at 210517_s_at 220026_at 230264_s_at 204532_x_at 210524_x_at 220037_s_at 230595_at 204570_at 210524_x_at 220075_s_at 230788_at 204607_at 210946_at 220266_s_at 230830_at 204688_at 211372_s_at 220376_at 231120_x_at 204697_s_at 211538_s_at 220468_at 231832_at 204719_at 211548_s_at 220812_s_at 231925_at 204745_x_at 211549_s_at 220834_at 231975_s_at 204818_at 211596_s_at 221004_s_at 232176_at 204894_s_at 211637_x_at 221305_s_at 232481_s_at 204897_at 211643_x_at 221667_s_at 233565_s_at 204931_at 211645_x_at 221747_at 234987_at 204938_s_at 211671_s_at 221748_s_at 235146_at 204939_s_at 211696_x_at 221841_s_at 235766_x_at 204940_at 211699_x_at 221874_at 235849_at 204955_at 211745_x_at 221896_s_at 235976_at 205097_at 211798_x_at 222513_s_at 236300_at 205112_at 211848_s_at 222717_at 236313_at 205259_at 211889_x_at 223235_s_at 236894_at 205267_at 211964_at 223343_at 237521_x_at 205403_at 211985_s_at 223395_at 238750_at 205412_at 211990_at 223484_at 241994_at 205433_at 211991_s_at 223551_at 242317_at 205464_at 212077_at 223597_at 242447_at 205480_s_at 212097_at 223623_at 242601_at 205547_s_at 212136_at 224352_s_at 243278_at 205554_s_at 212158_at 224412_s_at ABCA8 EGR1 LOC25845 PPID ABI3BP ELOVL5 LOC283666 PPP1R12B ACAT1 EMP1 LOC285382 PPP1R14A ACTA2 EMP3 LOC339562 PRDX6 ACTG2 ENTPD5 LOC387763 PRIMA1 ADH1B EPB41L3 LOC399959 PRKACB ADH1C ETHE1 LOC572558 PRKAR2B AKAP12 F13A1 LOC63928 PRNP AKR1B10 FABP1 LOC652128 PTGER4 ALDH1A1 FABP4 LOC652745 PTGIS ANK2 FAM107A LRIG1 PTRF ANK3 FAM129A LRRC19 QKI ANKRD25 FAM46C MAB21L2 RAB27A ANPEP FBLN1 MAFB RAB31 ANTXR1 FCGBP MAG1 RBMS1 AOC3 FGFR2 MALL RDX AP1S2 FHL1 MAOA RELL1 APOE FILIP1L MAP1B RGS1 AQP1 FKBP5 MEIS1 RGS2 AQP8 FLNA MEP1A RGS5 ARL14 FNBP1 METTL7A SCARA5 ATP2B4 FOSB MFSD4 SCNN1B ATP8A1 FOXF1 MGC14376 SDC2 AXL FOXF2 MIER3 SDCBP2 BCHE FOXP2 MLPH SDPR BEST2 FXYD6 MMP2 SELENBP1 C10orf56 GALNAC4S- MPEG1 SELM C10orf99 6ST MPEG1 SGCE C15orf48 GAS1 MRC1 SGK C1orf115 GCNT2 MRGPRF SI C20orf118 GCNT3 MS4A12 SLC20A1 C2orf40 GJA1 MS4A4A SLC26A2 C4orf34 GNG2 MS4A7 SLC26A3 C6orf105 GPA33 MSN SLC4A4 C6orf204 GPM6B MSRB3 SLITRK6 C7 GUCY1A3 MT1A SMOC2 C9orf19 HBA1 MT1E SMTN CA1 HBA2 MT1F SORBS1 CA2 HBB MT1G SRI CA4 HCLS1 MT1H SRPX CALD1 HHLA2 MT1M ST6GALNAC1 CALM1 HIGD1A MT1X STMN2 CAPN9 HLA-C MT2A STOM CAV1 HLA-DPA1 MUC12 SULT1A1 CCDC80 HLA-DPB1 MUCDHL SYNPO2 CCL28 HLA-DQA1 MXD1 TAGLN CD14 HLA-DRB1 MYL9 TBC1D9 CD163 HMGCS2 MYLK TCEAL7 CD36 HPGD NEXN TCF21 CDKN2B HSD11B2 NID1 TGFB1I1 CEACAM1 HSD17B2 NR3C1 TMEM47 CEACAM7 HSPA2 NR3C2 TNS1 CES2 HSPB6 OSTbeta TP53INP2 CFL2 HSPB8 P2RY1 TPM2 CHGA ID1 P2RY14 TRPM6 CITED2 IDH3A PAG1 TSC22D3 CKB IGHA1 PALLD TSPAN1 CLCA1 IGHM PALM2- TSPAN7 CLCA4 IGKV1D-13 AKAP2 TTRAP CLDN8 IGL@ PAPSS2 TUBB6 CLIC5 IGLJ3 PBLD TYROBP CMBL IL1R2 PCK1 UGDH CNN1 IQGAP2 PDCD4 UGP2 CNTN3 ITLN1 PDE9A UGT1A1 COL4A2 ITM2A PDGFRA UGT1A3 COL6A2 ITM2C PDK4 UGT1A6 COX7A1 KCNMA1 PDLIM3 UGT1A8 CRYAB KCNMB1 PGM5 UGT1A9 CTSE KCTD12 PIGR UGT2A3 CYP3A5 KIAA0828 PKIB UGT2B15 CYP3A5P2 KIAA1324 PLAC8 UGT2B17 DDR2 KLF4 PLCE1 VIM DES KLHL5 PLEKHC1 VSIG2 DMN KRT20 PLN WDR51B DNASE1L3 L1TD1 PLOD2 WWTR1 DSCR1 LGALS1 PMP22 XDH DUSP1 LGALS2 PNMA1 XLKD1 DUSP5 LIFR POU2AF1 ZSCAN18 EDG2 LMOD1 PPAP2A LOC253012 PPAP2B

Reference to “nucleic acid molecule” should be understood as a reference to both deoxyribonucleic acid molecules and ribonucleic acid molecules and fragments thereof. The present invention therefore extends to both directly screening for mRNA levels in a biological sample or screening for the complementary cDNA which has been reverse-transcribed from an mRNA population of interest. It is well within the skill of the person of skill in the art to design methodology directed to screening for either DNA or RNA. As detailed above, the method of the present invention also extends to screening for the protein product translated from the subject mRNA or the genomic DNA itself.

In one preferred embodiment, the level of gene expression is measured by reference to genes which encode a protein product and, more particularly, said level of expression is measured at the protein level. Accordingly, to the extent that the present invention is directed to screening for markers which are detailed in the preceding table, said screening is preferably directed to the encoded protein.

In another particularly preferred embodiment, said gene expression is assessed by analysing genomic DNA methylation. In another embodiment, expression is assessed by the association of DNA with chromatin proteins carrying repressive modifications, for example, methylation of lysines 9 or 27 of histone H3.

As detailed hereinbefore, it should be understood that although the present invention is exemplified with respect to the detection of expressed nucleic acid molecules (e.g. mRNA), it also encompasses methods of detection based on screening for the protein product of the subject genes. The present invention should also be understood to encompass methods of detection based on identifying both proteins and/or nucleic acid molecules in one or more biological samples. This may be of particular significance to the extent that some of the neoplastic markers of interest may correspond to genes or gene fragments which do not encode a protein product. Accordingly, to the extent that this occurs it would not be possible to test for a protein and the subject marker would have to be assessed on the basis of transcription expression profiles or changes to genomic DNA.

The term “protein” should be understood to encompass peptides, polypeptides and proteins (including protein fragments). The protein may be glycosylated or unglycosylated and/or may contain a range of other molecules fused, linked, bound or otherwise associated to the protein such as amino acids, lipids, carbohydrates or other peptides, polypeptides or proteins. Reference herein to a “protein” includes a protein comprising a sequence of amino acids as well as a protein associated with other molecules such as amino acids, lipids, carbohydrates or other peptides, polypeptides or proteins.

The proteins encoded by the neoplastic markers of the present invention may be in multimeric form meaning that two or more molecules are associated together. Where the same protein molecules are associated together, the complex is a homomultimer. An example of a homomultimer is a homodimer. Where at least one marker protein is associated with at least one non-marker protein, then the complex is a heteromultimer such as a heterodimer.

Reference to a “fragment” should be understood as a reference to a portion of the subject nucleic acid molecule or protein. This is particularly relevant with respect to screening for modulated RNA levels in stool samples since the subject RNA is likely to have been degraded or otherwise fragmented due to the environment of the gut. One may therefore actually be detecting fragments of the subject RNA molecule, which fragments are identified by virtue of the use of a suitably specific probe.

Reference to the “onset” of a neoplasm, such as adenoma or adenocarcinoma, should be understood as a reference to one or more cells of that individual exhibiting dysplasia. In this regard, the adenoma or adenocarcinoma may be well developed in that a mass of dysplastic cells has developed. Alternatively, the adenoma or adenocarcinoma may be at a very early stage in that only relatively few abnormal cell divisions have occurred at the time of diagnosis. The present invention also extends to the assessment of an individual's predisposition to the development of a neoplasm, such as an adenoma or adenocarcinoma. Without limiting the present invention in any way, changed levels of the neoplastic markers may be indicative of that individual's predisposition to developing a neoplasia, such as the future development of an adenoma or adenocarcinoma or another adenoma or adenocarcinoma.

In yet another related aspect of the present invention, markers have been identified which enable the characterisation of neoplastic tissue of the large intestine in terms of whether it is an adenoma or a cancer. This development now provides a simple yet accurate means of characterising tissue using means other than the traditional methods which are currently utilised.

According to this aspect of the present invention, there is provided a method of characterising a neoplastic cell or cellular population, which cell or cellular population is derived from the large intestine of an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:

200600_at 204006_s_at 213428_s_at 200665_s_at 204051_s_at 213524_s_at 200832_s_at 204122_at 213869_x_at 200974_at 204320_at 213905_x_at 200986_at 204475_at 214247_s_at 201058_s_at 204620_s_at 215049_x_at 201069_at 205479_s_at 215076_s_at 201105_at 205547_s_at 215646_s_at 201141_at 205828_at 216442_x_at 201147_s_at 207173_x_at 217430_x_at 201150_s_at 207191_s_at 217762_s_at 201162_at 208747_s_at 217763_s_at 201163_s_at 208782_at 217764_s_at 201185_at 208788_at 218468_s_at 201261_x_at 208850_s_at 218469_at 201289_at 208851_s_at 218559_s_at 201426_s_at 209101_at 218638_s_at 201438_at 209156_s_at 219087_at 201616_s_at 209218_at 221011_s_at 201645_at 209395_at 221729_at 201667_at 209396_s_at 221730_at 201744_s_at 209596_at 221731_x_at 201792_at 209875_s_at 37892_at 201842_s_at 209955_s_at 223122_s_at 201852_x_at 210095_s_at 223235_s_at 201859_at 210495_x_at 224560_at 201893_x_at 210511_s_at 224694_at 202237_at 210764_s_at 224724_at 202238_s_at 210809_s_at 225664_at 202283_at 211161_s_at 225681_at 202291_s_at 211571_s_at 225710_at 202310_s_at 211719_x_at 225799_at 202311_s_at 211813_x_at 226237_at 202403_s_at 211896_s_at 226311_at 202404_s_at 211959_at 226694_at 202450_s_at 211964_at 226777_at 202620_s_at 211966_at 226930_at 202766_s_at 211980_at 227099_s_at 202859_x_at 211981_at 227140_at 202878_s_at 212077_at 227566_at 202917_s_at 212344_at 229218_at 202998_s_at 212353_at 229802_at 203083_at 212354_at 231579_s_at 203325_s_at 212464_s_at 231766_s_at 203382_s_at 212488_at 231879_at 203477_at 212489_at 232458_at 203570_at 212667_at 233555_s_at 203645_s_at 213125_at 234994_at; and/or 203878_s_at

-   -   (ii)

COL1A2 LGALS1 SRGN CTHRC1 ELOVL5 LBH FN1 MGP CTGF POSTN MMP2 TNC SPP1 LOXL2 G0S2 MMP1 MYL9 SQLE SPARC DCN EFEMP1 LUM CALD1 APOE GREM1 FBN1 MSN IL8 MMP3 IGFBP3 IGFBP5 IGFBP7 SERPINF1 SFRP2 FSTL1 ISLR SULF1 COL4A2 HNT ASPN VCAN COL5A1 COL6A3 SMOC2 OLFML2B COL8A1 HTRA1 KIAA1913 COL12A1 CYR61 PALM2-AKAP2 COL5A2 FAP SERPING1 CDH11 VIM TYROBP THBS2 TIMP2 ACTA2 COL15A1 SCD COL3A1 COL11A1 TIMP3 PLOD2 S100A8 AEBP1 MMP11 FNDC1 GJA1 CD163 SFRP4 NNMT FCGR3B INHBA COL1A1 PLAU COL6A2 SULF2 MAFB ANTXR1 COL6A1 LOC541471 GPNMB SPON2 LOC387763 BGN CTSK CHI3L1 TAGLN MXRA5 THY1 COL4A1 C1S LOXL1 RAB31 DKK3 CD93 in said cell or cellular population wherein a lower level of expression of the genes of group (i) and/or group (ii) relative to a gastrointestinal cancer control level is indicative of an adenoma cell or a cell predisposed to the onset of an adenoma state.

In another aspect there is provided a method of characterising a neoplastic cell or cellular population, which cell or cellular population is derived from the large intestine of an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:

200884_at 203240_at 203963_at 204508_s_at 204607_at 204811_s_at 204895_x_at 204897_at 205259_at 205765_at 205927_s_at 208063_s_at 208937_s_at 210107_at 213106_at 214234_s_at 214235_at 214433_s_at 215125_s_at 215867_x_at 217109_at 217110_s_at 218211_s_at 219543_at 219955_at 221841_s_at 221874_at 223969_s_at 223970_at 226248_s_at 226302_at 227676_at 227719_at 227725_at 228232_s_at 229070_at 231832_at 232176_at 232481_s_at 235976_at 236894_at 237521_x_at 242601_at; and/or

-   -   (ii)

CLCA1 CTSE ATP8B1 FCGBP C6orf105 CACNA2D2 HMGCS2 CKB KLF4 RETNLB ATP8A1 CYP3A5P2 L1TD1 MUC4 CAPN9 SLITRK6 UGT1A1 NR3C2 VSIG2 SELENBP1 PBLD LOC253012 PTGER4 CA12 ST6GALNAC1 MLPH WDR51B ID1 KIAA1324 FAM3D CYP3A5 in a biological sample from said individual wherein a lower level of expression of the genes or transcripts of group (i) and/or group (ii) relative to a gastrointestinal adenoma control level is indicative of a cancer or a cell predisposed to the onset of a cancerous state.

Preferably, said gastrointestinal tissue is colorectal tissue.

In one embodiment, said expression is assessed by screening for DNA changes which impact on methylation, in particular hypermethylation. In another embodiment, expression is assessed by the association of DNA with chromatin proteins carrying repressive modifications, for example, methylation of lysines 9 or 27 of histone H3.

Reference to an “adenoma control level” or “cancer control level” should be understood as a reference to the level of said gene expression in a population of adenoma or cancer gastrointestinal cells, respectively. As discussed hereinbefore in relation to “normal levels”, the subject level may be a discrete level or a range of levels. Accordingly, the definition of “adenoma control level” or “cancer control level” should be understood to have a corresponding definition to “normal level”, albeit in the context of the expression of genes by a neoplastic population of large intestine cells.

In terms of this aspect of the present invention, the subject analysis is performed on a population of neoplastic cells. These cells may be derived in any manner, such as sloughed off neoplastic cells which have been collected via an enema wash or from a gastrointestinal sample, such as a stool sample. Alternatively, the subject cells may have been obtained via a biopsy or other surgical technique.

Without limiting this aspect of the invention in any way, several of the markers of this aspect of the present invention have been determined to be expressed at particularly significant levels below those of neoplastic cells. For example, decreased expression levels of 3 to 9 fold have been observed in respect of the following markers which are indicative of gastrointestinal adenomas, when assessed by the method herein exemplified.

Gene, genes or transcripts detected by Affymetrix Fold Decrease Probe No: Gene 9 202404_s_at COL1A2 8 225681_at CTHRC1 7 212464_s_at FN1 210809_s_at POSTN 6 209875_s_at SPP1 5 221740_at MMP1 204475_at 4 200665_s_at SPARC 201744_s_at LUM 218468_s_at GREM1 202859_x_at IL8 211959_at IGFBP5 3 223122_s_at SFRP2 212353_at SULF1 219087_at ASPN 201438_at COL6A3 226237_at COL8A1 225664_at COL12A1 221730_at COL5A2 207173_x_at CDH11 203083_at THBS2 203477_at COL15A1 37892_at COL11A1 202917_s_at S100A8 226930_at FNDC1 204051_s_at SFRP4 210511_s_at INHBA 209156_s_at COL6A2 224694_at ANTXR1 201141_at GPNMB 213905_x_at BGN 205547_s_at TAGLN

In another example, decreased expression levels of between 3 to 5 fold have been observed in respect of the following markers which are indicative of gastrointestinal cancers, when assessed by the method herein exemplified.

Gene, genes or transcripts detected by Affymetrix Fold Decrease Probe No: Gene 5 210107_at CLCA1 3 203240_at FCGBP 204607_at HMGCS2 223969_s_at RETNLB 219955_at L1TD1 232481_s_at SLITRK6 228232_s_at VSIG2 242601_at LOC253012 227725_at ST6GALNAC1

According to this embodiment, there is therefore provided a method of characterising a neoplastic cell or cellular population, which cell or cellular population is derived from the large intestine of an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene or genes detected by Affymetrix probeset IDs:         -   202404_s_at, 212464_s_at, 210809_s_a, 225681_at; and/or     -   (ii) COL1A2, CTHRC1, FN1, POSTN         in a biological sample from said individual wherein a lower         level of expression of the genes or transcripts of group (i)         and/or group (ii) relative to a gastrointestinal cancer control         level is indicative of an adenoma cell or a cell predisposed to         the onset of an adenoma state.

In another embodiment, there is provided a method of characterising a neoplastic cell or cellular population, which cell or cellular population is derived from the large intestine of an individual, said method comprising assessing the level of expression of one or more genes selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:         -   209875_s_at 227140_at 204475_at; and/or     -   (ii) SPP1 MMP1         in a biological sample from said individual wherein a lower         level of expression of the genes or transcripts of group (i)         and/or group (ii) relative to a gastrointestinal cancer control         level is indicative of an adenoma cell or a cell predisposed to         the onset of an adenoma state.

Preferably, said gastrointestinal tissue is colorectal tissue.

Still more preferably, said biological sample is a tissue sample.

In another preferred embodiment the present invention is directed to a method of characterising a cell or cellular population, which cell or cellular population is derived from the large intestine of an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:

200665_s_at 226237_at 226930_at 201744_s_at 225664_at 204051_s_at 218468_s_at 221730_at 210511_s_at 202859_x_at 207173_x_at 209156_s_at 211959_at 203083_at 224694_at 223122_s_at 203477_at 201141_at 212353_at 37892_at 213905_x_at 219087_at 202917_s_at 205547_s_at 201438_at; and/or

-   -   (ii)

SPARC COL8A1 SFRP4 LUM COL12A1 INHBA GREM1 COL5A2 COL6A2 IL8 CDH11 ANTXR1 IGFBP5 THBS2 GPNMB SFRP2 COL15A1 BGN SULF1 COL11A1 TAGLN ASPN S100A8 COL6A3 FNDC1 in a biological sample from said individual wherein a lower level of expression of the genes or transcripts of group (i) and/or (ii) relative to a gastrointestinal cancer control level is indicative of an adenoma or a cell predisposed to the onset of an adenoma state.

In yet another preferred embodiment the present invention is directed to a method of characterising a cell or cellular population, which cell or cellular population is derived from the large intestine of an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:         -   210107_at; and/or     -   (ii) CLCA1         in a biological sample from said individual wherein a lower         level of expression of the genes or transcripts of group (i)         and/or (ii) relative to a gastrointestinal adenoma control level         is indicative of a cancer or a cell predisposed to the onset of         a cancerous state.

In still yet another preferred embodiment the present invention is directed to a method of characterising a cell or cellular population, which cell or cellular population is derived from the large intestine of an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene, genes or transcripts detected by Affymetrix         probeset IDs:         -   203240_at, 204607_at, 223969_s_at, 219955_at, 232481_s_at,             242601_at, 227725_at, 228232_s_at; and/or     -   (ii) FCGBP, HMGCS2, RETNLB, L1TD1, SLITRK6, VSIG2, LOC253012,         ST6GALNAC1         in a biological sample from said individual wherein a lower         level of expression of the genes or transcripts of group (i)         and/or (ii) relative to a gastrointestinal adenoma control level         is indicative of a cancer or a cell predisposed to the onset of         a cancerous state.

Preferably, said gastrointestinal tissue is colorectal tissue.

Even more preferably, said biological sample is a tissue sample.

In still another related aspect it has been determined that a subset of the markers of this aspect of the present invention are useful as qualitative markers of neoplastic tissue characterisation in that these markers, if not detectable at levels substantially above background levels in neoplastic tissue are indicative of cancerous tissue.

According to this aspect, the present invention provides a method of characterising a neoplastic cell or cellular population, which cell or cellular population is derived from the large intestine of an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from:

-   -   (i) the gene or genes detected by Affymetrix probeset IDs:         -   235976_at 236894_at 237521; and/or     -   (ii) SLITRK6 L1TD1         in a biological sample from said individual wherein expression         of the genes or transcripts of group (i) and/or (ii) at a level         which is not substantially greater than background neoplastic         tissue levels is indicative of a cancer or a cell predisposed to         the onset of a cancerous state.

Preferably, said gastrointestinal tissue is colorectal tissue.

Still more preferably, said biological sample is a tissue sample.

In a most preferred embodiment, the methods of the present invention are preferably directed to screening for proteins encoded by the markers of the present invention or changes to DNA methylation of genomic DNA. In another embodiment, expression is assessed by the association of DNA with chromatin proteins carrying repressive modifications, for example, methylation of lysines 9 or 27 of histone H3.

Although the preferred method is to detect the expression product or DNA changes of the neoplastic markers for the purpose of diagnosing neoplasia development or predisposition thereto, the detection of converse changes in the levels of said markers may be desired under certain circumstances, for example, to monitor the effectiveness of therapeutic or prophylactic treatment directed to modulating a neoplastic condition, such as adenoma or adenocarcinoma development. For example, where reduced expression of the subject markers indicates that an individual has developed a condition characterised by adenoma or adenocarcinoma development, for example, screening for an increase in the levels of these markers subsequently to the onset of a therapeutic regime may be utilised to indicate reversal or other form of improvement of the subject individual's condition.

The method of the present invention is therefore useful as a one off test or as an on-going monitor of those individuals thought to be at risk of neoplasia development or as a monitor of the effectiveness of therapeutic or prophylactic treatment regimes directed to inhibiting or otherwise slowing neoplasia development. In these situations, mapping the modulation of neoplastic marker expression levels in any one or more classes of biological samples is a valuable indicator of the status of an individual or the effectiveness of a therapeutic or prophylactic regime which is currently in use. Accordingly, the method of the present invention should be understood to extend to monitoring for increases or decreases in marker expression levels in an individual relative to their normal level (as hereinbefore defined), background control levels, cancer levels, adenoma levels or relative to one or more earlier marker expression levels determined from a biological sample of said individual.

Means of assessing the subject expressed neoplasm markers in a biological sample can be achieved by any suitable method, which would be well known to the person of skill in the art. To this end, it would be appreciated that to the extent that one is examining either a homogeneous cellular population (such as a tumour biopsy or a cellular population which has been enriched from a heterogeneous starting population) or a tissue section, one may utilise a wide range of techniques such as in situ hybridisation, assessment of expression profiles by microassays, immunoassays and the like (hereinafter described in more detail) to detect the absence of or downregulation of the level of expression of one or more markers of interest. However, to the extent that one is screening a heterogenous cellular population or a bodily fluid in which heterogeneous populations of cells are found, such as a blood sample, the absence of or reduction in level of expression of a particular marker may be undetectable due to the inherent expression of the marker by non-neoplastic cells which are present in the sample. That is, a decrease in the level of expression of a subgroup of cells may not be detectable. In this situation, a more appropriate mechanism of detecting a reduction in a neoplastic subpopulation of the expression levels of one or more markers of the present invention is via indirect means, such as the detection of epigenetic changes.

Without limiting the present invention to any one theory or mode of action, during development gene expression is regulated by processes that alter the availability of genes for expression in different cell lineages without any alteration in gene sequence, and these states can be inherited through a cell division—a process called epigenetic inheritance. Epigenetic inheritance is determined by a combination of DNA methylation (modification of cytosine to give 5-methyl cytosine, 5 meC) and by modifications of the histone chromosomal proteins that package DNA. Thus methylation of DNA at CpG sites and modifications such as deacetylation of histone H3 on lysine 9, and methylation on lysine 9 or 27 are associated with inactive chromatin, while the converse state of a lack of DNA methylation, acetylation of lysine 9 of histone H3 is associated with open chromatin and active gene expression. In cancer, this epigenetic regulation of gene expression is frequently found to be disrupted (Esteller & Herman, 2000; Jones & Baylin, 2002). Genes such as tumour suppressor or metastasis suppressor genes are often found to be silenced by DNA methylation, while other genes may be hypomethylated and inappropriately expressed. Thus, among genes that show a decrease or loss of expression in cancer, this is often characterised by methylation of the promoter or regulatory region of the gene.

A variety of methods are available for detection of aberrantly methylated DNA of a specific gene, even in the presence of a large excess of normal DNA (Clark 2007). Thus, loss of expression of a gene which can be difficult to detect at the protein or RNA level except by immunohistochemistry can often be detected in tumour samples and in bodily fluids of cancer patients by the presence of hypermethylated DNA of the gene's promoter. Similarly DNA hypomethylation may be used for the detection of certain genes whose expression is elevated in cancer. Epigenetic alterations and chromatin changes in cancer are also evident in the altered association of modified histones with specific genes (Esteller, 2007); for example repressed genes are often found associated with histone H3 that is deacetylated and methylated on lysine 9. The use of antibodies targeted to altered histones allows for the isolation of DNA associated with particular chromatin states and its potential use in cancer diagnosis.

Other methods of detecting changes to gene expression levels, particularly where the subject biological sample is not contaminated with high numbers of non-neoplastic cells, include but are not limited to:

-   (i) In vivo detection.     -   Molecular Imaging may be used following administration of         imaging probes or reagents capable of disclosing altered         expression of the markers in the intestinal tissues.     -   Molecular imaging (Moore et al., BBA, 1402:239-249, 1988;         Weissleder et al., Nature Medicine 6:351-355, 2000) is the in         vivo imaging of molecular expression that correlates with the         macro-features currently visualized using “classical” diagnostic         imaging techniques such as X-Ray, computed tomography (CT), MRI,         Positron Emission Tomography (PET) or endoscopy. -   (ii) Detection of downregulation of RNA expression in the cells by     Fluorescent In Situ Hybridization (FISH), or in extracts from the     cells by technologies such as Quantitative Reverse Transcriptase     Polymerase Chain Reaction (QRTPCR) or Flow cytometric qualification     of competitive RT-PCR products (Wedemeyer et al., Clinical Chemistry     48:9 1398-1405, 2002). -   (iii) Assessment of expression profiles of RNA, for example by array     technologies (Alon et al., Proc. Natl. Acad. Sci. USA: 96,     6745-6750, June 1999).     -   A “microarray” is a linear or multi-dimensional array of         preferably discrete regions, each having a defined area, formed         on the surface of a solid support. The density of the discrete         regions on a microarray is determined by the total numbers of         target polynucleotides to be detected on the surface of a single         solid phase support. As used herein, a DNA microarray is an         array of oligonucleotide probes placed onto a chip or other         surfaces used to amplify or clone target polynucleotides. Since         the position of each particular group of probes in the array is         known, the identities of the target polynucleotides can be         determined based on their binding to a particular position in         the microarray.     -   Recent developments in DNA microarray technology make it         possible to conduct a large scale assay of a plurality of target         nucleic acid molecules on a single solid phase support. U.S.         Pat. No. 5,837,832 (Chee et al.) and related patent applications         describe immobilizing an array of oligonucleotide probes for         hybridization and detection of specific nucleic acid sequences         in a sample. Target polynucleotides of interest isolated from a         tissue of interest are hybridized to the DNA chip and the         specific sequences detected based on the target polynucleotides'         preference and degree of hybridization at discrete probe         locations. One important use of arrays is in the analysis of         differential gene expression, where the profile of expression of         genes in different cells or tissues, often a tissue of interest         and a control tissue, is compared and any differences in gene         expression among the respective tissues are identified. Such         information is useful for the identification of the types of         genes expressed in a particular tissue type and diagnosis of         conditions based on the expression profile.     -   In one example, RNA from the sample of interest is subjected to         reverse transcription to obtain labelled cDNA. See U.S. Pat. No.         6,410,229 (Lockhart et al.) The cDNA is then hybridized to         oligonucleotides or cDNAs of known sequence arrayed on a chip or         other surface in a known order. In another example, the RNA is         isolated from a biological sample and hybridised to a chip on         which are anchored cDNA probes. The location of the         oligonucleotide to which the labelled cDNA hybridizes provides         sequence information on the cDNA, while the amount of labelled         hybridized RNA or cDNA provides an estimate of the relative         representation of the RNA or cDNA of interest. See Schena, et         al. Science 270:467-470 (1995). For example, use of a cDNA         microarray to analyze gene expression patterns in human cancer         is described by DeRisi, et al. (Nature Genetics 14:457-460         (1996)).     -   In a preferred embodiment, nucleic acid probes corresponding to         the subject nucleic acids are made. The nucleic acid probes         attached to the biochip are designed to be substantially         complementary to the nucleic acids of the biological sample such         that specific hybridization of the target sequence and the         probes of the present invention occurs. This complementarity         need not be perfect, in that there may be any number of base         pair mismatches that will interfere with hybridization between         the target sequence and the single stranded nucleic acids of the         present invention. It is expected that the overall homology of         the genes at the nucleotide level probably will be about 40% or         greater, probably about 60% or greater, and even more probably         about 80% or greater; and in addition that there will be         corresponding contiguous sequences of about 8-12 nucleotides or         longer. However, if the number of mutations is so great that no         hybridization can occur under even the least stringent of         hybridization conditions, the sequence is not a complementary         target sequence. Thus, by “substantially complementary” herein         is meant that the probes are sufficiently complementary to the         target sequences to hybridize under normal reaction conditions,         particularly high stringency conditions.     -   A nucleic acid probe is generally single stranded but can be         partly single and partly double stranded. The strandedness of         the probe is dictated by the structure, composition, and         properties of the target sequence. In general, the         oligonucleotide probes range from about 6, 8, 10, 12, 15, 20, 30         to about 100 bases long, with from about 10 to about 80 bases         being preferred, and from about 15 to about 40 bases being         particularly preferred. That is, generally entire genes are         rarely used as probes. In some embodiments, much longer nucleic         acids can be used, up to hundreds of bases. The probes are         sufficiently specific to hybridize to a complementary template         sequence under conditions known by those of skill in the art.         The number of mismatches between the probe's sequences and their         complementary template (target) sequences to which they         hybridize during hybridization generally do not exceed 15%,         usually do not exceed 10% and preferably do not exceed 5%,         as-determined by BLAST (default settings).     -   Oligonucleotide probes can include the naturally-occurring         heterocyclic bases normally found in nucleic acids (uracil,         cytosine, thymine, adenine and guanine), as well as modified         bases and base analogues. Any modified base or base analogue         compatible with hybridization of the probe to a target sequence         is useful in the practice of the invention. The sugar or         glycoside portion of the probe can comprise deoxyribose, ribose,         and/or modified forms of these sugars, such as, for example,         2′-O-alkyl ribose. In a preferred embodiment, the sugar moiety         is 2′-deoxyribose; however, any sugar moiety that is compatible         with the ability of the probe to hybridize to a target sequence         can be used.     -   In one embodiment, the nucleoside units of the probe are linked         by a phosphodiester backbone, as is well known in the art. In         additional embodiments, internucleotide linkages can include any         linkage known to one of skill in the art that is compatible with         specific hybridization of the probe including, but not limited         to phosphorothioate, methylphosphonate, sulfamate (e.g., U.S.         Pat. No. 5,470,967) and polyamide (i.e., peptide nucleic acids).         Peptide nucleic acids are described in Nielsen et al. (1991)         Science 254: 1497-1500, U.S. Pat. No. 5,714,331, and         Nielsen (1999) Curr. Opin. Biotechnol. 10:71-75.     -   In certain embodiments, the probe can be a chimeric molecule;         i.e., can comprise more than one type of base or sugar subunit,         and/or the linkages can be of more than one type within the same         primer. The probe can comprise a moiety to facilitate         hybridization to its target sequence, as are known in the art,         for example, intercalators and/or minor groove binders.         Variations of the bases, sugars, and internucleoside backbone,         as well as the presence of any pendant group on the probe, will         be compatible with the ability of the probe to bind, in a         sequence-specific fashion, with its target sequence. A large         number of structural modifications, are possible within these         bounds. Advantageously, the probes according to the present         invention may have structural characteristics such that they         allow the signal amplification, such structural characteristics         being, for example, branched DNA probes as those described by         Urdea et al. (Nucleic Acids Symp. Ser., 24:197-200 (1991)) or in         the European Patent No. EP-0225,807. Moreover, synthetic methods         for preparing the various heterocyclic bases, sugars,         nucleosides and nucleotides that form the probe, and preparation         of oligonucleotides of specific predetermined sequence, are         well-developed and known in the art. A preferred method for         oligonucleotide synthesis incorporates the teaching of U.S. Pat.         No. 5,419,966.     -   Multiple probes may be designed for a particular target nucleic         acid to account for polymorphism and/or secondary structure in         the target nucleic acid, redundancy of data and the like. In         some embodiments, where more than one probe per sequence is         used, either overlapping probes or probes to different sections         of a single target gene are used. That is, two, three, four or         more probes, are used to build in a redundancy for a particular         target. The probes can be overlapping (i.e. have some sequence         in common), or are specific for distinct sequences of a gene.         When multiple target polynucleotides are to be detected         according to the present invention, each probe or probe group         corresponding to a particular target polynucleotide is situated         in a discrete area of the microarray.     -   Probes may be in solution, such as in wells or on the surface of         a micro-array, or attached to a solid support. Examples of solid         support materials that can be used include a plastic, a ceramic,         a metal, a resin, a gel and a membrane. Useful types of solid         supports include plates, beads, magnetic material, microbeads,         hybridization chips, membranes, crystals, ceramics and         self-assembling monolayers. One example comprises a         two-dimensional or three-dimensional matrix, such as a gel or         hybridization chip with multiple probe binding sites (Pevzner et         al., J. Biomol. Struc. & Dyn. 9:399-410, 1991; Maskos and         Southern, Nuc. Acids Res. 20:1679-84, 1992). Hybridization chips         can be used to construct very large probe arrays that are         subsequently hybridized with a target nucleic acid. Analysis of         the hybridization pattern of the chip can assist in the         identification of the target nucleotide sequence. Patterns can         be manually or computer analyzed, but it is clear that         positional sequencing by hybridization lends itself to computer         analysis and automation. In another example, one may use an         Affymetrix chip on a solid phase structural support in         combination with a fluorescent bead based approach. In yet         another example, one may utilise a cDNA microarray. In this         regard, the oligonucleotides described by Lockkart et al (i.e.         Affymetrix synthesis probes in situ on the solid phase) are         particularly preferred, that is, photolithography.

As will be appreciated by those in the art, nucleic acids can be attached or immobilized to a solid support in a wide variety of ways. By “immobilized” herein is meant the association or binding between the nucleic acid probe and the solid support is sufficient to be stable under the conditions of binding, washing, analysis, and removal. The binding can be covalent or non-covalent. By “non-covalent binding” and grammatical equivalents herein is meant one or more of either electrostatic, hydrophilic, and hydrophobic interactions. Included in non-covalent binding is the covalent attachment of a molecule, such as streptavidin, to the support and the non-covalent binding of the biotinylated probe to the streptavidin. By “covalent binding” and grammatical equivalents herein is meant that the two moieties, the solid support and the probe, are attached by at least one bond, including sigma bonds, pi bonds and coordination bonds. Covalent bonds can be formed directly between the probe and the solid support or can be formed by a cross linker or by inclusion of a specific reactive group on either the solid support or the probe or both molecules. Immobilization may also involve a combination of covalent and non-covalent interactions.

-   -   Nucleic acid probes may be attached to the solid support by         covalent binding such as by conjugation with a coupling agent or         by covalent or non-covalent binding such as electrostatic         interactions, hydrogen bonds or antibody-antigen coupling, or by         combinations thereof. Typical coupling agents include         biotin/avidin, biotin/streptavidin, Staphylococcus aureus         protein A/IgG antibody F_(c) fragment, and streptavidin/protein         A chimeras (T. Sano and C. R. Cantor, Bio/Technology 9:1378-81         (1991)), or derivatives or combinations of these agents. Nucleic         acids may be attached to the solid support by a photocleavable         bond, an electrostatic bond, a disulfide bond, a peptide bond, a         diester bond or a combination of these sorts of bonds. The array         may also be attached to the solid support by a selectively         releasable bond such as 4,4′-dimethoxytrityl or its derivative.         Derivatives which have been found to be useful include 3 or 4         [bis-(4-methoxyphenyl)]-methyl-benzoic acid, N-succinimidyl-3 or         4 [bis-(4-methoxyphenyl)]-methyl-benzoic acid, N-succinimidyl-3         or 4 [bis-(4-methoxyphenyl)]-hydroxymethyl-benzoic acid,         N-succinimidyl-3 or 4         [bis-(4-methoxyphenyl)]-chloromethyl-benzoic acid, and salts of         these acids.     -   In general, the probes are attached to the biochip in a wide         variety of ways, as will be appreciated by those in the art. As         described herein, the nucleic acids can either be synthesized         first, with subsequent attachment to the biochip, or can be         directly synthesized on the biochip.     -   The biochip comprises a suitable solid substrate. By “substrate”         or “solid support” or other grammatical equivalents herein is         meant any material that can be modified to contain discrete         individual sites appropriate for the attachment or association         of the nucleic acid probes and is amenable to at least one         detection method. The solid phase support of the present         invention can be of any solid materials and structures suitable         for supporting nucleotide hybridization and synthesis.         Preferably, the solid phase support comprises at least one         substantially rigid surface on which the primers can be         immobilized and the reverse transcriptase reaction performed.         The substrates with which the polynucleotide microarray elements         are stably associated and may be fabricated from a variety of         materials, including plastics, ceramics, metals, acrylamide,         cellulose, nitrocellulose, glass, polystyrene, polyethylene         vinyl acetate, polypropylene, polymethacrylate, polyethylene,         polyethylene oxide, polysilicates, polycarbonates, Teflon,         fluorocarbons, nylon, silicon rubber, polyanhydrides,         polyglycolic acid, polylactic acid, polyorthoesters,         polypropylfumerate, collagen, glycosaminoglycans, and polyamino         acids. Substrates may be two-dimensional or three-dimensional in         form, such as gels, membranes, thin films, glasses, plates,         cylinders, beads, magnetic beads, optical fibers, woven fibers,         etc. A preferred form of array is a three-dimensional array. A         preferred three-dimensional array is a collection of tagged         beads. Each tagged bead has different primers attached to it.         Tags are detectable by signalling means such as color (Luminex,         Illumina) and electromagnetic field (Pharmaseq) and signals on         tagged beads can even be remotely detected (e.g., using optical         fibers). The size of the solid support can be any of the         standard microarray sizes, useful for DNA microarray technology,         and the size may be tailored to fit the particular machine being         used to conduct a reaction of the invention. In general, the         substrates allow optical detection and do not appreciably         fluoresce.     -   In one embodiment, the surface of the biochip and the probe may         be derivatized with chemical functional groups for subsequent         attachment of the two. Thus, for example, the biochip is         derivatized with a chemical functional group including, but not         limited to, amino groups, carboxy groups, oxo groups and thiol         groups, with amino groups being particularly preferred. Using         these functional groups, the probes can be attached using         functional groups on the probes. For example, nucleic acids         containing amino groups can be attached to surfaces comprising         amino groups, for example using linkers as are known in the art;         for example, homo- or hetero-bifunctional linkers as are well         known. In addition, in some cases, additional linkers, such as         alkyl groups (including substituted and heteroalkyl groups) may         be used.     -   In this embodiment, the oligonucleotides are synthesized as is         known in the art, and then attached to the surface of the solid         support. As will be appreciated by those skilled in the art,         either the 5′ or 3′ terminus may be attached to the solid         support, or attachment may be via an internal nucleoside. In an         additional embodiment, the immobilization to the solid support         may be very strong, yet non-covalent. For example, biotinylated         oligonucleotides can be made, which bind to surfaces covalently         coated with streptavidin, resulting in attachment.     -   The arrays may be produced according to any convenient         methodology, such as preforming the polynucleotide microarray         elements and then stably associating them with the surface.         Alternatively, the oligonucleotides may be synthesized on the         surface, as is known in the art. A number of different array         configurations and methods for their production are known to         those of skill in the art and disclosed in WO 95/25116 and WO         95/35505 (photolithographic techniques), U.S. Pat. No. 5,445,934         (in situ synthesis by photolithography), U.S. Pat. No. 5,384,261         (in situ synthesis by mechanically directed flow paths); and         U.S. Pat. No. 5,700,637 (synthesis by spotting, printing or         coupling); the disclosure of which are herein incorporated in         their entirety by reference. Another method for coupling DNA to         beads uses specific ligands attached to the end of the DNA to         link to ligand-binding molecules attached to a bead. Possible         ligand-binding partner pairs include biotin-avidin/streptavidin,         or various antibody/antigen pairs such as         digoxygenin-antidigoxygenin antibody (Smith et al., Science         258:1122-1126 (1992)). Covalent chemical attachment of DNA to         the support can be accomplished by using standard coupling         agents to link the 5′-phosphate on the DNA to coated         microspheres through a phosphoamidate bond. Methods for         immobilization of oligonucleotides to solid-state substrates are         well established. See Pease et al., Proc. Natl. Acad. Sci. USA         91(11):5022-5026 (1994). A preferred method of attaching         oligonucleotides to solid-state substrates is described by Guo         et al., Nucleic Acids Res. 22:5456-5465 (1994). Immobilization         can be accomplished either by in situ DNA synthesis (Maskos and         Southern, supra) or by covalent attachment of chemically         synthesized oligonucleotides (Guo et al., supra) in combination         with robotic arraying technologies.     -   In addition to the solid-phase technology represented by biochip         arrays, gene expression can also be quantified using         liquid-phase arrays. One such system is kinetic polymerase chain         reaction (PCR). Kinetic PCR allows for the simultaneous         amplification and quantification of specific nucleic acid         sequences. The specificity is derived from synthetic         oligonucleotide primers designed to preferentially adhere to         single-stranded nucleic acid sequences bracketing the target         site. This pair of oligonucleotide primers form specific,         non-covalently bound complexes on each strand of the target         sequence. These complexes facilitate in vitro transcription of         double-stranded DNA in opposite orientations. Temperature         cycling of the reaction mixture creates a continuous cycle of         primer binding, transcription, and re-melting of the nucleic         acid to individual strands. The result is an exponential         increase of the target dsDNA product. This product can be         quantified in real time either through the use of an         intercalating dye or a sequence specific probe. SYBR(r) Green 1,         is an example of an intercalating dye, that preferentially binds         to dsDNA resulting in a concomitant increase in the fluorescent         signal. Sequence specific probes, such as used with TaqMan         technology, consist of a fluorochrome and a quenching molecule         covalently bound to opposite ends of an oligonucleotide. The         probe is designed to selectively bind the target DNA sequence         between the two primers. When the DNA strands are synthesized         during the PCR reaction, the fluorochrome is cleaved from the         probe by the exonuclease activity of the polymerase resulting in         signal dequenching. The probe signalling method can be more         specific than the intercalating dye method, but in each case,         signal strength is proportional to the dsDNA product produced.         Each type of quantification method can be used in multi-well         liquid phase arrays with each well representing primers and/or         probes specific to nucleic acid sequences of interest. When used         with messenger RNA preparations of tissues or cell lines, an         array of probe/primer reactions can simultaneously quantify the         expression of multiple gene products of interest. See Germer et         al., Genome Res. 10:258-266 (2000); Heid et al., Genome Res.         6:986-994 (1996).

-   (iv) Measurement of altered neoplastic marker protein levels in cell     extracts, for example by immunoassay.     -   Testing for proteinaceous neoplastic marker expression product         in a biological sample can be performed by any one of a number         of suitable methods which are well known to those skilled in the         art. Examples of suitable methods include, but are not limited         to, antibody screening of tissue sections, biopsy specimens or         bodily fluid samples.     -   To the extent that antibody based methods of diagnosis are used,         the presence of the marker protein may be determined in a number         of ways such as by Western blotting, ELISA or flow cytometry         procedures. These, of course, include both single-site and         two-site or “sandwich” assays of the non-competitive types, as         well as in the traditional competitive binding assays. These         assays also include direct binding of a labelled antibody to a         target.     -   Sandwich assays are a useful and commonly used assay. A number         of variations of the sandwich assay technique exist, and all are         intended to be encompassed by the present invention. Briefly, in         a typical forward assay, an unlabelled antibody is immobilized         on a solid substrate and the sample to be tested brought into         contact with the bound molecule. After a suitable period of         incubation, for a period of time sufficient to allow formation         of an antibody-antigen complex, a second antibody specific to         the antigen, labelled with a reporter molecule capable of         producing a detectable signal is then added and incubated,         allowing time sufficient for the formation of another complex of         antibody-antigen-labelled antibody. Any unreacted material is         washed away, and the presence of the antigen is determined by         observation of a signal produced by the reporter molecule. The         results may either be qualitative, by simple observation of the         visible signal, or may be quantitated by comparing with a         control sample. Variations on the forward assay include a         simultaneous assay, in which both sample and labelled antibody         are added simultaneously to the bound antibody. These techniques         are well known to those skilled in the art, including any minor         variations as will be readily apparent.     -   In the typical forward sandwich assay, a first antibody having         specificity for the marker or antigenic parts thereof, is either         covalently or passively bound to a solid surface. The solid         surface is typically glass or a polymer, the most commonly used         polymers being cellulose, polyacrylamide, nylon, polystyrene,         polyvinyl chloride or polypropylene. The solid supports may be         in the form of tubes, beads, discs of microplates, or any other         surface suitable for conducting an immunoassay. The binding         processes are well-known in the art and generally consist of         cross-linking, covalently binding or physically adsorbing, the         polymer-antibody complex is washed in preparation for the test         sample. An aliquot of the sample to be tested is then added to         the solid phase complex and incubated for a period of time         sufficient (e.g. 2-40 minutes) and under suitable conditions         (e.g. 25° C.) to allow binding of any subunit present in the         antibody. Following the incubation period, the antibody subunit         solid phase is washed and dried and incubated with a second         antibody specific for a portion of the antigen. The second         antibody is linked to a reporter molecule which is used to         indicate the binding of the second antibody to the antigen.     -   An alternative method involves immobilizing the target molecules         in the biological sample and then exposing the immobilized         target to specific antibody which may or may not be labelled         with a reporter molecule. Depending on the amount of target and         the strength of the reporter molecule signal, a bound target may         be detectable by direct labelling with the antibody.         Alternatively, a second labelled antibody, specific to the first         antibody is exposed to the target-first antibody complex to form         a target-first antibody-second antibody tertiary complex. The         complex is detected by the signal emitted by the reporter         molecule.     -   By “reporter molecule” as used in the present specification, is         meant a molecule which, by its chemical nature, provides an         analytically identifiable signal which allows the detection of         antigen-bound antibody. Detection may be either qualitative or         quantitative. The most commonly used reporter molecules in this         type of assay are either enzymes, fluorophores or radionuclide         containing molecules (i.e. radioisotopes) and chemiluminescent         molecules.     -   In the case of an enzyme immunoassay, an enzyme is conjugated to         the second antibody, generally by means of glutaraldehyde or         periodate. As will be readily recognized, however, a wide         variety of different conjugation techniques exist, which are         readily available to the skilled artisan. Commonly used enzymes         include horseradish peroxidase, glucose oxidase,         beta-galactosidase and alkaline phosphatase, amongst others. The         substrates to be used with the specific enzymes are generally         chosen for the production, upon hydrolysis by the corresponding         enzyme, of a detectable color change. Examples of suitable         enzymes include alkaline phosphatase and peroxidase. It is also         possible to employ fluorogenic substrates, which yield a         fluorescent product rather than the chromogenic substrates noted         above. In all cases, the enzyme-labelled antibody is added to         the first antibody hapten complex, allowed to bind, and then the         excess reagent is washed away. A solution containing the         appropriate substrate is then added to the complex of         antibody-antigen-antibody. The substrate will react with the         enzyme linked to the second antibody, giving a qualitative         visual signal, which may be further quantitated, usually         spectrophotometrically, to give an indication of the amount of         antigen which was present in the sample. “Reporter molecule”         also extends to use of cell agglutination or inhibition of         agglutination such as red blood cells on latex beads, and the         like.     -   Alternately, fluorescent compounds, such as fluorecein and         rhodamine, may be chemically coupled to antibodies without         altering their binding capacity. When activated by illumination         with light of a particular wavelength, the fluorochrome-labelled         antibody adsorbs the light energy, inducing a state to         excitability in the molecule, followed by emission of the light         at a characteristic color visually detectable with a light         microscope. As in the EIA, the fluorescent labelled antibody is         allowed to bind to the first antibody-hapten complex. After         washing off the unbound reagent, the remaining tertiary complex         is then exposed to the light of the appropriate wavelength the         fluorescence observed indicates the presence of the hapten of         interest. Immunofluorescence and EIA techniques are both very         well established in the art and are particularly preferred for         the present method. However, other reporter molecules, such as         radioisotope, chemiluminescent or bioluminescent molecules, may         also be employed.

-   (v) Determining altered expression of protein neoplastic markers on     the cell surface, for example by immunohistochemistry.

-   (vi) Determining altered protein expression based on any suitable     functional test, enzymatic test or immunological test in addition to     those detailed in points (iv) and (v) above.

A person of ordinary skill in the art could determine, as a matter of routine procedure, the appropriateness of applying a given method to a particular type of biological sample.

Without limiting the present invention in any way, and as detailed above, gene expression levels can be measured by a variety of methods known in the art. For example, gene transcription or translation products can be measured. Gene transcription products, i.e., RNA, can be measured, for example, by hybridization assays, run-off assays., Northern blots, or other methods known in the art.

Hybridization assays generally involve the use of oligonucleotide probes that hybridize to the single-stranded RNA transcription products. Thus, the oligonucleotide probes are complementary to the transcribed RNA expression product. Typically, a sequence-specific probe can be directed to hybridize to RNA or cDNA. A “nucleic acid probe”, as used herein, can be a DNA probe or an RNA probe that hybridizes to a complementary sequence. One of skill in the art would know how to design such a probe such that sequence specific hybridization will occur. One of skill in the art will further know how to quantify the amount of sequence specific hybridization as a measure of the amount of gene expression for the gene was transcribed to produce the specific RNA.

The hybridization sample is maintained under conditions that are sufficient to allow specific hybridization of the nucleic acid probe to a specific gene expression product. “Specific hybridization”, as used herein, indicates near exact hybridization (e.g., with few if any mismatches). Specific hybridization can be performed under high stringency conditions or moderate stringency conditions. In one embodiment, the hybridization conditions for specific hybridization are high stringency. For example, certain high stringency conditions can be used to distinguish perfectly complementary nucleic acids from those of less complementarity. “High stringency conditions”, “moderate stringency conditions” and “low stringency conditions” for nucleic acid hybridizations are explained on pages 2.10.1-2.10.16 and pages 6.3.1-6.3.6 in Current Protocols in Molecular Biology (Ausubel, F. et al., “Current Protocols in Molecular Biology”, John Wiley & Sons, (1998), the entire teachings of which are incorporated by reference herein). The exact conditions that determine the stringency of hybridization depend not only on ionic strength (e.g., 0.2.times.SSC, 0.1.times.SSC), temperature (e.g., room temperature, 42° C., 68° C.) and the concentration of destabilizing agents such as formamide or denaturing agents such as SDS, but also on factors such as the length of the nucleic acid sequence, base composition, percent mismatch between hybridizing sequences and the frequency of occurrence of subsets of that sequence within other non-identical sequences. Thus, equivalent conditions can be determined by varying one or more of these parameters while maintaining a similar degree of identity or similarity between the two nucleic acid molecules. Typically, conditions are used such that sequences at least about 60%, at least about 70%, at least about 80%, at least about 90% or at least about 95% or more identical to each other remain hybridized to one another. By varying hybridization conditions from a level of stringency at which no hybridization occurs to a level at which hybridization is first observed, conditions that will allow a given sequence to hybridize (e.g., selectively) with the most complementary sequences in the sample can be determined.

Exemplary conditions that describe the determination of wash conditions for moderate or low stringency conditions are described in Kraus, M. and Aaronson, S., 1991. Methods Enzymol., 200:546-556; and in, Ausubel et al., Current Protocols in Molecular Biology, John Wiley & Sons, (1998). Washing is the step in which conditions are usually set so as to determine a minimum level of complementarity of the hybrids. Generally, starting from the lowest temperature at which only homologous hybridization occurs, each ° C. by which the final wash temperature is reduced (holding SSC concentration constant) allows an increase by 1% in the maximum mismatch percentage among the sequences that hybridize. Generally, doubling the concentration of SSC results in an increase in T_(m) of about 17° C. Using these guidelines, the wash temperature can be determined empirically for high, moderate or low stringency, depending on the level of mismatch sought. For example, a low stringency wash can comprise washing in a solution containing 0.2.times.SSC/0.1% SDS for 10 minutes at room temperature; a moderate stringency wash can comprise washing in a pre-warmed solution (42° C.) solution containing 0.2.times.SSC/0.1% SDS for 15 minutes at 42° C.; and a high stringency wash can comprise washing in pre-warmed (68° C.) solution containing 0.1.times.SSC/0.1% SDS for 15 minutes at 68° C. Furthermore, washes can be performed repeatedly or sequentially to obtain a desired result as known in the art. Equivalent conditions can be determined by varying one or more of the parameters given as an example, as known in the art, while maintaining a similar degree of complementarity between the target nucleic acid molecule and the primer or probe used (e.g., the sequence to be hybridized).

A related aspect of the present invention provides a molecular array, which array comprises a plurality of:

-   (i) nucleic acid molecules comprising a nucleotide sequence     corresponding to any one or more of the neoplastic marker genes     hereinbefore described or a sequence exhibiting at least 80%     identity thereto or a functional derivative, fragment, variant or     homologue of said nucleic acid molecule; or -   (ii) nucleic acid molecules comprising a nucleotide sequence capable     of hybridising to any one or more of the sequences of (i) under     medium stringency conditions or a functional derivative, fragment,     variant or homologue of said nucleic acid molecule; or -   (iii) nucleic acid probes or oligonucleotides comprising a     nucleotide sequence capable of hybridising to any one or more of the     sequences of (i) under medium stringency conditions or a functional     derivative, fragment, variant or homologue of said nucleic acid     molecule; or -   (iv) probes capable of binding to any one or more of the proteins     encoded by the nucleic acid molecules of (i) or a derivative,     fragment or, homologue thereof     wherein the level of expression of said marker genes of (i) or     proteins of (iv) is indicative of the neoplastic state of a cell or     cellular subpopulation derived from the large intestine.

Preferably, said percent identity is at least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99%.

Low stringency includes and encompasses from at least about 1% v/v to at least about 15% v/v formamide and from at least about 1M to at least about 2M salt for hybridisation, and at least about 1M to at least about 2M salt for washing conditions. Alternative stringency conditions may be applied where necessary, such as medium stringency, which includes and encompasses from at least about 16% v/v at least about 30% v/v formamide and from at least about 0.5M to at least about 0.9M salt for hybridisation, and at least about 0.5M to at least about 0.9M salt for washing conditions, or high stringency, which includes and encompasses from at least about 31% v/v to at least about 50% v/v formamide and from at least about 0.01M to at least about 0.15M salt for hybridisation, and at least about 0.01M to at least about 0.15M salt for washing conditions. In general, washing is carried out at T_(m)=69.3+0.41 (G+C) % [19]=−12° C. However, the T_(m) of a duplex DNA decreases by 1° C. with every increase of 1% in the number of mismatched based pairs (Bonner et al (1973) J. Mol. Biol. 81:123).

Preferably, the subject probes are designed to bind to the nucleic acid or protein to which they are directed with a level of specificity which minimises the incidence of non-specific reactivity. However, it would be appreciated that it may not be possible to eliminate all potential cross-reactivity or non-specific reactivity, this being an inherent limitation of any probe based system.

In terms of the probes which are used to detect the subject proteins, they may take any suitable form including antibodies and aptamers.

A library or array of nucleic acid or protein probes provides rich and highly valuable information. Further, two or more arrays or profiles (information obtained from use of an array) of such sequences are useful tools for comparing a test set of results with a reference, such as another sample or stored calibrator. In using an array, individual probes typically are immobilized at separate locations and allowed to react for binding reactions. Primers associated with assembled sets of markers are useful for either preparing libraries of sequences or directly detecting markers from other biological samples.

A library (or array, when referring to physically separated nucleic acids corresponding to at least some sequences in a library) of gene markers exhibits highly desirable properties. These properties are associated with specific conditions, and may be characterized as regulatory profiles. A profile, as termed here refers to a set of members that provides diagnostic information of the tissue from which the markers were originally derived. A profile in many instances comprises a series of spots on an array made from deposited sequences.

A characteristic patient profile is generally prepared by use of an array. An array profile may be compared with one or more other array profiles or other reference profiles. The comparative results can provide rich information pertaining to disease states, developmental state, receptiveness to therapy and other information about the patient.

Another aspect of the present invention provides a diagnostic kit for assaying biological samples comprising an agent for detecting one or more neoplastic marker reagents useful for facilitating the detection by the agent in the first compartment. Further means may also be included, for example, to receive a biological sample. The agent may be any suitable detecting molecule.

The present invention is further described by the following non-limiting examples:

Example 1 Methods and Materials Affymetrix GeneChip Data

Gene expression profiling data and accompanying clinical data was purchased from GeneLogic Inc (Gaithersburg, Md. USA). For each tissue analysed, oligonucleotide microarray data for 44,928 probesets (Affymetrix HGU133A & HGU133B, combined), experimental and clinical descriptors, and digitally archived microscopy images of histological preparations were received. A quality control analysis was performed to remove arrays not meeting essential quality control measures as defined by the manufacturer.

Transcript expression levels were calculated by both Microarray Suite (MAS) 5.0 (Affymetrix) and the Robust Multichip Average (RMA) normalization techniques (Affymetrix. GeneChip expression data analysis fundamentals. Affymetrix, Santa Clara, Calif. USA, 2001; Hubbell et al. Bioinformatics, 18:1585-1592, 2002; Irizarry et al. Nucleic Acid Research, 31, 2003) MAS normalized data was used for performing standard quality control routines and the final data set was normalized with RMA for all subsequent analyses.

Univariate Differential Expression

Differentially expressed gene transcripts were identified using a moderated t-test implemented in the limma library downloaded from the Bioconductor repository for R. (G. K. Smyth. Statistical Applications in Genetics and Molecular Biology, 3(1):Article 3, 2004; G K Smyth. Bioinformatics and Computational Biology Solutions using R and Bioconductor. Springer, New York, 2005). Significance estimates (p-values) were corrected to adjust for multiple hypothesis testing using the Bonferonni correction.

Tissue Specific Expression Patterns

To construct a filter for hypothetically ‘turned off’ gene expression the mean expression level for all 44,928 probesets across the full range of 454 tissues was first estimated. To estimate an expression on/off threshold, the 44,928 mean values were ranked and the expression value equivalent to the 30th percentile across the dataset calculated. This arbitrary threshold was chosen because it was theorized that the majority of transcripts (and presumably more than 30%) in a given specimen should be transcriptionally silenced. Thus this threshold represents a conservative upper bound for what is estimated as non-specific, or background, signal.

Gene Symbol Annotations

To map Affymetrix probeset names to official gene symbols the annotation metadata available from Bioconductor was used. Hgu133plus2 library version 1.16.0, which was assembled using Entrez Gene data downloaded on 15 Mar. 2007, was used.

Estimates of Performance Characteristics

Diagnostic utility for each table of markers shown herein was estimated including: sensitivity, specificity, positive predictive value, negative predictive value, likelihood ratio positive, likelihood ratio negative. These estimates were calculated in the same data used to discover the markers and will therefore potentially overestimate the performance characteristics in future tissue samples. To improve the generalisabilty of the estimates a modified jackknife resampling technique was used to calculate a less biased value for each characteristic.

Results

A range of univariate statistical tests were applied on Affymetrix oligonucleotide microarray data to reveal human genes that could be used to discriminate colorectal neoplastic tissues from non-neoplastic tissues. There were further identified a number of gene transcripts that appear to be useful for differentiating colorectal adenomas from colorectal carcinoma. Also identified were a subset of these transcripts that may have particular diagnostic utility due to the protein products being either secreted or displayed on the cell surface of epithelial cells. Finally, there were identified a further subset of transcripts expressed specifically in neoplastic tissues and at low- or near-background levels in non-neoplastic tissues.

Genes Differentially Expressed in Neoplastic Tissues

From a total GeneChip set of 44,928 probesets it was determined that over 11,000 probesets were differentially expressed by moderated t-test using the limma package in BioConductor (G. K. Smyth, 2004 supra) employing conservative (Bonferroni) multiple test correction. When this list was further filtered to include only those probesets demonstrating a 2-fold or greater mean expression change between the neoplastic and non-neoplastic tissues, 560 probesets were found to be expressed lower in neoplasias relative to normal tissues.

These 560 probesets were annotated using the most recent metadata and annotation packages available for the chips. The 560 underexpressed probesets were mapped to 434 gene symbols.

Δ-expression ProbeSet ID Gene Symbol Maps DOWN 560 434

Hypothetical Markers Specific for Colorectal Neoplasia

While differential gene expression patterns are useful for diagnostic purposes this project also seeks to identify diagnostic proteins shed into the lumen of the gut by neoplastic colorectal epithelia. To discover candidate proteins, the list of differentially expressed transcripts was filtered with a selection criteria aimed at identifying markers specifically turned off in colorectal neoplasia tissues. To identify ‘off’ genes the filter criteria were designed to find genes with i) neoplastic expression levels below a theoretical on/off threshold and ii) normal signals at least 2-fold higher. The expression profile of an example transcript that is ‘turned-off’ in neoplastic tissues is shown in FIG. 1.

Example 2 Probesets Elevated in Non-Neoplasia Relative to Neoplastic Tissues

Differential expression analysis was applied to identify down-regulated probesets in Affymetrix gene chip data measuring RNA concentration in 454 colorectal tissues including 161 adenocarcinoma specimens, 29 adenoma specimens, 42 colitis specimens and 222 non-diseased tissues. Using conservative corrections for multiple hypothesis testing and a 2-fold absolute fold change cut-off it was determined that 560 probesets exhibit a decreased expression level in neoplastic tissues relative to non-neoplastic controls. 560 of these probesets have been mapped to 434 putative gene symbols based on transcript nucleotide sequence.

Validation/Hypothesis Testing

RNA expression levels of these candidates were measured in independently derived clinical specimens. 526 probesets were hybridised to RNA extracts from 68 clinical specimens comprising 19 adenomas, 19 adenocarcinomas, and 30 non-diseased controls using a custom-designed ‘Adenoma Gene Chip’. Thirty-four (34) probesets were not tested as they were not included on the custom design. It was confirmed that 459 of 526 of the target probesets (or directly related probesets with the same gene locus target) were likewise differentially expressed (P<0.05) in these independently-derived tissues. The results of differential expression analysis of these 459 probesets is shown in Table 1.

The 372 of the 434 unique gene loci to which the 560 probesets are understood to hybridise were further tested. The remaining 62 gene symbols were not represented in the validation data. It was observed that 328 of 372 gene symbols were represented in the validation data by at least one differentially expressed probeset and many symbols included multiple probesets against regions across the putative locus. A complete list of probesets that bind to target loci is shown in Table 2.

CONCLUSION

The candidate probesets and symbols shown in Tables 1 and 2. respectively, are differentially expressed lower in neoplastic colorectal tissues compared to non-neoplastic controls.

Example 3 Probesets Demonstrating a Non-Neoplasia Specific Profile

During analysis of the discovery data, a novel expression profile was observed between neoplastic and non-neoplastic phenotypes. It was hypothesized that a subset of quantitatively differentially expressed probesets are furthermore qualitatively differentially expressed. Such probesets show no evidence of a gene expression activity in neoplastic tissues, i.e. these probesets appear to be expressed above background levels in non-neoplastic tissues only. This observation and the resulting hypothesis are based on two principles:

-   1. That the majority of human transcripts that are present on a     genome-wide GeneChip (e.g. U133) will not likely be expressed in the     colorectal mucosa; and -   2. That microarray binding intensity for such ‘off’ probesets (to     labeled cRNA) will reflect technical assay background, i.e.     non-specific oligonucleotide binding.

To generate a list of non-neoplasia specific probesets the neoplastic intensity of differentially expressed probesets were compared with a hypothetical background signal threshold from across all probesets on the chip. We note that, by design, all probesets in the candidate pool from which the ‘on’ transcripts are chosen are at least two fold over-expressed in the non-diseased tissues relative to diseased tissues. Combined, these criteria yield the subset of differentially expressed transcript species that are specifically expressed in non-neoplastic tissues.

This analysis demonstrated that 42 probesets corresponding to approximately 41 gene loci exhibit a non-neoplasia specific transcription expression profile.

Validation/Hypothesis Testing

The custom gene chip design precludes testing the non-neoplasia-specific probesets using the same principles as used for discovery. In particular, the custom gene chip (by design) does not contain a large pool of probesets anticipated to hybridise to hypothetically ‘off’/‘non-transcribed’ gene, transcripts. This is because the custom gene chip design is heavily biased toward differentially expressed transcripts in colorectal neoplastic tissues.

The usual differential expression testing (limma) was therefore applied to these candidate probesets for specifically expressed in non-neoplastic tissues. Of the 37 (of 42) probesets on the custom gene chip, 33 probesets (or probesets which bind to the same locus) were differentially expressed between the 38 neoplastic tissues (adenoma & cancer) and non-neoplastic controls. The results of these validation experiments is shown in Table 3.

It was further aimed to test all probesets which are known to hybridise to the gene loci to which the probesets claimed herein. Of the 41 putative gene loci targeted by the probesets, 33 were present in the validation data. All thirty-three (33) of these 33 (100%) gene symbols demonstrated at least one hybridising probeset which was differentially expressed in the neoplastic tissues. Results for these experiments, including all probesets that bind to each target locus in a differentially expressed manner are shown in Table 4.

Example 4 Materials and Methods for Examples 2 and 3

Gene expression profiling data measured in 454 colorectal tissue specimens including neoplastic, normal and non-neoplastic disease controls was purchased from GeneLogic Inc (Gaithersburg, Md. USA). For each tissue specimen Affymetrix (Santa Clara, Calif. USA) oligonucleotide microarray data totaling 44,928 probesets (HGU133A & HGU133B, combined), experimental and clinical descriptors, and digitally archived microscopy images of histological preparations was received. Prior to applying discovery methods to these data, extensive quality control methods, including statistical exploration, review of clinical records for consistency and histopathology audit of a random sample of arrays was carried out. Microarrays that did not meet acceptable quality criteria were removed from the analysis.

Hypothesis Testing

Candidate transcription biomarkers were tested using a custom oligonucleotide microarray of 25-mer oligonucleotide probesets designed to hybridise to candidate RNA transcripts identified during discovery. Differential expression hypotheses were tested using RNA extracts derived from independently collected clinical samples comprising 30 normal colorectal tissues, 19 colorectal adenoma tissues, and 19 colorectal adenocarcinoma tissues. Each RNA extract was confirmed to meet strict quality control criteria.

Colorectal Tissue Specimens

All tissues used for hypothesis testing were obtained from a tertiary referral hospital tissue bank in metropolitan Adelaide, Australia (Repatriation General Hospital and Flinders Medical Centre). Access to the tissue bank for this research was approved by the Research and Ethics Committee of the Repatriation General Hospital and the Ethics Committee of Flinders Medical Centre. Informed patient consent was received for each tissue studied.

Following surgical resection, specimens were placed in a sterile receptacle and collected from theatre. The time from operative resection to collection from theatre was variable but not more than 30 minutes. Samples, approximately 125 mm3 (5×5×5 mm) in size, were taken from the macroscopically normal tissue as far from pathology as possible, defined both by colonic region as well as by distance either proximal or distal to the pathology. Tissues were placed in cryovials, then immediately immersed in liquid nitrogen and stored at −150° C. until processing.

RNA Extraction

RNA extractions were performed using Trizol(R)reagent (Invitrogen, Carlsbad, Calif., USA) as per manufacturer's instructions. Each sample was homogenised in 3004 of Trizol reagent using a modified Dremel drill and sterilised disposable pestles. Additional 2004 of Trizol reagent was added to the homogenate and samples were incubated at RT for 10 minutes. 100 μL of chloroform was then added, samples were shaken vortexed for 15 seconds, and incubated at RT for 3 further minutes. The aqueous phase containing target RNA was obtained by centrifugation at 12,000 rpm for 15 min, 40° C. RNA was then precipitated by incubating samples at RT for 10 min with 250 μL of isopropanol. Purified RNA precipitate was collected by centrifugation at 12,000 rpm for 10 minutes, 40° C. and supernatants were discarded. Pellets were then washed with 1 mL 75% ethanol, followed by vortexing and centrifugation at 7,500 g for 8 min, 40° C. Finally, pellets were air-dried for 5 min and resuspended in 804 of RNase free water. To improve subsequent solubility samples were incubated at 55° C. for 10 min. RNA was quantified by measuring the optical density at A260/280 nm. RNA quality was assessed by electrophoresis on a 1.2% agarose formaldehyde gel.

Gene Chip Processing

To test hypotheses related to biomarker candidates for colorectal neoplasia RNA extracts were assayed using a custom GeneChip designed by us in collaboration with Affymetrix (Santa Clara, Calif. USA). These custom GeneChips were processed using the standard Affymetrix protocol developed for the HU Gene ST 1.0 array described in (Affy:WTAssay).

Statistical Software and Data Processing

The R statistics environment R and BioConductor libraries (BioConductor, www.bioconductor.org) (BIOC) was used for most analyses. To map probeset IDs to gene symbol on the Custom GeneChip hgu133plus2 library version 2.2.0 was used which was assembled using Entrez Gene data downloaded on April 18 12:30:55 2008 (BIOC).

Hypothesis Testing of Differentially Expressed Biomarkers

To assess differential expression between tissue classes the Student's t test for equal means between two samples or the robust variant provided by the limma library (Smyth)(limma) was used. To mitigate the impact of false discovery due to multiple hypothesis testing, a Bonferroni adjustment to P values in the discovery process (MHT:Bonf) was applied. For hypotheses testing the slightly less conservative multiple hypothesis testing correction of Benjamini & Hochberg, which aims to control the false discovery rate of solutions (MHT:BH), was applied.

Discovery of Tissue-Specific Gene Expression Patterns

Discovery methods using gene expression data often yield numerous candidates, many of which are not suitable for commercial products because they involve subtle gene expression differences that would be difficult to detect in laboratory practice. Pepe et al. note that the ‘ideal’ biomarker is detectable in tumor tissue but not detectable (at all) in non-tumour tissue (Pepe:biomarker:development.) To bias the discovery toward candidates that meet this criteria, an analysis method was developed that aims to enrich the candidates for biomarkers whose qualitative absence or presence measurement is diagnostic for the phenotype of interest. This method attempts to select candidates that show a prototypical ‘turned-on’ or ‘turned-off’ pattern relative to an estimate of the background/noise expression across the chip. It is theorized that such RNA transcripts are more likely to correlate with downstream translated proteins with diagnostic potential or to predict upstream genomic changes (e.g. methylation status) that could be used diagnostically. This focus on qualitative rather than quantitative outcomes may simplify the product development process for such biomarkers.

The method is based on the assumption that the pool of extracted RNA species in any given tissue (e.g. colorectal mucosae) will specifically bind to a relatively small subset of the full set of probesets on a GeneChip designed to measure the whole genome. On this assumption, it is estimated that most probesets on a full human gene chip will not exhibit specific, high-intensity signals.

This observation is utilised to approximate the background or ‘non-specific binding’ across the chip by choosing a theoretical level equal to the value of e.g. lowest 25% quantile of the ranked mean values. This quantile can be arbitrarily set to some level below which there is made a reasonable assumption that the signals do not represent above-background RNA binding. Finally, this background estimate is used as a threshold to estimate the ‘OFF’ probesets in an experiment for, say, the non-neoplastic tissue specimens.

Conversely, it is further hypothesized that probesets which are 1) expressed above this theoretical threshold level and 2) at differentially higher levels in the tumour specimens may be a tumour specific candidate biomarker. It is noted that in this case the concept of ‘fold-change’ thresholds can also be conveniently applied to further emphasize the concept of absolute expression increases in a putatively ‘ON’ probeset.

Given the assumption of low background binding for a sizeable fraction of the measured probesets, this method was only used in the large GeneLogic data and discovery. To construct a filter for hypothetically ‘turned on’ biomarker in the GeneLogic discovery data, the mean expression level for all 44,928 probesets across the full range of 454 tissues was estimated. The 44,928 mean values were then ranked and the expression value equivalent to the 25th percentile across the dataset calculated. This arbitrary threshold was chosen because the majority of transcripts (and presumably more than 25%) in a given specimen should exhibit low concentration which effectively transcriptional silence. Thus this threshold represents a conservative upper bound for what is estimated is non-specific, or background, expression.

Example 5 DNA Methylation Data

Assays were developed for detection of methylation in the promoter regions the eight down-regulated genes in Table 5. Methods for bisulphite treatment of DNA and assays for determination of DNA methylation levels, including MSP and COBRA, are described in Clark et al. (2006).

Five MSP assays used the primer pairs shown in TABLE 7. A control PCR for unbiased amplification of the CAGE gene was used to determine the quantity of input DNA to provide a reference for quantification of the level of methylation of each gene. For PCRs, 25 μL reactions in Biorad iQ SyBr Green Super Mix contained 5 ng of bisulphite-treated DNAs (1 ng for cell line assays and 6 ng for clinical specimens) and 200 nM of forward and reverse primers. PCR cycling conditions were:

-   -   95.0° C. for 2 min     -   Followed by 50 cycles of     -   95.0° C./15 sec     -   Temp° C./30 sec     -   72.0° C./30 sec

Where “Temp” is the re-annealing temperature optimised for each gene as shown in Table yy.

For the DF gene, 3 preliminary cycles were done using a 95.0° C. melting temperature, followed by 50 cycles with a lower, 84.0° C. melting temperature (to reduce nonspecific amplification).

A standard curve was generated using DNA methylated with M.SssI methylase (100% methylated) and DNA that had been in vitro amplified using Phi29 DNA polymerase (0% methylation).

COBRA assays were developed for three genes as shown in TABLE 8. PCRs were setup as above with cycling conditions:

-   -   95.0° C. for 2 min     -   Followed by 50 cycles of:     -   95.0° C./15 sec     -   Temp° C./30 sec     -   72.0° C./30 sec

After PCR, 10 μL of PCR product was digested with the appropriate enzyme (TABLE 8), digestion products analysed by gel electrophoresis and methylation levels determined semiquantitatively.

The methylation state of the eight genes was determined in four colorectal cancer cell lines, Caco2, HCT116, HT29 and SW480 as well as normal blood DNA and the normal lung fibroblast cell line, MRCS. The level of methylation in summarised in Table 5. The promoter regions of all eight genes show strong methylation in 2 or 3 of the four colorectal cancer cell lines tested. All showed a lack or low level of methylation in DNA from normal blood DNA and the fibroblast cell line MRCS, except for methylation of DF in MRCS.

For two of these genes, MAMDC2 and GPM6B analysis has been extended to a set of 12 adenoma, 18 cancer and 22 matched normal tissue samples (FIGS. 2, A and B).

For MAMDC2 quantitative analysis demonstrated that 2 of 12 adenomas and 6 of 18 cancer samples showed elevated methylation compared with the highest level observed in normal tissue samples. Methylation levels of the GPM6B gene were determined by semiquantitative COBRA assays, scored on a scale of 0 to 5 based on visual inspection of restriction digestions. A clear trend toward increasing promoter methylation in progression from normal to adenoma to cancer was evident (FIG. 2, panel B).

These data demonstrate for a number of examples of the down-regulated genes that such downregulation in colorectal cancer cell lines and primary neoplasia tissue may be associated with DNA methylation and that assays of DNA methylation can be used to discriminate cancer and normal tissue.

Example 6 Determine Gene Identity of a Nucleic Acid Sequence of Interest which is Define by an Affymetrix Probeset

BLAST the Sequence of Interest Using Online Available Basic Local Alignment Search Tools [BLAST]. e.g. NCBI/BLAST

-   -   (http://blast.ncbi.nlm.nih.gov/Blast.cgi)         (a) Select “Human” in BLAST ASSEMBLED GENOMES on the web page     -   http://blast.ncbi.nlm.nih.gov/Blast.cgi         (b) Leave the default settings, i.e.:     -   Database: Genome (all assemblies)     -   Program: megaBLAST: compare highly related nucleotide sequences     -   Optional parameters: Expect: 0.01, Filter: default,         Descriptions: 100, Alignments: 100         (c) Copy/Paste Sequence into the “BLAST” window

(d) Click “Begin Search” (e) Click “View Report” Assessment of the Open BLAST Search Results

Multiple significant sequence alignments may be identified when “blasting” the sequence.

Identify Gene Nomenclature of the Identified Sequence Match

-   (a) Click the link to one of the identified hits -   (b) The new page will schematically depict the position of the hit     on one chromosome. It will be apparent which gene is hit. -   (c) Retrieve the “hit” sequence clicking on the link -   (d) Do a search for the gene in the provided “search” window. This     provides the gene nucleotide coordinates for the gene.

Determine Promiscuity of Sequence

-   (a) Open the NCBI/BLAST tool,     (http://blast.ncbi.nlm.nih.gov/Blast.cgi) -   (b) Click on “nucleotide Blast” under “basic BLAST” -   (c) Copy/paste the sequence of interest into the “Query Sequence”     window -   (d) Click “Blast”.     Assessment of the nBLAST Search Results of the Sequence -   (a) The nBLAST exercise with the Sequence may result in multiple     Blast hits of which some accession entry numbers are listed in     “Description”. -   (b) These hits should be reviewed.     Determine location of the Sequence in the Gene

The Ensembl database is an online database, which produces and maintains automatic annotation selected eukaryotic genomes (www.ensembl.org/index.html)

Identify Location of the Sequence in the Gene

-   (a) Set “Search” to Homo Sapiens, Type “the gene name” in the     provided Search Field Ensemble.org/index.html) -   (b) Click “Go” -   (c) Click the “vega protein_coding Gene: OTTHUMG000000144184” link     to get an annotation report -   (d) Click on “Gene DAS Report” to retrieve information regarding     Alternative splice site database: Type “the gene name” in search     field     -   Click on “the gene entry”     -   Scroll down to “evidences”     -   Review alternative splice sites     -   Click “Confirmed intron/exons” to get a list of coordinates for         the exons & introns.         Alternative Splicing and/or Transcription

The AceView Database provides curated and non-redundant sequence representation of all public mRNA sequences. The database is available through NCBI: http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/

Further Investigation of the Gene mRNA Transcripts

-   (a) Type “the gene name” into the provided “search” field -   (b) Click “Go” -   (c) The following information is available from the resulting entry     in AceView:     -   The number of cDNA clones from which the gene is constructed (ie         originated-from experimental work involving isolation of mRNA)     -   The mRNAs predicted to be produced by the gene     -   The existence of non-overlapping alternative exons and validated         alternative polyadenylation sites     -   The existence of truncations     -   The possibility of regulated alternate expression     -   Introns recorded as participating in alternatively splicing of         the gene -   (d) Classic splice site motives     Application of Method to LOC643911/hCG_(—)1815491

Materials and Methods Extraction of RNA

RNA extractions were performed using Trizol(R) reagent (Invitrogen, Carlsbad, Calif., USA) as per manufacturer's instructions. Each sample was homogenised in 300 μL of Trizol reagent using a modified dremel drill and sterilised disposable pestles. Additional 2000, of Trizol reagent was added to the homogenate and samples were incubated at RT for 10 minutes. 100 μL of chloroform was then added, samples were shaken vortexed for 15 seconds, and incubated at RT for 3 further minutes. The aqueous phase containing target RNA was obtained by centrifugation at 12,000 rpm for 15 min, 40° C. RNA was then precipitated by incubating samples at RT for 10 min with 250 μL of isopropanol. Purified RNA precipitate was collected by centrifugation at 12,000 rpm for 10 minutes, 40° C. and supernatants were discarded. Pellets were then washed with 1 mL 75% ethanol, followed by vortexing and centrifugation at 7,500 g for 8 min, 40° C. Finally, pellets were air-dried for 5 min and resuspended in 804 of RNase free water. To improve subsequent solubility samples were incubated at 55. C for 10 min. RNA was quantified by measuring the optical density at A260/280 nm. RNA quality was assessed by electrophoresis on a 1.2% agarose formaldehyde gel.

Gene Chip Processing

RNA samples to analyze on Human Exon 1.0 ST GeneChips were processed using the Affymetrix WT target labeling and control kit (part# 900652) following the protocol described in (Affymetrix 2007 P/N 701880 Rev.4). Briefly: First cycle cDNA was synthesized from 100 ng ribosomal reduced RNA using random hexamer primers tagged with T7 promoter sequence and SuperScript II (Invitrogen, Carlsbad Calif.), this was followed by DNA Polymerase I synthesis of the second strand cDNA. Anti-sense cRNA was then synthesized using T7 polymerase. Second cycle sense cDNA was then synthesised using SuperScript II, dNTP+ dUTP, and random hexamers to produce sense strand cDNA incorporating uracil. This single stranded uracil containing cDNA was then fragmented using a combination of uracil DNA glycosylase (UDG) and apurinic/apyrimidinic endonuclease1 (APE 1). Finally the DNA was biotin labelled using terminal deoxynucleotidyl transferase (TdT) and the Affymetrix proprietary DNA Labeling reagent. Hybridization to the arrays was carried out at 45° C. for 16-18 hours.

Washing and staining of the hybridized GeneChips was carried out using the Affymetrix Fluidics Station 450 and scanned with the Affymetrix Scanner 3000 following recommended protocols.

SYBR Green Based Quantitative Real Time-PCR

Quantitative real time polymerase chain reaction was performed on RNA isolated from clinical samples for the amplification and detection of the various hCG_(—)1815491 transcripts.

Firstly cDNA was synthesized from 2 ug of total RNA using the Applied Biosystems High Capacity Reverse transcription Kit (P/N 4368814). After synthesis the reaction was diluted 1:2 with water to obtain a final volume of 40 ul and 1 ul of this diluted cDNA used in subsequent PCR reactions.

PCR was performed in a 25 ul volume using 12.5 ul Promega 2×PCR master mix (P/N M7502), 1.5 ul 5 uM forward primer, 1.5 ul 5 uM reverse primer, 7.875 ul water, 0.625 ul of a 1:3000 dilution of 10,000× stock of SYBR green 1 pure dye (Invitrogen P/N S7567), and 1 ul of cDNA.

Cycling conditions for amplification were 95° for 2 minutes×1 cycle, 95° for 15 seconds and 60° for 1 minute×40 cycles. The amplification reactions were performed in a Corbett Research Rotor-Gene RG3000 or a Roche LightCycler480 real-time PCR machine. When the Roche LightCycler480 real-time PCR machine was used for amplification the reaction volume was reduced to 10 ul and performed in a 384 well plate but the relative ratios between all the components remained the same. Final results were calculated using the ΔΔCt method with the expression levels of the various hCG_(—)1815491 transcripts being calculated relative to the expression level of the endogenous house keeping gene HPRT.

End-Point PCR

End point PCR was performed on RNA isolated from clinical samples for the various hCG_(—) 1815491 transcripts. Conditions were identical to those described for the SYBR green assay above but with the SYBR green dye being replaced with water. The amplification reactions were performed in a MJ Research PTC-200 thermal cycler. 2.5 μl of the amplified products were analysed on 2% agarose E-gel (Invitrogen) along with a 100-base pair DNA Ladder Marker.

Results

The nucleotide structure and expression levels of transcripts related to hCG_(—)1815491 was analysed based on the identification of diagnostic utility of Affymetrix probesets 238021_s_at and 238022_at from the gene chip analysis.

The gene hCG_(—)1815491 is currently represented in NCBI as a single RefSeq sequence, XM_(—)93911. The RefSeq sequence of hCG_(—)1815491 is based on 89 GenBank accessions from 83 cDNA clones. Prior to March 2006, these clones were predicted to represent two overlapping genes, LOC388279 and LOC650242 (the latter also known as LOC643911). In March 2006, the human genome database was filtered against clone rearrangements, co-aligned with the genome and clustered in a minimal non-redundant way. As a result, LOC388272 and LOC650242 were merged into one gene named hCG_(—)1815491 (earlier references to hCG_(—)1815491 are: LOC388279, LOC643911, LOC650242, XM_(—)944116, AF275804, XM_(—)373688).

It has been determined that the Ref Sequence, which is defined by the genomic coordinates 8579310 to 8562303 on human chromosome 16 as defined by the NCBI contig reference NT_(—)010498.15|Hs16_(—)10655, NCBI 36 Mar. 2006 genome encompasses hCG_(—)1815491. The 10 predicted RNA variants derived from this gene have been aligned with the genomic nucleotide sequence residing in the map region 8579310 to 8562303. This alignment analysis revealed the existence of at least 6 exons of which several are alternatively spliced. The identified exons are in contrast to the just 4 exons specified in the NCBI hCG_(—)1815491 RefSeq XM_(—)93911. Two additional putative exons were also identified in the Ref Sequence by examination of included probesets on Affymetrix Genechip HuGene Exon 1.0 that target nucleotide sequences embedded in the Ref Sequence. The identified and expanded exon-intron structure of hCG_(—)1815491 have been used to design specific oligonucleotide primers, which allowed measurement of the expression of RNA variants generated from the Ref Sequence by using PCR-based methodology (FIG. 4)

Tables

The probeset designations include both HG-133plus2 probeset IDs and Human Gene 1.0ST array probe ids. The latter can be conveniently mapped to Transcript Cluster ID using the Human Gene 1.0ST probe tab file provided by Affymetrix (http://www.affymetrix.com/Auth/analysis/downloads/na22/wtgene/HuGene-1_(—)0-st-v1.probe.tab.zip). Using publicly available software such as NetAffx (provided by Affymetrix), the Transcript Cluster ID may be further mapped to gene symbol, chromosomal location, etc.

Table 1

Probesets demonstrated to be expressed higher in non-neoplastic tissues relative to neoplastic controls. TargetPS: Affymetrix HG-U133plus2 probeset id; Symbol: putative gene symbol corresponding to target probeset id—multiple symbol names indicate the possibility of probeset hybridisation to multiple gene targets; Signif. FDR: Adjusted p-value for mean difference testing between RNA extracted from neoplasia and non-neoplastic tissues. Adjustment is made using Benjamini & Hochberg correction for multiple hypothesis testing (Benjamini and Hochberg, 1995); D.value50: Diagnostic effectiveness parameter estimate corresponding to the area of a receiver operator characteristic ROC. This parameter provides a convenient estimate of diagnostic utility and is described in (Saunders, 2006); FC: fold change between mean expression level of non-neoplasia vs. neoplasia; Sens-Spec: Estimate of diagnostic performance corresponding to the ROC curve point demonstrating equal sensitivity and specificity; CI (95): 95% confidence interval of sensitivity and specificity estimates.

Table 2

Evidence of multiple probesets which correspond to gene symbols claimed herein exhibiting RNA concentration differences between non-neoplastic tissues and neoplastic controls. Symbol: gene symbol; ValidPS_DOWN: Affymetrix probeset IDs demonstrating statistically significant overexpression in non-neoplastic RNA extracts relative to neoplastic controls. Signif. FDR: Adjusted p-value for mean difference testing between RNA extracted from neoplasia and non-neoplastic tissues. Adjustment is made using Benjamini & Hochberg correction for multiple hypothesis testing (Benjamini and Hochberg, 1995); D.value50: Diagnostic effectiveness parameter estimate corresponding to the area of a receiver operator characteristic ROC. This parameter provides a convenient estimate of diagnostic utility and is described in (Saunders, 2006); FC: fold change between mean expression level of non-neoplasia vs. neoplasia; Sens-Spec: Estimate of diagnostic performance corresponding to the ROC curve point demonstrating equal sensitivity and specificity; CI (95): 95% confidence interval of sensitivity and specificity estimates.

Table 3

Probesets which demonstrate a qualitatively (in addition to quantitative) elevated profile in non-neoplastic tissues relative to neoplastic controls. TargetPS: Affymetrix HG-U133plus2 probeset id; Symbol: putative gene symbol corresponding to target probeset id—multiple symbol names indicate the possibility of probeset hybridisation to multiple gene targets; Signif FDR: Adjusted p-value for mean difference testing between RNA extracted from neoplasia and non-neoplastic tissues. Adjustment is made using Benjamini & Hochberg correction for multiple hypothesis testing (Benjamini and Hochberg, 1995); D.value50: Diagnostic effectiveness parameter estimate corresponding to the area of a receiver operator characteristic ROC. This parameter provides a convenient estimate of diagnostic utility and is described in (Saunders, 2006); FC: fold change between mean expression level of non-neoplasia vs. neoplasia; Sens-Spec: Estimate of diagnostic performance corresponding to the ROC curve point demonstrating equal sensitivity and specificity; CI (95): 95% confidence interval of sensitivity and specificity estimates.

Table 4

Evidence of multiple probesets which correspond to gene symbols claimed herein exhibiting qualitative changes in RNA concentration in non-neoplastic tissues compared to neoplastic tissues. Symbol: gene symbol; ValidPS_DOWN: Affymetrix probeset IDs demonstrating statistically significant overexpression in neoplastic RNA extracts relative to non-neoplastic controls. Signif. FDR: Adjusted p-value for mean difference testing between RNA extracted from neoplasia and non-neoplastic tissues. Adjustment is made using Benjamini & Hochberg correction for multiple hypothesis testing (Benjamini and Hochberg, 1995); D.value50: Diagnostic effectiveness parameter estimate corresponding to the area of a receiver operator characteristic ROC. This parameter provides a convenient estimate of diagnostic utility and is described in (Saunders, 2006); FC: fold change between mean expression level of non-neoplasia vs. neoplasia; Sens-Spec: Estimate of diagnostic performance corresponding to the ROC curve point demonstrating equal sensitivity and specificity; CI (95): 95% confidence interval of sensitivity and specificity estimates.

Those skilled in the art will appreciate that the invention described herein is susceptible to variations and modifications other than those specifically described. It is to be understood that the invention includes all such variations and modifications. The invention also includes all of the steps, features, compositions and compounds referred to or indicated in this specification, individually or collectively, and any and all combinations of any two or more of said steps or features.

TABLE 1 Sens- TargetPS Symbol Signif. FDR D.val5 FC Spec CI (95) 230788_at SPTLC3:GCNT2 2.16E−27 3.9512 13.36 97.6 94.2-99.2 207502_at GUCA2B 7.04E−25 3.6279 51.78 96.5 92.3-98.6 207003_at GUCA1B 7.32E−25 3.565 10.7 96.3   92-98.5 206208_at CA4 1.73E−24 3.6263 10.41 96.5 92.4-98.6 206209_s_at CA4 1.73E−24 3.6265 10.41 96.5 92.3-98.6 203908_at LOC727995:SLC4A4:LOC730895 2.23E−23 3.6298 3.58 96.5 92.4-98.6 206784_at AQP8 2.98E−22 3.3284 10.82 95.2 90.3-97.9 205950_s_at CA1 3.15E−22 3.368 38.27 95.4 90.6-98 209735_at ABCG2 1.09E−21 3.2584 31.53 94.8 89.7-97.7 230830_at OSTbeta 6.23E−21 3.1861 7.15 94.4 89.2-97.5 223754_at MGC13057 6.94E−21 3.2036 3.18 94.5 89.3-97.5 228195_at MGC13057 6.94E−21 3.2023 3.18 94.5 89.4-97.5 228706_s_at CLDN23 4.27E−20 3.0757 3.47 93.8 88.2-97.1 228707_at CLDN23 4.27E−20 3.072 3.47 93.8 88.3-97.1 223551_at PKIB 5.94E−20 3.1219 3.28 94.1 88.6-97.3 231120_x_at PKIB 5.94E−20 3.1226 3.28 94.1 88.6-97.3 226492_at SEMA6D 6.07E−20 3.0898 4.27 93.9 88.4-97.2 220026_at CLCA4 1.25E−19 3.1909 16.3 94.5 89.2-97.5 224836_at TP53INP2 1.45E−19 3.0248 3.78 93.5 87.9-96.9 220834_at MS4A12 2.13E−19 3.29 7.15 95   90-97.8 224412_s_at TRPM6 2.25E−19 3.01 7.5 93.4 87.7-96.8 220037_s_at XLKD1 3.60E−19 2.9412 7.44 92.9 87.1-96.6 219059_s_at XLKD1 3.60E−19 2.942 7.44 92.9 87-96.6 209612_s_at ADH1B:ADH1A 4.70E−19 3.0183 4.67 93.4 87.7-96.9 209613_s_at ADH1B:ADH1A 4.70E−19 3.0147 4.67 93.4 87.7-96.9 200845_s_at LOC389249:PRDX6 5.56E−19 2.8412 2.76 92.2 86.1-96.1 209301_at CA2 5.87E−19 2.9662 9.22 93.1 87.3-96.7 208399_s_at EDN3 6.42E−19 2.9342 11.21 92.9   87-96.5 228961_at MIER3 9.14E−19 2.9183 3.91 92.8 86.9-96.5 231975_s_at MIER3 9.14E−19 2.9172 3.91 92.8 86.8-96.4 204719_at ABCA8 1.26E−18 2.9172 6.82 92.8 86.8-96.5 207761_s_at METTL7A 1.35E−18 3.1247 1.93 94.1 88.6-97.3 207977_s_at DPT 1.53E−18 2.8967 9.07 92.6 86.6-96.4 213068_at DPT 1.53E−18 2.8973 9.07 92.6 86.7-96.4 213071_at DPT 1.53E−18 2.8962 9.07 92.6 86.7-96.4 218756_s_at MRM1:MGC4172 1.74E−18 2.9041 3.74 92.7 86.6-96.4 212288_at FNBP1:C1orf85:CCT3 1.76E−18 3.0475 2.04 93.6   88-97 204036_at EDG2 2.44E−18 2.8853 3.19 92.5 86.4-96.3 202037_s_at SFRP1 2.77E−18 2.8647 15.53 92.4 86.3-96.2 206143_at SLC26A3 4.18E−18 2.9202 21.4 92.8 86.9-96.5 215657_at SLC26A3 4.18E−18 2.9226 21.4 92.8 86.9-96.5 231773_at ANGPTL1 1.42E−17 2.7938 4.64 91.9 85.6-95.9 205480_s_at UGP2 1.64E−17 2.7911 2.41 91.9 85.6-95.9 204955_at SRPX 1.79E−17 2.7753 3.91 91.7 85.5-95.8 222722_at OGN 2.25E−17 2.7048 13.67 91.2 84.8-95.4 202555_s_at MYLK 2.33E−17 2.773 3.99 91.7 85.4-95.8 224823_at MYLK 2.33E−17 2.7727 3.99 91.7 85.4-95.8 225575_at LIFR 2.45E−17 2.7823 6.36 91.8 85.5-95.8 214142_at LOC653808:ZG16 2.51E−17 2.8119 8.14 92 85.8-95.9 206710_s_at EPB41L3 2.62E−17 2.8298 2.51 92.1 85.9-96.1 205464_at SCNN1B 3.20E−17 2.7209 16.15 91.3 84.9-95.5 220812_s_at HHLA2 3.47E−17 2.6717 10.02 90.9 84.4-95.3 203913_s_at HPGD 3.65E−17 2.8441 3.21 92.2 86.1-96.1 203914_x_at HPGD 3.65E−17 2.8456 3.21 92.3 86.1-96.1 211548_s_at HPGD 3.65E−17 2.8446 3.21 92.3 86.1-96.1 211549_s_at HPGD 3.65E−17 2.8466 3.21 92.3 86.1-96.1 206198_s_at CEACAM7 3.96E−17 2.7882 10.4 91.8 85.5-95.9 206199_at CEACAM7 3.96E−17 2.7855 10.4 91.8 85.6-95.8 211848_s_at CEACAM7 3.96E−17 2.7882 10.4 91.8 85.6-95.8 226430_at SMAD5:RELL1 4.10E−17 2.6968 2.5 91.1 84.6-95.4 202992_at C7 4.40E−17 2.7163 6.67 91.3 84.9-95.5 205112_at PLCE1 6.91E−17 2.7542 2.43 91.6 85.2-95.7 229839_at SCARA5 1.25E−16 2.6897 2.86 91.1 84.6-95.3 235849_at SCARA5 1.25E−16 2.6918 2.86 91.1 84.5-95.3 209763_at CHRDL1 1.49E−16 2.6093 13.88 90.4 83.7-94.9 205259_at NR3C2 2.08E−16 2.5812 3.19 90.2 83.4-94.7 202242_at TSPAN7 2.13E−16 2.6519 3.68 90.8 84.1-95.1 203000_at STMN2 2.25E−16 2.6115 6.13 90.4 83.7-94.9 203001_s_at STMN2 2.25E−16 2.6141 6.13 90.4 83.7-94.9 209074_s_at FAM107A 2.52E−16 2.6171 2.92 90.5 83.8-94.9 202920_at ANK2 2.59E−16 2.6499 6.76 90.7 84.1-95.1 213317_at CLIC5 3.68E−16 2.696 2.37 91.1 84.6-95.4 204697_s_at CHGA 5.54E−16 2.6087 7.21 90.4 83.7-94.9 212814_at KIAA0828 5.58E−16 2.5495 4.09 89.9   83-94.5 225275_at EDIL3 6.21E−16 2.6252 2.96 90.5 83.9-95 208370_s_at DSCR1 6.21E−16 2.6146 2.14 90.4 83.7-94.9 209147_s_at PPAP2A 6.43E−16 2.5961 2.4 90.3 83.6-94.8 210946_at PPAP2A 6.43E−16 2.5967 2.4 90.3 83.5-94.8 202731_at PDCD4 8.67E−16 2.4558 2.6 89   82-94 219799_s_at DHRS9:GORASP2 1.09E−15 2.7368 1.51 91.4 85.1-95.6 223952_x_at DHRS9:GORASP2 1.09E−15 2.7334 1.51 91.4   85-95.6 224009_x_at DHRS9:GORASP2 1.09E−15 2.7359 1.51 91.4 85.1-95.6 236313_at CDKN2B 1.34E−15 2.5442 10.09 89.8   83-94.5 231925_at P2RY1 1.41E−15 2.5354 3.6 89.8 82.9-94.4 238143_at LOC646627 1.58E−15 1.9142 5.02 83.1 74.8-89.4 224480_s_at LPAAT-THETA 2.06E−15 2.3867 2.63 88.4 81.1-93.5 212230_at PPAP2B 2.44E−15 2.5821 1.81 90.2 83.4-94.7 207080_s_at PYY 3.50E−15 2.4811 11.71 89.3 82.3-94.1 205200_at CLEC3B 4.65E−15 2.4426 4.46 88.9 81.8-93.8 228133_s_at NDE1 4.84E−15 2.514 1.99 89.6 82.7-94.3 214038_at CCL8 5.75E−15 2.4504 7.51 89 81.9-93.9 219014_at PLAC8 5.76E−15 2.4248 3.87 88.7 81.6-93.7 219796_s_at MUCDHL 5.81E−15 2.4346 3.06 88.8 81.6-93.8 220075_s_at MUCDHL 5.81E−15 2.4354 3.06 88.8 81.7-93.8 215299_x_at SULT1A1:SULT1A2 7.17E−15 2.4231 3.37 88.7 81.5-93.7 233565_s_at SDCBP2 9.28E−15 2.4871 2.37 89.3 82.3-94.1 228885_at RPL24:LOC731365 1.23E−14 2.5555 1.63 89.9 83.1-94.6 209687_at CXCL12 1.54E−14 2.4322 3.79 88.8 81.7-93.8 218546_at C1orf115 1.95E−14 2.4106 2.95 88.6 81.4-93.6 205097_at SLC26A2 2.08E−14 2.4219 7.83 88.7 81.5-93.7 224959_at SLC26A2 2.08E−14 2.4229 7.83 88.7 81.6-93.7 224963_at SLC26A2 2.08E−14 2.4205 7.83 88.7 81.5-93.7 204069_at MEIS1 2.49E−14 2.3759 5.44 88.3   81-93.4 223121_s_at SFRP2 3.05E−14 2.3937 7.39 88.4 81.2-93.5 223122_s_at SFRP2 3.05E−14 2.3967 7.39 88.5 81.2-93.5 209191_at TUBB3:MC1R:TUBB6 3.55E−14 2.3684 5.9 88.2 80.9-93.3 201348_at GPX3 5.68E−14 2.36 2.57 88.1 80.8-93.2 214091_s_at GPX3 5.68E−14 2.3613 2.57 88.1 80.7-93.3 228766_at CD36 6.27E−14 2.4671 1.65 89.1 82.1-94 221896_s_at HIGD1A 6.29E−14 2.3985 2.09 88.5 81.3-93.5 201865_x_at NR3C1 7.65E−14 2.3539 2.51 88 80.6-93.2 211671_s_at NR3C1 7.65E−14 2.3517 2.51 88 80.7-93.2 206149_at LOC63928 8.09E−14 2.3513 3.2 88 80.7-93.2 228846_at MXD1 8.35E−14 2.4074 2.11 88.6 81.4-93.6 225602_at C9orf19 1.74E−13 2.3619 1.95 88.1 80.9-93.3 225604_s_at C9orf19 1.74E−13 2.3646 1.95 88.1 80.8-93.3 201893_x_at DCN 2.05E−13 2.311 5.62 87.6 80.2-92.9 209335_at DCN 2.05E−13 2.3115 5.62 87.6 80.3-92.9 211813_x_at DCN 2.05E−13 2.3145 5.62 87.6 80.2-92.9 211896_s_at DCN 2.05E−13 2.3124 5.62 87.6 80.2-92.9 204818_at HSD17B2 2.32E−13 2.196 4.76 86.4 78.7-92 204931_at TCF21 2.51E−13 2.306 2.34 87.6 80.1-92.9 204438_at MRC1 2.72E−13 2.3105 2.6 87.6 80.2-92.9 206262_at ADH1A:ADH1C 2.94E−13 2.3719 3.1 88.2 80.9-93.3 205433_at BCHE 3.18E−13 2.2514 6.21 87 79.5-92.5 225242_s_at CCDC80 3.60E−13 2.2316 3.67 86.8 79.2-92.3 207980_s_at CITED2 5.29E−13 2.2709 1.64 87.2 79.7-92.6 209357_at CITED2 5.29E−13 2.2704 1.64 87.2 79.7-92.6 208383_s_at PCK1 5.74E−13 2.3242 3.6 87.7 80.4-93 206385_s_at ANK3:LOC729184:LOC731186 7.46E−13 2.2305 2.45 86.8 79.2-92.2 203305_at F13A1 8.82E−13 2.1821 4.74 86.2 78.6-91.8 206134_at ADAMDEC1 9.04E−13 2.2607 3.19 87.1 79.5-92.5 215118_s_at AHNAK:IGHG1 9.41E−13 2.3277 1.73 87.8 80.3-93 217022_s_at AHNAK:IGHG1 9.41E−13 2.3254 1.73 87.8 80.4-93 223395_at ABI3BP 9.47E−13 2.2207 3.62 86.7   79-92.2 225626_at PAG1 1.11E−12 2.2136 2.68 86.6 78.9-92.1 213953_at KRT20 1.26E−12 2.0964 5.49 85.3 77.4-91.1 226594_at ENTPD5 1.43E−12 2.1687 3.01 86.1 78.4-91.8 209373_at MALL 2.10E−12 2.1597 3.96 86 78.3-91.7 212713_at MFAP4 2.96E−12 2.1797 2.51 86.2 78.5-91.9 208920_at SRI 3.03E−12 2.0982 2.43 85.3 77.4-91.1 201739_at SGK 3.12E−12 2.1221 4.08 85.6 77.8-91.3 214696_at MGC14376 3.39E−12 2.1045 2.58 85.4 77.5-91.2 204034_at ETHE1 3.46E−12 2.2127 1.75 86.6   79-92.1 209667_at CES2 3.51E−12 2.102 2.87 85.3 77.4-91.2 209668_x_at CES2 3.51E−12 2.0978 2.87 85.3 77.4-91.1 213509_x_at CES2 3.51E−12 2.097 2.87 85.3 77.4-91.1 202291_s_at MGP:C12orf46 3.63E−12 2.1448 4.68 85.8   78-91.5 209167_at GPM6B 4.04E−12 2.1568 3.59 86 78.2-91.6 209170_s_at GPM6B 4.04E−12 2.1581 3.59 86 78.2-91.6 225720_at SYNPO2 5.07E−12 2.1053 6.43 85.4 77.5-91.2 225721_at SYNPO2 5.07E−12 2.1069 6.43 85.4 77.5-91.2 225894_at SYNPO2 5.07E−12 2.1043 6.43 85.4 77.5-91.2 225895_at SYNPO2 5.07E−12 2.1069 6.43 85.4 77.5-91.2 227662_at SYNPO2 5.07E−12 2.1043 6.43 85.4 77.5-91.2 206422_at GCG 5.58E−12 2.1185 12.56 85.5 77.7-91.3 205593_s_at PDE9A 6.56E−12 2.1443 3.91 85.8   78-91.5 220376_at LRRC19 6.75E−12 2.076 4.51 85 77.1-91 204130_at HSD11B2 6.97E−12 2.0896 2.53 85.2 77.3-91.1 224964_s_at GNG2 7.25E−12 2.1405 1.91 85.8   78-91.5 219508_at GCNT3 8.39E−12 2.0843 3.94 85.1 77.2-91 211645_x_at No Symbol 9.19E−12 2.1536 1.61 85.9 78.2-91.6 212233_at No Symbol 9.19E−12 2.1541 1.61 85.9 78.1-91.6 212764_at No Symbol 9.19E−12 2.1541 1.61 85.9 78.1-91.6 214777_at No Symbol 9.19E−12 2.1543 1.61 85.9 78.2-91.6 217235_x_at No Symbol 9.19E−12 2.155 1.61 85.9 78.2-91.6 225710_at No Symbol 9.19E−12 2.1539 1.61 85.9 78.1-91.6 226333_at No Symbol 9.19E−12 2.1529 1.61 85.9 78.1-91.6 226834_at No Symbol 9.19E−12 2.154 1.61 85.9 78.1-91.6 227061_at No Symbol 9.19E−12 2.152 1.61 85.9 78.1-91.6 228504_at No Symbol 9.19E−12 2.1533 1.61 85.9 78.1-91.6 228507_at No Symbol 9.19E−12 2.1538 1.61 85.9 78.2-91.6 228640_at No Symbol 9.19E−12 2.1532 1.61 85.9 78.2-91.6 228854_at No Symbol 9.19E−12 2.1532 1.61 85.9 78.2-91.7 236300_at No Symbol 9.19E−12 2.1532 1.61 85.9 78.2-91.6 242317_at No Symbol 9.19E−12 2.1529 1.61 85.9 78.1-91.6 210524_x_at No Symbol 9.19E−12 2.1554 1.61 85.9 78.2-91.7 224989_at No Symbol 9.19E−12 2.1526 1.61 85.9 78.2-91.6 227052_at No Symbol 9.19E−12 2.151 1.61 85.9 78.1-91.6 227682_at No Symbol 9.19E−12 2.1549 1.61 85.9 78.2-91.6 235146_at No Symbol 9.19E−12 2.1527 1.61 85.9 78.2-91.7 207126_x_at UGT1A10:UGTIA7:UGT1A8: 9.98E−12 2.0677 4.56 84.9   77-90.9 UGT1A1:UGT1A9:UGT1A6: UGT1A5:UGT1A3:UGT1A4 206094_x_at UGT1A10:UGT1A7:UGT1A8: 1.01E−11 2.0693 4.56 85   77-90.8 UGT1A1:UGT1A9:UGT1A6: UGT1A5:UGT1A3:UGTIA4 208596_s_at UGT1A10:UGT1A7:UGTIA8: 1.01E−11 2.0662 4.56 84.9 76.9-90.8 UGT1A1:UGT1A9:UGTIA6: UGT1A5:UGT1A3:UGT1A4 221305_s_at UGT1A10:UGT1A7:UGT1A8: 1.03E−11 2.0663 4.56 84.9   77-90.9 UGT1A1:UGT1A9:UGT1A6: UGT1A5:UGT1A3:UGT1A4 204532_x_at UGT1A10:UGT1A7:UGT1A8: 1.18E−11 2.0678 4.56 84.9   77-90.9 UGT1A1:UGT1A9:UGT1A6: UGT1A5:UGT1A3:UGT1A4 215125_s_at UGT1A10:UGT1A7:UGT1A8: 1.18E−11 2.0682 4.56 84.9   77-90.9 UGT1A1:UGT1A9:UGT1A6: UGT1A5:UGT1A3:UGT1A4 209791_at PADI2 1.46E−11 2.0258 3.98 84.4 76.4-90.5 219669_at CD177 1.49E−11 2.0618 5.77 84.9 76.9-90.8 201539_s_at FHL1 1.63E−11 2.0448 3.25 84.7 76.7-90.7 201540_at FHL1 1.63E−11 2.0466 3.25 84.7 76.7-90.7 210298_x_at FHL1 1.63E−11 2.0438 3.25 84.7 76.7-90.6 210299_s_at FHL1 1.63E−11 2.0458 3.25 84.7 76.6-90.6 214505_s_at FHL1 1.63E−11 2.0459 3.25 84.7 76.7-90.6 206576_s_at CEACAM1 2.66E−11 2.0448 2.85 84.7 76.7-90.7 209498_at CEACAM1 2.66E−11 2.0446 2.85 84.7 76.7-90.7 211889_x_at CEACAM1 2.66E−11 2.0471 2.85 84.7 76.7-90.7 202994_s_at FBLN1 2.82E−11 2.0183 3.55 84.4 76.3-90.4 202995_s_at FBLN1 2.82E−11 2.0191 3.55 84.4 76.3-90.4 201427_s_at SEPP1 2.83E−11 2.034 4.15 84.5 76.5-90.6 212956_at TBC1D9 3.89E−11 2.1428 1.54 85.8   78-91.5 203963_at CA12 4.32E−11 2.0024 2.65 84.2 76.1-90.2 204508_s_at CA12 4.32E−11 2.0029 2.65 84.2 76.2-90.3 210735_s_at CA12 4.32E−11 2.0016 2.65 84.2 76.1-90.2 214164_x_at CA12 4.32E−11 2.0016 2.65 84.2 76.1-90.3 215867_x_at CA12 4.32E−11 2.0027 2.65 84.2 76.1-90.3 203881_s_at DMD 5.01E−11 2.0159 4.74 84.3 76.2-90.4 213624_at SMPDL3A 5.84E−11 1.9409 3.14 83.4 75.2-89.6 226304_at HSPB6 6.16E−11 1.9486 6.88 83.5 75.4-89.8 206561_s_at LOC441282:AKR1B10:LOC340888 7.91E−11 1.9478 5.17 83.5 75.3-89.7 203343_at UGDH 8.72E−11 1.9619 2.4 83.7 75.6-89.9 205892_s_at FABP1 9.02E−11 1.9694 6.54 83.8 75.6-89.9 206637_at P2RY14 1.31E−10 1.9821 2 83.9 75.8-90.1 202266_at TTRAP 1.59E−10 1.9147 2.2 83.1 74.9-89.4 206000_at LOC642840:MEP1A:LOC389747:LOC644777 2.07E−10 1.9873 3.17 84 75.9-90.1 201496_x_at MYH11 2.15E−10 1.8577 5.35 82.4   74-88.8 201497_x_at MYH11 2.15E−10 1.8599 5.35 82.4 74.1-88.8 207961_x_at MYH11 2.15E−10 1.859 5.35 82.4 74.1-88.9 201495_x_at MYH11 2.15E−10 1.8585 5.35 82.4   74-88.8 204388_s_at MAOA 2.49E−10 2.0297 2.18 84.5 76.4-90.5 204389_at MAOA 2.49E−10 2.0256 2.18 84.4 76.5-90.5 212741_at MAOA 2.49E−10 2.0267 2.18 84.5 76.5-90.5 214598_at CLDN8 2.92E−10 1.862 12.96 82.4 74.2-88.9 202838_at FUCA1 4.24E−10 1.8831 2.03 82.7 74.4-89.1 217897_at MB:FXYD6 6.39E−10 1.8109 2.92 81.7 73.3-88.3 220468_at ARL14 7.01E−10 1.8242 3.06 81.9 73.5-88.4 201920_at SLC20A1 7.65E−10 1.7849 4.04 81.4 72.9-88.1 210302_s_at MAB21L2 1.05E−09 1.7744 5.2 81.3 72.8-87.9 209114_at TSPAN1 1.16E−09 1.7896 2.16 81.5   73-88.1 220266_s_at KLF4 1.19E−09 1.8515 2.27 82.3 73.8-88.7 221841_s_at KLF4 1.19E−09 1.8493 2.27 82.2 73.9-88.8 209283_at CRYAB 1.47E−09 1.7693 3.91 81.2 72.7-87.8 223484_at C15orf48 1.54E−09 1.8189 3.07 81.8 73.4-88.4 205412_at ACAT1 1.70E−09 1.8575 1.77 82.3 73.9-88.8 202888_s_at ANPEP 2.04E−09 1.7673 8.18 81.2 72.6-87.8 225458_at EXOC3 2.25E−09 1.7957 3.17 81.5 73.1-88.1 204834_at FGL2 2.64E−09 1.8245 2.07 81.9 73.4-88.5 227265_at FGL2 2.64E−09 1.8246 2.07 81.9 73.6-88.4 228469_at PPID 3.34E−09 1.8032 1.73 81.6 73.2-88.3 221004_s_at ITM2C 3.87E−09 1.7063 2.22 80.3 71.8-87.1 213921_at SST 4.16E−09 1.7652 6.14 81.1 72.6-87.8 230087_at PRIMA1 4.74E−09 1.7085 2.75 80.4 71.8-87.2 201842_s_at EFEMP1 5.80E−09 1.8196 1.69 81.9 73.4-88.4 222162_s_at ADAMTS1 6.42E−09 1.7467 2.37 80.9 72.3-87.6 210517_s_at AKAP12 7.41E−09 1.7454 2.83 80.9 72.3-87.6 227529_s_at AKAP12 7.41E−09 1.7437 2.83 80.8 72.3-87.6 228750_at COL14A1 7.60E−09 1.7813 1.67 81.3 72.9-88 219948_x_at LOC642329:UGT2A3 8.64E−09 1.7422 4.89 80.8 72.2-87.5 208131_s_at PTGIS 9.15E−09 1.7212 3.98 80.5 71.9-87.3 207432_at BTN2A2:BEST2 9.19E−09 1.7179 3.63 80.5 71.9-87.3 219607_s_at MS4A4A:LOC643680 9.59E−09 1.8197 1.55 81.9 73.4-88.4 204688_at SGCE 1.02E−08 1.7438 2.03 80.8 72.3-87.6 207134_x_at TPSB2 1.24E−08 1.3713 1.87 75.4 66.3-82.9 209156_s_at COL6A2 1.30E−08 1.68 2.08 80 71.3-86.8 202741_at PRKACB 1.30E−08 1.7217 2.18 80.5 71.9-87.3 202742_s_at PRKACB 1.30E−08 1.721 2.18 80.5 71.9-87.3 200795_at SPARCL1 1.33E−08 1.6379 2.85 79.4 70.7-86.3 219543_at PBLD 1.38E−08 1.6981 2.74 80.2 71.6-87.1 225207_at PDK4 1.45E−08 1.705 3.02 80.3 71.7-87.2 202222_s_at SPEG:LOC729871:DES 1.47E−08 1.7229 6.66 80.6   72-87.3 214027_x_at SPEG:LOC729871:DES 1.47E−08 1.7254 6.66 80.6   72-87.4 239272_at MMP28 1.80E−08 1.6622 2.47 79.7   71-86.6 222453_at THEM4:CYBRD1 1.84E−08 1.6934 2.7 80.1 71.6-87 212195_at MAGEA4:IL6ST 1.87E−08 1.764 1.58 81.1 72.6-87.8 203980_at FABP4 2.01E−08 1.6762 5.55 79.9 71.3-86.8 211985_s_at CALM1 2.12E−08 1.6839 1.72 80 71.4-86.9 221747_at TNS1:AKAP9 2.21E−08 1.7434 2.01 80.8 72.2-87.5 221748_s_at TNS1:AKAP9 2.21E−08 1.7409 2.01 80.8 72.3-87.5 201324_at EMP1 2.59E−08 1.7149 1.95 80.4 71.9-87.3 212397_at LOC643244:RDX 3.06E−08 1.7431 1.9 80.8 72.3-87.6 205382_s_at CFD 3.06E−08 1.6462 2.81 79.5 70.8-86.4 201141_at GPNMB 3.11E−08 1.6928 1.99 80.1 71.5-87 205683_x_at TPSAB1, TPSAB1 3.52E−08 1.7075 1.93 80.3 71.8-87.1 210084_x_at TPSAB1, TPSAB1 3.52E−08 1.7045 1.93 80.3 71.8-87.1 215382_x_at TPSAB1, TPSAB1 3.52E−08 1.7091 1.93 80.4 71.7-87.2 216474_x_at TPSAB1, TPSAB1 3.52E−08 1.7069 1.93 80.3 71.7-87.2 227006_at PPP1R14A 3.54E−08 1.619 2.51 79.1 70.3-86.1 242601_at LOC253012 3.59E−08 1.6517 4.46 79.6 70.8-86.5 212730_at DMN 4.36E−08 1.6046 4.05 78.9 70.2-86 226818_at MPEG1 4.58E−08 1.6466 1.86 79.5 70.8-86.5 226841_at MPEG1 4.58E−08 1.6484 1.86 79.5 70.8-86.5 203474_at IQGAP2 5.06E−08 1.6275 2.51 79.2 70.6-86.2 203766_s_at LMOD1 5.55E−08 1.58 2.97 78.5 69.8-85.6 214916_x_at LOC652128:IGHG1:IGHM:IGHV4- 5.75E−08 1.6352 3.1 79.3 70.6-86.3 31:LOC647189:IGHV1- 69:IGHA1:IL8:EXOC7:SIX6:IGHD: IGH@:IGHG3:C12orf32: ZCWPW2:IFI6:IGHG4:IGHA2: IGHG2:RAC1 226303_at PGM5 5.87E−08 1.6215 5.87 79.1 70.4-86.2 225442_at DDR2 5.89E−08 1.562 2.61 78.3 69.4-85.4 227561_at DDR2 5.89E−08 1.5604 2.61 78.2 69.4-85.5 202760_s_at AKAP2:PALM2:PALM2- 6.28E−08 1.6137 2.17 79 70.3-86.1 AKAP2 226694_at AKAP2:PALM2:PALM2- 6.28E−08 1.6143 2.17 79 70.2-86.1 AKAP2 204894_s_at AOC3 6.43E−08 1.556 2.92 78.2 69.4-85.4 203058_s_at PAPSS2 6.43E−08 1.6171 1.97 79.1 70.4-86.1 203060_s_at PAPSS2 6.43E−08 1.6159 1.97 79 70.4-86.1 208763_s_at TSC22D3 7.22E−08 1.6098 2.76 79 70.2-86 222717_at SDPR 9.62E−08 1.5998 2.21 78.8 70.1-85.9 203680_at PRKAR2B 1.05E−07 1.6759 2.1 79.9 71.2-86.8 201041_s_at DUSP1 1.06E−07 1.5295 2.44 77.8 68.9-85 209374_s_at LOC652128:IGHG1:IGHM:IGHV4- 1.12E−07 1.6333 3.1 79.3 70.6-86.3 31:LOC647189:IGHV1- 69:IGHA1:IL8:EXOC7:SIX6:IGHD: IGH@:IGHG3:C12orf32: ZCWPW2:IFI6:IGHG4:IGHA2: IGHG2:RAC1 216491_x_at LOC652128:IGHG1:IGHM:IGHV4- 1.12E−07 1.6335 3.1 79.3 70.5-86.3 31:LOC647189:IGHV1- 69:IGHA1:IL8:EXOC7:SIX6:IGHD: IGH@:IGHG3:C12orf32: ZCWPW2:IFI6:IGHG4:IGHA2: IGHG2:RAC1 229831_at CNTN3 1.20E−07 1.6157 3.93 79 70.2-86.1 235766_x_at RAB27A 1.22E−07 1.5984 1.79 78.8 70.1-85.9 229070_at C6orf105 1.38E−07 1.6049 2.13 78.9 70.1-86 226654_at MUC12 1.53E−07 1.4559 4.89 76.7 67.7-84.1 202686_s_at AXL 1.59E−07 1.5758 1.71 78.5 69.7-85.6 205403_at IL1R2 1.73E−07 1.5237 2.54 77.7 68.8-84.9 211372_s_at IL1R2 1.73E−07 1.5229 2.54 77.7 68.7-85 205929_at GPA33 1.86E−07 1.7056 1.61 80.3 71.7-87.2 202069_s_at IDH3A 2.08E−07 1.5696 1.75 78.4 69.5-85.5 202350_s_at MATN2 2.11E−07 1.506 2.23 77.4 68.4-84.7 212859_x_at NUTF2:MT1E:MT1M 2.14E−07 1.6442 2.41 79.4 70.8-86.4 217546_at NUTF2:MT1E:MT1M 2.14E−07 1.645 2.41 79.5 70.7-86.5 216336_x_at NUTF2:MT1E:MT1M 2.14E−07 1.645 2.41 79.5 70.8-86.4 221667_s_at HSPB8 2.61E−07 1.514 3.85 77.5 68.6-84.8 217757_at A2M 2.72E−07 1.598 1.64 78.8 70.1-85.9 216510_x_at LOC652128:IGHG1:IGHM:IGHV4- 2.80E−07 1.6346 3.1 79.3 70.6-86.4 31:LOC647189:IGHV1- 69:IGHA1:IL8:EXOC7:SIX6:IGHD: IGH@:IGHG3:C12orf32: ZCWPW2:IFI6:IGHG4:IGHA2: IGHG2:RAC1 223343_at NYD-SP21:MS4A7 2.92E−07 1.5396 2.27 77.9 69.1-85.1 202620_s_at PLOD2 3.06E−07 1.5551 2.33 78.2 69.3-85.4 207245_at UGT2B17 3.75E−07 1.4796 4.88 77 68.1-84.5 210139_s_at PMP22 3.97E−07 1.5183 2.23 77.6 68.7-84.9 204938_s_at PLN 4.14E−07 1.5454 2.01 78 69.1-85.2 204939_s_at PLN 4.14E−07 1.5425 2.01 78 69.1-85.2 204940_at PLN 4.14E−07 1.5436 2.01 78 69.1-85.2 203951_at CNN1 4.77E−07 1.4324 4.56 76.3 67.3-83.8 202746_at ITM2A 5.27E−07 1.4988 2.77 77.3 68.4-84.6 221584_s_at KCNMA1 6.86E−07 1.4959 2.37 77.3 68.4-84.6 241994_at XDH 8.13E−07 1.4709 2.03 76.9 67.9-84.3 209621_s_at PDLIM3 8.20E−07 1.4805 2.38 77   68-84.4 204326_x_at LOC645652:MT1X 9.84E−07 1.4427 4.35 76.5 67.4-83.9 208581_x_at LOC645652:MT1X 9.84E−07 1.4397 4.35 76.4 67.5-83.9 201616_s_at CALD1 1.02E−06 1.4583 3.29 76.7 67.8-84.1 201617_x_at CALD1 1.02E−06 1.4617 3.29 76.8 67.7-84.1 212077_at CALD1 1.02E−06 1.4581 3.29 76.7 67.8-84.1 225782_at MSRB3 1.20E−06 1.4747 2.24 77   68-84.3 209436_at SPON1 1.46E−06 1.4849 1.88 77.1 68.1-84.4 223623_at C2orf40 1.69E−06 1.416 2.97 76.1   67-83.5 218087_s_at SORBS1:KIAA0894 2.18E−06 1.4259 2.54 76.2 67.3-83.7 222513_s_at SORBS1:KIAA0894 2.18E−06 1.4263 2.54 76.2 67.2-83.7 224990_at C4orf34 2.55E−06 1.3853 1.95 75.6 66.5-83.1 203131_at FIP1L1:PDGFRA 2.94E−06 1.4845 1.37 77.1 68.2-84.5 203638_s_at FGFR2 3.55E−06 1.5287 1.31 77.8 68.9-85 201957_at PPP1R12B:LOC731632 4.26E−06 1.3611 2.21 75.2 66.2-82.8 217967_s_at FAM129A 4.59E−06 1.4131 1.8 76   67-83.5 210809_s_at POSTN 4.94E−06 1.3954 2.25 75.7 66.7-83.2 226302_at ATP8B1 5.73E−06 1.313 1.67 74.4 65.3-82.1 238750_at CCL28 6.01E−06 1.4932 1.53 77.2 68.3-84.6 226103_at NEXN 6.83E−06 1.3666 2.23 75.3 66.2-82.8 209101_at CTGF 6.96E−06 1.4774 1.3 77 68.1-84.4 229254_at MFSD4 7.19E−06 1.3235 2.12 74.6 65.4-82.3 219087_at ASPN 7.45E−06 1.3249 2.74 74.6 65.5-82.3 209457_at DUSP5 8.60E−06 1.3336 1.91 74.8 65.7-82.4 221541_at CRISPLD2 9.24E−06 1.3664 1.64 75.3 66.2-82.9 206377_at FOXF2 9.50E−06 1.3032 2.08 74.3 65.1-82 207392_x_at UGT2B11:LOC728160:UGT2B15, 9.73E−06 1.3478 5.72 75 65.8-82.6 UGT2B11:LOC728160:UGT2B15 202274_at ACTG2 1.07E−05 1.4015 1.82 75.8 66.8-83.4 227522_at CMBL 1.09E−05 1.3588 1.58 75.2   66-82.8 212192_at KCTD12 1.44E−05 1.3659 1.36 75.3 66.2-82.8 227727_at MRGPRF 1.52E−05 1.2965 2.99 74.2   65-82 234987_at C20orf118 1.75E−05 1.4278 1.3 76.2 67.3-83.7 209656_s_at TMEM47 1.86E−05 1.2983 2.02 74.2 65.1-82 212265_at QKI 1.93E−05 1.3443 1.31 74.9 65.9-82.6 228232_s_at VSIG2 2.01E−05 1.2957 2.05 74.1   65-81.9 200799_at HSPA1A, HSPA1A 2.16E−05 1.272 2.41 73.8 64.6-81.6 218312_s_at ZNF447 3.05E−05 1.107 1.39 71 61.6-79.1 230264_s_at AP1S2 3.39E−05 1.2546 1.92 73.5 64.3-81.4 224840_at FKBP5 3.41E−05 1.2371 1.71 73.2 63.9-81.1 209948_at KCNMB1 3.74E−05 1.2181 2.66 72.9 63.6-80.8 201426_s_at VIM 4.15E−05 1.2221 1.86 72.9 63.7-80.8 227826_s_at SORBS2 4.23E−05 1.3017 2.1 74.2 65.1-82 227827_at SORBS2 4.23E−05 1.3015 2.1 74.2 65.1-82 225728_at SORBS2 4.23E−05 1.3015 2.1 74.2 65.1-82 238751_at SORBS2 4.23E−05 1.3019 2.1 74.2 65.1-82 228202_at C6orf204 4.90E−05 1.2062 2.07 72.7 63.5-80.6 220645_at FAM55D 5.67E−05 1.1786 3.48 72.2   63-80.2 224560_at TIMP2 6.40E−05 1.2304 1.82 73.1 63.9-80.9 231579_s_at TIMP2 6.40E−05 1.2286 1.82 73 63.8-81 208788_at ELOVL5 8.15E−05 1.1804 2.05 72.2   63-80.2 200974_at ACTA2 1.00E−04 1.2299 1.81 73.1 63.8-81 202388_at RGS2 0.0001 1.1604 1.94 71.9 62.7-80 206461_x_at MT1A:MT1H:LOC645745:LOC727730 0.0001 1.189 4.55 72.4 63.2-80.4 208747_s_at C1S:PRB1:PRB2, C1S:PRB2:PRB1 0.0001 1.2884 1.61 74 64.9-81.9 208791_at CLU 0.0001 1.2303 1.42 73.1 63.9-80.9 208792_s_at CLU 0.0001 1.2302 1.42 73.1 63.9-81 212185_x_at NUTF2:LOC441019:MT2A:MT1M, 0.0001 1.1894 1.89 72.4 63.1-80.3 NUTF2:LOC441019:MT2A:MT1M 222043_at CLU 0.0001 1.2306 1.42 73.1 63.9-81 227099_s_at LOC387763 0.0001 1.1963 1.36 72.5 63.2-80.5 202766_s_at FBN1 0.0002 1.1359 1.93 71.5 62.2-79.6 204745_x_at NUTF2:MT1G 0.0002 1.0888 2.66 70.7 61.3-78.9 218418_s_at ANKRD25 0.0002 1.1139 1.56 71.1 61.9-79.3 201058_s_at MYL9 0.0003 1.131 2.18 71.4 62.1-79.5 205547_s_at TAGLN 0.0003 1.0914 2.12 70.7 61.4-78.9 205935_at FOXF1 0.0004 1.1743 1.28 72.1 62.9-80.1 208450_at LGALS2 0.0004 1.0845 3.07 70.6 61.4-78.8 203748_x_at RBMS1 0.0005 1.1435 1.55 71.6 62.3-79.7 207266_x_at RBMS1 0.0005 1.1428 1.55 71.6 62.4-79.7 209868_s_at RBMS1 0.0005 1.1437 1.55 71.6 62.3-79.7 225269_s_at RBMS1 0.0005 1.1446 1.55 71.6 62.3-79.6 212158_at SDC2 0.0006 1.0977 1.39 70.8 61.6-79.1 209209_s_at PLEKHC1 0.0007 1.0309 1.82 69.7 60.3-77.9 209210_s_at PLEKHC1 0.0007 1.0325 1.82 69.7 60.3-78 205554_s_at ACTB:DNASE1L3 0.0007 1.0979 1.5 70.8 61.4-78.9 202283_at SERPINF1 0.0009 1.0003 1.47 69.2 59.8-77.5 209496_at RARRES2:LOC648925 0.0009 1.0318 1.6 69.7 60.3-77.9 224352_s_at CFL2 0.0009 1.0586 1.75 70.2 60.8-78.4 224663_s_at CFL2 0.0009 1.0575 1.75 70.2 60.8-78.4 214433_s_at SELENBP1 0.0009 1.0574 1.7 70.1 60.8-78.3 212592_at ENAM 0.0011 1.0024 2.58 69.2 59.8-77.5 213629_x_at MT1F 0.0012 0.9664 2.2 68.6 59.2-76.9 217165_x_at MT1F 0.0012 0.9649 2.2 68.5 59.2-76.9 203645_s_at CD163 0.0013 1.0231 1.9 69.6   60-77.9 215049_x_at CD163 0.0013 1.0215 1.9 69.5 60.1-77.8 206641_at TNFRSF17 0.0015 1.0206 2.08 69.5 60.1-77.8 227235_at GUCY1A3 0.0015 1.0116 2.69 69.4 59.8-77.6 229530_at GUCY1A3 0.0015 1.0115 2.69 69.3   60-77.6 212097_at CAV1 0.0016 1.0199 1.58 69.5 60.1-77.7 200884_at CKB 0.0019 0.9758 2.27 68.7 59.2-77 202133_at WWTR1 0.002 0.9917 1.48 69 59.5-77.4 204607_at HMGCS2 0.0022 0.8777 2.67 67 57.5-75.5 218559_s_at MAFB 0.0034 0.9595 1.66 68.4   59-76.8 201061_s_at STOM 0.0035 1.0165 1.21 69.4   60-77.7 201743_at CD14 0.0035 0.9627 1.58 68.5 59.1-76.9 204895_x_at MUC4:TAF5L:LOC650855:LOC645744 0.0039 1.0448 1.2 69.9 60.6-78.2 217109_at MUC4:TAF5L:LOC650855:LOC645744 0.0039 1.0458 1.2 69.9 60.6-78.1 217110_s_at MUC4:TAF5L:LOC650855:LOC645744 0.0039 1.0453 1.2 69.9 60.5-78.2 203382_s_at APOE 0.0044 0.9388 1.56 68.1 58.7-76.5 206664_at SI 0.0054 0.9293 2.79 67.9 58.4-76.3 242447_at LOC285382 0.0058 0.7401 1.26 64.4 54.9-73.2 209312_x_at HLA-DRB1:HLA- 0.0063 1.0636 1.51 70.3 60.9-78.5 DRB6:LOC731247:LOC730415:HLA- DRB4:HLA- DRB5:HLA- DRB3:LOC651845 215193_x_at HLA-DRB1:HLA- 0.0063 1.0646 1.51 70.3 60.9-78.5 DRB6:LOC731247:LOC730415:HLA- DRB4:HLA- DRB5:HLA- DRB3:LOC651845 224694_at ANTXR1 0.0071 0.9531 1.29 68.3 58.8-76.7 226811_at FAM46C 0.0085 0.9163 1.38 67.7 58.1-76.1 201150_s_at TIMP3 0.0091 0.9049 1.81 67.5 57.9-76 226682_at LOC283666 0.0099 0.7784 1.22 65.1 55.7-73.8 218468_s_at GREM1 0.0106 0.8585 3.03 66.6 57.2-75.2 218469_at GREM1 0.0106 0.8579 3.03 66.6 57.1-75.2 203240_at FCGBP:LOC651441:LOC652599 0.0121 0.7868 1.99 65.3 55.8-73.9 211538_s_at HSPA2 0.0123 0.8916 1.43 67.2 57.7-75.7 212091_s_at COL6A1 0.0126 0.848 1.45 66.4 56.9-74.9 213428_s_at COL6A1 0.0126 0.8474 1.45 66.4 56.9-74.9 226051_at SELM 0.0133 0.8606 1.32 66.7 57.1-75.1 200859_x_at FLNA:WTAP 0.0157 0.7975 1.59 65.5 55.9-74 213746_s_at FLNA:WTAP 0.0157 0.7959 1.59 65.5   56-74.2 214752_x_at FLNA:WTAP 0.0157 0.798 1.59 65.5   56-74.1 204570_at COX7A1 0.0161 0.8622 1.32 66.7 57.2-75.2 203729_at EMP3 0.0164 0.8043 1.41 65.6 56.1-74.3 223597_at ITLN1 0.021 0.7148 2.54 64 54.4-72.7 227735_s_at C10orf99 0.0218 0.7254 1.76 64.2 54.6-72.9 227736_at C10orf99 0.0218 0.7259 1.76 64.2 54.6-72.9 200621_at CSRP1 0.023 0.7246 1.39 64.1 54.6-72.9 204897_at PTGER4:LOC730002:LOC730882 0.0237 0.8114 1.41 65.8 56.2-74.4 204083_s_at PPIL5:TPM2 0.026 0.7531 1.53 64.7 55.2-73.4 211643_x_at HLA-C:HLA- 0.0268 0.9237 1.24 67.8 58.3-76.3 B:LOC730410:LOC652614:LOC732037 211644_x_at HLA-C:HLA- 0.0268 0.9229 1.24 67.8 58.3-76.2 B:LOC730410:LOC652614:LOC732037 214768_x_at HLA-C:HLA- 0.0268 0.9245 1.24 67.8 58.3-76.3 B:LOC730410:LOC652614:LOC732037 226147_s_at PIGR 0.0278 0.7282 1.59 64.2 54.6-73 229659_s_at PIGR 0.0278 0.7253 1.59 64.2 54.7-72.9 201300_s_at PRNP 0.0288 0.7985 1.24 65.5   56-74.1 210133_at CCL11 0.0361 0.8534 1.32 66.5   57-75.1 225353_s_at C1QC 0.0391 0.7457 1.36 64.5   55-73.2 201289_at CYR61 0.0425 0.7849 1.47 65.3 55.8-73.9 210764_s_at CYR61 0.0425 0.7836 1.47 65.2 55.6-73.9 200986_at SERPING1 0.0503 0.7672 1.44 64.9 55.4-73.6 204122_at TYROBP:ZNF160 0.053 0.8181 1.17 65.9 56.4-74.5 201667_at GJA1 0.0561 0.784 1.76 65.2 55.7-73.9 208789_at PTRF 0.0624 0.736 1.5 64.4 54.8-73.1 210107_at CLCA1 0.0681 0.7868 1.61 65.3 55.7-73.9 200665_s_at SPARC 0.0684 0.6714 1.45 63.1 53.6-72.1 212667_at SPARC 0.0684 0.6732 1.45 63.2 53.6-71.9 211964_at COL4A2 0.0738 0.7064 1.32 63.8 54.2-72.6 201858_s_at PRG1 0.0972 0.5559 1.25 60.9 51.3-69.9 201859_at PRG1 0.0972 0.5563 1.25 61 51.4-69.9 228241_at BCMP11 0.102 0.4028 1.28 58 48.4-67.1 217762_s_at RAB31 0.1041 0.8135 1.14 65.8 56.3-74.4 217764_s_at RAB31 0.1041 0.8132 1.14 65.8 56.2-74.5 202007_at NID1 0.105 0.7425 1.33 64.5   55-73.1 210495_x_at FN1 0.1121 0.5756 1.73 61.3 51.8-70.2 211719_x_at FN1 0.1121 0.5767 1.73 61.3 51.8-70.2 212464_s_at FN1 0.1121 0.5765 1.73 61.3 51.6-70.3 216442_x_at FN1 0.1121 0.5745 1.73 61.3 51.7-70.3 200600_at MSN 0.1499 0.7232 1.15 64.1 54.6-72.9 209138_x_at IGL@:LOC651536:LOC731062: 0.1551 0.681 1.26 63.3 53.8-72.2 CPVL:IGLV2-14:IGLV4- 3:IGLV3-25:IGLV3- 21:IL8:RPL14 216984_x_at IGL@:LOC651536:LOC731062: 0.1551 0.6808 1.26 63.3 53.8-72.2 CPVL:IGLV2-14:IGLV4- 3:IGLV3-25:IGLV3- 21:IL8:RPL14 217148_x_at IGL@:LOC651536:LOC731062: 0.1551 0.6808 1.26 63.3 53.9-72.1 CPVL:IGLV2-14:IGLV4- 3:IGLV3-25:IGLV3- 21:IL8:RPL14 201069_at MMP2 0.1755 0.6214 1.24 62.2 52.6-71 202403_s_at COL1A2:LOC728628 0.1891 0.6508 1.9 62.8 53.2-71.5 202768_at FOSB 0.2076 0.6392 2.17 62.5 52.9-71.5 209116_x_at HBB 0.2357 0.6432 1.28 62.6 52.9-71.4 211696_x_at HBB 0.2357 0.6436 1.28 62.6 53.1-71.4 217232_x_at HBB 0.2357 0.6444 1.28 62.6 53.1-71.5 205267_at POU2AF1 0.2389 0.6573 1.18 62.9 53.3-71.7 201852_x_at COL3A1 0.2551 0.5524 1.35 60.9 51.3-69.8 211161_s_at COL3A1 0.2551 0.5509 1.35 60.9 51.3-69.9 215076_s_at COL3A1 0.2551 0.5513 1.35 60.9 51.3-69.8 217378_x_at LOC391427 0.2627 0.2759 1.15 55.5 45.9-64.8 223235_s_at SMOC2 0.2701 0.656 1.34 62.9 53.2-71.7 204673_at MUC5AC:LOC652741:MUC2 0.2802 0.8531 1.22 66.5   57-75.1 212414_s_at Sep-06 0.3109 0.5714 1.21 61.2 51.7-70.2 201744_s_at LUM 0.3157 0.5425 1.54 60.7   51-69.7 202953_at C1QB 0.3668 0.4998 1.24 59.9 50.3-68.9 209651_at TGFB1I1 0.4093 0.4932 1.35 59.7 50.2-68.8 212224_at ALDH1A1 0.4232 0.3525 1.4 57 47.4-66.2 211596_s_at LRIG1 0.4614 0.5988 1.26 61.8 52.2-70.7 218541_s_at C8orf4 0.475 0.4838 1.44 59.6   50-68.5 208894_at HLA-DRA:HLA-DQA1, HLA- 0.4823 0.3234 1.29 56.4 46.8-65.6 DRA:HLA-DQA1, HLA- DRA:HLA-DQA1 210982_s_at HLA-DRA:HLA-DQA1, HLA- 0.4823 0.3228 1.29 56.4 46.8-65.6 DRA:HLA-DQA1, HLA- DRA:HLA-DQA1 227404_s_at EGR1 0.4851 0.5387 1.38 60.6   51-69.6 216401_x_at LOC652745 0.4864 0.1728 1.09 53.4 43.9-62.8 216207_x_at IGKV1D-13 0.5177 0.16 1.1 53.2 43.6-62.6 203477_at COL15A1 0.6601 0.5385 1.22 60.6 51.1-69.7 211959_at IGFBP5 0.7663 0.3526 1.25 57 47.4-66.2 201105_at LGALS1 0.8555 0.4634 1.16 59.2 49.6-68.2 201438_at COL6A3 0.8739 0.4434 1.2 58.8 49.2-67.8 212671_s_at HLA-DQA1:HLA- 0.8836 0.5398 1.28 60.6 51.1-69.7 DQA2, HLA- DQA1:LOC731682:HLA- DQA2 227725_at ST6GALNAC1 0.9452 0.2599 1.15 55.2 45.6-64.5 211990_at HLA-DPA1, HLA-DPA1 0.9664 0.417 1.39 58.3 48.7-67.4 211991_s_at HLA-DPA1, HLA-DPA1 0.9664 0.4166 1.39 58.3 48.7-67.4 217179_x_at IGLV1-44 0.9777 0.2852 1.07 55.7 46.1-65 234764_x_at IGLV1-44 0.9777 0.2847 1.07 55.7 46.1-64.9 224342_x_at IGLV1-44 0.9777 0.2848 1.07 55.7 46.1-65 215176_x_at NTN2L:IGKC:IGKV1- 0.9858 0.4167 1.43 58.3 48.6-67.3 5:GJB6:HLA-C 216576_x_at NTN2L:IGKC:IGKV1- 0.9858 0.4171 1.43 58.3 48.6-67.4 5:GJB6:HLA-C 201645_at TNC 0.9905 0.3687 1.09 57.3 47.7-66.6 214414_x_at HBA1:HBA2, HBA1:HBA2 0.9979 0.4707 1.21 59.3 49.7-68.3 204018_x_at HBA1:HBA2, HBA1:HBA2 0.9979 0.4711 1.21 59.3 49.7-68.3 209458_x_at HBA1:HBA2, HBA1:HBA2 0.9979 0.4727 1.21 59.3 49.7-68.4 211699_x_at HBA1:HBA2, HBA1:HBA2 0.9979 0.4697 1.21 59.3 49.7-68.3 211745_x_at HBA1:HBA2, HBA1:HBA2 0.9979 0.4708 1.21 59.3 49.8-68.3 217414_x_at HBA1:HBA2, HBA1:HBA2 0.9979 0.469 1.21 59.3 49.7-68.4

TABLE 2 Gene Sens- Symbol ValidPS_DOWN Signif. FD

D.val5 FC Spec CI (95) GCNT2 935239-HuGene_st:225205-HuGene_st:1026280- 2.16E−27 3.9513 13.36 97.6 94.2-99.2 HuGene_st:668101-HuGene_st:1099985- HuGene_st:698568-HuGene_st:134540- HuGene_st:697147-HuGene_st:250092- HuGene_st:611927-HuGene_st:972833- HuGene_st:168891-HuGene_st:990860- HuGene_st:109287-HuGene_st:322116- HuGene_st:231019-HuGene_st:211020_at:959570- HuGene_st:858764-HuGene_st:215593_at:820195- HuGene_st:239606_at:41059-HuGene_st:669940- HuGene_st:215595_x_at:230788_at GUCA2B 276512-HuGene_st:1006871-HuGene_st:948364- 7.04E−25 3.6268 51.78 96.5 92.4-98.6 HuGene_st:46575-HuGene_st:207502_at:436788- HuGene_st:485636-HuGene_st:60132- HuGene_st:608718-HuGene_st:779511- HuGene_st:132431-HuGene_st:974232- HuGene_st:425596-HuGene_st:308287- HuGene_st:800088-HuGene_st:827119- HuGene_st:233789-HuGene_st:623623-HuGene_st GUCA1B 207003_at 7.32E−25 3.5625 10.7 96.3 91.9-98.5 CA4 636392-HuGene_st:206209_s_at:365396- 1.73E−24 3.6291 10.41 96.5 92.4-98.7 HuGene_st:978203-HuGene_st:987169- HuGene_st:638557-HuGene_st:206208_at:1033858- HuGene_st:597808-HuGene_st:756864- HuGene_st:326439-HuGene_st:356096- HuGene_st:478435-HuGene_st:31642- HuGene_st:682778-HuGene_st:1006162- HuGene_st:673533-HuGene_st:491473- HuGene_st:822299-HuGene_st:871453- HuGene_st:209666-HuGene_st:465368- HuGene_st:354896-HuGene_st SLC4A4 810103-HuGene_st:634869- 2.23E−23 3.6301 3.58 96.5 92.4-98.6 HuGene_st:210739_x_at:211494_s_at:268096- HuGene_st:70822-HuGene_st:940785- HuGene_st:484105- HuGene_st:210738_s_at:203908_at:99375- HuGene_st:238833-HuGene_st:149464- HuGene_st:874564-HuGene_st:161948- HuGene_st:501640-HuGene_st:65687- HuGene_st:886057-HuGene_st:495376- HuGene_st:247215-HuGene_st:847550- HuGene_st:190252-HuGene_st:244077- HuGene_st:477911-HuGene_st:904959- HuGene_st:218417-HuGene_st:1554027_a_at AQP8 486167-HuGene_st:126752-HuGene_st:93102- 2.98E−22 3.3311 10.82 95.2 90.3-97.9 HuGene_st:1090469-HuGene_st:980308- HuGene_st:107169-HuGene_st:829020- HuGene_st:1053234-HuGene_st:954102- HuGene_st:40331-HuGene_st:206784_at:990703- HuGene_st:459706-HuGene_st:863327- HuGene_st:965233-HuGene_st:459009- HuGene_st:180228-HuGene_st:944315- HuGene_st:814773-HuGene_st:810460- HuGene_st:228837-HuGene_st CA1 632246-HuGene_st:205950_s_at:382371- 3.15E−22 3.3666 38.27 95.4 90.6-98   HuGene_st:1004598-HuGene_st:405837- HuGene_st:551543-HuGene_st:242482- HuGene_st:267733-HuGene_st:1074039- HuGene_st:107073-HuGene_st:485365- HuGene_st:254908-HuGene_st:257502- HuGene_st:333301-HuGene_st:180359- HuGene_st:696950-HuGene_st:588557- HuGene_st:381399-HuGene_st:495540- HuGene_st:384192-HuGene_st:205949_at ABCG2 236197-HuGene_st:10623-HuGene_st:1005470- 1.09E−21 3.2599 31.53 94.8 89.8-97.7 HuGene_st:140860-HuGene_st:492719- HuGene_st:417387-HuGene_st:113831- HuGene_st:507347-HuGene_st:944251- HuGene_st:175319-HuGene_st:784920- HuGene_st:709551-HuGene_st:136344- HuGene_st:689536-HuGene_st:209735_at:167748- HuGene_st:759590-HuGene_st:805222- HuGene_st:945575-HuGene_st:294363- HuGene_st:958524-HuGene_st:402982- HuGene_st:301335-HuGene_st OSTbeta 552746-HuGene_st:57742-HuGene_st:461622- 6.23E−21 3.188 7.15 94.5 89.2-97.5 HuGene_st:965982-HuGene_st:413709- HuGene_st:230830_at:232719-HuGene_st:165400- HuGene_st:203597-HuGene_st:1025456- HuGene_st:625341-HuGene_st:881755- HuGene_st:490180-HuGene_st:113547- HuGene_st:605512-HuGene_st:179662- HuGene_st:280309-HuGene_st:647118-HuGene_st MGC13057 926449-HuGene_st:317301-HuGene_st:834797- 6.94E−21 3.2029 3.18 94.5 89.3-97.5 HuGene_st:173388-HuGene_st:127937- HuGene_st:182395-HuGene_st:800172- HuGene_st:1041848-HuGene_st:93911- HuGene_st:810617-HuGene_st:1035428- HuGene_st:644866-HuGene_st:343402- HuGene_st:223754_at:228195_at:509933-HuGene_st CLDN23 403960-HuGene_st:25144-HuGene_st:947653- 4.27E−20 3.0777 3.47 93.8 88.2-97.1 HuGene_st:228704_s_at:228706_s_at:320375- HuGene_st:441629:HuGene_st:367414- HuGene_st:855269-HuGene_st:228707_at:788659- HuGene_st:698816-HuGene_st:95789- HuGene_st:270197-HuGene_st:472976- HuGene_st:280539-HuGene_st:1056334- HuGene_st:516288-HuGene_st:579963-HuGene_st PKIB 866170-HuGene_st:1055812-HuGene_st:264946- 5.94E−20 3.1232 3.28 94.1 88.7-97.3 HuGene_st:684057-HuGene_st:124791- HuGene_st:134561-HuGene_st:1026756- HuGene_st:468593-HuGene_st:1045852- HuGene_st:939917-HuGene_st:110205- HuGene_st:660721-HuGene_st:905229- HuGene_st:223551_at:610426-HuGene_st SEMA6D 855766-HuGene_st:233882_s_at:543564- 6.07E−20 3.092 4.27 93.9 88.4-97.2 HuGene_st:277987-HuGene_st:1075165- HuGene_st:220574_at:732853-HuGene_st:410940- HuGene_st:384488-HuGene_st:1041056- HuGene_st:233801_s_at:535378-HuGene_st:477671- HuGene_st:626423-HuGene_st:101599- HuGene_st:714098-HuGene_st:301505- HuGene_st:53682-HuGene_st:177281- HuGene_st:596415- HuGene_st:244746_at:226492_at:699792- HuGene_st:73748-HuGene_st:692437-HuGene_st CLCA4 220026_at:1000955-HuGene_st:215807- 1.25E−19 3.1922 16.3 94.5 89.2-97.5 HuGene_st:108406-HuGene_st:538359- HuGene_st:366726-HuGene_st:727431- HuGene_st:240891-HuGene_st:485685- HuGene_st:205213-HuGene_st:476179- HuGene_st:283676-HuGene_st:933390- HuGene_st:601908-HuGene_st:844633- HuGene_st:846667-HuGene_st:99723- HuGene_st:376041-HuGene_st:71188- HuGene_st:261183-HuGene_st:498330- HuGene_st:500064-HuGene_st:785031-HuGene_st TP53INP2 224836_at:294906-HuGene_st:857693- 1.45E−19 3.0229 3.78 93.5 87.8-96.9 HuGene_st:852970-HuGene_st:594178- HuGene_st:868173-HuGene_st:353925- HuGene_st:212485-HuGene_st:804363- HuGene_st:778869-HuGene_st:427072- HuGene_st:451529-HuGene_st:808765- HuGene_st:205314-HuGene_st:415164- HuGene_st:1048358-HuGene_st MS4A12 220834_at:582400-HuGene_st:354845- 2.13E−19 3.2962 7.15 95   90-97.8 HuGene_st:341876-HuGene_st:769180- HuGene_st:740541-HuGene_st:436753- HuGene_st:570027-HuGene_st:26519- HuGene_st:956581-HuGene_st:335315- HuGene_st:206721-HuGene_st:589444- HuGene_st:16629-HuGene_st:113533- HuGene_st:201614-HuGene_st:774878- HuGene_st:786494-HuGene_st:493550- HuGene_st:403871-HuGene_st:192686- HuGene_st:846528-HuGene_st:249799-HuGene_st TRPM6 767074-HuGene_st:695352-HuGene_st:411125- 2.25E−19 3.0106 7.5 93.4 87.7-96.8 HuGene_st:221102_s_at:234864_s_at:240389_at:358229- HuGene_st:755964-HuGene_st:840301- HuGene_st:959234-HuGene_st:782639- HuGene_st:833079-HuGene_st:1066034- HuGene_st:678013-HuGene_st:249083- HuGene_st:143934-HuGene_st:159130- HuGene_st:486486-HuGene_st:185057- HuGene_st:878793-HuGene_st:133981- HuGene_st:224412_s_at:202194-HuGene_st XLKD1 520080-HuGene_st:1091117-HuGene_st:943125- 3.60E−19 2.94 7.44 92.9 87.1-96.6 HuGene_st:444068-HuGene_st:648558- HuGene_st:346991-HuGene_st:1006205- HuGene_st:373107-HuGene_st:682535- HuGene_st:1083245-HuGene_st:863143- HuGene_st:820120-HuGene_st:1044561- HuGene_st:220037_s_at:541228-HuGene_st:220256- HuGene_st:289122-HuGene_st:219059_s_at:246683- HuGene_st:775976-HuGene_st:207399- HuGene_st:1052557-HuGene_st:92121-HuGene_st ADH1B 1078343-HuGene_st:512808-HuGene_st:614446- 4.70E−19 3.0172 4.67 93.4 87.7-96.9 HuGene_st:910188-HuGene_st:422504- HuGene_st:731361-HuGene_st:209612_s_at:258079- HuGene_st:568239-HuGene_st:879930- HuGene_st:420417-HuGene_st:1025048- HuGene_st:908335-HuGene_st:654633- HuGene_st:947292-HuGene_st:1087125- HuGene_st:1004870-HuGene_st:209613_s_at:579636- HuGene_st:681018-HuGene_st:822774-HuGene_st PRDX6 353187-HuGene_st:520885-HuGene_st:919334- 5.56E−19 2.8414 2.76 92.2 86.1-96.1 HuGene_st:646105-HuGene_st:390352- HuGene_st:200844_s_at:855125- HuGene_st:200845_s_at:54231-HuGene_st:612931- HuGene_st:837652-HuGene_st:538086- HuGene_st:796167-HuGene_st:208992- HuGene_st:39945-HuGene_st:489353- HuGene_st:963499-HuGene_st:376244- HuGene_st:297536-HuGene_st:495777- HuGene_st:1005253-HuGene_st:833460-HuGene_st CA2 762141-HuGene_st:111686-HuGene_st:512916- 5.87E−19 2.9625 9.22 93.1 87.2-96.7 HuGene_st:9132-HuGene_st:995083: HuGene_st:209301_at:578483-HuGene_st:583428- HuGene_st:961832-HuGene_st:11748- HuGene_st:1056641-HuGene_st:545067- HuGene_st:952781-HuGene_st:689246- HuGene_st:246103-HuGene_st:803284- HuGene_st:828842-HuGene_st:694989- HuGene_st:808226-HuGene_st:199030-HuGene_st EDN3 314103-HuGene_st:217154_s_at:820613- 6.42E−19 2.937 11.21 92.9   87-96.5 HuGene_st:1050996-HuGene_st:348157- HuGene_st:338856-HuGene_st:594687- HuGene_st:38595-HuGene_st:270770- HuGene_st:817067-HuGene_st:766407- HuGene_st:256284-HuGene_st:208399_s_at:200417- HuGene_st:496738-HuGene_st:590141- HuGene_st:137170-HuGene_st:499250- HuGene_st:478524-HuGene_st:720694- HuGene_st:543565-HuGene_st MIER3 884917-HuGene_st:740856-HuGene_st:107094- 9.14E−19 2.9162 3.91 92.8 86.8-96.5 HuGene_st:408774-HuGene_st:461523- HuGene_st:153511-HuGene_st:207042- HuGene_st:737492-HuGene_st:43443- HuGene_st:614740-HuGene_st:1559652_at:783045- HuGene_st:887606-HuGene_st:996253- HuGene_st:1041635-HuGene_st:142612- HuGene_st:1553336_a_at:220555-HuGene_st:975347- HuGene_st:470750-HuGene_st:1554450_s_at:804524- HuGene_st:265536-HuGene_st:774142- HuGene_st:231975_s_at:34726- 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2.8977 9.07 92.6 86.7-96.4 HuGene_st:1005554-HuGene_st:178625- HuGene_st:701967-HuGene_st:35076- HuGene_st:33432-HuGene_st:897771- HuGene_st:304494-HuGene_st:445757- HuGene_st:491297-HuGene_st:646408- HuGene_st:842542-HuGene_st:87795- HuGene_st:213068_at:207977_s_at:553389- HuGene_st:477075-HuGene_st:213071_at:1046282- HuGene_st MGC4172 339712-HuGene_st:1089815-HuGene_st:265870- 1.74E−18 2.9044 3.74 92.7 86.7-96.4 HuGene_st:895908-HuGene_st:226292- HuGene_st:322910-HuGene_st:575887- HuGene_st:416485-HuGene_st:1055581- HuGene_st:1088692-HuGene_st:442194- HuGene_st:218756_s_at:775684-HuGene_st:773137- HuGene_st:373028-HuGene_st:512667- HuGene_st:164027-HuGene_st:541185- HuGene_st:593729-HuGene_st:506796-HuGene_st FNBP1 728822-HuGene_st:845505-HuGene_st:1054016- 1.76E−18 3.0483 2.04 93.6 88-97 HuGene_st:383098-HuGene_st:230389_at:31865- HuGene_st:981305-HuGene_st:213940_s_at:755179- HuGene_st:839717- HuGene_st:230086_at:239453_at:985213- HuGene_st:125814:HuGene_st:451336- 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HuGene_st:68008-HuGene_st:317350- HuGene_st:239950-HuGene_st:604210- HuGene_st:20407-HuGene_st:1099546- HuGene_st:395466-HuGene_st:548603- HuGene_st:931079-HuGene_st:159325- HuGene_st:251067-HuGene_st:1056116- HuGene_st:224253-HuGene_st:885069- HuGene_st:1075816-HuGene_st:592859-HuGene_st PAG1 572231-HuGene_st:431317-HuGene_st:342766- 1.11E−12 2.215 2.68 86.6   79-92.1 HuGene_st:1080197-HuGene_st:225622_at:81123- HuGene_st:859237-HuGene_st:287765- HuGene_st:225626_at:743424-HuGene_st:759835- HuGene_st:622195-HuGene_st:208082- HuGene_st:768207-HuGene_st:657358- HuGene_st:506609-HuGene_st:226184- HuGene_st:540710-HuGene_st:236888- HuGene_st:36408-HuGene_st:546382- HuGene_st:498489-HuGene_st:227354_at KRT20 11827-HuGene_st:50958-HuGene_st:684746- 1.26E−12 2.0981 5.49 85.3 77.4-91.1 HuGene_st:574501-HuGene_st:270813- HuGene_st:421213-HuGene_st:213953_at:225474- HuGene_st:310071-HuGene_st:356429- HuGene_st:997077-HuGene_st:963515- HuGene_st:944854-HuGene_st:178191- HuGene_st:613655-HuGene_st:337174- HuGene_st:268017-HuGene_st:81041- HuGene_st:85506-HuGene_st:798272- HuGene_st:925916-HuGene_st:780714- HuGene_st:138025-HuGene_st ENTPD5 760608-HuGene_st:231676_s_at:831252- 1.43E−12 2.1686 3.01 86.1 78.3-91.7 HuGene_st:497317-HuGene_st:712688- HuGene_st:259180-HuGene_st:832617- HuGene_st:785663-HuGene_st:205757_at:553118- HuGene_st:384386-HuGene_st:911183- HuGene_st:440835-HuGene_st:150070- HuGene_st:821276-HuGene_st:14461- HuGene_st:520930-HuGene_st:181407- HuGene_st:294287-HuGene_st:226594_at:551172- HuGene_st:1040872-HuGene_st:1048020-HuGene_st MALL 209373_at:628866-HuGene_st:1092892- 2.10E−12 2.1585 3.96 86 78.2-91.7 HuGene_st:488187-HuGene_st:515617- HuGene_st:649198-HuGene_st:991653- HuGene_st:301852-HuGene_st:1067925- HuGene_st:451072-HuGene_st:102723- HuGene_st:670639-HuGene_st:848482- HuGene_st:928502-HuGene_st:787192- HuGene_st:916920-HuGene_st:959742- HuGene_st:711672-HuGene_st:20252- HuGene_st:225337-HuGene_st MFAP4 308095-HuGene_st:1004622-HuGene_st:754788- 2.96E−12 2.1813 2.51 86.2 78.5-91.9 HuGene_st:212713_at:911082-HuGene_st:767889- HuGene_st:5569-HuGene_st:308458- HuGene_st:699815-HuGene_st:658908- HuGene_st:73048-HuGene_st:515283- HuGene_st:671512-HuGene_st:792571- HuGene_st:689375-HuGene_st:590963- HuGene_st:821074-HuGene_st:132543- HuGene_st:655171-HuGene_st:341975- HuGene_st:1048103-HuGene_st SRI 1018107-HuGene_st:929936-HuGene_st:596109- 3.03E−12 2.0985 2.43 85.3 77.4-91.1 HuGene_st:469173-HuGene_st:235900- HuGene_st:303619-HuGene_st:792372- HuGene_st:1034405-HuGene_st:145638- HuGene_st:76828-HuGene_st:103032- HuGene_st:788729-HuGene_st:262807- HuGene_st:452805-HuGene_st:208921_s_at:863794- HuGene_st:172167-HuGene_st:309679- HuGene_st:1058573-HuGene_st:208920_at:235325- HuGene_st:813384-HuGene_st SGK 425210-HuGene_st:201739_at:137804- 3.12E−12 2.1186 4.08 85.5 77.7-91.4 HuGene_st:182666-HuGene_st:271994- HuGene_st:629671-HuGene_st:350855- HuGene_st:179953-HuGene_st:1039396- HuGene_st:664449-HuGene_st:1049246- HuGene_st:1100037-HuGene_st:1094410- HuGene_st:677142-HuGene_st:231137- HuGene_st:393473-HuGene_st IGHM 1001583-HuGene_st:162285-HuGene_st:1061429- 3.25E−12 2.3285 1.73 87.8 80.4-93   HuGene_st:359832-HuGene_st:60182: HuGene_st:1002550-HuGene_st:311771- HuGene_st:790352-HuGene_st:977059- HuGene_st:587401-HuGene_st:343597- HuGene_st:25657-HuGene_st:640259- HuGene_st:184414-HuGene_st:336659- HuGene_st:1008406-HuGene_st:1044209- HuGene_st:519020-HuGene_st:427467- HuGene_st:669553-HuGene_st:722843- HuGene_st:126162-HuGene_st:654578- HuGene_st:146515-HuGene_st:1100721- HuGene_st:823307-HuGene_st:899494- HuGene_st:952685-HuGene_st:215118_s_at:235399- HuGene_st:802521-HuGene_st:126175- HuGene_st:910847-HuGene_st:212827_at:722700- HuGene_st:173623-HuGene_st:1042953- HuGene_st:38807-HuGene_st:408026-HuGene_st ZCWPW2 1001583-HuGene_st:162285-HuGene_st:1061429- 3.25E−12 2.3264 1.73 87.8 80.4-93   HuGene_st:359832-HuGene_st:60182- HuGene_st:1002550-HuGene_st:311771- HuGene_st:790352-HuGene_st:977059- HuGene_st:587401-HuGene_st:343597- HuGene_st:25657-HuGene_st:640259- HuGene_st:184414-HuGene_st:336659- HuGene_st:1008406-HuGene_st:1044209- HuGene_st:519020-HuGene_st:427467- HuGene_st:669553-HuGene_st:722843- HuGene_st:126162-HuGene_st:654578- HuGene_st:146515-HuGene_st:1100721- HuGene_st:823307-HuGene_st:899494- HuGene_st:952685-HuGene_st:215118_s_at:235399- HuGene_st:802521-HuGene_st:126175- HuGene_st:910847-HuGene_st:212827_at:722700- HuGene_st:173623-HuGene_st:1042953- HuGene_st:38807-HuGene_st:408026-HuGene_st IL8 1001583-HuGene_st:162285-HuGene_st:1061429- 3.28E−12 2.3266 1.73 87.8 80.4-93   HuGene_st:359832-HuGene_st:60182- HuGene_st:1002550-HuGene_st:311771- HuGene_st:790352-HuGene_st:977059- HuGene_st:587401-HuGene_st:343597- HuGene_st:25657-HuGene_st:640259- HuGene_st:184414-HuGene_st:336659- HuGene_st:1008406-HuGene_st:1044209- HuGene_st:519020-HuGene_st:427467- HuGene_st:669553-HuGene_st:722843- HuGene_st:126162-HuGene_st:654578- HuGene_st:146515-HuGene_st:1100721- HuGene_st:823307-HuGene_st:899494- HuGene_st:952685-HuGene_st:215118_s_at:235399- HuGene_st:802521-HuGene_st:126175- HuGene_st:910847-HuGene_st:212827_at:722700- HuGene_st:173623-HuGene_st:1042953- HuGene_st:38807-HuGene_st:408026-HuGene_st IGHA1 1001583-HuGene_st:162285-HuGene_st:1061429- 3.28E−12 2.3276 1.73 87.8 80.4-93   HuGene_st:359832-HuGene_st:60182- HuGene_st:1002550-HuGene_st:311771- HuGene_st:790352-HuGene_st:977059- HuGene_st:587401-HuGene_st:343597- HuGene_st:25657-HuGene_st:640259- HuGene_st:184414-HuGene_st:336659- HuGene_st:1008406-HuGene_st:235364_at:1044209- HuGene_st:519020-HuGene_st:427467- HuGene_st:669553-HuGene_st:722843- HuGene_st:208763_s_at:207001_x_at:126162- HuGene_st:654578-HuGene_st:146515- HuGene_st:1100721-HuGene_st:823307- HuGene_st:899494-HuGene_st:952685- HuGene_st:215118_s_at:235399-HuGene_st:802521- HuGene_st:126175-HuGene_st:910847- HuGene_st:212827_at:722700-HuGene_st:173623- HuGene_st:1042953-HuGene_st:38807- HuGene_st:408026-HuGene_st MGC14376 20793-HuGene_st:228915-HuGene_st:630688- 3.39E−12 2.1014 2.58 85.3 77.5-91.2 HuGene_st:117325-HuGene_st:532108- HuGene_st:373670-HuGene_st:552164- HuGene_st:1004615-HuGene_st:527421- HuGene_st:880155-HuGene_st:10973- HuGene_st:395595-HuGene_st:312241- HuGene_st:644241-HuGene_st:214696_at:234825- HuGene_st:1002029-HuGene_st:1032648-HuGene_st ETHE1 1008653-HuGene_st:507181-HuGene_st:435886- 3.46E−12 2.2097 1.75 86.5 78.9-92.1 HuGene_st:296660-HuGene_st:764234- HuGene_st:918966-HuGene_st:1078682- HuGene_st:789091-HuGene_st:100698- HuGene_st:204034_at:301334-HuGene_st:869871- HuGene_st:841094-HuGene_st:612751- HuGene_st:43763-HuGene_st:853527- HuGene_st:593768-HuGene_st:52787- HuGene_st:555225-HuGene_st:1028299-HuGene_st CES2 817786-HuGene_st:63720-HuGene_st:527565- 3.51E−12 2.0993 2.87 85.3 77.4-91.1 HuGene_st:678893-HuGene_st:209668_x_at:825633- HuGene_st:336873-HuGene_st:409854- HuGene_st:213509_x_at:134988-HuGene_st:446296- HuGene_st:842160-HuGene_st:827636- HuGene_st:209667_at:882043-HuGene_st:279172- HuGene_st:1081267-HuGene_st:756682- HuGene_st:90632-HuGene_st GPM6B 599862-HuGene_st:754598-HuGene_st:503642- 4.04E−12 2.1563 3.59 86 78.2-91.6 HuGene_st:224935-HuGene_st:754449- HuGene_st:577489-HuGene_st:1073242- HuGene_st:560873-HuGene_st:1003662- HuGene_st:430217-HuGene_st:903323- HuGene_st:231962-HuGene_st:244945- HuGene_st:562460-HuGene_st:583561- HuGene_st:209168_at SYNPO2 800385-HuGene_st:938576-HuGene_st:54552- 5.07E−12 2.1029 6.43 85.3 77.5-91.2 HuGene_st:946854-HuGene_st:278208- HuGene_st:170777-HuGene_st:796143- HuGene_st:544243-HuGene_st:469048- HuGene_st:364454-HuGene_st:400491- HuGene_st:22204-HuGene_st:315299- HuGene_st:526384-HuGene_st:841867- HuGene_st:244108_at:2158-HuGene_st:283531- HuGene_st:407855- HuGene_st:225721_at:225720_at:225895_at:225894_at: 1017102-HuGene_st:227662_at:232119_at GCG 1044997-HuGene_st:682227-HuGene_st:368693- 5.58E−12 2.1165 12.56 85.5 77.7-91.3 HuGene_st:25836-HuGene_st:228935- HuGene_st:1030502-HuGene_st:12466- HuGene_st:1098133-HuGene_st:994392- HuGene_st:581476-HuGene_st:799068- HuGene_st:350795-HuGene_st:705389- HuGene_st:981135-HuGene_st:736837- HuGene_st:253854-HuGene_st:1032660- HuGene_st:273941-HuGene_st:206422_at:940866- HuGene_st:514731-HuGene_st MGP 696658-HuGene_st:618386- 6.11E−12 2.1428 4.68 85.8   78-91.5 HuGene_st:202291_s_at:195765-HuGene_st:3486- HuGene_st:829319-HuGene_st:731815- HuGene_st:829950-HuGene_st:601468- HuGene_st:366689-HuGene_st:460503- HuGene_st:712045-HuGene_st:545937- HuGene_st:148839-HuGene_st:704906- HuGene_st:612318-HuGene_st:708651- HuGene_st:722064-HuGene_st:846497- HuGene_st:1084237-HuGene_st:854168-HuGene_st PDE9A 779446-HuGene_st:768516-HuGene_st:609563- 6.56E−12 2.145 3.91 85.8   78-91.5 HuGene_st:387613-HuGene_st:594122- HuGene_st:774367-HuGene_st:221476- HuGene_st:140410-HuGene_st:812534- HuGene_st:581440-HuGene_st:205593_s_at:142832- HuGene_st:767027-HuGene_st:464973- HuGene_st:97182-HuGene_st:128487- HuGene_st:206471-HuGene_st:878522- HuGene_st:237139_at:988884-HuGene_st:237283_at LRRC19 177641-HuGene_st:1070020-HuGene_st:1055140- 6.75E−12 2.0763 4.51 85 77.1-91   HuGene_st:525999-HuGene_st:937256- HuGene_st:620791-HuGene_st:891251- HuGene_st:707559-HuGene_st:892056- HuGene_st:764919-HuGene_st:382143- HuGene_st:52584-HuGene_st:920414- HuGene_st:1028155-HuGene_st:755055- HuGene_st:678651-HuGene_st:1080156- HuGene_st:530282-HuGene_st:523877- HuGene_st:335198-HuGene_st:787709- HuGene_st:153175-HuGene_st:220376_at HSD11B2 78582-HuGene_st:653519-HuGene_st:630341- 6.97E−12 2.0895 2.53 85.2 77.3-91.1 HuGene_st:919091-HuGene_st:132633- HuGene_st:907106-HuGene_st:621993- HuGene_st:1089280-HuGene_st:34729- HuGene_st:342165-HuGene_st:887157- HuGene_st:323862-HuGene_st:870050- HuGene_st:204130_at:635792-HuGene_st:606173- HuGene_st:867938-HuGene_st:113467- HuGene_st:806665-HuGene_st GNG2 1555766_a_at:224965_at:1011730-HuGene_st:77527- 7.25E−12 2.1437 1.91 85.8   78-91.5 HuGene_st:669616-HuGene_st:223943_s_at:938512- HuGene_st:450519-HuGene_st:1025129- HuGene_st:30927-HuGene_st:382458- HuGene_st:330996-HuGene_st:545415- HuGene_st:774093-HuGene_st:758152- HuGene_st:176111-HuGene_st:743969-HuGene_st GCNT3 230376_at:254999-HuGene_st:476622- 8.39E−12 2.0861 3.94 85.2 77.2-91   HuGene_st:219508_at:45261-HuGene_st:732602- HuGene_st:306264-HuGene_st:696871- HuGene_st:721027-HuGene_st:235453- HuGene_st:676136-HuGene_st:777254- HuGene_st:506598-HuGene_st:598423- HuGene_st:699538-HuGene_st:220940- HuGene_st:804174-HuGene_st:12527- HuGene_st:802770-HuGene_st:403287- HuGene_st:351721-HuGene_st:581784- HuGene_st:700724-HuGene_st:398939-HuGene_st UGT1A6 116025-HuGene_st:6488-HuGene_st:881135- 1.32E−11 2.07 4.56 85   77-90.9 HuGene_st:230953_at:221304_at:221305_s_at:511516- HuGene_st:594963-HuGene_st:396121- HuGene_st:123777-HuGene_st:1016481- HuGene_st:204532_x_at:683377-HuGene_st:1055169- HuGene_st:1035103-HuGene_st:1088102- HuGene_st:207126_x_at:42874- HuGene_st:215125_s_at:206094_x_at:208596_s_at:97211- HuGene_st:1009861-HuGene_st:603368- HuGene_st:232654_s_at:625897-HuGene_st:998604- HuGene_st UGT1A8 116025-HuGene_st:6488-HuGene_st:881135- 1.32E−11 2.0687 4.56 85   77-90.9 HuGene_st:230953_at:221304_at:221305_s_at:511516- HuGene_st:594963-HuGene_st:396121- HuGene_st:123777-HuGene_st:1016481- HuGene_st:204532_x_at:683377-HuGene_st:1055169- HuGene_st:1035103-HuGene_st:1088102- HuGene_st:207126_x_at:42874- HuGene_st:215125_s_at:206094_x_at:208596_s_at:97211- HuGene_st:1009861-HuGene_st:603368- HuGene_st:232654_s_at:625897-HuGene_st:998604- HuGene_st UGT1A1 116025-HuGene_st:6488-HuGene_st:881135- 1.32E−11 2.0661 4.56 84.9   77-90.8 HuGene_st:230953_at:221304_at:221305_s_at:511516- HuGene_st:594963-HuGene_st:396121- HuGene_st:123777-HuGene_st:1016481- HuGene_st:204532_x_at:683377-HuGene_st:1055169- 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HuGene_st:241148_at:575416-HuGene_st CMBL 157156-HuGene_st:305010- 1.09E−05 1.3583 1.58 75.1 66.1-82.8 HuGene_st:227522_at:553921-HuGene_st:529224- HuGene_st:1032780-HuGene_st:204886- HuGene_st:623086-HuGene_st:451862- HuGene_st:537678-HuGene_st:918595- HuGene_st:178105-HuGene_st:417861- HuGene_st:230995_at:986212-HuGene_st:405624- HuGene_st:424469-HuGene_st:836099- HuGene_st:665079-HuGene_st:234981_x_at KCTD12 509699-HuGene_st:77199- 1.44E−05 1.3636 1.36 75.2 66.2-82.8 HuGene_st:212188_at:229632-HuGene_st:502611- HuGene_st:931430-HuGene_st:908582- HuGene_st:769157-HuGene_st:312044- HuGene_st:212192_at:43415-HuGene_st:412026- HuGene_st:247270-HuGene_st:770750- HuGene_st:827060-HuGene_st:714432-HuGene_st MRGPRF 717973-HuGene_st:226058-HuGene_st:541082- 1.52E−05 1.2986 2.99 74.2 65.1-82   HuGene_st:60861-HuGene_st:1024643- HuGene_st:354954-HuGene_st:1099895- HuGene_st:672489-HuGene_st:489062- HuGene_st:435421-HuGene_st:227727_at:99658- HuGene_st C20orf118 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65.1-81.9 HuGene_st:1093892-HuGene_st:675062- HuGene_st:788466-HuGene_st:826720- HuGene_st:997596-HuGene_st:1069591- HuGene_st:228232_s_at:223925-HuGene_st:637781- HuGene_st:265221-HuGene_st:652010- HuGene_st:265186-HuGene_st:343187- HuGene_st:1095607-HuGene_st HSPA1A 979726-HuGene_st:1069731-HuGene_st:50191- 2.16E−05 1.2699 2.41 73.7 64.6-81.5 HuGene_st:799087-HuGene_st:200799_at:539596- HuGene_st:150764-HuGene_st:200800_s_at:492579- HuGene_st AP1S2 230413_s_at:230264_s_at:99873-HuGene_st:57979- 3.39E−05 1.2572 1.92 73.5 64.3-81.3 HuGene_st:985324-HuGene_st:203300_x_at:84828- HuGene_st:910415-HuGene_st FKBP5 204560_at:224856_at:246403-HuGene_st:513199- 3.41E−05 1.2369 1.71 73.2 64-81 HuGene_st:69253-HuGene_st:642461- HuGene_st:467598-HuGene_st:1038165- HuGene_st:512075-HuGene_st:224840_at:797941- HuGene_st:633285-HuGene_st:511644- HuGene_st:469540-HuGene_st:209829- HuGene_st:800516-HuGene_st:247764- HuGene_st:468711-HuGene_st:112353- HuGene_st:746630-HuGene_st:337035- HuGene_st:1014328-HuGene_st:292916-HuGene_st KCNMB1 17348-HuGene_st:414025-HuGene_st:792493- 3.74E−05 1.2189 2.66 72.9 63.7-80.8 HuGene_st:131717-HuGene_st:569127- HuGene_st:17962-HuGene_st:504462- HuGene_st:758432-HuGene_st:209948_at:772102- HuGene_st:518039-HuGene_st VIM 564251-HuGene_st:201426_s_at:234475- 4.15E−05 1.2225 1.86 72.9 63.7-80.9 HuGene_st:319318-HuGene_st:339807- HuGene_st:527110-HuGene_st:994975- HuGene_st:837477-HuGene_st:302722- HuGene_st:516025-HuGene_st:1079757- HuGene_st:398387-HuGene_st:155888- HuGene_st:139661-HuGene_st:192324- HuGene_st:1093618-HuGene_st:364983- HuGene_st:436158-HuGene_st:410777- HuGene_st:1555938_x_at SORBS2 238751_at:805920-HuGene_st 4.23E−05 1.3007 2.1 74.2 65.1-82   C6orf204 486932-HuGene_st:573436-HuGene_st:400510- 4.90E−05 1.2042 2.07 72.6 63.5-80.6 HuGene_st:228202_at:123307-HuGene_st:181714- HuGene_st:206020-HuGene_st:949623- HuGene_st:814579-HuGene_st:515524- HuGene_st:514175-HuGene_st FAM55D 633727-HuGene_st:966568-HuGene_st:625133- 5.67E−05 1.1792 3.48 72.2 62.9-80.2 HuGene_st:858568-HuGene_st:220645_at:201856- HuGene_st:1013940-HuGene_st:316604- HuGene_st:450702-HuGene_st:1028406- HuGene_st:1090862-HuGene_st:741930- HuGene_st:981211-HuGene_st:970069- HuGene_st:259706-HuGene_st:291282- HuGene_st:56493-HuGene_st:888970- HuGene_st:821065-HuGene_st:53354- HuGene_st:752570-HuGene_st:539086- HuGene_st:204142-HuGene_st TIMP2 1087828-HuGene_st:231579_s_at:436546- 6.40E−05 1.2298 1.82 73.1 63.8-80.9 HuGene_st:799495-HuGene_st:563754- HuGene_st:914626-HuGene_st:526357- HuGene_st:203167_at:760416-HuGene_st:651774- HuGene_st:965142-HuGene_st:224540- HuGene_st:690107-HuGene_st:224560_at:319958- HuGene_st:437652-HuGene_st:43390- HuGene_st:727465-HuGene_st:310783- HuGene_st:750028-HuGene_st:957648- HuGene_st:106688-HuGene_st:289430- HuGene_st:740790-HuGene_st ELOVL5 NA 8.15E−05 1.1814 2.05 72.3   63-80.3 ACTA2 215787_at:743686-HuGene_st:200974_at:1070983- 1.00E−04 1.2318 1.81 73.1 63.9-80.9 HuGene_st:120087-HuGene_st:980364- 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HuGene_st:305131-HuGene_st:715557- HuGene_st:373579-HuGene_st:177871- HuGene_st:106318-HuGene_st:662795- HuGene_st:38090-HuGene_st CFL2 545956-HuGene_st:833414-HuGene_st:214239- 0.0009 1.0592 1.75 70.2 60.8-78.4 HuGene_st:192253-HuGene_st:224663_s_at:694174- HuGene_st:233496_s_at:992798-HuGene_st:328584- HuGene_st:950857-HuGene_st:612593- HuGene_st:95686-HuGene_st:177218- HuGene_st:451953-HuGene_st:800232- HuGene_st:575557-HuGene_st:794701-HuGene_st RBMS1 375424-HuGene_st:87825-HuGene_st:1046943- 0.0009 1.1417 1.55 71.6 62.3-79.7 HuGene_st:209868_s_at:207266_x_at:225269_s_at:238185_at SELENBP1 914892-HuGene_st:582091-HuGene_st:643114- 0.0009 1.0563 1.7 70.1 60.7-78.4 HuGene_st:532506-HuGene_st:823159- HuGene_st:171447-HuGene_st:189960- HuGene_st:75763-HuGene_st:834358- HuGene_st:245623- HuGene_st:214433_s_at:233267_at:564186- HuGene_st:637748-HuGene_st:200643- HuGene_st:781415-HuGene_st:208204- HuGene_st:730504-HuGene_st:1008117- HuGene_st:801694-HuGene_st:433986- HuGene_st:183676-HuGene_st:634656- HuGene_st:1087258-HuGene_st ENAM 212592_at 0.0011 1.0044 2.58 69.2 59.9-77.5 MT1F 987574-HuGene_st:213629_x_at:171840- 0.0012 0.9654 2.2 68.5 59.1-76.9 HuGene_st:217165_x_at:867979-HuGene_st:354284- HuGene_st:424055-HuGene_st:998184- HuGene_st:616693-HuGene_st:459005- HuGene_st:221141-HuGene_st:338518- HuGene_st:951452-HuGene_st:915306- HuGene_st:506126-HuGene_st:845635- HuGene_st:1048483-HuGene_st:1094672- HuGene_st:576368-HuGene_st:414800-HuGene_st CD163 620892-HuGene_st:215049_x_at:32161- 0.0013 1.0234 1.9 69.6 60.2-77.9 HuGene_st:867013-HuGene_st:899841- HuGene_st:662901-HuGene_st:97726- HuGene_st:180883-HuGene_st:706228- HuGene_st:849505-HuGene_st:217692- HuGene_st:566183-HuGene_st:154492- HuGene_st:737668-HuGene_st:203645_s_at:948100- HuGene_st:900552-HuGene_st:288236:HuGene_st GUCY1A3 560981-HuGene_st:1088572-HuGene_st:692186- 0.0015 1.0136 2.69 69.4   60-77.7 HuGene_st:648114-HuGene_st:783434- HuGene_st:221942_s_at:1026405-HuGene_st:256104- HuGene_st:965063-HuGene_st:889044- HuGene_st:752296-HuGene_st:239580_at:185668- HuGene_st:120195-HuGene_st:324658- HuGene_st:229530_at TNFRSF17 1062688-HuGene_st:38682-HuGene_st:558270- 0.0015 1.0199 2.08 69.5 60.1-77.7 HuGene_st:631025-HuGene_st:24518- HuGene_st:240754-HuGene_st:193693- HuGene_st:255074-HuGene_st:493368- HuGene_st:191710-HuGene_st:610232- HuGene_st:544680-HuGene_st:205576- HuGene_st:738267-HuGene_st:746498-HuGene_st CAV1 793412-HuGene_st:1007317- 0.0016 1.0215 1.58 69.5 60.1-77.8 HuGene_st:212097_at:203065_s_at:812832- HuGene_st:505037-HuGene_st:819580- HuGene_st:348883-HuGene_st:659416- HuGene_st:698493-HuGene_st:861877- HuGene_st:518081-HuGene_st:35773-HuGene_st CKB 718720-HuGene_st:769422-HuGene_st:581051- 0.0019 0.9741 2.27 68.7 59.2-77   HuGene_st:549987-HuGene_st:24890- HuGene_st:1041238-HuGene_st:16603- HuGene_st:480007-HuGene_st:435665- HuGene_st:25470-HuGene_st:40899- HuGene_st:896708-HuGene_st:373774- HuGene_st:963331-HuGene_st:23457- HuGene_st:766369-HuGene_st:200884_at:405417- HuGene_st:888623-HuGene_st:396007-HuGene_st WWTR1 202132_at:249804-HuGene_st:735408- 0.002 0.9904 1.48 69 59.6-77.3 HuGene_st:925151-HuGene_st:213564- HuGene_st:561456-HuGene_st:125734- HuGene_st:367743-HuGene_st:153369- HuGene_st:628871-HuGene_st:942493- HuGene_st:949013-HuGene_st:202134_s_at:426662- HuGene_st:586249-HuGene_st:228629_s_at:506281- HuGene_st HMGCS2 729816-HuGene_st:658722-HuGene_st:253113- 0.0022 0.8767 2.67 66.9 57.5-75.5 HuGene_st:900260-HuGene_st:253100- HuGene_st:283650-HuGene_st:624250- HuGene_st:439478-HuGene_st:407398- HuGene_st:171889-HuGene_st:397691- HuGene_st:448587-HuGene_st:593619- HuGene_st:371076-HuGene_st:228587- HuGene_st:888308-HuGene_st:538023- HuGene_st:204607_at:43162-HuGene_st:865416- HuGene_st:619083-HuGene_st:789982- HuGene_st:616916-HuGene_st MAFB 876871-HuGene_st:600037-HuGene_st:177002- 0.0034 0.9563 1.66 68.4   59-76.8 HuGene_st:3125-HuGene_st:1057503- HuGene_st:274807-HuGene_st STOM 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HuGene_st:511913-HuGene_st:1099818- HuGene_st:33219-HuGene_st:663513-HuGene_st SI 9605-HuGene_st:514814-HuGene_st:809314- 0.0054 0.9299 2.79 67.9 58.5-76.4 HuGene_st:576613-HuGene_st:45502- HuGene_st:369676-HuGene_st:438636- HuGene_st:267204-HuGene_st:326716- HuGene_st:897825-HuGene_st:377666- HuGene_st:519273-HuGene_st:325741- HuGene_st:245381-HuGene_st:108368- HuGene_st:464198-HuGene_st:679193- HuGene_st:168180-HuGene_st LOC285382 242447_at 0.0058 0.7422 1.26 64.5   55-73.2 HLA- 971813-HuGene_st 0.0063 1.0668 1.51 70.3 60.9-78.6 DRB1 ANTXR1 241549_at:232956_at 0.0071 0.9507 1.29 68.3 58.8-76.7 FAM46C 197110-HuGene_st:220306_at:110466- 0.0085 0.9172 1.38 67.7 58.2-76.1 HuGene_st:988119-HuGene_st:1098424- HuGene_st:560529-HuGene_st:387944- HuGene_st:38645-HuGene_st:221689- HuGene_st:322082-HuGene_st TIMP3 767021-HuGene_st:201150_s_at:201148_s_at:228752- 0.0091 0.9064 1.81 67.5 58-76 HuGene_st:241221-HuGene_st:201147_s_at:125730- HuGene_st LOC283666 235567_at:236266_at:1562682_at:240951_at 0.0099 0.7796 1.22 65.2 55.6-73.8 GREM1 569365-HuGene_st:407017- 0.0106 0.8579 3.03 66.6   57-75.1 HuGene_st:218468_s_at:292333-HuGene_st:330742- HuGene_st:546941-HuGene_st:556201- HuGene_st:484435-HuGene_st:326978- HuGene_st:144073-HuGene_st:411208- HuGene_st:1081939-HuGene_st:345681- HuGene_st:2445-HuGene_st:864620-HuGene_st FCGBP 22847-HuGene_st:203240_at:338164- 0.0121 0.7889 1.99 65.3 55.7-74   HuGene_st:516715-HuGene_st:88809- HuGene_st:948682-HuGene_st:311904- HuGene_st:997435-HuGene_st:841000- HuGene_st:508230-HuGene_st:226428- HuGene_st:634071-HuGene_st:948120- HuGene_st:1079875-HuGene_st:71797- HuGene_st:781083-HuGene_st:426005- HuGene_st:27264-HuGene_st:16108- HuGene_st:63672-HuGene_st:1085208- HuGene_st:708701-HuGene_st HSPA2 831351-HuGene_st:270747-HuGene_st:720913- 0.0123 0.8908 1.43 67.2 57.7-75.7 HuGene_st:660812-HuGene_st:939000- HuGene_st:920196-HuGene_st COL6A1 138366-HuGene_st:528191-HuGene_st:884210- 0.0126 0.8452 1.45 66.4 56.9-75   HuGene_st:57954-HuGene_st:737256- HuGene_st:858575- HuGene_st:212937_s_at:214200_s_at:190064- HuGene_st:216904_at SELM NA 0.0133 0.8596 1.32 66.6 57.2-75.2 FLNA 296693-HuGene_st:685285-HuGene_st:704065- 0.0157 0.7967 1.59 65.5 55.9-74.1 HuGene_st:445061-HuGene_st:11735- HuGene_st:1066792- HuGene_st:214752_x_at:213746_s_at:871038- HuGene_st:396236-HuGene_st:200859_x_at:786282- HuGene_st:136680-HuGene_st:50466- HuGene_st:955232-HuGene_st:588605- HuGene_st:40025-HuGene_st:1002306- HuGene_st:833338-HuGene_st:86435- HuGene_st:172457-HuGene_st COX7A1 386303-HuGene_st:354428-HuGene_st 0.0161 0.8613 1.32 66.7 57.2-75.3 EMP3 736604-HuGene_st:155271-HuGene_st:584704- 0.0164 0.8053 1.41 65.6 56.1-74.2 HuGene_st ITLN1 389198-HuGene_st:496499-HuGene_st:48547- 0.021 0.7137 2.54 63.9 54.4-72.7 HuGene_st:552029-HuGene_st:126777- HuGene_st:223597_at:281671-HuGene_st:45052- HuGene_st:573120:HuGene_st:137624- HuGene_st:948945-HuGene_st:527196- HuGene_st:358648-HuGene_st:45640- HuGene_st:512550-HuGene_st:839317- HuGene_st:634036-HuGene_st:101083- HuGene_st:857541-HuGene_st:404069-HuGene_st C10orf99 227735_s_at:563767-HuGene_st:963471- 0.0218 0.724 1.76 64.1 54.7-72.9 HuGene_st:965947-HuGene_st:1081062- HuGene_st:354432-HuGene_st:602661- HuGene_st:227736_at:1009594-HuGene_st:969063- HuGene_st:77052-HuGene_st:483367- HuGene_st:50662-HuGene_st:738457- HuGene_st:69019-HuGene_st:215415- HuGene_st:1003926-HuGene_st:676577- HuGene_st:676855-HuGene_st:225297- HuGene_st:560897-HuGene_st:886384- HuGene_st:303754-HuGene_st CSRP1 453033-HuGene_st:673637-HuGene_st:607761- 0.023 0.7234 1.39 64.1 54.6-72.9 HuGene_st:582630-HuGene_st:654799- HuGene_st:258474-HuGene_st:200621_at:1028504- HuGene_st:802909-HuGene_st:339914- HuGene_st:533385-HuGene_st:256461- HuGene_st:1043113-HuGene_st:72101- HuGene_st:105671-HuGene_st:339691- HuGene_st:108781-HuGene_st:133369- HuGene_st:614016-HuGene_st:629648- HuGene_st:81550-HuGene_st PTGER4 450915-HuGene_st:1067155-HuGene_st:812085- 0.0237 0.8101 1.41 65.7 56.2-74.4 HuGene_st:1943-HuGene_st:109314- HuGene_st:204897_at:252442-HuGene_st:800125- HuGene_st:965220:HuGene_st:446764- HuGene_st:204896_s_at:23686-HuGene_st:548266- HuGene_st:392964:HuGene_st:986807- HuGene_st:619166-HuGene_st TPM2 828216-HuGene_st:373854-HuGene_st:981165- 0.026 0.7539 1.53 64.7 55.2-73.4 HuGene_st:191586-HuGene_st:445912- HuGene_st:446500-HuGene_st:922931- HuGene_st:336603-HuGene_st:272114- HuGene_st:375166-HuGene_st:8388- HuGene_st:204083_s_at:544548-HuGene_st:945443- HuGene_st:628440-HuGene_st:763118- HuGene_st:538951-HuGene_st PIGR 748831-HuGene_st:226147_s_at:166398- 0.0278 0.7282 1.59 64.2 54.7-73   HuGene_st:593192-HuGene_st:204213_at:557727- HuGene_st:229659_s_at:242106-HuGene_st:146237- HuGene_st:883137-HuGene_st:691362- HuGene_st:201991-HuGene_st:1045753- HuGene_st:589879-HuGene_st:1017162- HuGene_st:325979-HuGene_st:105903- HuGene_st:1063932-HuGene_st:207526- HuGene_st:566905-HuGene_st HLA-C 754900-HuGene_st 0.0279 0.9253 1.24 67.8 58.3-76.2 PRNP 178399-HuGene_st:201300_s_at:386578- 0.0288 0.798 1.24 65.5   56-74.2 HuGene_st:783439-HuGene_st CCL11 495934-HuGene_st 0.0361 0.8547 1.32 66.5 57.1-75   C1QC 137801-HuGene_st:851445-HuGene_st 0.0391 0.7457 1.36 64.5 54.9-73.3 CYR61 736150-HuGene_st:385534-HuGene_st:48239- 0.0425 0.7875 1.47 65.3 55.7-73.9 HuGene_st:242630-HuGene_st SERPING1 NA 0.0503 0.7659 1.44 64.9 55.4-73.6 TYROBP NA 0.053 0.8176 1.17 65.9 56.3-74.5 GJA1 NA 0.0561 0.7839 1.76 65.2 55.6-73.9 PTRF NA 0.0624 0.7354 1.5 64.3 54.8-73.1 CLCA1 NA 0.0681 0.7855 1.61 65.3 55.8-74   SPARC NA 0.0684 0.6702 1.45 63.1 53.5-71.9 COL4A2 NA 0.0738 0.7081 1.32 63.8 54.3-72.5 RAB31 NA 0.1041 0.8159 1.14 65.8 56.3-74.4 NID1 NA 0.105 0.7428 1.33 64.5 54.9-73.2 FN1 NA 0.1121 0.5769 1.73 61.3 51.7-70.2 MSN NA 0.1499 0.7215 1.15 64.1 54.6-72.9 MMP2 NA 0.1755 0.6219 1.24 62.2 52.5-71.2 COL1A2 NA 0.1891 0.65 1.9 62.7 53.2-71.6 FOSB NA 0.2076 0.6389 2.17 62.5 52.9-71.4 HBB NA 0.2357 0.6434 1.28 62.6   53-71.5 POU2AF1 NA 0.2389 0.6564 1.18 62.9 53.3-71.7 COL3A1 NA 0.2551 0.5538 1.35 60.9 51.3-69.9 SMOC2 NA 0.2701 0.6533 1.34 62.8 53.2-71.7 MUC2 NA 0.2802 0.8523 1.22 66.5 57-75 Sep-06 NA 0.3109 0.5713 1.21 61.2 51.7-70.2 LUM NA 0.3157 0.5442 1.54 60.7 51.1-69.7 C1QB NA 0.3668 0.5005 1.24 59.9 50.4-69   TGFB1I1 NA 0.4093 0.4951 1.35 59.8 50.1-68.8 ALDH1A1 NA 0.4232 0.354 1.4 57 47.4-66.2 LRIG1 NA 0.4614 0.5998 1.26 61.8 52.2-70.7 C8orf4 NA 0.475 0.483 1.44 59.5 49.9-68.5 EGR1 NA 0.4851 0.5374 1.38 60.6   51-69.6 LOC652745 NA 0.4864 0.1722 1.09 53.4 43.8-62.8 IGKV1D- NA 0.5177 0.1597 1.1 53.2 43.7-62.5 13 COL15A1 NA 0.6601 0.54 1.22 60.6   51-69.6 IGFBP5 NA 0.7663 0.3504 1.25 57 47.4-66.3 LGALS1 NA 0.8555 0.4626 1.16 59.1 49.5-68.3 COL6A3 NA 0.8739 0.4412 1.2 58.7 49.1-67.9 HLA- NA 0.9084 0.5417 1.28 60.7 51.1-69.6 DQA1 HLA-DRA NA 0.9084 0.5391 1.28 60.6   51-69.6 ST6GALNAC1 NA 0.9452 0.2594 1.15 55.2 45.6-64.5 HLA-DPA1 NA 0.9664 0.4166 1.39 58.3 48.7-67.4 IGLV1-44 NA 0.9777 0.2865 1.07 55.7 46.1-64.9 TNC NA 0.9905 0.3682 1.09 57.3 47.7-66.5 HBA1 NA 0.9979 0.47 1.21 59.3 49.6-68.4 HBA2 NA 0.9979 0.4705 1.21 59.3 49.6-68.3

indicates data missing or illegible when filed

TABLE 3 TargetPS Symbol Signif. FDR D.val5 FC Sens-Spec CI (95) 230788_at SPTLC3: GCNT2 2.1587E−27 3.9562 13.36 97.6 94.2-99.2 228706_s_at CLDN23 4.2694E−20 3.0727 3.47 93.8 88.3-97.1 231120_x_at PKIB 5.9397E−20 3.1191 3.28 94.1 88.6-97.3 224412_s_at TRPM6 2.2514E−19 3.0115 7.5 93.4 87.7-96.8 220037_s_at XLKD1 3.5991E−19 2.9405 7.44 92.9  87-96.5 209613_s_at ADH1B: ADH1A 4.6957E−19 3.0158 4.67 93.4 87.7-96.9 204719_at ABCA8 1.2559E−18 2.9171 6.82 92.8 86.8-96.5 231773_at ANGPTL1 1.4172E−17 2.7946 4.64 91.9 85.6-95.9 225575_at LIFR 2.4532E−17 2.7797 6.36 91.8 85.5-95.8 220812_s_at HHLA2 3.4739E−17 2.6718 10.02 90.9 84.4-95.2 211549_s_at HPGD 3.6502E−17 2.8451 3.21 92.3 86.1-96.1 202920_at ANK2 2.5934E−16 2.6488 6.76 90.7 84.2-95.1 231925_at P2RY1 1.4091E−15 2.5329 3.6 89.7 82.8-94.4 207080_s_at PYY 3.5022E−15 2.4783 11.71 89.2 82.2-94  228885_at RPL24: LOC731365 1.2312E−14 2.5575 1.63 90 83.1-94.6 228766_at CD36 6.2677E−14 2.4687 1.65 89.1 82.1-94  204931_at TCF21 2.5147E−13 2.3036 2.34 87.5 80.1-92.8 205433_at BCHE 3.1756E−13 2.2538 6.21 87 79.5-92.5 207980_s_at CITED2 5.2905E−13 2.2709 1.64 87.2 79.7-92.6 209170_s_at GPM6B 4.0429E−12 2.1588 3.59 86 78.1-91.6 220376_at LRRC19 6.7548E−12 2.0763 4.51 85 77.1-90.9 228504_at No Symbol 9.1926E−12 2.152 1.61 85.9 78.2-91.6 228854_at No Symbol 9.1926E−12 2.1538 1.61 85.9 78.2-91.6 235146_at No Symbol 9.1926E−12 2.1537 1.61 85.9 78.2-91.6 221305_s_at UGT1A10: UGT1A7: UGT1A8: 1.0319E−11 2.0677 4.56 84.9 77.1-90.9 UGT1A1: UGT1A9: UGT1A6: UGT1A5: UGT1A3: UGT1A4 203881_s_at DMD 5.0063E−11 2.0137 4.74 84.3 76.3-90.4 206637_at P2RY14 1.3104E−10 1.9836 2 83.9 75.8-90.1 214598_at CLDN8 2.9225E−10 1.8624 12.96 82.4 74.1-88.9 227529_s_at AKAP12 7.4077E−09 1.7434 2.83 80.8 72.3-87.5 219948_x_at LOC642329: UGT2A3 8.638E−09 1.741 4.89 80.8 72.3-87.6 222717_at SDPR 9.6207E−08 1.5993 2.21 78.8 70.1-85.9 229831_at CNTN3 1.1953E−07 1.6145 3.93 79 70.3-86.1 204940_at PLN 4.1416E−07 1.5439 2.01 78 69.2-85.2 227827_at SORBS2 4.2323E−05 1.3016 2.1 74.2 65.1-81.9 238751_at SORBS2 4.2323E−05 1.3015 2.1 74.2 65.1-82  209209_s_at PLEKHC1 0.0007 1.0304 1.82 69.7 60.3-78  206664_at SI 0.0054 0.9301 2.79 67.9 58.4-76.3

TABLE 4 Gene Symbol ValidPS_DOWN Signif. FDR D.val5 FC Sens-Spec CI (95) ANK2 314086-HuGene_st: 282874-HuGene_st: 382431- 2.59E−16 2.6515 6.76 90.8 84.1-95.1 HuGene_st: 229308-HuGene_st: 779600-HuGene_st: 297624- HuGene_st: 385943-HuGene_st: 730140-HuGene_st: 442277- HuGene_st: 699309-HuGene_st: 182816- HuGene_st: 202921_s_at: 799860-HuGene_st: 868462- HuGene_st: 634421-HuGene_st: 571536-HuGene_st: 1050903- HuGene_st: 649509-HuGene_st: 239935-HuGene_st: 202920_at DMD 945600-HuGene_st: 12596-HuGene_st: 434657- 5.01E−11 2.0162 4.74 84.3 76.3-90.4 HuGene_st: 676962-HuGene_st: 1020969-HuGene_st: 170680- HuGene_st: 855670-HuGene_st: 909848-HuGene_st: 134644- HuGene_st: 887814-HuGene_st: 649184-HuGene_st: 110990- HuGene_st: 914217-HuGene_st: 961622-HuGene_st: 514011- HuGene_st: 842792-HuGene_st: 445483- HuGene_st: 208086_s_at: 987362-HuGene_st: 997308- HuGene_st ABCA8 57305-HuGene_st: 111752-HuGene_st: 61357- 1.26E−18 2.9182 6.82 92.8 86.8-96.5 HuGene_st: 123451-HuGene_st: 740746-HuGene_st: 512280- HuGene_st: 389185-HuGene_st: 427721-HuGene_st: 346028- HuGene_st: 224566-HuGene_st: 149653-HuGene_st: 680699- HuGene_st: 76772-HuGene_st: 742091-HuGene_st: 423333- HuGene_st: 559944-HuGene_st: 341399- HuGene_st: 1565780_at: 863400-HuGene_st: 921748- HuGene_st: 623719-HuGene_st: 204719_at: 123143- HuGene_st: 1077391-HuGene_st TCF21 804657-HuGene_st: 106365-HuGene_st: 710514- 2.51E−13 2.3037 2.34 87.5 80.1-92.9 HuGene_st: 299556-HuGene_st: 608149-HuGene_st: 242233- HuGene_st: 655881-HuGene_st: 356773-HuGene_st: 788445- HuGene_st: 709897-HuGene_st: 605488-HuGene_st: 652466- HuGene_st: 204931_at: 830709-HuGene_st: 273418- HuGene_st: 1004754-HuGene_st: 990861-HuGene_st: 238739- HuGene_st: 836241-HuGene_st: 110045- HuGene_st: 229529_at: 1001969-HuGene_st PLN 204938_s_at: 418214-HuGene_st: 769837-HuGene_st: 603329- 4.14E−07 1.5399 2.01 77.9 69.2-85.2 HuGene_st: 1048096-HuGene_st: 944510-HuGene_st: 430402- HuGene_st: 86633-HuGene_st: 795093-HuGene_st: 377757- HuGene_st: 770145-HuGene_st: 920628-HuGene_st: 594048- HuGene_st: 800583-HuGene_st: 204939_s_at: 556723- HuGene_st: 818339-HuGene_st: 175524-HuGene_st: 498924- HuGene_st: 204940 at BCHE 228090-HuGene_st: 752051-HuGene_st: 800167- 3.18E−13 2.2544 6.21 87 79.4-92.5 HuGene_st: 221362-HuGene_st: 155900-HuGene_st: 717363- HuGene_st: 536584-HuGene_st: 146780-HuGene_st: 302487- HuGene_st: 508472-HuGene_st: 516293-HuGene_st: 968992- HuGene_st: 666625-HuGene_st: 923158-HuGene_st P2RY14 528057-HuGene_st: 780310-HuGene_st: 235178- 1.31E−10 1.9805 2 83.9 75.9-90  HuGene_st: 352954-HuGene_st: 699489-HuGene_st: 38001- HuGene_st: 637791-HuGene_st: 25606-HuGene_st: 40647- HuGene_st: 896487-HuGene_st: 672149-HuGene_st: 863820- HuGene_st: 352427-HuGene_st: 632821-HuGene_st: 116148- HuGene_st: 561792-HuGene_st: 840910-HuGene_st: 296420- HuGene_st: 974643-HuGene_st: 206637_at PYY 656845-HuGene_st: 816022-HuGene_st: 633572- 3.50E−15 2.4828 11.71 89.3 82.2-94  HuGene_st: 20355-HuGene_st: 240779-HuGene_st: 638358- HuGene_st: 879780- HuGene_st: 207080_s_at: 211253_x_at: 368591-HuGene_st CITED2 125201-HuGene_st: 410723-HuGene_st: 463405- 5.29E−13 2.269 1.64 87.2 79.7-92.6 HuGene_st: 401168-HuGene_st: 1012057-HuGene_st: 235057- HuGene_st: 361772-HuGene_st: 207980_s_at: 1091907- HuGene_st: 985355-HuGene_st: 175990- HuGene_st: 227287_at: 48433-HuGene_st: 209357_at: 477746- HuGene_st: 243264-HuGene_st: 904401-HuGene_st: 328536- HuGene_st: 1095110-HuGene_st: 89784-HuGene_st: 206734- HuGene_st: 927615-HuGene_st GPM6B 599862-HuGene_st: 754598-HuGene_st: 503642- 4.04E−12 2.1547 3.59 85.9 78.2-91.7 HuGene_st: 224935-HuGene_st: 754449-HuGene_st: 577489- HuGene_st: 1073242-HuGene_st: 560873-HuGene_st: 1003662- HuGene_st: 430217-HuGene_st: 903323-HuGene_st: 231962- HuGene_st: 244945-HuGene_st: 562460-HuGene_st: 583561- HuGene_st: 209168_at PLEKHC1 831786-HuGene_st: 88016-HuGene_st: 1087035- 7.00E−04 1.0307 1.82 69.7 60.4-78  HuGene_st: 530331-HuGene_st: 209209_s_at: 184398- HuGene_st: 904923-HuGene_st: 193550-HuGene_st: 468805- HuGene_st: 104495-HuGene_st: 604317-HuGene_st: 501652- HuGene_st: 118096-HuGene_st: 321532-HuGene_st: 675257- HuGene_st: 79496-HuGene_st: 590867-HuGene_st: 147248- HuGene_st: 627402-HuGene_st: 377514-HuGene_st ADH1B 1078343-HuGene_st: 512808-HuGene_st: 614446- 4.70E−19 3.0174 4.67 93.4 87.7-96.9 HuGene_st: 910188-HuGene_st: 422504-HuGene_st: 731361- HuGene_st: 209612_s_at: 258079-HuGene_st: 568239- HuGene_st: 879930-HuGene_st: 420417-HuGene_st: 1025048- HuGene_st: 908335-HuGene_st: 654633-HuGene_st: 947292- HuGene_st: 1087125-HuGene_st: 1004870- HuGene_st: 209613_s_at: 579636-HuGene_st: 681018- HuGene_st: 822774-HuGene_st XLKD1 520080-HuGene_st: 1091117-HuGene_st: 943125- 3.60E−19 2.9461 7.44 93 87.1-96.6 HuGene_st: 444068-HuGene_st: 648558-HuGene_st: 346991- HuGene_st: 1006205-HuGene_st: 373107-HuGene_st: 682535- HuGene_st: 1083245-HuGene_st: 863143-HuGene_st: 820120- HuGene_st: 1044561-HuGene_st: 220037_s_at: 541228- HuGene_st: 220256-HuGene_st: 289122- HuGene_st: 219059_s_at: 246683-HuGene_st: 775976- HuGene_st: 207399-HuGene_st: 1052557-HuGene_st: 92121- HuGene_st LRRC19 177641-HuGene_st: 1070020-HuGene_st: 1055140- 6.75E−12 2.0779 4.51 85.1 77.1-91  HuGene_st: 525999-HuGene_st: 937256-HuGene_st: 620791- HuGene_st: 891251-HuGene_st: 707559-HuGene_st: 892056- HuGene_st: 764919-HuGene_st: 382143-HuGene_st: 52584- HuGene_st: 920414-HuGene_st: 1028155-HuGene_st: 755055- HuGene_st: 678651-HuGene_st: 1080156-HuGene_st: 530282- HuGene_st: 523877-HuGene_st: 335198-HuGene_st: 787709- HuGene_st: 153175-HuGene_st: 220376_at SDPR 878908-HuGene_st: 781527-HuGene_st: 331976- 9.62E−08 1.6036 2.21 78.9  70-85.9 HuGene_st: 238150-HuGene_st: 306039-HuGene_st: 535903- HuGene_st: 302361-HuGene_st: 1005813-HuGene_st: 71118- HuGene_st: 992629-HuGene_st: 218711_s_at: 293110- HuGene_st: 779040-HuGene_st: 222717_at: 970479- HuGene_st: 581654-HuGene_st TRPM6 767074-HuGene_st: 695352-HuGene_st: 411125- 2.25E−19 3.0111 7.5 93.4 87.7-96.8 HuGene_st: 221102_s_at: 234864_s_at: 240389_at: 358229- HuGene_st: 755964-HuGene_st: 840301-HuGene_st: 959234- HuGene_st: 782639-HuGene_st: 833079-HuGene_st: 1066034- HuGene_st: 678013-HuGene_st: 249083-HuGene_st: 143934- HuGene_st: 159130-HuGene_st: 486486-HuGene_st: 185057- HuGene_st: 878793-HuGene_st: 133981- HuGene_st: 224412_s_at: 202194-HuGene_st LIFR 275506-HuGene_st: 323055-HuGene_st: 444251- 2.45E−17 2.7814 6.36 91.8 85.5-95.8 HuGene_st: 1056178-HuGene_st: 398104-HuGene_st: 917434- HuGene_st: 1044918-HuGene_st: 167500-HuGene_st: 423760- HuGene_st: 837336-HuGene_st: 321505-HuGene_st: 918321- HuGene_st: 252278-HuGene_st: 884504-HuGene_st: 124845- HuGene_st: 499777-HuGene_st: 969722-HuGene_st: 709439- HuGene_st: 611505-HuGene_st: 227771_at: 287217- HuGene_st: 205876_at: 225571_at: 229185_at: 233367_at: 1093011-HuGene_st AKAP12 212419-HuGene_st: 231067_s_at: 379659- 7.41E−09 1.7456 2.83 80.9 72.4-87.6 HuGene_st: 1010338-HuGene_st: 1075094-HuGene_st: 42401- HuGene_st: 522584-HuGene_st: 480972-HuGene_st: 948623- HuGene_st: 701945-HuGene_st: 276784-HuGene_st: 64858- HuGene_st: 210517_s_at: 874382-HuGene_st: 909976- HuGene_st: 182037-HuGene_st: 417182-HuGene_st: 722881- HuGene_st CLDN23 403960-HuGene_st: 25144-HuGene_st: 947653- 4.27E−20 3.0748 3.47 93.8 88.2-97.1 HuGene_st: 228704_s_at: 228706_s_at: 320375- HuGene_st: 441629-HuGene_st: 367414-HuGene_st: 855269- HuGene_st: 228707_at: 788659-HuGene_st: 698816- HuGene_st: 95789-HuGene_st: 270197-HuGene_st: 472976- HuGene_st: 280539-HuGene_st: 1056334-HuGene_st: 516288- HuGene_st: 579963-HuGene_st CD36 392196-HuGene_st: 274514-HuGene_st: 477005- 6.27E−14 2.4696 1.65 89.2 82.1-94  HuGene_st: 691585-HuGene_st: 872909-HuGene_st: 543050- HuGene_st: 603343-HuGene_st: 514557-HuGene_st: 296850- HuGene_st: 945913-HuGene_st: 495755- HuGene_st: 206488_s_at: 1035854-HuGene_st: 887301- HuGene_st: 836370-HuGene_st: 209555_s_at: 939919- HuGene_st: 507440-HuGene_st: 151788-HuGene_st: 146280- HuGene_st: 360545-HuGene_st: 1051486- HuGene_st: 228766_at: 512885-HuGene_st RPL24 1559655_at: 1559656_a_at: 228885_at 1.23E−14 2.5568 1.63 89.9 83.1-94.6 GCNT2 935239-HuGene_st: 225205-HuGene_st: 1026280- 2.16E−27 3.9536 13.36 97.6 94.1-99.2 HuGene_st: 668101-HuGene_st: 1099985-HuGene_st: 698568- HuGene_st: 134540-HuGene_st: 697147-HuGene_st: 250092- HuGene_st: 611927-HuGene_st: 972833-HuGene_st: 168891- HuGene_st: 990860-HuGene_st: 109287-HuGene_st: 322116- HuGene_st: 231019-HuGene_st: 211020_at: 959570- HuGene_st: 858764-HuGene_st: 215593_at: 820195- HuGene_st: 239606_at: 41059-HuGene_st: 669940- HuGene_st: 215595_x_at: 230788_at PKIB 866170-HuGene_st: 1055812-HuGene_st: 264946- 5.94E−20 3.1204 3.28 94.1 88.6-97.3 HuGene_st: 684057-HuGene_st: 124791-HuGene_st: 134561- HuGene_st: 1026756-HuGene_st: 468593-HuGene_st: 1045852- HuGene_st: 939917-HuGene_st: 110205-HuGene_st: 660721- HuGene_st: 905229-HuGene_st: 223551_at: 610426-HuGene_st ANGPTL1 572942-HuGene_st: 891312-HuGene_st: 953040- 1.42E−17 2.7964 4.64 91.9 85.6-95.9 HuGene_st: 232844-HuGene_st: 145730-HuGene_st: 142205- HuGene_st: 227771-HuGene_st: 80584-HuGene_st: 982090- HuGene_st: 999640-HuGene_st: 672931-HuGene_st: 148578- HuGene_st: 224339_s_at: 1046706- HuGene_st: 239183_at: 155600-HuGene_st: 284674- HuGene_st: 231773_at: 818064-HuGene_st: 978991- HuGene_st: 728775-HuGene_st SI 9605-HuGene_st: 514814-HuGene_st: 809314- 5.40E−03 0.9299 2.79 67.9 58.4-76.4 HuGene_st: 576613-HuGene_st: 45502-HuGene_st: 369676- HuGene_st: 438636-HuGene_st: 267204-HuGene_st: 326716- HuGene_st: 897825-HuGene_st: 377666-HuGene_st: 519273- HuGene_st: 325741-HuGene_st: 245381-HuGene_st: 108368- HuGene_st: 464198-HuGene_st: 679193-HuGene_st: 168180- HuGene_st HPGD 291863-HuGene_st: 375608-HuGene_st: 793406- 3.65E−17 2.8462 3.21 92.3 86.2-96.1 HuGene_st: 436293-HuGene_st: 75568- HuGene_st: 211549_s_at: 684728-HuGene_st: 674596- HuGene_st: 527856-HuGene_st: 329920-HuGene_st: 748432- HuGene_st: 259392-HuGene_st: 769902-HuGene_st: 620673- HuGene_st: 450707-HuGene_st: 203913_s_at: 304752- HuGene_st: 447604-HuGene_st: 170968-HuGene_st: 852359- HuGene_st: 836377-HuGene_st: 242733_at: 243846- HuGene_st: 136281-HuGene_st: 203914_x_at: 1018006- 211548_s_at: 288252-HuGene_st CLDN8 HuGene_st: 190634-HuGene_st: 590280- 2.92E−10 1.8639 12.96 82.4 74.1-88.9 HuGene_st: 186468-HuGene_st: 954438-HuGene_st: 428391- HuGene_st: 480543-HuGene_st: 944337-HuGene_st: 179725- HuGene_st: 508584-HuGene_st: 1009114-HuGene_st: 948216- HuGene_st: 658285-HuGene_st: 1022600-HuGene_st: 737498- HuGene_st: 470015-HuGene_st: 103315-HuGene_st: 699348- HuGene_st: 89877-HuGene_st: 56937-HuGene_st: 862663- HuGene_st: 504945-HuGene_st: 214598_at UGT2A3 149647-HuGene_st: 860083-HuGene_st: 922544- 8.64E−09 1.7422 4.89 80.8 72.3-87.5 HuGene_st: 244206-HuGene_st: 503323-HuGene_st: 353576- HuGene_st: 603619-HuGene_st: 787458-HuGene_st: 219796- HuGene_st: 333564-HuGene_st: 257402-HuGene_st: 366699- HuGene_st: 461685-HuGene_st: 891681-HuGene_st: 644952- HuGene_st: 621618-HuGene_st: 737617-HuGene_st: 88682- HuGene_st: 529761-HuGene_st: 895203-HuGene_st: 658594- HuGene_st: 455115-HuGene_st HHLA2 371335-HuGene_st: 978721-HuGene_st: 1065567- 3.47E−17 2.6743 10.02 90.9 84.3-95.2 HuGene_st: 282548-HuGene_st: 240410-HuGene_st: 170899- HuGene_st: 947848-HuGene_st: 438234- HuGene_st: 220812_s_at: 927495-HuGene_st: 351364- HuGene_st: 234673_at: 993142-HuGene_st: 1009637- HuGene_st: 335000-HuGene_st: 285313-HuGene_st: 533646- HuGene_st: 234624_at: 458597-HuGene_st: 104838- HuGene_st: 26687-HuGene_st: 258409-HuGene_st: 493304- HuGene_st: 378019-HuGene_st: 576796-HuGene_st UGT1A8 116025-HuGene_st: 6488-HuGene_st: 881135- 1.32E−11 2.0703 4.56 85 77.1-90.9 HuGene_st: 230953_at: 221304_at: 221305_s_at: 511516- HuGene_st: 594963-HuGene_st: 396121-HuGene_st: 123777- HuGene_st: 1016481-HuGene_st: 204532_x_at: 683377- HuGene_st: 1055169-HuGene_st: 1035103- HuGene_st: 1088102-HuGene_st: 207126_x_at: 42874- HuGene_st: 215125_s_at: 206094_x_at: 208596_s_at: 97211- HuGene_st: 1009861-HuGene_st: 603368-HuGene_st: 232654_s_at: 625897-HuGene_st: 998604-HuGene_st CNTN3 267567-HuGene_st: 782053-HuGene_st: 550157- 1.20E−07 1.6155 3.93 79 70.3-86.1 HuGene_st: 541394-HuGene_st: 989173-HuGene_st: 15899- HuGene_st: 78622-HuGene_st: 339738-HuGene_st: 585282- HuGene_st: 661814-HuGene_st: 360715-HuGene_st: 695033- HuGene_st: 483058-HuGene_st: 555394-HuGene_st: 315011- HuGene_st: 905374-HuGene_st: 1067212-HuGene_st: 557263- HuGene_st: 233502_at: 811729-HuGene_st: 87414-HuGene_st P2RY1 628249-HuGene_st: 113454-HuGene_st: 627857- 1.41E−15 2.5326 3.6 89.7 82.8-94.4 HuGene_st: 461281-HuGene_st: 207455_at: 259065- HuGene_st: 797734-HuGene_st: 135788-HuGene_st: 42916- HuGene_st: 315405-HuGene_st: 340050-HuGene_st: 173225- HuGene_st: 919818-HuGene_st: 591228-HuGene_st: 899117- HuGene_st: 785070-HuGene_st: 286200-HuGene_st: 231925_at SORBS2 238751_at: 805920-HuGene_st 4.23E−05 1.3026 2.1 74.3 65.1-82 

TABLE 5 Normal Gene Blood MRC5 CaCo2 HCT116 HT29 SW480 CXCL12 Unmeth low unmeth meth meth unmeth DF Low meth meth meth unmeth meth MAMDC2 Unmeth unmeth meth unmeth unmeth meth CA4 unmeth unmeth meth meth meth unmeth MT1M low low low meth low meth P2RY14 unmeth Low Meth Meth Unmeth Meth GPM6B Low Low Low Meth Meth Meth ADAMDEC1 low Unmeth Meth Meth unmeth meth

TABLE 6 Probe Set ID Target Sequence 1 200600_at tagtcttggggcaggatgattttggcctcattactttaccacccccacacctggaaagcatatactatattacaaaatgacattttgccaaaattattaatataagaag ctttcagtattagtgatgtcatctgtcactataggtcatacaatccattcttaaagtacttgttatttgtttttattattactgtttgtcttctccccagggttcagtccctcaaggg gccatcctgtcccaccatgcagtgccccctagcttagagcctccctcaattccccctggccaccaccccccactctgtgcctgaccttgaggagtcttgtgtgcattg ctgtgaattagctcacttggtgatatgtcctatattggctaaattgaaacctggaattgtggggcaatctattaatagctgccttaaagtcagtaacttacccttaggga ggctgggggaaaaggttagattttgtattcaggggttttttgtgtactttttgggtttttaaaaaattgtttttggaggggtttatgctcaatccatgt 2 200621_at gatagcctcccactaggactgggaggagaataacccaggtcttaaggaccccaaagtcaggatgttgtttgatcttctcaaacatctagttccctgcttgatgggag gatcctaatgaaatacctgaaacatatattggcatttatcaatggctcaaatcttcatttatctctggccttaaccctggctcctgaggctgcggccagcagagccca ggccagggctctgttcttgccacacctgcttgatcctcagatgtggagggaggtaggcactgcctcagtcttcatccaaacacctttccctttgccctgagacctcag aatcttccctttaacccaagaccctgcctcttccactccacccttctccagggacccttagatcacatcactccacccctgccaggccccaggttaggaatagtggt gggaggaaggggaaagggctgggcctcaccgctcccagcaactgaaaggacaacactatctggagccacccactgaaagggctgcaggcatgggctgtac 3 200665_s_at gttggttcaaacttttgggagcacggactgtcagttctctgggaagtggtcagcgcatcctgcagggcttctcctcctctgtcttttggagaaccagggctcttctcagg ggctctagggactgccaggctgtttcagccaggaaggccaaaatcaagagtgagatgtagaaagttgtaaaatagaaaaagtggagttggtgaatcggttgttc tttcctcacatttggatgattgtcataaggtttttagcatgttcctccttttcttcaccctcccctttgttcttctattaatcaagagaaacttcaaagttaatgggatggtcggat ctcacaggctgagaactcgttcacctccaagcatttcatgaaaaagctgcttcttattaatcatacaaactctcaccatgatgtg 4 200795_at aacactgcataacccgtttctttgaggagtgtgaccccaacaaggataagcacatcaccctgaaggagtggggccactgctttggaattaaagaagaggacat agatgaaaatctcttgttttgaacgaagattttaaagaactcaactttccagcatcctcctctgttctaaccacttcagaaatatatgcagctgtgatacttgtagatttat atttagcaaaatgttagcatgtatgacaagacaatgagagtaattgcttgacaacaacctatgcaccaggtatttaacattaactttggaaacaaaaatgtacaatt aagtaaagtcaacatatgcaaaatactgtacattgtgaacagaagtttaattcatagtaatttcactctctgcattgacttatgagataattaatgattaaactattaatg ataaaaataatgcatttgtattgttcataatatcatgtgcacttcaagaaaatggaatgctactcttttgtggtttac 5 200799_at ggccgacaagaagaaggtgctggacaagtgtcaagaggtcatctcgtggctggacgccaacaccttggccgagaaggacgagtttgagcacaagaggaag gagctggagcaggtgtgtaaccccatcatcagcggactgtaccagggtgccggtggtcccgggcctgggggcttcggggctcagggtcccaagggagggtct gggtcaggccccaccattgaggaggtagattaggggcctttccaagattgctgtttttgttttggagcttcaagactttgcatttcctagtatttctgtttgtcagttctcaatt tcctgtgtttgcaatgttgaaattttttggtgaagtactgaacttgctttttttccggtttctacatgcagagatgaatttatactgccatcttacgactatttcttctttttaataca cttaactcaggccatttttt 6 200845_s_at tcctgtcacccattttgaagagtggcagaacttgaagttcaacttcctctgtaaatatccaagtataaagcccaggaacttctagaataacccagatgcgctttaatttt ttttaatatgttttgatcacagaacttctagaataacccagatgctctttcatattcttttaatacatcttgatcacagctgggggaaaaaaagctttttaattctgtaccttcc tagtagataagtgaagagcagggaaagagacctttaaatattttgctataaaaaaatttgtgataagtttctatcaaaatggggagattgcagaaaaggcttccctt ggctcccaaggaggtgtagcaggtgtgagcaatattagtgccatgtgcctttcacacagggtttgcatttatcagtctgttttccgatgatgtgtacatgaaagagtac accatgtgaagagaagagagaatgattgaaaatgttttagtatagaactcttcttgcagtgggttgctattttctagatttta 7 200859_x_at gtttgtagactctctgaccaaggccacctgtgccccccagcatggggccccgggtcctgggcctgctgacgccagcaaggtggtggccaagggcctggggctg agcaaggcctacgtaggccagaagagcagcttcacagtagactgcagcaaagcaggcaacaacatgctgctggtgggggttcatggcccaaggaccccct gcgaggagatcctggtgaagcacgtgggcagccggctctacagcgtgtcctacctgctcaaggacaagggggagtacacactggtggtcaaatgggggcac gagcacatcccaggcagcccctaccgcgttgtggtgccctgagtctggggcccgtgccagccggcagcccccaagcctgccccgctacccaagcagccccg ccctcttcccctcaaccccggcccaggccgccctggccgcccgcctgtcactgcagctgcccctgccctgtgccgtgctgcgctcacctgcctccccagccagcc gctgacctctcggctttcacttgggcagagggagccatttggtggcgctgct 8 200884_at cctcacccagattgaaactctcttcaagtctaaggactatgagttcatgtggaaccctcacctgggctacatcctcacctgcccatccaacctgggcaccgggctg cgggcaggtgtcgatatcaagctgcccaacctgggcaagcatgagaagttctcggaggtgcttaagcggctgcgacttcagaagcgaggcacaggcggtgtg gacacggctgcggtgggcggggtcttcgacgtctccaacgctgaccgcctgggcttctcagaggtggagctggtgcagatggtggtggacggagtgaagctgct catcgagatggaacagcggctggagcagggccaggccatcgacgacctcatgcctgcccagaaatgaagcccggcccacacccgacaccagccctgctg cttcctaacttattgcctgcagtgcccaccatgcacccctcgatgttgccgtctggcgagcccttagccttgctgtaaggaaggcttccgtcacccttggtagagtttat 9 200897_s_at ctctcttagctcagttactcaattcatacgtagtattttttaaaataattttatatctgtgtaccaccccatatatttcatattactgtttcacatgtacagctttctacttctttgtaa gaacaccaaccaaccaaggtttaagtgattaataggcttgagcaccgggtggcagatgttctatgcagtgtggttcaagtttctttgaccgcacttatatgcattgcta atatggaatttaagataccatacacagtctctcatggacctatctctattgtagaattatgacttatgtcttacttggcaaatttttctgaatgtgacctttttttgctgatttgct gggtttgggattaactagcattattttgccacctt 10 200974_at aagagttacgagttgcctgatgggcaagtgatcaccatcggaaatgaacgtttccgctgcccagagaccctgttccagccatccttcatcgggatggagtctgctg gcatccatgaaaccacctacaacagcatcatgaagtgtgatattgacatcaggaaggacctctatgctaacaatgtcctatcagggggcaccactatgtaccctg gcattgccgaccgaatgcagaaggagatcacggccctagcacccagcaccatgaagatcaagatcattgcccctccggagcgcaaatactctgtctggatcg gtggctccatcctggcctctctgtccaccttccagcagatgtggatcagcaaacaggaatacgatgaagccgggccttccattgtccaccgcaaatgcttctaaaa cactttcctgctcctctctgtctctagcacacaactgtgaatgtcctgtggaattatgccttcagttcttttccaaatcattcctagccaaagctctgactcgt 11 200986_at gacgaccagccaggatatgctctcaatcatggagaaattggaattcttcgatttttcttatgaccttaacctgtgtgggctgacagaggacccagatcttcaggtttct gcgatgcagcaccagacagtgctggaactgacagagactggggtggaggcggctgcagcctccgccatctctgtggcccgcaccctgctggtctttgaagtgc agcagcccttcctcttcgtgctctgggaccagcagcacaagttccctgtcttcatggggcgagtatatgaccccagggcctgagacctgcaggatcaggttaggg cgagcgctacctctccagcctcagctctcagttgcagccctgctgctgcctgcctggacttgcccctgccacctcctgcctcaggtgtccgctatccaccaaaaggg ctcctgagggtctgggcaagggacctgcttctattagcccttctccatggccctgccatgctctccaaaccactttttgcagctttctc 12 201041_s_at gcaataactctgggaggggctcgagagggctggtccttatttatttaacttcacccgagttcctctgggtttctaagcagttatggtgatgacttagcgtcaagacattt gctgaactcagcacattcgggaccaatatatagtgggtacatcaagtccatctgacaaaatggggcagaagagaaaggactcagtgtgtgatccggtttctttttg ctcgcccctgttttttgtagaatctcttcatgcttgacatacctaccagtattattcccgacgacacatatacatatgagaatataccttatttatttttgtgtaggtgtctgcct tcacaaatgtcattgtctactcctagaa 13 201058_s_at gcatcctcaaacatggcgccaaggataaacacgactaggccatccccagccccctgacacccagcccccgccagtcacccctccccgcacacacccgtcca taccagctccctgcccatgaccctcgctcagggatccccctttgagggttagggtcccagttcccagtggaagaaacaggccaggagagtgcgtgccgagctg aggcagatgttcccacagtgaccccagagccctgggctatagtctctgacccctccaaggaaagaccaccttctggggacatgggctggagggcaggaccta gaggcaccaagggaaccgcattccggggctgttccccgaggaggaagggaagcctctgtgtgccccccaggaggaagaggccctgagtcctgggatcaga caccccttcacgtgtatcccacacaaatgcaagctcaccaaggtccc 14 201061_s_at tatagctctctttagctcaaccactctgtccatccagccaatggatgtccttccctgtacccaattcaagcttattttagggaagccttgaaactaccatgtatctggctct agctgagttattgaggattgagccagtgcaacgttaaactcagtgcacttacatttgatttaaatgatggttttatctgttgtgtgaagtggttcacccttgaggaccagg agcctccatatcctgactgaaaaccttttctgagacttagagtaacagtacttttggttccttgagttctcctgtctccagatacctaaatgaccttgacttttctgccttgtg aattcgtagtccaatcagctgaaattaaatcacttgggagggacgcatagaaggagctctaggaacacagtgccagtgcagaagtttctccaggtggcc 15 201069_at ctcagagccacccctaaagagatcctttgatattttcaacgcagccctgctttgggctgccctggtgctgccacacttcaggctcttctcctttcacaaccttctgtggct cacagaacccttggagccaatggagactgtctcaagagggcactggtggcccgacagcctggcacagggcagtgggacagggcatggccaggtggccact ccagacccctggcttttcactgctggctgccttagaacctttcttacattagcagtttgctttgtatgcactttgtttttttctttgggtcttgttttttttttccacttagaaattgcatt tcctgacagaaggactcaggttgtctgaagtcactgcacagtgcatctcagcccacatagtgatggttcccctgttcactctacttagcatgtccctaccgagtctctt ctccactggatggaggaaaaccaagccgtggcttcccgctcagccctccctgcccctcccttcaaccattccccatgggaaat 16 201105_at ctcctggactcaatcatggcttgtggtctggtcgccagcaacctgaatctcaaacctggagagtgccttcgagtgcgaggcgaggtggctcctgacgctaagagc ttcgtgctgaacctgggcaaagacagcaacaacctgtgcctgcacttcaaccctcgcttcaacgcccacggcgacgccaacaccatcgtgtgcaacagcaag gacggcggggcctgggggaccgagcagcgggaggctgtctttcccttccagcctggaagtgttgcagaggtgtgcatcaccttcgaccaggccaacctgaccg tcaagctgccagatggatacgaattcaagttccccaaccgcctcaacctggaggccatcaactacatggcagctgacggtgacttcaa 17 201137_s_at ggcagcattcaagtccgatggttcctgaatggacaggaggaaacagctggggtcgtgtccaccaacctgatccgtaatggagactggaccatccagatcctggt gatgctggaaatgaccccccagcagggagacgtctacatctgccaagtggagcacaccagcctggatagttccgtcaccgtggagtggaaggcacagtctga ttctgcccagagtaagacattgacgggagctgggggcttcgtgctggggctcatcatctgtggagtgggactcttcatgcacaggaggagcaagaaagttcaac gaggatctgcataaacagggttcctgacctcaccgaaaagactaatgtgccttagaacaagcatttgctgtgttttgttaacacctggttccaggacagaccctcag cttcccaagaggatactgctgccaagaagttgctctgaagtcagtttctatcgttctgctctttgattcaaa 18 201141_at agaggcgggatactttcagctttccatgtaactgtatgcataaagccaatgtagtccagtttctaagatcatgttccaagctaactgaatcccacttcaatacacactc atgaactcctgatggaacaataacaggcccaagcctgtggtatgatgtgcacacttgctagactcagaaaaaatactactctcataaatgggtgggagtattttggt gacaacctactttgcttggctgagtgaaggaatgatattcatatattcatttattccatggacatttagttagtgctttttatataccaggcatgatgctgagtgacactctt gtgtatatttccaaatttttgtatagtcgctgcacatatttgaaatcatatattaagactttccaaagatgaggtccctggtttttcatggcaacttgatcagtaaggatttca cctctgtttgtaacta 19 201150_s_at gactttttggaatagccctgtctagggcaaactgtggcccccaggagacactacccttccatgccccagacctctgtcttgcatgtgacaattgacaatctggacta ccccaagatggcacccaagtgtttggcttctggctacctaaggttaacatgtcactagagtatttttatgagagacaaacattataaaaatctgatggcaaaagcaa aacaaaatggaaagtaggggaggtggatgtgacaacaacttccaaattggctctttggaggcgagaggaaggggagaacttggagaatagtttttgctttgggg gtagaggcttcttagattctcccagcatccgcctttccctttagccagtctgctgtcctgaaacccagaagtgatggagagaaaccaacaagagatctcgaaccct gtctagaaggaatgtatttgttgctaaatttcgtagcactgtttacagttttcctccatgttatttatg 20 201289_at gccacgattggagaatactttgcttcatagtattggagcacatgttactgcttcattttggagcttgtggagttgatgactttctgttttctgtttgtaaattatttgctaagcat attttctctaggcttttttccttttggggttctacagtcgtaaaagagataataagattagttggacagtttaaagcttttattcgtcctttgacaaaagtaaatgggagggc attccatcccttcctgaagggggacactccatgagtgtctgtgagaggcagctatctgcactctaaactgc 21 201300_s_at ttaggtcaagttcatagtttctgtaattggcttttgaatcaaagaatagggagacaatctaaaaaatatcttaggttggagatgacagaaatatgattgatttgaagtg gaaaaagaaattctgttaatgttaattaaagtaaaattattccctgaattgtttgatattgtcacctagcagatatgtattacttttctgcaatgttattattggcttgcactttg tgagtatctatgtaaaaatatatatgtatataaaatatatattgcataggacagacttaggagttttgtttagagcagttaacatctgaagtgtctaatgcattaacttttgt aaggtactgaatacttaatatgtgggaaacccttttgcgtggtccttaggcttacaatgtgcactgaatcgtttcatgtaagaatccaaagtggacaccattaacaggt ctttgaaatatgcatgtactttatattttctatatttgtaactttgcatgttcttgttttgtta 22 201324_at caccaaattacctaggctgaggttagagagattggccagcaaaaactgtgggaagatgaactttgtcattatgatttcattatcacatgattatagaaggctgtctta gtgcaaaaaacatacttacatttcagacatatccaaagggaatactcacattttgttaagaagttgaactatgactggagtaaaccatgtattcccttatcttttactttttt tctgtgacatttatgtctcatgtaatttgcattactctggtggattgttctagtactgtattgggcttcttcgttaat 23 201348_at accagctctaggtccaattgttctgctctaactgatacctcaaccttggggccagcatctcccactgcctccaaatattagtaactatgactgacgtccccagaagttt ctgggtctaccacactccccaaccccccactcctacttcctgaagggccctcccaaggctacatccccaccccacagttctccctgagagagatcaacctccctg agatcaaccaaggcagatgtgacagcaagggccacggaccccatggcaggggtggcgtcttcatga 24 201426_s_at tgtggatgtttccaagcctgacctcacggctgccctgcgtgacgtacgtcagcaatatgaaagtgtggctgccaagaacctgcaggaggcagaagaatggtaca aatccnagtttgctgacctctctgaggctgccaaccggnacnatgacgccctgcgccaggcnaagcaggagtccnctgagtaccggagacaggtgcagtccc tcacctgtgaagtggatgcccttaaaggaaccaatgagtccctggaacgccagatgcgtgaaatggaagagaactttgccgttgaagctgctaactaccaaga cactattggccgcctgcaggatgagattcagaatatgaaggaggaaatggctcgtcaccttcgtgaataccaagacctgctcaatgttaagatggcccttgacatt gagattgccacct 25 201427_s_at gatccagaaatacttaacacgtgaatattttgctaaaaaagcatatataactattttaaatatccatttatcttttgtatatctaagactcatcctgatttttactatcacacat gaataaaggcctttgtatctttctttctctaatgttgtatcatactcttctaaaacttgagtggctgtcttaaaagatataaggggaaagataatattgtctgtctctatattgc ttagtaagtatttccatagtcaatgatggtttaataggtaaaccaaaccctataaacctgacctcctttatggttaatactattaagcaagaatgcagtacagaattgg atacagtacggatttgtccaaat 26 201438_at ctccagcagttctctcgaatactttgaatgttgtgtaacagttagccactgctggtgtttatgtgaacattcctatcaatccaaattccctctggagtttcatgttatgcctgtt gcaggcaaatgtaaagtctagaaaataatgcaaatgtcacggctactctatatacttttgcttggttcattttttttcccttttagttaagcatgactttagatgggaagcct gtgtatcgtggagaaacaagagaccaactttttcattccctgcccccaatttcccagactagatttcaagctaattttctttttctgaagcctctaacaaatgatctagttc agaaggaagcaaaatcccttaatctatgtgcaccgttgggaccaatgccttaattaaagaatttaaaaaagttgtaatagagaatatttttggcattcctctcaatgtt gtgtgtt 27 201495_x_at caagtgcagcgatggggagcgggcccgggcggagctcaatgacaaagtccacaagctgcagaatgaagttgagagcgtcacagggatgcttaacgaggc cgaggggaaggccattaagctggccaaggacgtggcgtccctcagttcccagctccaggacacccaggagctgcttcaagaagaaacccggcagaagctc aacgtgtctacgaagctgcgccagctggaggaggagcggaacagcctgcaagaccagctggacgaggagatggaggccaagcagaacctggagcgcca catctccactctcaacatccagctctccgactcgaagaagaagctgcaggactttgccagcaccgtggaagctctggaagaggggaagaagaggttccagaa ggagatcgagaacctcacccag 28 201496_x_t tcaagtccaagttcaagtccaccatcgcggcgctggaggccaagattgcacagctggaggagcaggtcgagcaggaggccagagagaaacaggcggcca ccaagtcgctgaagcagaaagacaagaagctgaaggaaatcttgctgcaggtggaggacgagcgcaagatggccgagcagtacaaggagcaggcaga gaaaggcaatgccagggtcaagcagctcaagaggcagctggaggaggcagaggaggagtcccagcgcatcaacgccaaccgcaggaagctgcagcgg gagnnggatgaggccacggagagcaacgaggccatgggccgcgaggtgaacgcactcaagagcaagctcagagggccccccccacaggaaacttcgc agtgatgcaccaggcgaggaaacgagacctctttcgttccttctagaaggtctggaggacgtagagttattgaaaatgcagatggttctgaggaggaaacggac actcgagacgcagacttcaatggaaccaaggccagtgaataagcaactttctacagttttgcaccacgg 29 201497_x_at tgagccaggaagaacgctccagcccaggacttcgaggctgcaatgagctataattgcatcattgcactccagcctgggcaacagagaccctgtctcaaccacc accaccaccaccacccctactacccctgtattcaaggtaaaaattgaagtttgtatgatgtaagagatgagaaaaacccaacaggaaacacagacacatcctc cagttctatcaatggattgtgcagacactgagtttttagaaaaacatatccacggtaaccggtccctggcaattctgtttacatgaaatggggagaaagtcaccgaa atgggtgccgccggcccccactcccaattcattccctaacctgcaaacctttccaacttctcacgtcaggcctttgagaattctttccccctctcctggtttccacacctc agacacgcacagttcaccaagtgccttctgtagtcacatgaattgaaaaggagacgctgctcccacggaggggagcaggaatgctgcactgtttacaccctga ctgtgcttaaaa 30 201539_s_at tgaagtgcaacaaggccatcacatctggaggaatcacttaccaggatcagccctggcatgccgattgctttgtgtgtgttacctgctctaagaagctggctgggca gcgtttcaccgctgtggaggaccagtattactgcgtggattgctacaagaactttgtggccaagaagtgtgctggatgcaagaaccccatcactgg 31 201540_at cagggctgtcatcaacatggatatgacatttcacaacagtgactagttgaatcccttgtaacgtagtagttgtctgctctttgtccatgtgttaatgaggactgcaaagt cccttctgttgtgattcccaggacttttcctcaagaggaaatctggatttccacctaccgcttacctgaaatgcaggatcacctacttactgtattctacattattatatgac atagtataatgagacaatatcaaaagtaaacatgtaatgacaatacatactaacattcttgtaggagtggttagagaagctgatgcctcatttctacattctgtcatta gctattatcatctaacgtttcagtg 32 201616_s_at cttgagaccaggagacgtatccagcaagcggaacctctgggaaaagcaatctgtggataaggtcacttcccccactaaggtttgagacagttccagaaagaac ccaagctcaagacgcaggacgagctcagttgtagagggctaattcgctctgttttgtatttatgttgatttactaaattgggttcattatcttttatttttcaatatcccagtaa acccatgtatattatcactatatttaataatcacagtctagagatgttcatggtaaaagtactgcctttgcacaggagcctgtttctaaagaaacccatgctgtgaaata gagacttttctactgatcatcataactctgtatctgagcagtgataccaaccacatctgaagtcaacagaagatccaagtttaaaattgcctgcggaatgtgtgcagt atctagaaa 33 201617_x_at tgttgtttctgcactttataataaagcatggaagaaattatcttagtaggcaattgtaacactttttgaaagtaacccatttcagatttgaaatactgcaataatggttgtctt taaaaaaaaaaagaatgtactgttaaggtattactttttttcatgctgatgattcatatctaaattacattattatgttagctgacagtggtactgattttttaggttggttgtttt gtggatttctttagtagtgatagtagcctgaaccacattttagataactcaattatgtatgtatgtgcatacacatatacaaacacactaatggtagaatgcttttttatgtg ctagactattatatttagtagtatgtcattgtaactagccaatatcacagcttttgaaaaattaaaaaatcatcatcactataatatttcatatttgccaacagaaacatg gcagataggtatcaatatgttttcaatgcctgatgacctat 34 201645 at ttttaccaaagcatcaatacaaccagcccaaccatcggtccacacctgggcatttggtgagaatcaaagctgaccatggatccctggggccaacggcaacagc atgggcctcacctcctctgtgatttctttctttgcaccaaagacatcagtctccaacatgtttctgttttgttgtttgattcagcaaaaatctcccagtgacaacatcgcaat agttttttacttctcttaggtggctctgggatgggagaggggtaggatgtacaggggtagtttgttttagaaccagccgtattttacatgaagctgtataattaattgtcatt atttttgttagcaaagattaaatgtgtcattggaagccatccctttttttacatttcatacaacagaaaccagaaaagcaatactgtttccattttaaggatatgattaatat tattaatataataatgatgatgatgatgatgaaaactaaggatttttcaagagatctttctttccaaaacatttctggacagtacctgattgt 35 201667_at gagtggactattaaatgtgcctaaatgaattttgcagtaactggtattcttgggttttcctacttaatacacagtaattcagaacttgtattctattatgagtttagcagtctttt ggagtgaccagcaactttgatgtttgcactaagattttatttggaatgcaagagaggttgaaagaggattcagtagtacacatacaactaatttatttgaactatatgtt gaagacatctaccagtttctccaaatgccttttttaaaactcatcacagaagattggtgaaaatgctgagtatgacacttttcttcttgcatgcatgtcagctacataaa cagttttgtacaatgaaaattactaatttgtttgacattccatgttaaactacggtcatgttcagcttcattgcatgtaatgtagacctagtccatcaga 36 201739_at tgctgtgtgaaccgtcgtgtgagtgtggtatgcctgatcacagatggattttgttataagcatcaatgtgacacttgcaggacactacaacgtgggacattgtttgtttct tccatatttggaagataaatttatgtgtagacttttttgtaagatacggttaataactaaaatttattgaaatggtcttgcaatgactcgtattcagatgcctaaagaaagc attgctgctacaaatatttctatttttagaaagggtttttatggaccaatgccccagttgtcagtcagagccgttggtgtttttcattgtttaaaatgtcacctgtaaaatggg cattatttatgtttttttttttgcattcctgataattgtatgtattgtataaagaacgtctgtacattgggttataacactagtatatttaaacttacaggcttatttgtaatgtaaac caccattttaatgtactgtaattaacatggttataatacgtacaatccttccctcatcccatcacacaactttttttg 37 201743_at ccatccagaatctagcgctgcgcaacacaggaatggagacgcccacaggcgtgtgcgccgcactggcggcggcaggtgtgcagccccacagcctagacct cagccacaactcgctgcgcgccaccgtaaaccctagcgctccgagatgcatgtggtccagcgccctgaactccctcaatctgtcgttcgctgggctggaacagg tgcctaaaggactgccagccaagctcagagtgctcgatctcagctgcaacagactgaacagggcgccgcagcctgacgagctgcccgaggtggataacctg acactggacgggaatcccttcctggtccctggaactgccctcccccacgagggctcaatgaactccggcgtggtcccagcctgtgcacgttcgaccctgtcggtg ggggtgtcgggaaccctggtgctgctccaaggggcccggggctttgcctaagatccaagacagaataatgaatggactcaaactgccttggcttcaggggagtc ccgtcaggacgttgaggacttttcgaccaattcaacc 38 201744_s_at caaatgatgtgcaaaaccttttactggttgcatggaaatcagccaagttttataatccttaaatcttaatgttcctcaaagcttggattaaatacatatggatgttactctct tgcaccaaattatcttgatacattcaaatttgtctggtaaaaaaataggtggtagatattgaggccaagaatattgcaaaatacatgaagcttcatgcacttaaagaa gtatttttagaataagaatttgcatacttacctagtgaaacttttctagaattatttttcactctaagtcatgtatgtttctct 39 201842_s_at tcagcagtatagggaccttccgcacaagctctgtgttaagattgacaataatagtggggccattttcattttagtcttttctaagagtcaaccacaggcatttaagtcag ccaaagaatattgttaccttaaagcactattttatttatagatatatctagtgcatctacatctctatactgtacactcacccataattcaaacaattacaccatggtataa agtgggcatttaatatgtaaagattcaaagtttgtctttattactatatgtaaattagacattaatccactaaactggtcttcttcaagagagctaagtatacactatctggt gaaacttggattctttcctataaaagtgggaccaagcaatgatgatcttctgtggtgcttaaggaaacttactagagctccactaacagtctcataaggaggcagcc atcataaccattga 40 201852_x_at gtgccaatcctttgaatgttccacggaaacactggtggacagattctagtgctgagaagaaacacgtttggtttggagagtccatggatggtggttttcagtttagcta cggcaatcctgaacttcctgaagatgtccttgatgtgcagctggcattccttcgacttctctccagccgagcttcccagaacatcacatatcactgcaaaaatagcat tgcatacatggatcaggccagtggaaatgtaaagaaggccctgaagctgatggggtcaaatgaaggtgaattcaaggctgaaggaaatagcaaattcaccta cacagttctggaggatggttgcacgaaacacactggggaatggagcaaaacagtctttgaatatcgaacacgcaaggctgtgagactacctattgtagatattgc accctatgacattggtggtcctgatcaagaatttggtgtggacgttggccct 41 201858_s_at cctggttctggaatcctcagttcaaggttatcctacgcagagagccaggtaccaatgggtgcgctgcaatccagacagtaattctgcaaactgccttgaagaaaa aggaccaatgttcgaactacttccaggtgaatccaacaagatcccccgtctgaggactgacctttttccaaagacgagaatccaggacttgaatcgtatcttccca ctttctgaggactactctggatcaggcttcggctccggctccggctctggatcaggatctgggagtggcttcctaacggaaatggaacaggattaccaactagtag acgaaagtgatgctttccatgacaaccttaggtctcttgacaggaatctgccctcagac 42 201859_at tatgctttaatgctgttatctatcttattgttcttgaaaatacctgcattttttggtatcatgttcaaccaacatcattatgaaattaattagattcccatggccataaaatggctt taaagaatatatatatatttttaaagtagcttgagaagcaaattggcaggtaatatttcatacctaaattaagactctgacttggattgtgaattataatgatatgcccctt ttcttataaaaacaaaaaaaaaataatgaaacacagtgaatttgtagagtgggggtatttgacatattttacagggtggagtgtactatatactattacctttgaatgtg tttgcagagctagtggatgtgtttgtctacaagtatgattgctgttacataacaccccaaattaactcccaaattaaaacacagttgtgctgtcaatacctcatactgctt tacctttttttcctggatatctgtgtattttc 43 201865_x_at gttgagtcgtcatcacttttcagtgatgggagagtagatggtgaaatttattagttaatatatcccagaaattagaaaccttaatatgtggacgtaatctccacagtcaa agaaggatggcacctaaaccaccagtgcccaaagtctgtgtgatgaactttctcttcatactttttttcacagttggctggatgaaattttctagactttctgttggtgtatc ccccccctgtatagttaggatagcatttttgatttatgcatggaaacctgaaaaaaagtttacaagtgtatatcagaaaagggaagttgtgccttttatagctattactgt ctggttttaacaatttcctttatatttagtgaactacgcttgctcattttttcttacataattttttattcaagttattgtacagctgtttaagatgggcagctagttcgtagctttccc aaataaactctaaacattaatcaatcatctgtgtgaaaatgggttggtgcttctaacctgatggcacttagctatcagaagaccacaaaaattgactcaaatctcca gtattcttg 44 201893_x_at tctcctacatccgcattgctgataccaatatcaccagcattcctcaaggtcttcctccttcccttacggaattacatcttgatggcaacaaaatcagcagagttgatgc agctagcctgaaaggactgaataatttggctaagttgggattgagtttcaacagcatctctgctgttgacaatggctctctggccaacacgcctcatctgagggagc ttcacttggacaacaacaagcttaccagagtacctggtgggctggcagagcataagtacatccaggttgtctaccttcataacaacaatatctctgtagttggatca agtgacttctgcccacctggacacaacaccaaaaaggcttcttattcgggtgtgagtcttttcagcaacccggtccagtactgggagatacagccatccaccttca gatgtgtctacgtgcgctctgccattcaactcggaaactataagtaattctcaagaaagccctcatttttataacctgg 45 201920_at gtatcaggcttcaattccattatgttttaatgttgtctctgaagatgacttgtgatttttttttcttttttttaaaccatgaagagccgtttgacagagcatgctctgcgttgttggtt tcaccagcttctgccctcacatgcacagggatttaacaacaaaaatataactacaacttcccttgtagtctcttatataagtagagtccttggtactctgccctcctgtc agtagtggcaggatctattggcatattcgggagcttcttagagggatgaggttctttgaacacagtgaaaatttaaattagtaacttttttgcaagcagtttattgactgtt attgctaagaagaagtaagaaagaaaaagcctgttggcaatcttggttatttctttaagatttctggcagtgtgggatggatgaatgaagtggaatgtgaactttggg caagttaaatgggacagccttccatgttcatttgtctacctcttaactga 46 201957_at gttgtgcctaccactggctggcacaccagggcaatgatttccctgcagaaggaaggaaagaatgtttcacccttgcatccttcttggagaagctacagcctgtgct cagttgagtggttcacactcagactttggctttatggttttccttcctccttgtctttgccctgaccttgatcaacaggggtgaaaagaaccaccctgaggtttccatgcct ctcccattttagtggtagcattttgtgtctttactccacccttcaccctagttccaccaaggttcacacaccagatgtaactgtttttcagctgagttgtatggattaacttca gtccactgtaaatacacctgggatggggtggggttggggttgtttagggagaagcagccagacttgctttgtgaactgaatgtatttttatgcaattttgagtggcctttc aaccctaaga 47 202007_at tatcagtagctcgtgttatctttttatcaactgcttcccagngtcctaaaacaatagaaattttggattgaaaagttcagcataaggagtttgagtcagtaaaggatggg ataaaggagtcgagatgattcaatgaaaagtatcacaaaaaagagattgatcaacaagagaaataaaaaagcccaagaggaagtggtaggggaaggaat ttaagaacagcaataagtaaaactcttaagtaactccaaaaagaaaatggtacattttgccaaagaccacttatacttgagaacatggaagaatttgcctgatact ctctttggggaaaagagtctctcctcttttcctcaaaccccagtacactcagcctctctgccccaccttctcctgactttgtcctcacttgcttctgcagtacattggaacct gaattgaaagaaagtcttccttgaataattggagtttgtcttgagaggcaaatatagccccaagaatcacaagattcgaggaccatgtaggtcttttacgtagccca aatccataaattagtctcactttttgtatttatcgtttcatattaaaccctctatatca 48 202037_s_at taacacttggctcttggtacctgtgggttagcatcaagttctccccagggtagaattcaatcagagctccagtttgcatttggatgtgtaaattacagtaatcccatttcc caaacctaaaatctgtttttctcatcagactctgagtaactggttgctgtgtcataacttcatagatgcaggaggctcaggtgatctgtttgaggagagcaccctaggc agcctgcagggaataacatactggccgttctgacctgttgccagcagatacacaggacatggatgaaattcccgtttcctctagtttcttcctgtagtactcctctttta gatcc 49 202069_s_at cagtcactctaaatggacaccacatgaacctctgtttagaatacctacgtatgtatgcattggtttgcttgtttcttgacagtacatttttagatctggccttttcttaacaaa atctgtgcaaaagatgcaggtggatgtccctaggtctgttttcaaagaactttttccaagtgcttgttttatttattaagtgtctacctggtaaatgttttttttgtaaactctga gtggactgtatcatttgctattctaaaccattttacacttaagttaaaatagtttctcttcagctgtaaataacaggatacagaattaacaagagaaaatgtctaacttttt aagaaaaaccttattttcttcggtttttgaaaaacataatggaaataaaacaggatattgacataatagcacaaaatgacactcttctaaaactaaatgggcacaa gagaattttcctggga 50 202133_at gtcaaaacctaattgcaattctgttaaatctaagtaatttttagacagtgtttcaccgtattatttaggatgtgaaatgccatttctttcactgattacaccatatacaggaa acaggtaaaacagtgaaaactttattgtgctggttgatgccaacttggttgaaaagctctctgcagaagaagtgatctagactgacagaagtgttgctaattacaag ttgtgttctcatgacgtaattagaaagtaacttctcaaagtacaacttttatgaaaaaaataagctgttaaaaaaaggaaatcgtaggttaatttaattgggaaaatgg gcaattgacagagaccattttcctaacacatatatgtgctagtactttaactttttaaaattttacttctacgttttgtaatataaaaatttctattttaagtttagaatgttatac gtaccgaaagtatgcagccaaatcgatcagatcaaaccattttacctggagtt 51 202222_s_at agctgtgagccttggctgttggcagtgagtgagcctggctcttgtgctggatggagcccaggcgggagcggtggccctgtccctcccacctctgtgacctgaggcc tacgctttggctctggagatagccccagagcagggtgttgggatactgcagggccaggactgagcccc 52 202242_at ctgttagctcctcactgtggtaaatgccacacacctttaagtagataagcagacgatagttatctgttcttttgacttaatctcatttggtttgattttccctctactaaggcttt cctaccttcttcaggctgcctaagacatgtaagcgaaacacttcaataattgtccatgaggagaaaaaaagcattgtcatgcatgaaggaaactgaacttgaggt ggcctccttgcttgttacatacctgggtatgtgtaggcagtttagtgcatctttgcctctcagttgaaacctgtataaccctgttacaaagctgtgttgttgcttcttgtgaag gccatgatattttgttttttccccaattaattgctattgtgttattttactaacttctctctgtattttttcttgcattgacattatagacattgaggacctcatccaaacaatttaaa aatgagtgtgaagggggaacaagtcaaaatatttttaaaagatcttcaaaaataatgcctctgtctagcatgccaac 53 202266_at tgtcagagttttcaacggtgcttatagctgccagctggattccaaacaggtaccccattgtctctgagctaatgtttatatttttccattcaggcaccgaaatagttaatat ttaaaataagtcttcaaaagaaaacataagagattattgagttcttgggactggatcctttatttcataagttcagatcatcttaaatgaaaatgccatgattatctgcag ttaagtagatgacagctattctacatcagacttgatttttgtcagctaattacataattggtaagctataattgaaaccttatggcttaaaattccttaactcctttttgattca tgtttgtagtcatgttgtcaacagaggcaaagttaagcttgatgatggttaaaatcggtttgatagcaccatgggacatttttctaacaaaaataaatgcatgaagag acatagccttttagttttgct 54 202274_at aagagctatgagctgccagatgggcaggttatcaccattggcaatgagcgcttccgctgccctgagaccctcttccagccttcctttattggcatggagtccgctgg aattcatgagacaacctacaattccatcatgaagtgtgacattgacatccgtaaggacttatatgccaacaatgtcctctctgggggcaccaccatgtaccctggc attgctgacaggatgcagaaggagatcacagccctggcccccagcaccatgaagatcaagattattgctcccccagagcggaagtactcagtctggatcggg ggctctatcctggcctctctctccaccttccagcagatgtggatcagcaagcctgagtatgatgaggcagggccctccattgtccacaggaagtgcttctaaagtca gaacaggttctccaaggatcccc 55 202283_at caactgcccttgaccggaagcatgagtatcatcttcttcctgcccctgaaagtgacccagaatttgaccttgatagaggagagcctcacctccgagttcattcatga catagaccgagaactgaagaccgtgcaggcggtcctcactgtccccaagctgaagctgagttacgaaggcgaagtcaccaagtccctgcaggagatgaagc tgcaatccttgtttgattcaccagactttagcaagatcacaggcaaacccatcaagctgactcaggtggaacaccgggctggctttgagtggaacgaggatggg gcgggaaccacccccagcccagggctgcagcctgcccacctcaccttcccgctggactatcaccttaaccagcctttcatcttcgtactgagggacacagacac aggggcccttctcttcattggcaagattctggaccccaggggcccctaatatcccagtttaatattccaataccctagaagaaaacccgagggacagcagattcc acag 56 202291_s_at ctgacctgcaggacgaaaccatgaagagcctgatccttcttgccatcctggccgccttagcggtagtaactttgtgttatgaatcacatgaaagcatggaatcttatg aacttaatcccttcattaacaggagaaatgcaaataccttcatatcccctcagcagagatggagagctaaagtccaagagaggatccgagaacgctctaagcct gtccacgagctcaatagggaagcctgtgatgactacagactttgcgaacgctacgccatggtttatggatacaatgctgcctataatcgctacttcaggaagcgcc gaggggccaaatgagactgagggaagaaaaaaaatctctttttttctggaggctggcacctgattttgtatccccctgtagcagcattactgaaatacataggcttat atacaatgcttctttcct 57 202350_s_at gaagccctggaaaatcgcctgagatacagatgaagattagaaatcgcgacacatttgtagtcattgtatcacggattacaatgaacgcagtgcagagccccaa agctcaggctattgttaaatcaataatgttgtgaagtaaaacaatcagtactgagaaacctggtttgccacagaacaaagacaagaagtatacactaacttgtata aatttatctaggaaaaaaatccttcagaattctaagatgaatttaccaggtgagaatgaataagctatgcaaggtattttgtaatatactgtggacacaacttgcttctg cctcatcctgccttagtgtgcaatctcatttgactatacgataaagtttgcacagtcttacttctgtagaacactggccataggaaatgctgtttttttgtactggactttacc ttgatatatgt 58 202388_at gctggtatcagaacagcttccctcactgtgtacagaacgcaagaagggaataggtggtctgaacgtggtgtctcactctgaaaagcaggaatgtaagatgatga aagagacaatgtaatactgttggtccaaaagcatttaaaatcaatagatctgggattatgtggccttaggtagctggttgtacatctttccctaaatcgatccatgttac cacatagtagttttagtttaggattcagtaacagtgaagtgtttactatgtgcaagggtattgaagttcttatgaccacagatcatcagtactgttgtctcatgtaatgcta aaactgaaatggtccgtgtttgcattgttaaaaatgatgtgtgaaatagaatgagtgctatggtgttgaaaactgcagtgtccgttatgagtgccaaaaatctgtcttg aaggcagctacactt 59 202403_s_at aacctgaaaacatcccagccaagaactggtataggagctccaaggacaagaaacacgtctggctaggagaaactatcaatgctggcagccagtttgaatata atgtagaaggagtgacttccaaggaaatggctacccaacttgccttcatgcgcctgctggccaactatgcctctcagaacatcacctaccactgcaagaacagc attgcatacatggatgaggagactggcaacctgaaaaaggctgtcattctacagggctctaatgatgttgaacttgttgctgagggcaacagcaggttcacttaca ctgttcttgtagatggctgctctaaaaagacaaatgaatggggaaagacaatcattgaatacaaaacaaataagccatcacgcctgcccttccttgatattgcacc tttggacatcggtggtgctgaccaggaattctttgtggacattggcccagtctgtt 60 202555_s_at gagccattggaagactgtcctctatggcaatgatctcagggctcagtggcaggaaatcctcaacagggtcaccaaccagcccgctcaatgcagaaaaactag aatctgaagatgtgtcccaagctttccttgaggctgttgctgaggaaaagcctcatgtaaaaccctatttctctaagaccattcgcgatttagaagttgtggagggaa gtgctgctagatttgactgcaagattgaaggatacccagaccccgaggttgtctggttcaaagatgaccagtcaatcagggagtcccgccacttccagatagact acgatgaggacgggaactgctctttaattattagtgatgtttgcggggatgacgatgccaagtacacctgcaaggctgtcaacagtcttggagaagccacctgcac 61 202620_s_at ttatcaagtgtcaagatcagcaagtgtccttaagtcaaataggtttttttttgttggtggttgtgcttgctttccttttttagaaagttctagaaaataggaaaacgaaaaatt tcattgagatgagtagtgcatttaattattttttaaaaaactttttaagtacttgaattttatatcaggaaaacaaagttgttgagccttgcttcttccgttttgccctttgtctcg ctccttattcttttttggggggagggttatttgcttttttatcttcctggcataatttccattttattcttctgagtgtctatgttaacttccctcttcccgcttataaaaaaattctcc aacaaaaatacttgttgacttgatgttttatcacttctctaagtaaggttgaaatatccttattgtagctactgtttttaatgtaaaggttaaacttgaaaagaaattcttaat cacggtgccaaaattcattttctaacaccatgtgtt 62 202686_s_at agattctaacggtctgttctgtttcaaggcactctagattccattggtccaagattccggatcctaagcatctaagttataagactctcacactcagttgtgactaactag acaccaaagttctaataatttctaatgttggacacctttaggttctttgctnnttctgcctctctaggaccatggttaagagtccaagaatccacatttctaaaatcttat agttctaggcactgtagttctaagactcaaatgttctaagtttctaagattctaaaggtccacaggtctagactattaggtgcaatttcaaggttctaaccctatactgta gtattctttggggtgcccctctccttcttagctatcattgcttcctcctccccaactgtgggggtgtgcccccttcaagcctgtgcaatgcattagggatgcctcctttccgc aggggatggacgatctcccacctttcgggccatgttgcccccgtgagccaatccctcaccttctgagtacagagtgtggactctggtgcctcca 63 202731_at ggctctggaggtgggcagcaatctgtcaatcaccttgttaaagagattgatatgctgctgaaagaatatttactctctggagacatatctgaagctgaacattgcctta aggaactggaagtacctcattttcaccatgagcttgtatatgaagctattataatggttttagagtcaactggagaaagtacatttaagatgattttggatttattaaagt ccctttggaagtcttctaccattactgtagaccaaatgaaaagaggttatgagagaatttacaatgaaattccggacattaatctggatgtcccacattcatactctgt gctggagcggtttgtagaagaatgttttcaggctggaataatttggaaacaactcagagatctttgtccttcaaggggcagaaagcgttttgtaagcgaaggagat ggaggtcgtcttaaaccagagagctactgaatataagaactcttgcagtcttagatgttat 64 202741_at gtaagattcctcctaactttcacagtcgatgacaagattgtctttttatctgatattttgaagggtatattgctttgaagtaagtctcaataaggcaatatattttagggcatc tttcttcttatctctgacagtgttcttaaaattatttgaatatcataagagccttggtgtctgtcctaattcctttctcactcaccgatgctgaatacccagttgaatcaaactgt caacctaccaaaaacgatattgtggcttatgggtattgctgtctcattcttggtatattcttgtgttaactgcccattggcctgaaaatactcattgtaagcctgaaaaaa aaaatctttcccactgttttttctgcttgttgtaagaatcaaatgaaataatgtatgtgaaagcaccttgtaaactgtaacctatcaatgtaaaatgttaaggtgtgttgttat ttcattaattacttctttgtttagaatggaatttcctatgcactactgtagc 65 202742_s_at tacacttttttttgccaactgacttaacaacattgctgtcaggtggaaatttcaagcacttttgcacatttagttcagtgtttgttgagaatccatggcttaacccacttgtttt gctatttttttctttgcttttaattttccccatctgattttatctctgcgtttcagtgacctaccttaaaacaacacacgagaagagttaaactgggttcattttaatgatcaattt acctgcatataaaatttatttttaatcaagctgatcttaatgtatataatcattctatttgctttattatcggtgcaggtaggtcattaacaccacttcttttcatctgtaccaca ccctggtgaaacctttgaagacataaaaaaaacctgtctgagatgttctttctaccaatctatatgtctttcggttatcaagtgtttctgcatggtaatgtc 66 202746_at aaactactaaccactgcaagctcttgtcaaattttagtttaattggcattgcttgttttttgaaactgaaattacntgagtttcattttttctttgaatttatagggtttagatttctg aaagcagcatgaatatatcacctaacatcctgacaataaattccatccgttgttttttttgtttgtttgttttttcttttcctttaagtaagctctttattcatcttatggtgcagcaa ttttaaaatttgaaatattttaaattgtttttgaactttttgtgtaaaatatatcagatctcaacattgttggtttcttttgtttttcattttgtacaactttcttgaatttagaaattacat ctttgcagttctgttaggtgctctgtaattaacctgacttatatgtgaacaattttcatgagacagtcatttttaactaatgcagtgattctttctcactactatctgtattgtgga atgcacaaaattgtgtaggtgctgaatgctgtaaggagtttaggttgtatgaattctacaaccctataata 67 202760_s_at gagatactatttttgctgagcaaccagtgtgtttcaggatgatacaaagaaaaatatagaatagaaataagtgcaggcttggaatcagctacaaatcctaaagat ggggtgtgtgtggatgtgtgtgtgtgtgtgtgtacaccattgtgtgtttgtaaaatgtgtatgttcatgagtaagggtgtgtgtgtgtgtgtattaaaattccagagtgaccg tggcacttgggtgtacaggtaattcctccagagctgtttgctggcttcaggagtggagtgagaatttcttttttatgaaaagggatataaaggcaccgagctgatgca gtatttgtaatattaagttgacctaacaaggtatttgcatgagtcacaattacaaagttttgagcggttttgtaatttgacatttaggaaagtctcctatttattctcatacttta cattcatgcttagtatactatagaggatgccagctttaatctttctg 68 202766_s_at gctttcaattgatggactactctattttttgcaaatttgtaaactttgcttctccaaatacaagtactaggttgtccatttatggtacctatttggtgctagtaaattttcaaacta gatttataaatgcactgtaatatgtacacaacttagaaaccaaattacaagtattcagttccaatacttcattaatttcaatcaaccaaagttagttcagtagcttatctc agttatgagtataatacattacatgtaaattaagtgtgtgtatactgtaatcgtgctattttttatcattgaaacatttataaactagaataataatgcccttaatgtgagggt ttgtaatggtgcttattaagaccaaagacttgttaaatgtatacaccaagtggtaatgaaatttcgtgactggcccacacgtgcatagaggtctgggaggaccagg aaacagcctcagtggccagaggatcaccagtgcatccttcatcacagcatgtgcaatatgccaagattaccctcggtcattcctgtcaacaaggg 69 202768_at gcgtgagtgtgtgagcgcttctgcagcctcggcctaggtcacgttggccctcaaagcgagccgttgaattggaaactgcttctagaaactctggctcagcctgtctc gggctgacccttttctgatcgtctcggcccctctgattgttcccgatggtctctctccctctgtcttttctcctccgcctgtgtccatctgaccgttttcacttgtctcctttctgac tgtccctgccaatgctccagctgtcgtctgactctgggttcgttggggacatgagattttattttttgtgagtgagactgagggatcgtagatttttacaatctgtatctttga caattctgggtgcgagtgtgagagtgtgagcagggcttgctcctgccaaccacaattcaatgaatccccgacccccctaccccatgctgtacttgtggttctctttttgt attttgcatctgaccccggggggctgggacagattggcaatgggccgtccc 70 202838_at agaaagaggcgctgctcactgttttcctgcttcagtttttctcttatagtaccatcactataatcaacgaacttctcttctccacccagagatggcttttccaacacatttta attaaaggaactgagtacattaccctgatgtctaaatggaccaaagatctgagatccattgtgattatatctgtatcaggtcagcagaagaaggaactgagcagtt gaactctgagttcatcaattctaatatttggaaattatctacaatggaatcttccctctgttctctgataacctacttgcttactcaatgcctttaagccaagtcaccctgttg cctatgggaggaggtggaaggatttggcaagctcaaccacatgctatttagttagcatcagttgtcaccaacagtctttctgcaaagggcaggagagctttggggg aaaggaaaaggcttaccaggctgctatggtcaactcttcagaa 71 202888_s_at agccctggagaagacgaaagccaacatcaagtgggtgaaggagaacaaggaggtggtgctccagtggttcacagaaaacagcaaatagtccccagccctt gaagtcacccggccccgatgcaaggtgcccacatgtgtccatcccagcggctggtgcagggcctccattcctggagcccgaggcaccagtgtcctcccctcaa ggacaaagtctccagcccacgttctctctgcctgtgagccagtctagttcctgatgacccaggctgcctgagcacctcccagcccctgcccctcatgccaaccccg ccctaggcctggcatggcacctgtcgcccagtgccctggggctgatctcagggaagcccagctccagggccagatgagcagaagctctcgatggacaatgaa cggccttgctgggggccgccctgtaccctctttcacctttccctaaagaccctaaatctgaggaatcaacagggcagcagatctgtatatttttttc 72 202920_at attatctggtcttttcctgttgtgcaaaaatgactcattgctccgaatgtcaaaaacaaatgcgacaaacaatggcacttcatcatttaaagtaatgttgccaagagaa aaaatttcctgggagggaggtttcccacaagccaaatctcctaagcctcaaatgctagcactttttggcagttggataggaaatgagacattctttggcagccaaa ataagagaggccgatggtgaaactttttgagacaccctatggccttcttgtcaaaaccttcactggagctcaagaaaagcatttctgttgtgttatttgcagtgcagat gatgtctgtgtaacaacataatggttattcacctttttttgattttgatttttgctgtgttatcaaaaacttgaatactgtgagaagaagtgaattttcagttgacgaatcagc atcttgttcccatggtgataac 73 202953_at cttcgaccacgtgatcaccaacatgaacaacaattatgagccccgcagtggcaagttcacctgcaaggtgcccggtctctactacttcacctaccacgccagctc tcgagggaacctgtgcgtgaacctcatgcgtggccgggagcgtgcacagaaggtggtcaccttctgtgactatgcctacaacaccttccaggtcaccaccggtg gcatggtcctcaagctggagcagggggagaacgtcttcctgcaggccaccgacaagaactcactactgggcatggagggtgccaacagcatcttttccgggtt cctgctctttccagatatggaggcctgacctgtgggctgcttcacatccaccccggctccccctgccagcaacgctcactctacccccaacaccaccccttgccca gccaatggacacagtagggcttggtgaatgctgctgagtgaatgagtaaataaactcttcaaggccaaggaacagtggtctaattcaactctgtgtcccagcact ggcacaccagaagtgccatgctcagaaa 74 202957_at tgatgagctttcctttgatccggacgacgtaatcactgacattgagatggtggacgagggctggtggcggggacgttgccatggccactttggactcttccctgcaa attatgtcaagcttctggagtgactagagctcactgtctactgcaactgtgatttcccatgtccaaagtggctctgctccaccccctccctattcctgatgcaaatgtcta accagatgagtttctggacagacttccctctcctgcttcattaagggcttggggcagagacagcatggggaaggaggtccccttccccaagagtcctctctatcctg gatgagctcatgaacatttctcttgtgttcctgactccttcccaatgaacacctctctgccaccccaagctctgctctcctcctctgtgagctctgggcttcccagtttgttt acccgggaaagtacgtctagattgtgtggtttgcctcattgtgctatttgcccactttccttccctgaagaaatatctgtgaaccttctttctgttcagtccta 75 202992_at gctggaatacttactcttgtcgggagattgaaccactaaaatgttagagcagaattcattatgctgtggtcacaggggtgtcttgtctgagaacaaatacaattcagt cttctctttggggttttagtatgtgtcaaacataggactggaagtttgcccctgttcttttttcttttgaaagaacatcagttcatgcctgaggcatgagtgactgtgcatttga gatagttttccctattctgtggatacagtcccagagttttcagggagtacacaggtagattagtttgaagcattgaccttttatttattccttatttctctttcatcaaaacaaa acagcagctgtgggaggagaaatgagagggcttaaatgaaatttaaaataagctatattatacaaatactatctctgtattgttctgaccctggtaaa 76 202994_s_at aatgcgaaggctaagtgtcaccccctttctctgcctctggctgggccttgctaagggccaaggaaagaaagacattttttagggggcagccagtccaaatgccaa aagaagaccagttcttgccctgattgtatgaaatttgacattttggcactttttttttttttttnggccaatcagattttctatgttctaaggacatggctgctgtagaatagca cagacgtggatgataaattatccccagaagcagcatgacagaatgcctcggggagcacttggaagggaaattgcagttctgttgaaatagaggaaaatccctt ggtaaagacacagcctgttaggctcgtgtgggcctccagtatgttcaccaggggaa 77 202995_s_at aacgatgtcacatgcgtgttcgaccccgtgcacaccatctcccacaccgtcatctcgctgcctaccttccgcgagttcacccgccctgaagagatcatcttcctccg ggccatcacgccaccgcatcctgccagccaggctaacatcatcttcgacatcacggaagggaacctgcgggactcttttgacatcatcaagcgttacatggacg gcatgaccgtgggtgtcgtgcgccaggtgcggcccatcgtgggcccatttcatgccgtcctgaagctggagatgaactatgtggtcgggggcgtggtttcccacc gaaatgttgtcaacgtccgcatcttcgtctctgagtactggttctgagggctggtctgccgcacagccgcaggtgcacctccaggccaaatcattgctgccagtgac tgtggtctgtacttgtttataccctcag 78 203000_at gacagacctgagaccaatctgggtagaagcaaaaagttgaaccttttaaagtgctgaacacaaatccaaattcgaatggttcaagcagccgtgaaatcgctctt cataaagtgggcttaattctctagtttaagttcttttgatggaatgaattaattaatgtgtcaggtggcttatttgtggatgccatgattgatgatgttcattttaagctcttacc tatagtacaagtacatgatgctactgaatatttttccacttggaaactgtgagctggttgttgcattaaaacacacatacaaacaaaatcaaaaacactgcggacttt cactcaagctggtctttcttccccagtgtaaggcaatcctgcctactaacaacaccaacaacaaaacactccatctgtgaanntgacgcagttaagggggctagg cagggcatttgtgccaactaagaatcaccagatacccaccataagtacctatcgcagttttgaagtc 79 203001_s_at acctcgcaacatcaacatctatacttacgatgatatggaagtgaagcaaatcaacaaacgtgcctctggccaggcttttgagctgatcttgaagccaccatctcct atctcagaagccccacgaactttagcttctccaaagaagaaagacctgtccctggaggagatccagaagaaactggaggctgcaggggaaagaagaaagt ctcaggaggcccaggtgctgaaacaattggcagagaagagggaacacgagcgagaagtccttcagaaggctttggaggagaacaacaacttcagcaagat ggcggaggaaaagctgatcctgaaaatggaacaaattaaggaaaaccgtgaggctaatctagctgctattattgaacgtctgcaggaaaaggagaggcatgc tgcggaggtgcgcaggaacaaggaactccaggttgaactgtctggctgaagcaagggagggtctggcacgcc 80 203058_s_at atggcctctgtgaataatgtaactccagttacacggtgacttttaatagcatacagtgatttgatgaaaggacgtcaaacaatgtggcgatgtcgtggaaagttatctt tcccgctctttgctgtggtcattgtgtcttgcagaaaggatggccctgatgcagcagcagcgccagctgtaataaaaaataattcacactatcagactagcaaggc actagaactggaaaagaccacagaaaacaaagaatccaaccctttcatcttacaggtgaacaaactgtgatgatgcacatgtatgtgttttgtaagctgtgagca ccgtaacaaaatgtaaatttgccattattaggaaagtgctggtggcagtgaagaagcacccaggccacttgactcccagtctggtgccctgtctacaccagacaa cacaggagctgggtcagattcccctcagctgcttaacaaagttcctcgaacagaaagtgcttacaaagctgccttctcggatact 81 203060_s_at agctgccttctcggatactgaaaggtcgagttttctgaactgcactgattttattgcagttgaaaaacccaaagctattccaaagatttcaagctgttctgagacatctt ctgatggctttacttcctgagaggcaatgtttttactttatgcataattcattgttgccaaggaataaagtgaagaaacagcacctttttaatatataggtctctctggaag agacctaaatttagaaagagaaaactgtgacaattttcatattctcattcttaaaaaacactaatcttaactaacaaaagttcttttgagaataagttacacacaatgg ccacagcagtttgtctttaatagtatagtgcctatactcatgtaatcggttactcactactgcctttaaaaaaaaccagcatatttattgaaaacatgagacaggattat agtgccttaaccgatatattttgtgacttaaaaaatacatttaaaactgctcttctgctctagtaccatgcttagtgcaaatgattatttctatgtacaactgatgcttgttctt attt 82 203066_at ttcagttgctaatgaggctcctccgctctggacacaacccttttatagattaatttctctgccaattaacttgtcattttcagtacatattttactattccacaccaaccataat tacaacaagggatttttcttatgcactcctatgcatgtgaataacatgtggtgtaattctgcttcttacagaagtattactgaaggtattatttccaatattatttggtttattat gcggatcttttttatatatgcagtcccatcccttctgtgccactcaatgccatccagacatggtttttccctccaggggcctttctctccagagggcacttcggctgcctct gcttcctctcattcgaggcccggctcttgctgacagaataggttccgttctgggcggtggttctcgagcctgccattcaaaaccaaagcaaattggagcatttctcac aacatggtattgaagttcctttttgttctcaaaagttgtgaccgtgttaaattgtactcccttagtcctgtaaggtatgttaagtgaatcgcagttacgctgtactttta 83 203131_at agaaaatttgccaatctttcctactttctatttttatgatgacaatcaaagccggcctgagaaacactatttgtgactttttaaacgattagtgatgtccttaaaatgtggtct gccaatctgtacaaaatggtcctatttttgtgaagagggacataagataaaatgatgttatacatcaatatgtatatatgtatttctatatagacttggagaatactgcc aaaacatttatgacaagctgtatcactgccttcgtttatatttttttaactgtgataatccccacaggcacattaactgttgcacttttgaatgtccaaatttatattttagaa ataataaaaagaaagatacttacatgttcccaaaacaatggtgtggtgaatgtgtgagaaaaactaacttgatagggtctaccaatacaaaatgtattacgaatg cccctgttcatgtt 84 203240_at ccaggactacagaataccatcccctggtaccgtgtagttgccgaagtccagatctgccatggcaaaacggaggctgtgggccaggtccacatcttcttccaggat gggatggtgacgttgactccaaacaagggtgtgtgggtgaatggtctccgagtggatctcccagctgagaagttagcatctgtgtccgtgagtcgtacacctgatg gctccctgctagtccgccagaaggcaggggtccaggtgtggcttggagccaatgggaaggtggctgtgattgtcagcaatgaccatgctgggaaactgtgtggg gcctgtggaaactttgacggggaccagaccaatgattggcatgactcccaggagaagccagcgatggagaaatggagagcgcaggacttctccccatgttat ggctgatcagtcatccaccaggaacgaagatttcctgaagaagacctggtccctctggaggttgcggtggctgaaggatgcatcatgtgctcctaccctgctctac cgcttttctgggtcacagag 85 203296_s_at aaagacaagcattgggtcagacccataaaccacctcccaaaggctgtcatttcattgcactggaattttgctttatcagaagcaaggaagtaagggagtcattgc cttgggcctgggaatctaagtgggagacaatattaatttggatccgattaattggagattactaactgtggacaaaagtttatctttgcacaatcaataaaaatggcat ttttttagtaaattaagagcataaacaatattgctagaggtggcatgtttagtctaccaaaaacaatacttttcaggcactttagaaatatccttttagaagcagcgagt gcatgggctaattatcatcaatctttatgtatttgttaaagaaacatctacaggatctttattggtgaccttttgta 86 203305_at gtccttcacatcaccattttgagacctcagcttggcactcaggtgctgaagggtaatatggactcagccttgcaaatagccagtgctagttctgacccaaccacaga ggatgctgacatcatttgtattatgttccaaggctactacagagaaggctgcctgctatgtatttgcaaggctgatttatggtcagaatttccctctgatatgtctagggtg tgatttaggtcagtagactgtgattcttagcaaaaaatgaacagtgataagtatactgggggcaaaatcagaatggaatgctctggtctatataaccacatttctgag cctttgagactgttcctgagccttcagcactaacctatgagggtgagctggtcccctctatatatacatcatacttaactttactaagtaatctcacagcatttgccaagt ctcccaatatccaatt 87 203343_at atgtgtcactgattttttagctcaaaatcatcactgttaatttccagtcaccccaaatatggttaaaagatttttttttttaatcatgaagagaaaattagtagcatttctttctc tccccattatttattggttttcctcactaatctttttttttttagtccaaaagccaaaaatatttatcttggttttacattttaatttccattcttaattgtaatttttttctttaaataagga aaccaatataatctcatgtataaaaacttaaatattttacaagttacatatagcatcattctaaaataagaattttttttgttttctgtctgcttttttcttatgtctcttgttgagtttt atattttcagtggttatttttgcttgtgttagatcattattaaaatatatccaatgtccctttgatacttgtgctctgctgagaatgtacagtttgcattaaacatcccaggtctca tccttcaggaattt 88 203382_s_at gaagcgcctggcagtgtaccaggccggggcccgcgagggcgccgagcgcggcctcagcgccatccgcgagcgcctggggcccctggtggaacagggcc gcgtgcgggccgccactgtgggctccctggccggccagccgctacaggagcgggcccaggcctggggcgagcggctgcgcgcgcggatggaggagatgg gcagccggacccgcgaccgcctggacgaggtgaaggagcaggtggcggaggtgcgcgccaagctggaggagcaggcccagcagatacgcctgcaggc cgaggccttccaggcccgcctcaagagctggttcgagcccctggtggaagacatgcagcgccagtgggccgggctggtggagaaggtgcaggctgccgtgg gcaccagcgccgcccctgtgcccagcgacaatcactgaacgccgaagcc 89 203474_at actgtgatataggtactctgatttaaaactttggacatcctgtgatctgttttaaagttggggggtgggaaatttagctgactagggacaaacatgtaaacctattttcct atgaaaaaagttttaaatgtcccacttgaataacgtaattcttcatagtttttttaatctatggataaatggaaacctaattatttgtaatgaattatttagacagttctaagc cctgtcttctgggagttatcaattttaaagagaacttttgtgcaattcaaatgaagtttttataagtaattgaaaatgacaacacaataacactttctgtataaaagtatat attttatgtgatttattcctactaaatgaaagtgcactactgcctcatgtaaagactcttgcacgcagagcctttaagtgactaaggaacaacatagatagtgagcata gtccccacctccacccctcacaatttatttgaatacttcaattgtgcctctcaa 90 203477_at ttcagacagttatatcctccttttaaaccattgttgttgagtgtaagatgtccttcatgttttcttataaagtcagtgtttagaaatgttaccctttctaagttatatacagatca aatgcttttttctttcacgtacatccatcatttgcaactgctgttcgtacacagaaacaggactgctcaaatgatcctatttgtattttctgatgctatcagactctaatgtttttt tccctaaaatattattgccatcatgctttaggaatttttatatttttacacaatcatattttagtatggtgtctgtttatgtaactctgacttgctggaaaagttgaaactccaaa taatctgaaactagaaaagaaatagcacataattactaccttccccttggcggctctcctcccccaacccccaccccacaattttatgacttcca 91 203638_s_at caacgtctaactggacttcccaagataaatggtaccagcgtcctcttaaaagatgccttaatccattccttgaggacagaccttagttgaaatgatagcagaatgtg cttctctctggcagctggccttctgcttctgagttgcacattaatcagattagcctgattctcttcagtgaattttgataatggcttccagactctttgcgttggagacgcctg ttaggatcttcaagtcccatcatagaaaattgaaacacagagttgttctgctgatagttttggggatacgtccatctttttaagggattgctttcatctaattctggcagga cctcaccaaaagatccagcctcatacctacatcagacaaaatatcgccgttgttccttctgtactaaagtattgtgttttgctttggaaacacccactcact 92 203645_s_at gccagacgctggggccatagtgagtgtgggcacaaggaagacgctgcagtgaattgcacagatatttcagtgcagaaaaccccacaaaaagccacaacag gtcgctcatcccgtcagtcatcctttattgcagtcgggatccttggggttgttctgttggccattttcgtcgcattattcttcttgactaaaaagcgaagacagagacagc ggcttgcagtttcctcaagaggagagaacttagtccaccaaattcaataccgggagatgaattcttgcctgaatgcagatgatctggacctaatgaattcctcagg aggccattctgagccacactgaaaaggaaaatgggaatttataacccagtgagttcagcctttaagataccttgatgaagacctggactattgaatggagcaga aattcacctctctcactgactattacagttgcatttttatggagttcttcttctcctaggattcc 93 203680_at ttttcattgttcattgatatgctcagtatgctgccacataagatgaatttaattatattcaaccaaagcaatatactcttacatgatttctaggccccatgacccagtgtcta gagacattaattctaaccagttgtttgcttttaaatgagtgatttcattttgggaaacaggtttcaaatgaatatatatacatgggtaaaattactctgtgctagtgtagtctt actagagaatgtttatggtcccacttgtatatgaaaatgtggttagaatgttaattggataatgtatatataagaagttaaagtatgtaaagtataacttcagccacatttt tagaacactgtttaacatttttgcaaaaccttcttgtaggaaaagagagctctctacatgaagatgacttgttttatatttcagattttattttaaaagccatgtctgttaaac aagaaaaaacacaaaagaactccagattcctggttcatcattctgtattcttactcactttttcaagtt 94 203729_at atcctcattcttatactgcttttcgtggccactttggacaagtcctggtggactctccctgggaaagagtccctgaatctctggtacgactgcacgtggaacaacgaca ccaaaacatgggcctgcagtaatgtcagcgagaatggctggctgaaggcggtgcaggtcctcatggtgctctccctcattctctgctgtctctccttcatcctgttcat gttccagctctacaccatgcgacgaggaggtctcttctatgccaccggcctctgccagctttgcaccagcgtggcggtgtttactggcgccttgatctatgccattcac gccgaggagatcctggagaagcacccgcgagggggcagcttcggatactgcttcgccctggcctgggtggccttccccctcgccctggtcagcggcatcatcta catccacctacggaagcgggagtgagcgccccgc 95 203748_x_at caagtatcggggctctgctatcaaggtgcaaagtccttcgtggatgcaacctcaaccatatattctacagcaccctggtgccgtgttaactccctcaatggagcaca ccatgtcactacagcccgcatcaatgatcagccctctggcccagcagatgagtcatctgtcactaggcagcaccggaacatacatgcctgcaacgtcagctatg caaggagcctacttgccacagtatgcacatatgcagacgacagcggttcctgttgaggaggcaagtggtcaacagcaggtggctgtcgagacgtctaatgacc attctccatatacctttcaacctaataagtaactgtgagatgtacagaaaggtgttcttacatgaagaagggtgtgaaggctgaacaatcatggatttttctgatcaatt gtgctttaggaaattattgacagttttgcacaggttcttgaaaacgttatttataatgaaatcaactaaaactatttttgctataagttctataaggtgcataaaacccttaa attcatctagtagctgttccccc 96 203766_s_at caccttgggtctgtgtcacttgtaggtttctctgcctccaggttgcctcaacagcaggaggcacagcagtttcaccatctttgaggtgagggtggggtgccccagcta ggaagcaagatcgctgtgctaggtctgaccaaaaccagagggcagtctagtcctgggggtaaagccctcagatcccagggtacactcttctccattccctccac ccacttgcctgtcaccccagtcacctaagcaatcactgggcccagaggagaggagacagacacacactggctcctggacctaaagggtatgagctggagcta aggccagctagagcttccactgtcagccctcactgtcagccccactgcacccccctgtgcctgctgggcactgggcactagctagatgctttaggttgcttcagctg atccttcaactctgtgaggtg 97 203881_s_at tatgtgacgctggaccttttctttacccaaggatttttaaaactcagatttaaaacaaggggttactttacatcctactaagaagtttaagtaagtaagtttcattctaaaa tcagaggtaaatagagtgcataaataattttgttttaatctttttgtttttcttttagacacattagctctggagtgagtctgtcataatatttgaacaaaaattgagagctttat tgctgcattttaagcataattaatttggacattatttcgtgttgtgttctttataaccaccgagtattaaactgtaaatcataatgtaactgaagcataaacatcacatggc atgttttgtcattgttttcaggtactgagttcttacttgagtatcataatatattgtgttttaacaccaacactgtaacatttacgaattatttttttaaacttcagttttactgcatttt cacaacatatcagacttcaccaa 98 203908_at tgtgtaatacgccaaccagtcaagttgtgttttggccagagatttagatatgtccaatttcctggctcatttcattgtgctctatgggtacgtataaaaagcaagaattctg tttcctaggcaaacattgcaactcagggctaaagtcatccagtgaaacttttagagccagaagtaactttgtcccagtcctacaatgtgaaaagagtgaatagttgc ctctttttagccattttcatggctggtacatattcgtacgcattacttttcagaatcaatacgcactttcagatattcttatttttattctcttaagtctttattaactttggagagag aaatgatgcatctttttattttaaatgaagtagatcaacatggtggaacaaaatgataaagaacagaaaacatttcaatatattactaataactttttccaatataaatc ctaaaattcctataacatagtattttacagttttatgaagctttctattgtgacttttatg 99 203913_s_at aacactcacatacaagttcatactttaaaagaggaaagctacttaacaatgacaaatatttcacaataataatttttacttatataccatctttcaactgaacatttcagt tcttccaagagcttcttagagtagtatattttgggggcagtcaaggaataaactacagtgtaaacatatcccagatgaaaactgctgtatggaaaaatgacagaaa gtaactgattgacactgttgattcacagttcangcctcctatctgggaaagacatttctttcctctgctcactttaagaacttttaccgactccaaaaatctcaggaatta aacttttaacagttacagcaataaagaatagttagtactccaaaaatattatatttaagatgctcaacaagaaaaaaatgcaaatgtaatatttttttcaaattacttctt tattgacttgtcca 100 203914_x_at gatttccaaatcagtcgttttctcaaaaaaatatcgtataagtgactcatcctgtctgctaactccagacctcccagcttgaagccaaatctttccatgtgagattgatat ggatttcctagaagtactggaatgttgtcatatcttgccctattttaattctgctatagaaaacaattgccttcacttttaaggagtaatttgaatattaataactctggtcta gattttcatataatgtattaaagacaaagtagtgaacatcaatgaacatctgatagagataaactgtaatcaggcataagcttgtttgtatgttctggcagtgactaat cagtaaatgatgtcggtttgcccagtatcacttatcttctgtatttttcctctgtcgtgtaaatagtataaccttttcatttatggacaattttttggactagtagccttcaatata cattctgctt 101 203951_at acgcacacaactactacaattccgcctaggtccacaaggccttcactgttttccccccaagggaggctgctgctgctcttggctggagccagccagggccagcc gaccccctctccctgcatggcatcctccagcccctgtagaactcaacctctacagggttagagtttggagagagcagactggcggggggcccattggggggaa ggggaccctccgctctgtagtgctacagggtccaacatagaacagggtgtccccaacagcgcccaaaggacgcactgagcaacgctattccagctgtccccc cactccctcacaagtgggtacccccaggaccagaagctcccccagcaaagcccccagagcccaggctcggcctgcccccaccccattcccgcagtgggag caaactgcatgcccagagacccagcggacacacgcggtttggtttgcagcgactggcatac 102 203963_at ccaaatttcatttcagccacttctgcaggatccctactgccaacctggaatggagacttttatctacttctctctctctgaagatgtcaaatcgtggtttagatcaaatata tttcaagctataaaagcaggaggttatctgtgcagggggctggcatcatgtatttaggggcaagtaataatggaatgctactaagatactccatattcttccccgaat cacacagacagtttctgacaggcgcaactcctccattttcctcccgcaggtgagaaccctgtggagatgagtcagtgccatgactgagaaggaaccgaccccta gttgagagcaccttgcagttccccgagaactttctgattcacagtctcattttgacagcatgaaatgtcctcttgaagcatagctttttaaatatctttttccttctactcctcc ctctgactctaagaattctctcttctggaatcgcttg 103 203980_at gtgtgatgcttttgtaggtacctggaaacttgtctccagtgaaaactttgatgattatatgaaagaagtaggagtgggctttgccaccaggaaagtggctggcatggc caaacctaacatgatcatcagtgtgaatggggatgtgatcaccattaaatctgaaagtacctttaaaaatactgagatttccttcatactgggccaggaatttgacga agtcactgcagatgacaggaaagtcaagagcaccataaccttagatgggggtgtcctggtacatgtgcagaaatgggatggaaaatcaaccaccataaaga gaaaacgagaggatgataaactggtggtggaatgcgtcatgaaaggcgtcacttccacgagagtttatgagagagcataagccaagggacgttgacctggac tgaagttcgcattgaactctacaacattctgtgggatatattgttcaaaaagatattgttgttttccctgatttagcaagca 104 204018_x_at ggtccccacagactcagagagaacccaccatggtgctgtctcctgccgacaagaccaacgtcaaggccgcctggggtaaggtcggcgcgcacgctggcga gtatggtgcggaggccctggagaggatgttcctgtccttccccaccaccaagacctacttcccgcacttcgacctgagccacggctctgcccaggttaagggcca cggcaagaaggtggccgacgccctgaccaacgccgtggcgcacgtggacgacatgcccaacgcgctgtccgccctgagcgacctgcacgcgcacaagctt cgggtggacccggtcaacttcaagctcctaagccactgcctgctggtgaccctggccgcccacctccccgccgagttcacccctgcggtgcacgcctccctgga caagttcctggcttctgtgagcaccgtgctgacctccaaataccgttaagctg 105 204034_at gcccaggctgacttacacattgaggatggagactccatccgcttcgggcgcttcgcgttggagaccagggccagccctggccacaccccaggctgtgtcacctt cgtcctgaatgaccacagcatggccttcactggagatgccctgttgatccgtgggtgtgggcggacagacttccagcaaggctgtgccaagaccttgtaccactc ggtccatgaaaagatcttcacacttccaggagactgtctgatctaccctgctcacgattaccatgggttcacagtgtccaccgtggaggaggagaggactctgaa ccctcggctcaccctcagctgtgaggagtttgtcaaaatcatgggcaacctgaacttgcctaaacctcagcagatagactttgctgttccagccaacatgcgctgtg gggtgcagacacccactgcctgatctcacttctgtcagatgctcccatccactattaatgcactaggtgggaggagagggcggcaatgacactgcacct 106 204036_at aattgccacattttcttatggcattaaaaattttacaaaaacataattttaatggctatattatattccatttaatggatgcaactcangtttatttaaccattcccatngttgtt aactatttaggttgtttctaattttcattattataaagttgcagaaatttggtgtacataaaactgtctccatataattgattattaggatatattcccatgaaggattcnttttttt aaaaaaatgtgaaatntcatcttgtacttacacctttcatgnaaagggatttcctgcttttgtactgcatgggtggcagttgtgaggaaaagccagtcaaatgacctttt tacaaaagaaatgcagtggtcacttcagttgagagtgactttttaatacaacaagatcaactagaagaattcaactgtctcaagaatcaaggtaccccaatatatct cgcaattccaaactttgtttgagggactcgttatccagctcttggtagccacacctgcaatgta 107 204069_at aagccttacagttatcctgcaagggacaggaaggtctgatttgcaggatttttagagcattaaaataactatcaggcagaagaatctttcttctcgcctaggatttcag ccatgcgcgcgctctctctctttctctctcttttcctctctctccctctttctagcctggggcttgaatttgcatgtctaattcatttactcaccatatttgaattggcctgaacag atgtaaatcgggaaggatgggaaaaactgcagtcatcaacaatgattaatcagctgttgcaggcagtgtcttaaggagactggtaggaggaggcatggaaacc aaaaggccgtgtgtttagaagcctaattgtcacatcaagcatcattgtccccatgcaacaaccaccaccttatacatcacttcctgttttaagcagctctaaaacata gactgaagatttatttttaatatgttgactttatttctgagcaaagcatcggtcatgtgtgtattttttcatagtcccaccttggagcatttatg 108 204083_s_at gaaggcggctgatgagagcgagagaggaatgaaggtcatcgaaaaccgggccatgaaggatgaggagaagatggaactgcaggagatgcagctgaag gaggccaagcacatcgctgaggattcagaccgcaaatatgaagaggtggccaggaagctggtgatcctggaaggagagctggagcgctcggaggagagg gctgaggtggccgagagccgagccagacagctggaggaggaacttcgaaccatggaccaggccctcaagtccctgatggcctcagaggaggagtattcca ccaaagaagataaatatgaagaggagatcaaactgttggaggagaagctgaaggaggctgagacccgagcagagtttgccgagaggtctgtggcaaagtt ggagaaaaccatcgatgac 109 204122_at catggggggacttgaaccctgcagcaggctcctgctcctgcctctcctgctggctgtaagtggtctccgtcctgtccaggcccaggcccagagcgattgcagttgct ctacggtgagcccgggcgtgctggcagggatcgtgatgggagacctggtgctgacagtgctcattgccctggccgtgtacttcctgggccggctggtccctcggg ggcgaggggctgcggaggcagcgacccggaaacagcgtatcactgagaccgagtcgccttatcaggagctccagggtcagaggtcggatgtctacagcga cctcaacacacagaggccgtattacaaatgagcccgaatcatgacagtcagcaa 110 204130_at tccccagcagtggctcggtgagccatgtgcacctatggcccagccactgcagcacaggaggctccgtgagccttggttcctccccgaaaacccccagcattac gatcccccaagtgtcctggaccctggcctaaagaatcccacccccacttcatgcccactgccgatgcccaatccaggcccggtgaggccaaggtttcccagtga gcctctgcgcctctccactgtttcatgagcccaaacaccctcctggcacaacgctctaccctgcagcttggagaactccgctggatgggagtctcatgcaagactt cactgcagcctttcacaggactctgcagatagtgcctctgcaaactaaggagtgactaggtgggttggggaccccctcaggattgtttctcggcaccagtgcctca gtgctgcaattgagggctaaatcccaagtgtctcttgactggctcaagaattagggcccca 111 204135_at cagaccggcagtcatcatggcagtttcagcgttcaaacagcaatagctcaagtgtgataactactgaggataataaaatccacattcacttaggaagtccttacat gcaagctgtagccagcccttcagcaccactgcaggataaccgaactcaaggcttaattaacggggcactaaacaaaacaaccaataaagtcaccagcagta ttactatcacaccaacagccacacctcttcctcgacaatcacaaattacagtaagtaatatatataactgaccacgctcaccctcatccagtccatactgatatttttg caaggaactcaatccttttttaatcatccctccatatcccccaagactgactgaactcgtactttgggaaggtttgtgcatgaactatacaagagtatctgaaactaac tgttgcctgcatagtcatatcgagtgtgcacttactgtatatcttttcat 112 204326_x_at gcgtgttttcctcttgatcgggaactcctgcttctccttgcctcgaaatggaccccaactgctcctgctcgcctgttggctcctgtgcctgtgccggctcctgcaaatgca aagagtgcaaatgcacctcctgcaagaagagctgctgctcctgctgccctgtgggctgtgcnaagtgtgcccagggctgcatctgcaaagggacgtcagacaa gtgcagctgctgtgcctgatgccaggacagctgtgctctcagatgtaaatagagcaacctatataaacctggatttttttttttttttttttgtacaaccctgacccgtttgct acatctttttttctat 113 204388_s_at ttccacatcagtaactgccctggggtttgtgctgtacaaatacaagctcctgccacggtcttgaagttctgttcttatgctctctgctcactggttttcaataccaccaaga ggaaaatattgacaagtttaaaggctgtgtcattgggccatgtttaagtgtactggatttaactacctttggcttaattccaatcattgttaaagtaaaaacaattcaaag aatcacctaattaatttcagtaagatcaagctccatcttatttgtcagtgtagatcaactcatgttaattgatagaataaagccttgtgatcact 114 204389_at ctttgcgggcacagagactgccacaaagtggagcggctacatggaaggggcagttgaggctggagaacgagcagctagggaggtcttaaatggtctcggga aggtgaccgagaaagacatctgggtacaagaacctgaatcaaaggacgttccagcggtagaaatcacccacaccttctgggaaaggaacctgccctctgtttc tggcctgctgaagatcattggattttccacatcagtaactgccctggggtttgtgctgtacaaatacaagctcctgccacggtcttgaagttctgttcttatgctctctgct cactggttttcaataccaccaagaggaaaatattgacaagtttaaaggctgtgtcattgggccatgtttaagtgtactggatttaactacctttg 115 204438_at taattgcttgttttctagcctggcaagatattttcataaaagagggataacaatgctgattactaccttttaaaatattttagataaatgcacagcaccacagcaccaca tctaagcattagtgatgggtagctgatgtcagcttcatgtggattttaagcactctagaaacaatgaagcttcttggcatattttaaggagctcccaaaatgtgttacct attaaattgtaactcagcaagtagaagaccatttgaaaagtcaggtacaaatttcctcaagtggcataaaaatgtagtcagttttctcttttaccagtttttatttccactc caattatttagaactttatttgtacatgtgcagaagaataaggcagctgagaatcttgtttcccccaagagagttttacaggctgagtgttgcaaatgtgttctttgtcctg ttatatgtat 116 204457_s_at gcactgccatgtatgaaagtctctttatgatgtttgtttttttgtcatttttgttctttacatcaagaaattttatgtttaaatatgcggagaatgtatattgcctctgctcctatcag ggttgctaaaccctggtacatcgtatataaaatgtattaaaactggggtttgttaccagttgctgtactttgtatatagaatttttataaattgtatgcttcagaaataatttat ttttaaaaagaaattaaaagttttaaactcacatccatattacacctttcccccctgaaatgtatagaatccatttgtcatcaggaatcaaaacccacagtccattgtga agtgtgctatatttagaacagtcttaaaatgtacagtgtattttatagaattgaagttaacattcttattttcaagagaatttatggacgttgtagaaatgtacaaatgcattt ccaaactgccttaaacgttgtatt 117 204508_s_at gggactgtctgtcaaaagactctgtatatcttttgtggatgagttttgtgagagaacagagagaccattgtacctggcacaagggctcttcatgaaaagggagactt actgggaggtgcaagacagtggcatttctcctctcctcttgctgctcagcacagccctggattgcagccccgaggctgagaccagacaaagcccgggaggcag aaagatgctccaagaaccaacactatcaatgtctttgcaaatcctcacaggattcctgtgggtccagctttggaactgggaaacctttcttcggatccgcactcattc cactgatgccagctgcccctgaaggatgccagtactgtggtgtgtgagtctcagcagccgcccacacgctcctaactctgctgcatggcagatgcctaggtgga 118 204532_x_at attaatcagccccagagtgctttaaaaaattctcttaaataaaaataatagactcgctagtcagtaaagatatttgaatatgtatcgtgccccctccggtgtctttgatc aggatgacatgtgccatttttcagaggacgtgcagacaggctggcattctagattacttttcttactctgaaacatggcctgtttgggagtgcgggattcaaaggtggt cccaccgctgcccctactgcaaatggcagttttaatcttatcttttggcttctgcagatggttgcaattgatccttaaccaataatggtcagtcctcatctctgtcctgcttc ataggtgccaccttgtgtgtttaaa 119 204570_at ctacgcgtgtccttgggcggagaagggaggtgactccggcggaagaggacaaggcagaatgcaggcccttcgggtgtcccaggcgctgatccgctccttcag ctccaccgcccggaaccgctttcagaaccgagtgcgcgagaaacagaagctcttccaggaggacaatgacatcccgttgtacctgaagggcggcatcgttga caacatcctgtaccgagtgacaatgacgctgtgtctgggcggcactgtctacagcttgtactcccttggctgggcctccttccccaggaattaagaccaagaagcc tggggggcctgagagact 120 204607_at tggtgacacaaacagccttttcccaggtacttggtacctggagcgagtggacgagcagcatcgccgaaagtatgcccggcgtcccgtctaaaggtgttctgcag atccatggaaagcttcctgggaaacgtatgctagcagagcttctccccgtgaatcatatttttaagatcccactcttagctggtaaatgaatttgaatcgacatagtag ccccataagcatcagccctgtagagtgaggagccatctctagcgggcccttcattcctctccatgctgcaatcactgtcctgggcttatggtgcctatggactaggg gtcctttgtgaaagagcaagatggagcaatggagagaagacctcttcctgaatcactggactccagaaatgtgcatgcagatcagctgttgccttca 121 204673_at ttgatgccagcatttgcatcccgggctccatcacattcatgcccaatggatgctgcaagacctgcacccctcgcaatgagaccagggtgccctgctccaccgtccc cgtcaccacggaggtttcgtacgccggctgcaccaagaccgtcctcatgaatcattgctccgggtcctgcgggacatttgtcatgtactcggccaaggcccaggc cctggaccacagctgctcctgctgcaaagaggagaaaaccagccagcgtgaggtggtcctgagctgccccaatggcggctcgctgacacacacctacaccc acatcgagagctgccagtgccaggacaccgtctgcgggctccccaccggcacctcccgccgggcccggcgctcccctaggcatctggggagcgggtgagcg gggtgggcacagcccccttcactgccctcgacagctttacctcccccggaccctctgagcctcctaagctcggcttcctctcttcagatatttattgtctgagtctttgttc agtccttg 122 204688_at cttgcttatatcatgtgctgccgacgggaaggcgtggaaaagagaaacatgcaaacaccagacatccaactggtccatcacagtgctattcagaaatctaccaa ggagcttcgagacatgtccaagaatagagagatagcatggcccctgtcaacgcttcctgtgttccaccctgtgactggggaaatcatacctcctttacacacagac aactatgatagcacaaacatgccattgatgcaaacgcagcagaacttgccacatcagactcagattccccaacagcagactacaggtaaatggtatccctgaa gaaagaaaactgactgaagcaatgaatttataatcagacaatatagcagttacatcacatttcttttctcttccaataatgcatgagcttttctggcatatgtt 123 204697_s_at cctcccgggaggacagccttgaggcgggcctgcccctccaggtccgaggctaccccgaggagaagaaagaggaggagggcagcgcaaaccgcagacc agaggaccaggagctggagagcctgtcggccattgaagcagagctggagaaagtggcccaccagctgcaggcactacggcggggctgagacaccggctg gcagggctggccccagggcaccctgtggccctggctctgctgtccccttggcaggtcctggccagatggcccggacgctgcttccggtagggaggcagcctcc agcctgcccaagcccaggccaccctatcgccccctacgcgccttgtctcctactcctgactcctacctgccctggaacatcctttgcagggcagccccacaacttt aaacattgacgattccttctctgaacacaggcagctttctagaagtttcccttcctccatcctatccactgggcacaactgcaataacttctgaccttttggtgaaagct gagaactcctgactgtaacatattctg 124 204719_at gcaggccatactggttccattgttctgtataatactgaataaataaatttacttttacatgatcgtataagtttctagataagataaacaaattctgtttaaatttttttaataa aaatcttaaaacactttttttctaacctagactgagaaattcatgtttacttttctaggtgtatgatactttgtaaagttgatactttcctaagaatttaacatgtcatatttttga aatagatttaagtgtgcttcttattgctaaaaatactaaatgtcatgggtcatagtatctgatatcaatatcgttgataacatatccacaggtaacaccatgatgtaggc ataaatggaaaacaaaaaccctactatttcaaatatattgtacttttttatttctgtaagccaactgtgtgccattttcactggacttttaaatctagactttagtgatgtctac attgtaaatgatcttttgtggatatttgtcacttggtttcagaaagttcacaaatgtagcaacagctcacatgactgagt 125 204745_x_at tcccttctcgcttgggaactctagtctcgcctcgggttgcaatggaccccaactgctcctgtgccgctggtgtctcctgcacctgcgccagctcctgcaagtgcaaag agtgcaaatgcacctcctgcaagaagagctgctgctcctgctgccctgtgggctgtgccaagtgtgcccaaggctgcatctgcaaaggggcatcggagaagtg cagctgctgcgcctgatgtcgggacagccctgctcccaagtacaaatagagtgacccgtaaaatctaggattttttgttttttgctacaatcttgacccct 126 204818_at aaaggctggcatcttatggctcatcaaaggcggctgtgaccatgttctcatcagttatgagactggagctttccaagtggggaattaaagttgcttccatccaacctg gaggcttcctaacaaatatcgcaggcaccagtgacaagtgggaaaagctggagaaggacattctggaccacctccccgctgaggtacaggaagactacggc caggactacatcttagcacagcggaatttcctcctattgatcaactcgttagccagcaaggacttctctccggtgctgcgggacatccagcatgctatcttggcgaa gagcccttttgcctattacacgccagggaaaggcgcttacttgtggatctgccttgctcactatttgcctattggca 127 204834_at ggtgtcgaactatatgccttgtatgatcagttttatgtggctaatgagtttctcaaatatcgtttacacgttggtaactataatggcacagctggagatgcattacgtttca acaaacattacaaccacgatctgaagtttttcaccactccagataaagacaatgatcgatatccttctgggaactgtgggctgtactacagttcaggctggtggtttg atgcatgtctttctgcaaacttaaatggcaaatattatcaccaaaaatacagaggtgtccgtaatgggattttctggggtacctggcctggtgtaagtgaggcacacc ctggtggctacaagtcctccttcaaagaggctaagatgatgatcagacccaagcactttaagccataaatcactctgttcattcctccaggtattcgttatctaatagg gcaattaattccttcagcacttt 128 204894_s_at ccaggaggggctgtccaatcacattcaggcatgcgaatgagctgggccctgggtgaggtgggggtctggcctagtggggaggggcctggcctgggtggggca gggcctggcctggtccaggcttgggctccattcccatcactgctgtccctcctgaggtctggattggggatggggacaaagaaatagcaagagatgagaaacaa cagaaacttttttctctaaaggactggttaaatcaattctgatacagccttacaatacaatagtatgcagctaaaaaataattgtatgtctttatatactaatatgtaataa tcttcaggtgaaaaaggcaagccacagaaatgtgtatagcgcacttcccatttgtgtttcagaaaggagtagaatataaacacataattgcttatgtatgcctattca gaataaatgggtaacactgattacttttgggaggggaaccagtaggttgaggacaggagagggaagggtcttaacacttacacccttttgtacattttg 129 204895_x_at aggagcccaggaacgacgtggtcttccagcccatttccggggaagacgtgcgcgatgtgacagccctgaacgtgagcacgctgaaggcttacttcagatgcg atggctacaagggctacgacctggtctacagcccccagagcggcttcacctgcgtgtccccgtgcagtaggggctactgtgaccatggaggccagtgccagca cctgcccagtgggccccgctgcagctgtgtgtccttctccatctacacggcctggggcgagcactgtgagcacctgagcatgaaactcgacgcgttcttcggcatc ttctttggggccctgggcggcctcttgctgctgggggtcgggacgttcgtggtcctgcgcttctggggttgctccggggccaggttctcctatttcctgaactcagctga ggccttgccttgaaggggcagctgtggcctaggctacctcaagactcacctcatccttaccgcacatttaaggcgccattgcttttgggagact 130 204897_at agcagcttattgtttctctgaaagtgtgtgtagttttactttcctaaggaattaccaagaatatcctttaaaatttaaaaggatggcaagttgcatcagaaagctttattttg agatgtaaaaagattcccaaacgtggttacattagccattcatgtatgtcagaagtgcagaattggggcacttaatggtcaccttgtaacagttttgtgtaactcccag tgatgctgtacacatatttgaagggtctttctcaaagaaatattaagcatgttttgttgctcagtgtttttgtgaattgcttggttgtaattaaattctgagcctgatattgatatg 131 204931_at gagaacgggtacattcacccggtcaacctgacgtggccctttatggtggccgggaaacccgagagtgacctgaaagaagtggtgaccgcgagccgcttatgtg gaaccaccgcgtcctgaccttggaggtgcgagtctgggaaaggcgcgctcccggggggagcgggccccgggaaggcgacccctgccctcagtgctctctgtc tctgcttccccctcgcaatgctcctctctctgtcccaccccgcgagaacactttacaacgacgaggagattcgtttccaaaccagaggagatcaattgtacttacaa agattcccatctatttaactttattaacttctaccgtgaatgactctgcaagccttgctggtcca 132 204938_s_at ttctctcgaccacttaaaacttcagacttcctgtcctgctggtatcatggagaaagtccaatacctcactcgctcagctataagaagagcctcaaccattgaaatgcc tcaacaagcacgtcaaaagctacagaatctatttatcaatttctgtctcatcttaatatgtctcttgctgatctgtatcatcgtgatgcttctctgaagttctgctacaacctc tagatctgcagcttgccacatcagcttaaa 133 204939_s_at tggcccatctattacatctacagctgacccttgaacatgggggttaggggagctgacaattcgtgggtccgcaaaatcttaactacctaatagcctactattgaccat aaaccttactgataacataaacagtaaattaacacatattttgcgtgttatatgtattatacactatattcctacaataaagt 134 204940_at aaatctgttctaagacatatgatcaacagatgagaactggtggttaatatgtgacagtgagattagtcatatcactaatatactaacaacagaatctaatcttcattta aggcactgtagtgaattatctgagctagagttacctagcttaccatactatatctttggaatcatgaaaccttaagacttcagaatgattttgcaggttgtcttccattcca gcctaacatccaatgcaggcaaggaaaataaaagatttccagtgacagaaaaatatattatctcaagtattttttaaaaatatatgaattctctctccaaatattaact aattattagattatattttgaaatgaacttgttggcccatc 135 204955_at ggacaaagagcgctatgtctccctggtgatgcctgtggccctgttcaacctgattgacacttttcccttgagaaaagaagagatggtcctacaagccgaaatgagc cagacctgtaacacctgacatgatggttcctctcttggcaattcctcttcattgtctacatagtgacatgcacacgggaaagccttaaaaatatccttgatgtacagatt ttatttgtaattttaaaagtctattttattatgagctttctttgcacttaaaaattagcatgctgctttttgtacttggaagtgtttcaaaaaattatatgaccatatttactctttcta acctttctttactccatcatggctggttgatttgtagagaaattagaacccataaccatacacaggctatcaacatgttattcaatgtgacacctaactcttttc 136 205097_at tactcatgcctttttgtttaggataaataggtaagcacaaagagctcttcaaaatcagaaaaaacaataggagtccttccttgtcttttctgtgatctctgtccttgtttctg agactttctctaccattaagctctattttagctttcagttattctagtttgtttcccatggaatctgtcctaaactggtgtttttgtcagtgacagtcttgccagtcagcaatttcta acagcattttaaatgagtttgatgtacagtaaatattgatgacaatgacagcttttaactcttcaagtcacctaaagctattatgcaggaggatttagaagtcacattca taaaacccaagngctatgggtgtattattcatgatagctggcccacaggtcatgaattgag 137 205112_at agaagctcaccaagtcaactaaacagccccgaggacttacatcaccttctcagctcttgacctcagaaagtatccaaaccaaggaggagaaacctgtgggtg gcttgtcctccagtgacacaatggattaccgacagtgactaagggcagcatgtttaacccaggtgaagatct 138 205200_at tttctggccttcacccagacgaagaccttccacgaggccagcgaggactgcatctcgcgcgggggcaccctgagcacccctcagactggctcggagaacgac gccctgtatgagtacctgcgccagagcgtgggcaacgaggccgagatctggctgggcctcaacgacatggcggccgagggcacctgggtggacatgaccg gcgcccgcatcgcctacaagaactgggagactgagatcaccgcgcaacccgatggcggcaagaccgagaactgcgcggtcctgtcaggcgcggccaacg gcaagtggttcgacaagcgctgccgcgatcagctgccctacatctgccagttcgggatcgtgtagccggc 139 205259_at gcagactgggagttgctagcaaacaaatggcttacttacaaaagcagcttttagttcagacttagtttttataaaatgagaattctgacttacttaaccaggtttgggat ggagatggtctgcatcagctttttgtattaacaaagttactggctctttgtgtgtctccaggtaactttgcttgattaaacagcaaagccatattctaaattcactgttgaat gcctgtcccagtccaaattgtctgtctgctcttatttttgtaccatattgctcttaaaaatcttggtttggtacagttcataattcaccaaaaagttcatataatttaaagaaa cactaaattagtttaaaatgaagcaatttatatctttatgcaaaaacatatgtctgtctttgcaaagga 140 205267_at gcacccagccttttaccatgtgggtttctttagtgtcttaaaagcgtccataagccaccattctgtggaaccaaggccccctccacgcaaacaccctccctcctggg gacctctggagcctcagccagaagtaccattaggtttaattttaatttgttttgctggagaaacatcaggtttgtaggagactgagttgttagcaggtgtgcttagctctt gatagtgaacgtgtaccttgggaactggctcacccacctgctaatagcaccatcgtcactattaagcagacatttcagttggtagaatccatgtagaagtcatggac ttttctgggaaatgacttttctgggaaatgacagtttctttgacatattttctttgcccactt 141 205382_s_at cgccatcaccgagcgcttgatgtgcgcggagagcaatcgccgggacagctgcaagggtgactccgggggcccgctggtgtgcgggggcgtgctcgagggc gtggtcacctcgggctcgcgcgtttgcggcaaccgcaagaagcccgggatctacacccgcgtggcgagctatgcggcctggatcgacagcgtcctggcctag ggtgccggggcctgaaggtcagggtcacccaagcaacaaagtcccgagcaatgaagtcatccactcctgcatctggttggtctttattgagcacctactatatgc agaaggggag 142 205403_at gggccacgccaggaatattcagaaaataatgagaactacattgaagtgccattgatttttgatcctgtcacaagagaggatttgcacatggattttaaatgtgttgtc cataataccctgagttttcagacactacgcaccacagtcaaggaagcctcctccacgttctcctggggcattgtgctggccccactttcactggccttcttggttttggg gggaatatggatgcacagacggtgcaaacacagaactggaaaagcagatggtctgactgtgctatggcctcatcatcaagactttcaatcctatcccaa 143 205412_at gctgctctggttctcatgacggcagatgcagcgaagaggctcaatgttacaccactggcaagaatagtagcatttgctgacgctgctgtagaacctattgattttcca attgctcctgtatatgctgcatctatggttcttaaagatgtgggattgaaaaaagaagatattgcaatgtgggaagtaaatgaagcctttagtctggttgtactagcaa acattaaaatgttggagattgatccccaaaaagtgaatatcaatggaggagctgtttctctgggacatccaattgggatgtctggagccaggattgttggtcatttga ctcatgccttgaagcaaggagaatacggtcttgccagtatttgcaatggaggaggaggtgcttctgccatgctaattcagaagctgtagacaacctctgctatttaa ggagacaaccctatgtgaccagaa 144 205433_at ggaaagcaggattccatcgctggaacaattacatgatggactggaaaaatcaatttaacgattacactagcaagaaagaaagttgtgtgggtctctaattaatag atttaccctttatagaacatattttcctttagatcaaggcaaaaatatcaggagcttttttacacacctactaaaaaagttattatgtagctgaaacaaaaatgccaga aggataatattgattcctcacatctttaacttagtattttacctagcatttcaaaacccaaatggctagaacatgtttaattaaatttcacaatataaagttctacagttaat tatgtgcatattaaaacaatggcctggttcaatttctttctttccttaataaatttaagttttttccccccaaaattatcagtgctctgcttttagtcacgtgtattttcattaccact cgtaaaaaggtatcttttttaaatgaattaaatattgaaacactgtacaccatagtttaca 145 205464_at gagggtgatgccatctaaccctgcccctgtccaccccgggtgggtgaaactcactgagcagccaagactgttgcccgaggactcactgtatggtgccctctccaa agggtcgggagggtagctctccaggccagagcttgtgtccttcaacagagaggccagcggcaactggtccgttactggccaagggctctgaagaatcaacggt gctggtacaggatacaggaataaattgtatcttcacctggttcctaccctcgtccctacctgtcctgatcctggtcctgaagacccctcggaacaccctctcctggtgg caggccacttccctcccagtgccagtctccatccaccccagagaggaacaggcgggtgggccatgtggttttctccttcctggccttggctggcctctggggcagg ggtggtggagagatggaagggcatcaggtgtagggaccctgccaagtggcacctgatttactctag 146 205480_s_at ttaatgtgccaaggagccgttttctgcctgtcaaaaccacatcagatctcttgctggtgatgtcaaacctctatagtcttaatgcaggatctctgacaatgagtgaaaa gcgggaatttcctacagtgcccttggttaaattaggcagttcttttacgaaggttcaagattatctaagaagatttgaaagtataccagatatgcttgaattggatcacc tcacagtttcaggagatgtgacatttggaaaaaatgtttcattaaagggaacggttatcatcattgcaaatcatggtgacagaattgatatcccacctggagcagtat tagagaacaagatagtgtctggaaaccttcgcatcttggaccactgaaatgaaaaatactgtggacacttaaataatgggctagtttcttacaatgaaatgttctcta ggatttaggcactaaaaggtactttactatgttactgtaccctgc 147 205547_s_at caagaatgatgggcactaccgtggagatcccaactggtttatgaagaaagcgcaggagcataagagggaattcacagagagccagctgcaggagggaaa gcatgtcattggccttcagatgggcagcaacagaggggcctcccaggccggcatgacaggctacggacgacctcggcagatcatcagttagagcggagagg gctagccctgagcccggcgctcccccagctccttggctgcagccatcccgcttagcctgcctcacccacacccgtgtggtaccttcagccctggccaagctttgag gctctgtcactgagcaatggtaactgcacctgggcagctcctccctgtgcccccagcctcagcccaacttcttacccgaaagcatcactgccttggcccctccctcc cggcggcccccatcacctctactgtctcctccctgggctaagcaggggagaagcgggctgggggtagcctggatgtgggcgaagtccactgtcctccttggcgg caaaagcccatt 148 205554_s_at tcaaagacttcgtgattatccccctgcacaccaccccagagacatccgttaaggagatcgatgagttggttgaggtctacacggacgtgaaacaccgctggaag gcggagaatttcattttcatgggtgacttcaatgccggctgcagctacgtccccaagaaggcctggaagaacatccgcttgaggactgaccccaggtttgtttggct gatcggggaccaagaggacaccacggtgaagaagagcaccaactgtgcatatgacaggattgtgcttagaggacaagaaatcgtcagttctgttgttcccaag tcaaacagtgtttttgacttccagaaagcttacaagctgactgaagaggaggccctggatgtcagcgaccactttccagttgaatttaaactacagtcttcaagggc cttcaccaacagcaaaaaatctgtcactctaaggaagaaaacaaagagcaaacgctcctagacccaagggtctcatcttattaaccatttcttgcctctaaata 149 205593_s_at aacgaggagcacatgaccctgctgaagatgattttgataaaatgctgtgatatctctaacgaggtccgtccaatggaagtcgcagagccttgggtggactgtttatt agaggaatattttatgcagagcgaccgtgagaagtcagaaggccttcctgtggcaccgttcatggaccgagacaaagtgaccaaggccacagcccagattgg gttcatcaagtttgtcctgatcccaatgtttgaaacagtgaccaagctcttccccatggttgaggagatcatgctgcagccactttgggaatcccgagatcgctacga ggagctgaagcggatagatgacgccatgaaagagttacagaagaagactgacagcttgacgtctggggccaccgagaagtccagagagagaagcagag atgtgaaaaacagtgaaggagactgtgcctgaggaaagcggggggcgtggctgcagttctggacgggctggccgagctgcgcgggatccttgtgcagggaa gagctgccctgggcacctggcaccacaagaccatgttttctaa 150 205683_x_at tgacgcaaaataccaccttggcgcctacacgggagacgacgtccgcatcgtccgtgacgacatgctgtgtgccgggaacacccggagggactcatgccagg gcgactccggagggcccctggtgtgcaaggtgaatggcacctggctgcaggcgggcgtggtcagctggggcgagggctgtgcccagcccaaccggcctggcctggc atctacacccgtgtcacctactacttggactggatccaccactatgtccccaaaaagccgtgagtcaggcctgggttggccacctgggtcactggaggaccaacc cctgctgtccaaaacaccactgcttcctacccaggtggcgactgccccccacaccttccctgccccgtcctgagtgccccttcctgtcctaagccccctgctctcttct gagccccttcccctgtcctgaggacccttccctatcctgagcccccttccctgtcctaagcctgacgcctgcaccgggccctccagccctcccctgcccagatagct ggtggtgggcgctaatcct 151 205892_s_at gaagagggagctctattgccaccatgagtttctccggcaagtaccaactgcagagccaggaaaactttgaagccttcatgaaggcaatcggtctgccggaaga gctcatccagaaggggaaggatatcaagggggtgtcggaaatcgtgcagaatgggaagcacttcaagttcaccatcaccgctgggtccaaagtgatccaaaa cgaattcacggtggg 152 205929_at ccttctctggtctccttgagatgatcgtagacacagggatgattcccacccaaacccacgtattcattcagtgagttaaacacgaattgatttaaagtgaacacaca caagggagcttgcttgcagatggtctgagttcttgtgtcctggtaattcctctccaggccagaataattggcatgtctcctcaacccacatggggttcctggttgttcctg catcccgatacctcagccctggccctgcccagcccatttgggctctggttttctggtggggctgtcctgctgccctcccacagcctccttctgtttgtcgagcatttcttct actcttgagagctcaggcagcgttagggctgcttaggtctcatggaccagtggctggtctcacccaactgcagtttactattgctatcttttctggatgatcagaaaaat aattccataaatctattgtctacttgcgattttttaaaaaatgtatatttttatatatattgttaaatcctttgcttcattcca 153 205935_at tctcccaacctctactgtaaactttctggtccgagaacgagccgaacacagcgcgacgcagggactaggacggcccggtgaccgcgcggattcaggattgcg gggacgcagaaaggttaaggcacttttaaaaactatagcaaggctcctgtttatttattctactttctttccctaataatcaaaacaccgcgtaggctcctccgtttatca gtattaatggtgtaactttgttggcaatatttgccgtgtagaattttttttagatatccattgtaaatttgaaacaaagaccgatctgtgtaaaaacaaatttccatatgtttta tataaatatatatataatatgaaggactaccctcctttttttttttttgtattttggctgctagagtgcagcatttgtgacacgtatttgaaatttgaaatttccttctgcactgtat aaaaggaccatttgaggatgttttgccttttgtgtatttt 154 205950_s_at gagccccattcacaaattttgacccctctactctccttccttcatccctggatttctggacctaccctggctctctgactcatcctcctttatgagagtgtaacttggatc atctgtaaggagagcatcagtgtcagctcagagcagctggcacaattccgcagccttctatcaaatgttgaaggtgataacgctgtccccatgcagcacaacaa ccgcccaacccaacctctgaagggcagaacagtgagagcttcattttgatgattctgagaagaaacttgtccttcctcaagaacacagccctgcttctgacataat ccagttaaaataataatttttaagaaataaatttatttcaatattagcaagacagcatgccttcaaatcaatctgtaaaactaagaaacttaaattttagttcttactgctt aattcaaataataattagtaagctagcaaatagtaatctgtaagcataagcttatcttaaattcaagtttagtttgaggaattctttaaaattacaactaagtgatttgtat gtctatttttttc 155 206000_at ggcagcttttttatcagccttgctttggataggacctccaaggactaagcctccagccccatgtgtgacccttgtcatctctctgccccacataattatgttactttgctat gtgctcctaatgtatctagtgtgtcctgtgacaacactcatcacacttcattgtaaatcacttgttttattgactgtctttcctatagactgtaagctccatgagggcaggca catgttgttctcattgaccgtgctggccccagtgcctagatgcatggctggcacattgttggcactcaacaatggttgaatgaataaaacaataaatgaatgaataa ctaagatatagaaactctcatttatattgcagattgaatatatatgatgaaattcttatgttgaatatgttagaatcaaatactcatttttcattagatacagtagtgtcatca ctcttttaagatcttgttaaagatttcaaataaaggtacttctggcgagccaggctgcacagcatttgctttcct 156 206094_x_at tatttgaatatgtatcgtgccccctccggagtctttgatcaggatgacatgtgccatttttcagaggacgtgcagacaggctggcattctagattacttttcttactctgaa acatggcctgtttgggagtgcgggattcaaaggtggtcccacggctgcccctactgcaaatggcagttttaatcttatcttttggcttctgcagatggttgcattgatcctt aaccaataatggtcagtcctcatctctgtcctgacttcataggt 157 206134_at ctttctatattgttatcagtccaggaaacaggtaaacagatgtaattagagacattggctctttgtttaggcctaatctttctttttacttttttttttcttttttctttttttttaaagatc atgaatttgtgacttagttctgccctttggagaacaaaagaaagcagtcttccatcaaatcaccttaaaatgcacggctaaactattcagagttaacactccagaatt gttaaattacaagtactatgctttaatgcttctttcatcttactagtatggcctataaaaaaaataataccacttgatgggtgaaggctttggcaatagaaagaagaata gaattcaggttttatgttattcctctgtgttcacttcgccttgctcttgaaagtgcagtatttttctacatcatgtcgagaatgattcaatgtaaatatttttcattttatcatgtata tcctatacacacatctccttcatcatcatatatgaagtttattttgagaagtctacattgcttacattt 158 206143_at taacaatccatgatgctgttttgcatattttgatgaagaaagattacagtacttcaaagtttaatcccagtcaggaaaaagatggaaaaattgattttaccataaatac aaatggaggattacgtaatcgggtatatgaggtgccagttgaaacaaaattctaatcaacatataattcagaaggatcttcatctgactatgacataaaaacaactt tatacccagaaagttattgataagttcatacattgtacgaagagtatttttgacagaatatgtttcaaactttggaacaagatggttctagcatggcatatttttcacatat ctagtatgaaattatataagtattctaaattttatatcttgtagctttatcaaagggtgaaaattattttgttcatacatatttttgtagcactgacagatttccatcctagtcact accttcatgcataggtttagcagtatagtggcgccactgttttgaatct 159 206149_at tcatcaggctccagttattctccatctcccagctcagctttttctgtctgtaagcctgattttcaggaaggctctttcctagtgatggagatgaccaccatcagctccagg cttctatcctgctaacccagtaacccagtgggaagagatttacttattccaataattccaagtggagagtgtcattgacccgtttggggtctcatctctacttctagggg aatgaaacactttgagtggccaggcctgtgtcatgtgctaattcctagagccagggaaataaggtctgaggattcaggatggggtgaaaggtggttgcttaaagg aaaatgaaatacaattagcagaataaggggaaacgagtggtctgctctgctcgggcaaaacaagagatgcccattactgtgagggacccttgaagtctggact cttaaatgggtttttgctgatttcctgggtgcatgctagg 160 206198_s_at accagcaacaacttcaatccggtggagaacaaagatattgtggttttaacctgtcaacctgagactcagaacacaacctacctgtggtgggtaaacaatcagag cctcctggtcagtcccaggctgctgctctccactgacaacaggaccctcgttctactcagcgccacaaagaatgacataggaccctatgaatgtgaaatacaga acccagtgggtgccagccgcagtgacccagtcaccctgaatgtccgctatgagtcagtaca 161 206199_at atattagttaccctggtgtgctgtattctctaaaacctttaaatgtttgcatgcagccattcgtcaaatgtcaaatattctctctttggctggaatgacaaaaactcaaata aatgtatgattaggaggacatcataacctatgaatgatggaagtccaaaatgatggtaactgacagtagtgttaatgccttatgtttagtcaaactctcatttaggtga cagcctggtgactccagaatggagccagtcatgctaaatgccatatactcacactgaaacatgaggaagcaggtagatcccagaacagacaaaactttcctaa aaacatgagagtccaggctgtctgagtcagcacagtaagaaagtcctttctgctttaactcttagaaaaaagtaatatgaagtattctgaaattaaccaatcagttta tttaaatcaatttatttatattcttctgttcctggattcccattttacaaaacccactgttctactgttgtattgcccagt 162 206208_at cccaggaccctgaagacgaaattgcggtgctggcctttctggtggaggctggaacccaggtgaacgagggcttccagccactggtggaggcactgtctaatatc cccaaacctgagatgagcactacgatggcagagagcagcctgttggacctgctccccaaggaggagaaactgaggcactacttccgctacctgggctcactc accacaccgacctgcgatgagaaggtcgtctggactgtgttccgggagcccattcagcttcacagagaacagatcctggcattctctcagaagctgtactacgac aaggaacagacagtgagcatgaaggacaatgtcaggcccctgca 163 206209_s_at accacaccgacctgcgatgagaaggtcgtctggactgtgttccgggagcccattcagcttcacagagaacagatcctggcattctctcagaagctgtactacgac aaggaacagacagtgagcatgaaggacaatgtcaggcccctgcagcagctggggcagcgcacggtgataaagtccggggccccgggtcggccgctgccc tgggccctgcctgccctgctgggccccatgctggcctgcctgctggccggcttcctgcgatgatggctcacttctgcac 164 206262_at actgactggacgcacgtggaaaggagctatttttggaggctttaagagtaaagaatctgtcccgaaacttgtggctgactttatggctaagaagttttcactggatgc attaataacaaatattttaccttttgaaaaaataaatgaaggatttgacctgcttcgctctggaaagagtatccgtaccgtcctgacgttttgaaacaatacagatgcct tcccttgtagcagttttcagcctcctctaccctacatgatctggagcaacagctaggaaatatcattaattctgctcttcagagatgttaaaaataaattacacgtggga gctttccaa 165 206377_at gttggtcactgttatttgcctactgctggaagaaggacaaccgctggcaaggtagcgttccccaatctgaatacctgcaggctcccacatgagggagagggcag actcaggtgggaagatgtgccatgcgtaaggcatcaacgtgtatctgtgggatcttcgttgccttcagtaatcagggtgtgaaaaaagcagacaagttgtgtgtgtg tgtgtgtgtctaagaaaacttgtgtgcttttcaaaaaggcagtgctaagcacaagatttcaagaaagcctcttcttgttgcctagctgagtgggagagtcattttcccca gacactacatttggatacaggtgccaaagaacattattaaggaattatttagaaacaatgtgtctagtttaagaaagtggttttcagtattgtgacaatacaacgttttt acaaggttgttttctaccaccatattttaaagatatttttatgaccgtgtatactcacactttgctt 166 206385_s_at aaagcccttcatctaatatttgttgctattgccaatttttcaatgaaatgacctaaaaacaacaaaaaaaaataacctatacggtagttgctttagggggtgggggga tgctatctgttagtgcttaaaagggggtaaatgcttgccgctttagaggtggatggtgctcataaaaggccccagtcgggggtatttaaaaaggactgaacagaaa tccttagctagtagaatggcagcacgctgtaaaattattactgtattgtgtactggctataagatgtagacacctttcagtaagccaatcatttgtaaccattctagcagt gtcatattaggttaataaggctgctgtgttttaaagggcatttttatttgggttttggtgaaattctttaatttgttgattatattcacataaaatcagcattcattgacacatag ctctaatgacatatgtatgaaaaaccatacactggatgacctagtcga 167 206422_at ctgatggttctttctctgatgagatgaacaccattcttgataatcttgccgccagggactttataaactggttgattcagaccaaaatcactgacaggaaataactatat cactattcaagatcatcttcacaacatcacctgctagccacgtgggatgtttgaaatgttaagtcctgtaaatttaagaggtgtattctgaggccacattgctttgcatg ccaataaataaattttcttttagtgttgtgtagccaaaaattacaaatggaataaagttttatcaaaatattgctaaaatatcagctttaaaatatgaaagtgctagattct gttattttcttcttattttggatgaagtaccccaacctgtttacatttagcgataaaattatttttctatgatataatttgtaaatgtaaattattccgatctgacatatctgcattat aataataggagaatagaagaactggtagccacagtggtgaaattggaaagagaactttcttcctgaaacctttgtcttaaaaatactcagctttcaatgtatcaa 168 206461_x_at gccggctcctgcaagtgcaaaaagtgcaaatgcacctcctgcaagaagagctgctgctcctgttgccccctgggctgtgccaagtgtgcccagggctgcatctg caaaggggcgtcagagaagtgcagctgctgtgcctgatgtcgggacagccctgctgtcagatgaaaacagaatgacacgtaaaatccgaggttttttttttctaca actccgactcatttgctacattcctttttttctg 169 206561_s_at ttccctgctggaggatcccaagattaaggagattgctgcaaagcacaaaaaaaccgcagcccaggttctgatccgtttccatatccagaggaatgtgattgtcatc cccaagtctgtgacaccagcacgcattgttgagaacattcaggtctttgactttaaattgagtgatgaggagatggcaaccatactcagcttcaacagaaactgga gggcctgtaacgtgttgcaatcctctcatttggaagactatcccttcaatgcagaatattgaggttgaatctcctggtgagattatacaggagattctctttcttcgctga agtgtgactacctccactcatgtcccattttagccaagcttatttaagatcacagtgaacttagtcctgttatagacgagaatcgaggtgctgttttagacatttatttctgt atgttcaactaggatcagaatatcacagaaaagcatggcttgaataaggaaatgacaattttttccacttatctgatcagaacaaatgtttattaagcatcagaaact ctgccaacactga 170 206576_s_at taagtccagtagtagcaaagccccaaatcaaagccagcaagaccacagtcacaggagataaggactctgtgaacctgacctgctccacaaatgacactgga atctccatccgttggttcttcaaaaaccagagtctcccgtcctcggagaggatgaagctgtcccagggcaacaccaccctcagcataaaccctgtcaagaggga ggatgctgggacgtattggtgtgaggtcttcaacccaatcagtaagaaccaaagcgaccccat 171 206637_at tgagcctggggttctggtgttagaatatttttaagtaggctttactgagagaaactaaatattggcatacgttatcagcaacttcccctgttcaatagtatgggaaaaat aagatgactgggaaaaagacacacccacaccgtagaacatatattaatctactggcgaatgggaaaggagaccattttcttagaaagcaaataaacttgattttt ttaaatctaaaatttacattaatgagtgcaaaataacacataaaatgaaaattcacacatcacatttttctggaaaacagacggattttacttctggagacatggcat acggttactgacttatgagctaccaaaactaaattctttctctgctattaactggctagaagacattcatctatttttcaaatgttctttcaaaacatttttataagtaatgtttg tatctatttcatgctttact 172 206641_at atttctttggcagttttcgtgctaatgtttttgctaaggaagataagctctgaaccattaaaggacgagtttaaaaacacaggatcaggtctcctgggcatggctaaca ttgacctggaaaagagcaggactggtgatgaaattattcttccgagaggcctcgagtacacggtggaagaatgcacctgtgaagactgcatcaagagcaaacc gaaggtcgactctgaccattgctttccactcccagctatggaggaaggcgcaaccattcttgtcaccacgaaaacgaatgactattgcaagagcctgccagctgc tttgagtgctacggagatagagaaatcaatttctgctaggtaattaaccatttcgactcgagcagtgccactttaaaaatcttttgtcagaatagatgatgtgtcagatc tctttaggatgactgtatttttcagttgccgatacagctttttgtcctctaactg 173 206664_at gaagacactaccaacatgatattacgtattgatctgaccacacacaatgttactctagaagaaccaatagaaatcaactggtcatgaagatcaccatcaattttag ttgtcaatgggaaaaaacaccaggatttaagtttcacagcacttacaattttccctcttcacttggttcttgtactctacaaaatatagctttcataacatcgaaaagttat tttgtagcgtacatcaatgataatgctaattttattatagtaatgtgacttggattcaattttaaggcatatttaacaaaatttgaatagccctatttatccttgttaagtatca gctacaattgtaaactagttactaaacatgtatgtaaatagctaagatataatttaaacgtgatttttaaattaaataaaatttttatgtaattatatatactatatttttctcaa tgtttagcagatttaagatatgtaacaacaattatttgaagatttaattacttcttagtatgtgcattta 174 206710_s_at attgcaatttcttaggtaaccttatatttacaataaatgaagattaccctcaaatgctagaagctgtctaggtccgtccggtgtgtcagatttcctcagattagatgtgcc aataaccaagtttattcagtaaacaacttgtacttgtttcatctggtttattactctcacccataaacagtaatgactctctgaccctctggaaatatgtaatgcttccaatc ttg 175 206784_at ttttggacctgcggtggtggccaaccactggaacttccactggatctactggctgggcccactcctggctggcctgcttgttggactgctcattaggtgcttcattggag atgggaagacccgcctcatcctgaaggctcggtgagcagagctcgtgggattcctgctgctccaggtgtcctcagctcacctgtcccagactgaggacagggga gttcctgcatttcctgccagggcagaggcccagaggagcgaccccctgcttccactgcttgggcctgctttctcagatagactgactgctgaggaggctctaggttc ttggaattcctttgtgctcatcagagaccccagcctggggaacacgctgcccgcactgcccagagagcagtgcaaacaccacaacacgagcgtgtttcttgaga ggaatgtccccgagttggacaaggaggctgtttctgcacatcagctcatttcc 176 207003_at gaggggtcaccgtgcaggatggaaatttctccttttctctggagtcagtgaagaagctcaaagacctccaggagccccaggagcccagggttgggaaactcag gaactttgcacccatccctggtgaacctgtggttcccatcctctgtagcaacccgaactttccagaagaactcaagcctctctgcaaggagcccaatgcccagga gatacttcagaggctggaggaaatcgctgaggacccgggcacatgtgaaatctgtgcctacgctgcctgtaccggatgctaggggggcttgcccactgcctgcc tcccctccgcagcagggaagctcttttctcctgcagaaagggccacccatgatactccactcccagcagctcaacctaccctggtccagtcgggaggagcagcc cggggaggaactgggtgact 177 207080_s_at tcgtctgcttcacaagctatcgctatggtgttcgtgcgcaggccgtggcccgccttgaccacagtgcttctggccctgctcgtctgcctaggggcgctggtcgacgcc taccccatcaaacccgaggctcccggcgaagacgcctcgccggaggagctgaaccgctactacgcctccctgcgccactacctcaacctggtcacccggca gcggtatgggaaaagagacggcccg 178 207126_x_at tatttgaatatgtatcgtgccccctccggtgtctttgatcaggatgacatgtgccatttttcagaggacgtgcagacaggctggcattctagattacttttcttactctgaa acatggcctgtttgggagtgcgggattcaaaggtggtcccaccgctgcccctactgcaaatggcagttttaatcttatcttttggcttctgcagatggttgcaattgatcc ttaaccaataatggtcagtcctcatctctgtcctgcttcataggtgccaccttgtgtgtttaaa 179 207134_x_at tgacgcaaaataccaccttggcgcctacacgggagacgacgtccgcatcgtccgtgacgacatgctgtgtgccgggaacacccggagggactcatgccagg gcgactccggagggcccctggtgtgcaaggtgaatggcacctggctgcaggcgggcgtggtcagctggggcgagggctgtgcccagcccaaccggcctggc atctacacccgtgtcacctactacttggactggatccaccactatgtccccaaaaagccgtgagtcaggcctgggttggccacctgggtcactggaggaccaacc cctgctgtccaaaacaccactgcttcctacccaggtggcgactgccccccacaccttccctgccccgtcctgagtgccccttcctgtcctaagccccctgctctcttct gagccccttcccctgtcctgaggacccttccccatcctgagcccccttccctgtcctaagcctgacgcctgcaccgggccctccggccctcccctgcccaggcag ctggtggtgggcgct 180 207245_at atgatcacaaaatgttgcctgttttgtttccgaaagcttgccaaaacaggaaagaagaagaaaagggattagttatatcaaaagcctgaagtggaatgaccaaa agatgggactcctcctttattccagcatggagggttttaaatggaggatttcctttttcctgcgacaaaacgtcttttcacaacttaccctgttaagtcaaaatttattttcca ggaatttaatatgtactttagttggaattattctatgtcaatgatttttaagctatgaaaaataataatataaaaccttatgggcttatattgaaatttattattctaatccaaa agttaccccacacaaaagttactgagcttccttatgtttcacacattgtatttgaacacaaaacattaacaactccactcatagtatcaacattgttttgcaaatactca gaatattttggcttcattttgagcagaat 181 207266_x_at caagtatcggggctctgctatcaaggtgcaaagtccttcgtggatgcaacctcaaccatatattctacagcaccctggtgccgtgttaactccctcaatggagcaca ccatgtcactacagcccgcatcaatgatcagccctctggcccagcagatgagtcatctgtcactaggcagcaccggaacatacatgcctgcaacgtcagctatg caaggagcctacttgccacagtatgcacatatgcagacgacagcggttcctgttgaggaggcaagtggtcaacagcaggtggctgtcgagacgtctaatgacc attctccatatacctttcaa 182 207390_s_at tggactggtgtcgagccaagactcggggcctacgagcacgtcgacatccagaacttctcctccagctggagtgatgggatggccttctgtgccctggtgcacaac ttcttccctgaggccttcgactatgggcagcttagccctcagaaccgacgccagaacttcgaggtggccttctcatctgcggagatgctggtggactatgtgcccct ggtggaggtggacgacatgatgatcatgggcaagaagcctgaccccaagtgtgtcttcacctatgtgcagtcgctctacaaccacctgcgacgccacgaactg gcctcgcgcggcaagaatgtctagcctgcccgcccgcatggccagccagtggcaactgccgcccccactctccgggcaccgtctcctgcctgtgcgtccgccc accgctgccctgtctgttgcgacaccctcccccccacatacacacgcagcgttttga 183 207392_x_at ggatgtgatagcattcctgctggcctgcgtggcaactgtgatatttatcatcacaaaattttgcctgttttgtttccgaaagcttgccaaaacaggaaagaagaagaa aagagattagttatatcaaaagcctgaagtggaatgactgaaagatgggactcctcctttatttcagcatggagggttttaaatggaggatttcctttttcctgtgacaa aacatcttttcacaacttaccttgttaagacaaaatttattttccagggatttaatacgtactttagttggaattattctatgtcaatgatttttaagctatgaaaaatacaatg gggggaaggatagcatttggagatatacctaatgttaaatgacgagttactggatgcagcacgcaacatggcacatgtgtatacatatgtagctaacccttcgttgt gcacatgtaccctaaaacttaaagtataatttaaaaaaagcaaaaaaaaaaaataccaactcttttttttaaaccaggaaggaaaatgtgaacatggaaacaac ttctagtattggatctg 184 207432_at gccccggagtgcagctgcggggacccgctgctcgaccccggcctgccggagcccgaggccccgccccctgcgggtcccgaaccgcttaccctcatccctgg gcctgtcgagcccttcagcatcgtgaccatgcccgggccccggggtccggcgccaccctggctgcccagccctattggcgaggaggaggagaatctggcctg agatcttagagcccagccccctaaggacagggaaccaggtccctgcacggcacccacgcaggtgtcccggtctgcataagcctcgtatgcctttgtaaagtcca cctacacttttgaccagctctcgctgcccgcatgtgtttggcgctgtgctaggggcgggagttcttccagactcttggaccagcccgccctgaccaccagctctactt cccaacccccactgcctgagaggtctctatcagtgtcctgcctgaattctttccttcaagtgaagatgtgactgactacctcctcgagttgtcatga 185 207502_at gaacccagggagcgcgatgggctgcagggctgcgtcagggctcctgccaggagtggccgtggtcctcctgctgctgctgcagagcacacagtcagtctacatc cagtaccaaggcttccgggtccagctggaatccatgaagaagctgagtgacctggaggcacagtgggcacccagcccccgcctgcaggcccagagcctcct gcccgccgtgtgccaccaccctgctctgcctcaggaccttcagcctgtctgcgcctcgcaggaggcttccagcatcttcaagaccctgaggaccatcgctaacga cgactgtgagctgtgtgtgaacgttgcgtgtaccggctgcctctgagatagccctgggtaccctgagcccaccagggacacctcgcccttcagcccaccaccctg gcaggcttccatccccgtccatgctcaagatgggtc 186 207761_s_at ttattcttagcgtcactggtctggctttcagaattaacatacaaggttgccacacctagttctgcccagctttatgtcttttattccagtattccaccaaagtttgttttcctgc attccagttctcaagtcttaagataaagattgtacttgacagtttagtatatccataaaactatttgaggtggttaaggttcttgggttcattttccttaatactttgctgaatat tgtagattgtaggcaatgaaaaagtctactaaattaggaaaaccttgaataattaggtatcctaggtaagagcccctaaacatcaagcaatctgtgagtctgtaaa gaaataaatattttttggattattcttatctaattccacccctgttggaagatgatttctttgttctttgcaactatggaagctgtgaaaatcatcacaagtgcctctgaaagc gagtgttaggttggttagagggt 187 207961_x_at gtgacggtgctgaagaaggccctggatgaagagacgcggtcccatgaggctcaggtccaggagatgaggcagaaacacgcacaggcggtggaggagctc acagagcagcttgagcagttcaagagggccaaggcgaacctagacaagaataagcagacgctggagaaagagaacgcagacctggccggggagctgc gggtcctgggccaggccaagcaggaggtggaacataagaagaagaagctggaggcgcaggtgcagacactgagtttttagaaaaacatatccacggtaac cggtccctggcaattctgtttacatgaaatggggagaaagtcaccgaaatgggtgccgccggcccccactcccaattcattccctaacctgcaaacctttccaactt ctcacgtcaggcctttgagaattctttccccctctcctggtttccacacctcagacacgcacagttcaccaagtgccttctgtagtcacatgaattgaaaaggagacg ctgctcccacggaggggagcaggaatgctgcactgtttacaccctgactgtgcttaaa 188 207977_s_at tagtggccgtgaggagcatcttcagtaagaaggaaggttctgacagacaatggaactacgcctgcatgcccacgccacagagcctcggggaacccacggag tgctggtgggaggagatcaacagggctggcatggaatggtaccagacgtgctccaacaatgggctggtggcaggattccagagccgctacttcgagtcagtgc tggatcgggagtggcagttttactgttgtcgctacagcaagaggtgcccatattcctgctggctaacaacagaatatccaggtcactatggtgaggaaatggacat gatttcctacaattatgattactatatccgaggagcaacaaccactttctctgcagtggaaagggatcgccagtggaagttcataatgtgccggatgactgaatacg actgt 189 207980_s_at aatgtcatagacactgatttcatcgacgaggaagttcttatgtccttggtgatagaaatgggtttggaccgcatcaaggagctgcccgaactctggctggggcaaa acgagtttgattttatgacggacttcgtgtgcaaacagcagcccagcagagtgagctgttgactcgatcgaaacccc 190 208131_s_at ccccccaattgctgccaatagtggataacatgtatcactcactgccaaaaatagaaagtgaccatgaaaaataaattcgctggggaagggggctccatgctggt gtggccaaggctgagagctctctcttctctgttacaaaacgagataagcaagtnttagaattgccttaaggccacactggcatctccctgaccttctccagggaca gaagcaggagtaagtttctcatcccatgggcgaccagggccatctcctcccaccagtggcccccactcacagggagctggcaatgccctacctgcctgttctcc agatggagaaacaggctctgagatttcacaggtcttgcccaaagtcattgattttaatgattaaaaagaataaacacagtgtttcctgagtagcagtgattgttatgc cttgctatttta 191 208370_s_at gatgtattaacctacctgtgaatcatatgttgtaggaaaagctgttcccatgtctaacaggacttgaattcaaagcatgtcaagtggatagtagatctgtggcgatatg agagggatgcagtgcctttccccattcattcctgatggaattgttatactaggttaacatttgtaatttttttctagttgtaatgtgtatgtctggtaaataggtattatattttgg ccttacaataccgtaacaatgtttgtcattttgaaatacttaatgccaagtaacaatgcatgctttggaaatttggaagatggttttattctttgagaagcaaatatgtttgc attaaatgctttgattgttcatatcaagaaattgattgaacgttctcaaaccctgtttacggtacttggtaagagggagccggtttgggagagaccattgcatcgctgtc caagtgtttcttgt 192 208383_s_at agggcaagtgttcccaaattgacgccacctaataatcatcaccacaccgggagcagatctgaaggcacactttgatttttttaaggataagaaccacagaacact gggtagtagctaatgaaattgagaagggaaatcttagcatgcctccaaaaattcacatccaatgcatactttgttcaaatttaaggttactcaggcattgatcttttca gtgttttttcacttagctatgtggattagctagaatgcacaccaaaaagatacttgagctgtatatatatatgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgcatgtatgtgc acatgtgtctgtgtgatatttggtatgtgtatttgtatgtactgttattcaaaatatatttaatacctttggaaaatcttgggcaagatgacctactagttttccttgaaaaaaa gttgctttgttattaatattgtgct 193 208399_s_at ccgagccgagcttactgtgagtgtggagatgttatcccaccatgtaaagtcgcctgcgcaggggagggctgcccatctccccaacccagtcacagagagatag gaaacggcatttgagtgggtgtccagggccccgtagagagacatttaagatggtgtatgacagagcattggccttgaccaaatgttaaatcctctgtgtgtatttcat aagttattacaggtataaaagtgatgacctatcatgaggaaatgaaagtggctgatttgctggtaggattttgtacagtttagagaagcgattatttattgtgaaactgt tctccactccaactcctttatgtggatctgttcaaagtagtcactgtatatacgtatagagaggtagataggtaggtagattttaaattgcattctgaatacaaactcata ctccttagagcttgaattacatttttaaaatgcatatgtgctgtttggcaccgtggcaagatggtatcagagagaaacccatcaattgctcaaatactc 194 208450_at ggagctgtcaccatgacgggggaacttgaggttaagaacatggacatgaagccggggtcaaccctgaagatcacaggcagcatcgccgatggcactgatgg ctttgtaattaatctgggccaggggacagacaagctgaacctgcatttcaaccctcgcttcagcgaatccaccattgtctgcaactcattggacggcagcaactgg gggcaagaacaacgggaagatcacctgtgcttcagcccagggtcagaggtcaagttcacagtgacctttgagagtgacaaattcaaggtgaagctgccagat gggcacgagctgacttttcccaacaggctgggtcacagccacctgagctacctgagcgtaaggggcgggttcaacatgtcctc 195 208581_x_at gcgtgttttcctcttgatcgggaactcctgcttctccttgcctcgaaatggaccccaactgctcctgctcgcctgttggctcctgtgcctgtgccggctcctgcaaatgca aagagtgcaaatgcacctcctgcaagaagagctgctgctcctgctgccctgtcggctgtgccaagtgtgcccagggctgcatctgcaaagggacgtcagacaa gtgcagctgctgtgcctga 196 208596_s_at cccgaccatcgaatcttgcgaacaacacgatacttgttaagtggctaccccaaaacgatctgcttggtcacccgatgacccgtgcctttatcacccatgctggttcc catggtgtttatgaaagcatatgcaatggcgttcccatggtgatgatgcccttgtttggtgatcagatggacaatgcaaagcgcatggagactaagggagctggag tgaccctgaatgttctggaaatgacttctgaagatttagaaaatgctctaaaagcagtcatcaatgacaaaagttacaaggagaacatcatgcgcctctccagcct tcacaaggaccgcccggtggagccgctggacctggccgtgttctgggtggagtttgtgatgaggcacaagggcgcgccacacctgcgccccgcagcccacg acctcacctggtaccagtaccattccttggacgtgattggtttcctcttggccgtcgtgctgacagtggccttcatcacctttaaatgttgtgcttatggctaccggaaatg cttggggaaaaaagggcgagttaagaaagcccacaaatccaagacc 197 208747_s_at tgcagaggcctatgttttcactcctaacatgatctgtgctggaggagagaagggcatggatagctgtaaaggggacagtggtggggcctttgctgtacaggatccc aatgacaagaccaaattctacgcagctggcctggtgtcctgggggccccagtgtgggacctatgggctctacacacgggtaaagaactatgttgactggataat gaagactatgcaggaaaatagcaccccccgtgaggactaatccagatacatcccaccagcctctccaagggtggtgaccaatgcattaccttctgttccttatgat attctcattatttcatcatgactgaaagaagacacgagcgaatgatttaaatagaacttgattgttgagacgccttgctagaggtagagtttgatcatagaattgtgctg gtcatacatttgtggtctgactccttggggtcctttccccggagtacctattgtagataacactatgggtggggcactccttt 198 208763_s_at gggcctaaccagccttgggagtattgactggtcccttacctcttatggctaagtctttgactgtgttcatttaccaagttgacccagtttgtcttttaggttaagtaagactc gagagtaaaggcaaggaggggggccagcctctgaatgcggccacggatgccttgctgctgcaaccctttccccagctgtccactgaaacgtgaagtcctgtttt gaatgccaaacccaccattcactggtgctgactacatagaatggggttgagagaagatcagtttgggcttcacagtgtcatttgaaaacgttttttgttttgttttgtaatt attgtggaaaactttcaagtgaacagaaggatggtgtcctactgtggatgagggatgaacaaggggatggctttgatccaatggagcctgggaggtgtgcccag aaagcttgtctgtagcgggttttgtgagagtgaacactttccactttttgacaccttatcctgatgtatggttc 199 208788_at agatgtgtttagaacctcttgtttaaaaataatagactgcttatcataaaatcacatctcacacatttgaggcagtggtcaaacaggtaaagcctatgatgtgtgtcatt ttaaagtgtcggaatttagcctctgaataccttctccattgggggaaagatattcttggaaccactcatgacatatcttagaaggtcattgacaatgtataaactaattg ttggtttgatatttatgtaaatatcagtttaccatgctttaattttgcacattcgtactatagggagcctattggttctctattagtcttgtgggttttctgtttgaaaaggagtcat ggcatctgtttacatttaccttatcaaacctagaatgtgtatatttataaatgtatgtcttcattgctaggtactaatttgcagatgtctttacatatttcaatacagaaactat aacattcaatagtgtgctgtcaaagtgtgcttagctcacctggatatacctacattg 200 208789_at gaagggagtgttgctcccagtccagaggcctgattctgttcggactgggttctcaagacacgaccaggttctcaagacacgagtccccttgttcctccccattaaag ggggtttgtcagaagcaagaacagcccctctccccagtcacagcctgaagggaggccccgagagcttcctccttccccccacctgctccttaccttctctgccctg ctttttagaactgcagttcattgttttaagggattgggggagggagcctggggacacaaaccttttatacaatacaaagctttgctttttttttttttttnnnnnnnccttttcc ctttctcggttctcttctctcctctgaatggctgaagacccctctgccgagggaggttggggattgtgggacaaggtcccttggtgctgatggcctgaaggggcctga gctgtgggcagatgcagttttctgtgggcttggggaacctctcacgttgctgtgtcctggtgagcagcccgaccaataaacctgcttt 201 208791_at ggctgcctgcggatgaaggaccagtgtgacaagtgccgggagatcttgtctgtggactgttccaccaacaacccctcccaggctaagctgcggcgggagctcg acgaatccctccaggtcgctgagaggttgaccaggaaatataacgagctgctaaagtcctaccagtggaagatgctcaacacctcctccttgctggagcagctg aacgagcagtttaactgggtgtcccggctggcaaacctcacgcaaggcgaagaccagtactatctgcgggtcaccacggtggcttcccacacttctgactcgga cgttccttccggtgtcactgaggtggtcgtgaagctctttgactctgatcccatcactgtgacggtccctgtagaagtctccaggaagaacccta 202 208792_s_at agcagctgaacgagcagtttaactgggtgtcccggctggcaaacctcacgcaaggcgaagaccagtactatctgcgggtcaccacggtggcttcccacacttct gactcggacgttccttccggtgtcactgaggtggtcgtgaagctctttgactctgatcccatcactgtgacggtccctgtagaagtctccaggaagaaccctaaattt atggagaccgtggcggagaaagcgctgcaggaataccgcaaaaagcaccgggaggagtgagatgtggatgttgc 203 208894_at cgatcaccaatgtacctccagaggtaactgtgctcacgaacagccctgtggaactgagagagcccaacgtcctcatctgtttcatagacaagttcacccca 204 208920_at gatataccatgtattcacactttaaaaaatacacatagcagagtatcggaaagtatgtaccaaaacattgatctggctaccactgggagtcaggatcatgagttcat cttcttcntncttnnnactgcttttccaaacattctccagtaagcaggtactacatttataatggaaggaattttttaaaaaattttaagctgtacactttcaagtaagatct gaattctaatgctggcttgtgcctcttactatgtggtttggtcattatagataatgcccagtttcagtttccccatctttgaaaaggagataatatgttatctcttgggagtag ttctgaatatgaagtgtgttgatacaagaagcactgacaatgtttctgtttcttaaatttaaaactggcctggtttgccttttttatcaagagagcttaacagataaaaaat gaaattagtctattttctacttgccagcagagtatctgtcttattttaggatgcagtgtgaaacttaccattcaactgaacaac 205 209047_at gaaggctggattctatctacataagtcctttcaattccaccagggccagagcagctccaccactgtgcacttagccatgatggcaacagaaaccaagagacaca attacgcaggtatttagaagcagagggacaaccagaaggcccttaactatcaccagtgcatcacatctgcacactctcttctccattccctagcaggaacttctag ctcatttaacagataaagaaactgaggcccacggtttcagctagacaatgatttggccaggcctagtaaccaaggccctgtctctggctactccctggaccacga ggctgattcctctcatttccagcttctcagtttctgcctgggcaatggccaggggccaggagtggggagagttgtgatggaggggagaggggtcacacccacccc ctgcctggttntaggctgctgcacaccaaggccctgcatctgtctgctctgcatatatgt 206 209074_s_at agacagctgtttagggtcttctcccctcacccatgctttcatcatcccctccgcacagcctccccgtccaggccttctaaccacacctacccagggctgccgcattcc tgcactcagaagtctgcagcggtgcctcacaaacttgattgtgcataaaaatcactggggatcttgttaatacagattctaactcaatagatctgggagatcctgcat ttctaacaagctcccaggtaaggcggaggctgctggtgtgaggaccatgctgtgagcagcagggcgagagtgcccagggctgatatatattggaaatatcacc cctgaagccatcgctggcccccacctcctgtggactgatgccccagggattcccaccccacttctgcaaccccaggtatccttcattatccaccccatcccagact cccaccccagggattgcccgtgaagactttggcctagcaaattgtgttggttatgtgagtgttgttttaatcagagatgtacatgattgccaatctgcatttcttaccagt gtgaccacac 207 209101_at atcatcagatcgactcttatacgagtaatatgcctgctatttgaagtgtaattgagaaggaaaattttagcgtgctcactgacctgcctgtagccccagtgacagcta ggatgtgcattctccagccatcaagagactgagtcaagttgttccttaagtcagaacagcagactcagctctgacattctgattcgaatgacactgttcaggaatcg gaatcctgtcgattagactggacagcttgtggcaagtgaatttgcctgtaacaagccagattttttaaaatttatattgtaaatattgtgtgtgtgtgtgtgtgtgtatatata tatatatatgtacagttatctaagttaatttaaagttgtttgtgcctttttatttttgtttttaatgctttgatatttcaatgttagcctcaatttctgaacaccataggtagaatgtaa agcttgtctgatcgttcaaagcatgaaatggatacttatatggaaattctgctcagatagaatgacagtccgtcaaaacagattgtttgcaaaggggaggcatcagt gtcttg 208 209114_at tacaccacaatggctgagcacttcctgacgttgctggtagtgcctgccatcaagaaagattatggttcccaggaagacttcactcaagtgtggaacaccaccatg aaagggctcaagtgctgtggcttcaccaactatacggattttgaggactcaccctacttcaaagagaacagtgcctttcccccattctgttgcaatgacaacgtcac caacacagccaatgaaacctgcaccaagcaaaaggctcacgaccaaaaagtagagggttgcttcaatcagcttttgtatgacatccgaactaatgcagtcacc gtgggtggtgtggcagctggaattgggggcctcgagctggctgccatgattgtttccatgtatctgtactgcaatctacaataagtccacttctgcctctgccactactg ctgccacatgggaaactgtgaagaggcaccctgggcaagcagcagtgattgggggaggggacaggatctaacaatgtcacttgggccagaatggacctggc ctttctgctcccagacttgggggctag 209 209116_x_at gcagttatgggcaaccctaaggtgaaggctcatggcaagaaagtgctcggtgcctttagtgatggcctggctcacctggacaacctcaagggcacctttgccac actgagtgagctgcactgtgacaagctncangtggatcctgagaacttcaggctnctnggcaacgtgntngtctgngtgctggcccatcactttggcaaagaatt caccccaccag 210 209138_x_at tctctgggctccaggctgaggacgaggctgattattactgctgctcatatgcaggtagttacactgtggttttcggcggagggaccaaactgaccgtcctaggtcag cccaaggctgccccctcggtcactctgttcccgccctcctctgaggagcttcaagccaacaaggccacactggtgtgtctcataagtgacttctacccgggagccg tgacagtggcctggaaggcagatagcagccccgtcaaggcgggagtggagaccaccacaccctccaaacaaagcaacaacaagtacgcggccagcagc tatctgagcctgacgcctgagcagtggaagtcccacagaagctacagctgccaggtcacgcatgaagggagcaccgtggagaagacagtggcccctacag aatgtt 211 209147_s_at tttggtgcagctgctagtcagtccctgactgacattgccaagtattcaataggcagactgcggcctcacttcttggatgtttgtgatccagattggtcaaaaatcaactg cagcgatggttacattgaatactacatatgtcgagggaatgcagaaagagttaaggaaggcaggttgtccttctattcaggccactcttcgttttccatgtactgcatg ctgtttgtggcactttatcttcaagccaggatgaagggagactgggcaagactcttacgccccacactgcaatttggtcttgttgccgtatccatttatgtgggcctttct cgagtttctgattataaacaccactggagcgatgtgttgactggactcattcagggagctctggttgcaatattagttgctgtatatgtatcggatttcttcaaagaaag aacttcttttaaagaaagaaaagaggaggactctcatacaactctgcatgaaacaccaacaactgggaatcactatccgagcaatcaccagc 212 209156_s_at gcacgccatcaatgccatcgtgcgcagcccgcgtggcggggcccggaggcacgcagagctgtccttcgtgttcctcacggacggcgtcacgggcaacgaca gtctgcacgagtcggcgcactccatgcgcaacgagaacgtggtacccaccgtcctggccttgggcagcgacgtggacatggacgtgctcaccacgctcagcct gggtgaccgcgccgccgtgttccacgagaaggactatgacagcctggcgcaacccggcttcttcgaccgcttcatccgctggatctgctagcgccgccgcccg ggccccgcagtcgagggtcgtgagcccaccccgtccatggtgctaagcgggccc 213 209167_at tgtttcctcatagctagttctcaagctgcatgtaagattttaacgggaagagaaaataggcctggacctgaaggtctcaaatatgttgagaagaaagtatgaactat aaggaacttgagatgtagatttattttgcaggaaatacgaggaaaataggaaagaagtgtttgccgcatcaagtgtaaagaatgatactgaggatttttacattttat gaaatgaaataatggcatttacaaaatgaaaaatgtagtttcacaactaagttttgttaacagagactgcatgctttgcttatagttcttaattttggttttgacattcattta attttttccatgttaaatatgtagtttaattatttactcaaaataaacattgttcatgcttttaggcctttgggggaattgatttttatccacaggtagaaaatggtctttgcaca cactacacttatttcaaatatacaatgtgctcccgaactttcgcattagtctt 214 209170_s_at gaaatatcactgacactccagactaaagcagagtctaggtttctgcaattttgttacagtaatttgtaaatagctttagtaaactcaccttgcatggtagattaataaga tgacttactgtacatgaattacacaataatgagatctggtggctatttccacattttgaaaaggattcagttatttactgacagtggtgagcatcctttttaaaataatgttc tgatacttaaacattagagagcagtatctttaaatgaattattaacactttggaatacttacattttctgttatttttgattgcctgataaccagtttcaatgatgaaaatgaa aacaagtgctgaagatgaaatggaagagaaccgttttaatctggattttgttttgtcacacctggaaaatactttgcaaatatgttctaaattgaaaacaatttttttatg atcacatggttcactaccaaatgaccctcaaataagccagatg 215 209191_at gatagtcggaatagagccgccccaactcagatcctacaacacgcaagttccttcttgaaccctggtgcctcctaccctatggccctgaatggtgcactggtttaatt gtgttggtgtcggcccctcacaaatgcagccaagtcatgtaattagtcatctggaacaaagactaaaaacagcagagaattgcgggttctacccagtcagaaga tcacaccatggagactttctactagaggacttgaaagagaactgaggggccacaaaataaacttcaccttccattaagtgttcaagcatgtctgcaaattaggag ggagttagaaacagtctttttcatcctttgtgatgaagcctgaaattgtgccgtgttgccttatatgaatatg 216 209209_s_at tgtctccccgctatctaaaaaagtataagaacaagcagataacagcgagaatcttggaggcccatcagaatgtagctcagatgagtctaattgaagccaagatg agatttattcaagcttggcagtcactacctgaatttggcatcactcacttcattgcaaggttccaagggggcaaaaaagaagaacttattggaattgcatacaacag actgattcggatggatgccagcactggagatgcaattaaaacatggcgtttcagcaacatgaaacagtggaatgtcaactgggaaatcaaaatggtcaccgta gagtttgcagatgaagtacgattgtccttcatttgtactgaagtagattgcaaagtggttcatgaattcattggtggctacatatttctctcaacacgtgcaaaagacca aaacgagagtttagatgaagagatgttctacaaacttaccagtggttgggtgtgaatagaaatactgtttaatgaaactccacggccataa 217 209210_s_at aaaatgctattagtccgtcgtgcttnatttgtttttgtccttgaataagcatgttatgtatatngtctcgtgtttttatttttacaccatattgtattacacttttagtattcaccagc ataancactgtctgcctaaaatatgcaactctttgcattacaatatgaagtaaagttctatgaagtatgcattttgtgtaactaatgtaaaaacacaaattttataaaatt gtacagttttttaaaaactactcacaactagcagatggcttaaatgtagcaatctctgcgttaattaaatgcctttaagagatataattaacgtgcagttttaatatctact aaattaagaatgacttcattatgatcatgatttgccacaatgtccttaactctaatgcctggactggccatgttctagtctgttgcgctgttacaatctgtattggtgctagt cagaaaattcctagctcacatagcccaaaagggtgcgagggagaggtggattaccagtattgttcaataatccatggttca 218 209283_at gaccagttcttcggagagcacctgttggagtctgatcttttcccgacgtctacttccctgagtcccttctaccttcggccaccctccttcctgcgggcacccagctggttt gacactggactctcagagatgcgcctggagaaggacaggttctctgtcaacctggatgtgaagcacttctccccagaggaactcaaagttaaggtgttgggaga tgtgattgaggtgcatggaaaacatgaagagcgccaggatgaacatggtttcatctccagggagttccacaggaaataccggatcccagctgatgtagaccctc tcaccattacttcatccctgtcatctgatggggtcctcactgtgaatggaccaaggaaacaggtctctggccctgagcgcaccattcccatcacccgtgaaaagaa gcctgctgtcaccgcagcccccaagaaaaagatgccctttcttgaattgcattttttaaaacaagaaagtttccccaccagtgaatgaa 219 209301_at tgaatcttcgggtgtttccctttagctaagcacagatctaccttggtgatttggaccctggttgctttgtgtctagttttctagacccttcatctcttacttgatagacttactaat aaaatgtgaagactagaccaattgtcatgcttgacacaactgctgtggctggttggtgctttgtttatggtagtagtttttctgtaacacagaatataggataagaaata agaataaagtaccttgactttgttcacagcatgtagggtgatgagcactcacaattgttgactaaa 220 209312_x_at ctgtgtatccttcaaagacccagcccctgcagcaccataacctcctggtctgttctgtgagtggtttctatccaggcagcattgaagtcaggtggttccggaatggcc aggaagagaagactggggtggtgtccacaggcctgatccacaatggagactggaccttccagaccctggtgatgctggaaacagttcctcggagtggagagg tttacacctgccaagtggagcacccaagcgtgacaagccctctcacagtggaatggagagcacggtctgaatctgcacagagcaagatgctgagtggagtcg ggggctttgtgctgggcctgctcttccttggggccgggctgttcatctacttcaggaatcagaaaggacactctggacttcagcca 221 209335_at agtcaaatgccaaacactagctctgtattaatccccatcattactggtaaagcctcatttgaatgtgtgaattcaatacaggctatgtaaaatttttactaatgtcattattt tgaaaaaataaatttaaaaatacattcaaaattannannnnanacaagcttaattgttaatattccctaaacacaattttatgaagggagaagacattggtttgttga caataacagtacatcttttcaagttctcagctatttcttctacctctccctatcttacatttgagtatggtaacttatgtcatctatgttgaatgtaagcttataaagcacaaa gcatacatttcctgactggtctagagaactgatgtttcaatttacccctctgctaaataaa 222 209357_at ggcaaactgcttaatcttgtggattttgtagatggtttcaaatgactgaactgcattcagatttacgagtgaaaggaaaaattgcattagttggttgcatgaactttgaa gggcagatattactgcacaaactgccatctcgcttcatttttttaactatgcatttgagtacagactaatttttaaaatatgctaaactggaagattaaacagatgtggcc caaactgttctggatcaggaaagtcatactgttcactttcaagttggctgtcccccccgccgcccccccccacccccatatgtacagatgataatagggtgtggaat gtcgtcagtggcaaacatttcacagattattttgtttctgtcttcaacatttttgacactgtgctaat 223 209373_at ctcctccatgagtctgacatctcggaaactgagcagctgccggacgcctgggtcaggaatccaagaccccacctcttaaggactggttcctcagaaagcaccct cagggaaaaaggtgaaaacattacatccgtggattctcctgccacaaccgcattggaagaaaaggctgccgcaacatctcagcgaggagtgaaggacccat gtcccaggaaccgcgctgcgccacctgcactcacccccctcacattctcttaagcacccggtggccctccgaggcctggcggaatggtggtgcccacggggttg ggcaagggctcaccaggacctcaacgggcaaagttgtgcacactaaaatatcaaatcaaggtgcttggttttaaagtaaatgtttttctaaagaaagctgtgttcttc tgttgacccagacgaatagggcacagccctgtaactgcacgtgccttctgtcattgggaatg 224 209374_s_at caccatcacgtgcctggtgacgggcttctctcccgcggacgtcttcgtgcagtggatgcagagggggcagcccttgtccccggagaagtatgtgaccagcgccc caatgcctgagccccaggccccaggccggtacttcgcccacagcatcctgaccgtgtccgaagaggaatggaacacgggggagacctacacctgcgtggtg gcccatgaggccctgcccaacagggtcaccgagaggaccgtggacaagtccacc 225 209436_at ttcttttttatattgtcctccacctccatcattttcaataaaagatagggcttttgctcccttgttcttggagggaccattattacatctctgaactacctttgtatccaacatgttt taaatccttaaatgaattgctttctcccaaaaaaagcacaatataaagaaacacaagatttaattatttttctacttggggggaaaaaangtcctcatgtagaagca cccacttttgcaatgttgttaagctatctatctanctctcagcccatgataaagttccttaagctggtgattcctaatcaaggacaagccacccaccctagtgtctcatgtttg tat 226 209457_at ggaagcacaatttccaccttattttttgaactttggcagtttcaatgtctgtctctgttgcttcggggcataagctgatcaccgtctagttgggaaagtaaccctacaggg tttgtagggacatgatcagcatcctgatttgaaccctgaaatgttgtgtagacaccctcttgggtccaatgaggtagttggttgaagtagcaagatgttggcttttctgg attttttttgccatgggttcttcactgaccttggactttggcatgattcttagtcatacttgaacttgtctcattccacctcttctcagagcaactcttcctttgggaaaagagtt cttcagatcatagaccaaaaaagtcataccttcgaggtggtagcagtagattccaggaggagaagggtacttgctaggtatcctgggtcagtggcggtgcaaact ggtttcctcagctgcctgtccttctgtgtgcttatgtctcttgtgacaattgttttcctccct 227 209458_x_at agagaacccaccatggtgctgtctcctgccgacaagaccaacgtcaaggccgcctggggtaaggtcggcgcgcacgctggcgagtatggtgcggaggccct ggagaggatgttcctgtccttccccaccaccaagacctacttcccgcacttcgacctgagccacggctctgcccaggttaagggccacggcaagaaggtggcc gacgcgctgaccaacgccgtggcgcacgtggacgacatgcccaacgcgctgtccgccctgagcgacctgcacgcgcacaagcttcgggtggacccggtca acttcaagctcctaagccactgcctgctggtgaccctggccgcccacctccccgccgagttcacccctgcggtgcacgcctccctggacaagttcctggcttctgtg agcaccgtgctgacctccaaataccgttaagctg 228 209496_at tggaggaatttcacaagcacccgcccgtgcagtgggccttccaggagaccagtgtggagagcgccgtggacacgcccttcccagctggaatatttgtgaggct ggaatttaagctgcagcagacaagctgccggaagagggactggaagaaacccgagtgcaaagtcaggcccaatgggaggaaacggaaatgcctggcctg catcaaactgggctctgaggacaaagttctgggccggttggtccactgccccatagagacccaagttctgcgggaggctgaggagcaccaggagacccagtg cctcagggtgcagcgggctggtgaggacccccacagcttctacttccctggacagttcgccttctccaaggccctgccccgcagctaagccagcactgagctgc gtggtgcctccaggaccgctgccggtggtaaccagtggaagaccccagcccccagggagaggaccccgttctatccccagccatgataata 229 209498_at tttgtcaggaaaccttggcctctgctaaggtgtatttggtccttgagaagtgggagcaccctacagggacactatcactcatgctggtggcattgtttacagctagaa agctgcactggtgctaatgccccttggggaaatggggctgtgaggaggaggattataacttaggcctagcctcttttaacagcctctgaaatttatcttttcttctatgg ggtctataaatgtatcttataataaaaaggaaggacaggaggaagacaggcaaatgtacttctcacccagtcttctacacagatggaatctctttggggctaaga gaaaggttttattctatattgcttacctgatctcatgttaggcctaagaggctttctccaggaggattagcttggagttctctatactcaggtacctctttcagggttttctaa ccctgacacggactgtgcatactttccc 230 209612_s_at actggatgcgttaataacccatgttttaccttttgaaaaaataaatgaaggatttgacctgcttcactctgggaaaagtatccgtaccgtcctgacgttttgaggcaata gagatgccttcccctgtagcagtcttcagcctcctctaccctacaagatctggagcaacagctaggaaatatcattaattcagctcttcagagatgttatcaataaatt acacatgggggctttccaaagaaatggaaattgatgggaaattatttttcaggaaaatttaaaattcaagtgagaagtaaataaagtgttgaacatcagctgggga attgaagccaacaaaccttccttcttaaccattctactgtgtcacctttgccattgaggaaaaatattcctgtgacttcttgcatttttggtatcttcataatctttagtcatcg aatcccagtggaggggacccttttacttgccctgaacatacacatgctgggccattgtgattgaagtcttctaactctgtctcagt 231 209613_s_at gcagatttcttgcttcatatgacaaagcctcaattactaattgtaaaaactgaactattcccagaatcatgttcaaaaaatctgtaatttttgctgatcgaaagtgcttcat tgactaaacagtattagtttgtggctataaatgattatttagatgatgactgaaaatgtgtataaagtaattaaaagtaatatggtggctttaagtgtagagatgggatg gcaaatgctgtgaatgcagaatgtaaaattggtaactaagaaatggcacaaacaccttaagcaatatattttcctagtagatatatatatacacatacatatataca catatacaaatgtatatttttgcaaaattgttttcaatctagaacttttctattaactaccatgtcttaaaatcaagtctataatcctagcattagtttaatattttgaatatgtaa acacctgtgttaatgctttgttaatgcttttcccactctcatttgttaatgctttcccactctcgggaaggatttgcattttgagctttatctctaaatgtgacatgca 232 209621_s_at ggatgccgctctgtgacaaatgtggcagtggcatagtcggtgctgtggtgaaggcgcgggataagtaccggcaccctgagtgcttcgtgtgtgccgactgcaacc tcaacctcaagcaaaagggctacttcttcatagaaggggagctgtactgcgaaacccacgcaagagcccgcacaaaacccccaagaggctatgacacggtc actctgtatcccaaagcttaagtctctgcaggcgtggcacacgcacgcacccacccacgcgcacttacacgagaagacattcatggctttgggcagaaggattg tgcagattgtcaactccaaatctaaagtcaaggctttagacctttatcctattgtttattgaggaaaaggaatgggaggcaaatgcctgctatgtgaaaaaaacata cacttagctatgttttgcaactctttttggggctag 233 209651_at ttcctgaagctcttcggctgacagcccgctcggctcgccctctcccccggaggccgcgccctcccggaaaagccgggtcctccagaccccgaggccttgctctc agagcgggaggccccacccactggagagccccgcccctaaggtactatgagttctcaggggtcaagttcagaaacggcccagccagacctaaacccacac gcccacaaagtggattgcacacagacaagaactcccgtgcgggcctccactctattcccacccttgagggagcccccttactgggggagggtccttgcaattcc agcgaatcggaggccaggccaggacgtccttgctccctgcaccctcactgttctgtgcactttttctacctacataaacacacgcatt 234 209656_s_at gcagggctagttattccgatttcttgcacaattatttagctttttgtaagttcaacatgtaaattttaaagacataaatatagagagacttatgtgtttgaatataaatgatat atatggattagcatgtacctgtatattattaaacatgcaatgaactgactggtaagtgacgtctaattgtatggctagcaatgtaatttattcagactgtatttttgtacag agcagtgcactctaacctatgcctctgtgtcctctttaatgcctaaagctgtgcctagaaatttcatctgtcttaaaagtaaaatatacttcatgctgtttatgctattagtttc tgtactgctattctatatttattatttttaaatatatgacatgtttactacttaaacatgaattcatggtatcctggttattttttttaagtcatctgggggaaaacctgtttatcact ccagtgattttgagtttgcagtttcacaatcagttcttcat 235 209667_at caggccttttccactttgagggaggtgcttcgaagaatgttgcccacacctaagtgttagaagcctatgtccgttcatccctgagaggtctgaa 236 209668_x_at tggcggactccatgtttgtgatccctgcactccaagtagcacattttcagtgttcccgggcccctgtgtacttctacgagttccagcatcagcccagctggctcaaga acatcaggccaccgcacatgaaggcagaccatggtgatgagcttccttttgttttcagaagtttctttgggggcaactacattaaattcactgaggaagaggagca gctaagcaggaagatgatgaagtactgggccaactttgcgagaaatgggaacccgaatggcgagggtctgccacactggccgctgttcgaccaggaggagc aatacctgcagctgaacctacagcctgcggtgggccgggctctgaaggcccacaggctccagttctggaagaaggcgctgccccaaaagatccaggagctc gaggagcctgaagagagacacacagagctgtagctccctgtgccggggaggagggggtgggttcgctgacaggcgagggtcagcctgctgtg 237 209687_at gagagctcgctttgagtgactgggttttgtgattgcctctgaagcctatgtatgccatggaggcactaacaaactctgaggtttccgaaatcagaagcgaaaaaatc agtgaataaaccatcatcttgccactaccccctcctgaagccacagcagggtttcaggttccaatcagaactgttggcaaggtgacatttccatgcataaatgcga tccacagaaggtcctggtggtatttgtaactttttgcaaggcatttttttatatatatttttgtgcacatttttttttacgtttctttagaaaacaaatgtatttcaaaatatatttata gtcgaacaattcatatatttgaagtggagccatatgaatgtcagtagtttatacttctctattatctcaaactactggcaatttgtaaagaaatatatatgatatataaatg tgattgcagcttttcaatgttagccacagt 238 209735_at tgtggtttctgtagcaacacttctcatgaccatctgttttgtgtttatgatgattttttcaggtctgttggtcaatctcacaaccattgcatcttggctgtcatggcttcagtacttc agcattccacgatatggatttacggctttgcagcataatgaatttttgggacaaaacttctgcccaggactcaatgcaacaggaaacaatccttgtaactatgcaac atgtactggcgaagaatatttggtaaagcagggcatcgatctctcaccctggggcttgtggaagaatcacgtggccttggcttgtatgattgttattttcctcacaattg cctacctgaaattgttatttcttaaaaaatattcttaaatttccccttaattcagtatgatttatcctcacataaaaaagaagcactttgattgaagtattcaatcaagtttttt gttgttttctgttcccttgccatcacactgttgcacagca 239 209763_at gaacacgcagagagtttccctagatatactcctgcctccaggtgctgggacacacctttgcaaaatgctgtgggaagcaggagctggggagctgtgttaagtca aagtagaaaccctccagtgtttggtgttgtgtagagaataggacatagggtaaagaggccaagctgcctgtagttagtagagaagaatggatgtggttcttcttgtg tatttatttgtatcataaacacttggaacaacaaagaccataagcatcatttagcagttgtagccattttctagttaactcatgtaaacaagtaagagtaacataacag tattaccctttcactgttctcacaggacatgtacctaattatggtacttatttatgtagtcactgtatttctggattttt 240 209791_at ctccagccccagagctgaaaacaccaagtgcctatttgagggtgtctgtctggagacttagagtttgtcatgtgtgtgtgtgtnnttggttaatgtgggtttatgggttttc tttctttttttttttttttttttnnagtctacattagggggaagtgagcgcctcccatgtgcagacagtgtgtctttatagatttttctaaggctttccccaatgatgtcggtaatttct gatgtttctgaagttcccaggactcacacacccgttcccatctcacttgcccacccagtgtgacaaccctcggtgtggatatacccccgtggactcatggctcttccc cacccccactttctataaatgtaggcctagaatacgcttctctgttgcaaaactcagctaagttcctgcttccaccttgatgttgaaatatcttatgtaagagggcaggg gatgtcgtgaagatggc 241 209868_s_at ggaatgacacttacttacgacccaactacagctgctatacagaacggattttatccttcaccatacagtattgctacaaaccgaatgatcactcaaacttctattaca ccctatattgcatctcctgtatctgcctaccaggtgcaaagtccttcgtggatgcaacctcaaccatatattctacagcaccctggtgccgtgttaactccctcaatgga gcacaccatgtcactacagcccgcatcaatgatcagccctctggcccagcagatgagtcatctgtcactaggcagcaccggaacatacatgcctgcaacgtca gctatgcaaggagcctacttgccacagtatg 242 209948_at ggaacgaaaccagcgtcctattccagcgcctctacgggccccaggccctcctcttctccctcttctggcccaccttcctgctgaccggtggcctcctcattatcgcca tggtgaagagcaaccagtacctgtccatcctggcggcccagaagtagagccatccatccatgccataccacttgtcagggcacaggggactggctgggcccc cagggctgctccccacttgcagcacaatgccttctccacctgccctcccactcttccagtccaatccacgctgtcttctgttgcaggactaacctttgagaaatcctttt gtgaagtcattgcctgctcaagaatgtacagtggctccccaatgccttggagccataaggccagccagttctagctctctattacctgtccccactcaactgactcat acctgtttccggctgcatcactatgtgccccacagagaacgatgatcgtcacctctgtgcctgagttctccctgttgtctcaaagcggtacc 243 210084_x_at ccggtcagcaggatcatcgtgcacccacagttctacatcatccagactggagcggatatcgccctgctggagctggaggagcccgtgaacatctccagccgcg tccacacggtcatgctgccccctgcctcggagaccttccccccggggatgccgtgctgggtcactggctggggcgatgtggacaatgatgagcccctcccaccg ccatttcccctgaagcaggtgaaggtccccataatggaaaaccacatttgtgacgcaaaataccaccttggcgcctacacgggagacgacgtccgcatcatcc gtgacgacatgctgtgtgccgggaacacccggagggactcatgccagggcgactctggagggcccctggtgtgcaaggtgaatggcacctggctacaggcg ggcgtggtcagctgggacgagggctgtgcccagcccaaccggcctggcatctacacccgtgtcacctactacttggactggatccaccactatgtccccaaaaa gccgtgagtcaggcctggggtgt 244 210107_at ggccaaatcaccgacctgaaggcggaaattcacgggggcagtctcattaatctgacttggacagctcctggggatgattatgaccatggaacagctcacaagta tatcattcgaataagtacaagtattcttgatctcagagacaagttcaatgaatctcttcaagtgaatactactgctctcatcccaaaggaagccaactctgaggaagt ctttttgtttaaaccagaaaacattacttttgaaaatggcacagatcttttcattgctattcaggctgttgataaggtcgatctgaaatcagaaatatccaacattgcacg agtatctttgtttattcctccacagactccgccagagacacctagtcctgatgaaacgtctgctccttgtcctaatattcatatcaacagcaccattcctggcattcacat tttaaaaattatgtggaagtggataggagaactgcagctgtcaatagcctagggc 245 210133_at accccttcagcgactagagagctacaggagaatcaccagtggcaaatgtccccagaaagctgtgatcttcaagaccaaactggccaaggatatctgtgccga ccccaagaagaagtgggtgcaggattccatgaagtatctggaccaaaaatctccaactccaaagccataaataatcaccatttttgaaaccaaaccagagcct gagtgttgcctaatttgttttcccttcttacaatgcattctgaggtaacctcattatcagtccaaagggcatgggttttattatatatatatatattttttttttaaaaaaaaacgt attgcatttaatttattgaggctttaaaacttatcctccatgaatatcagttatttttaaactgtaaagctttgtgcagattctttaccccctgggagccccaattcgatcccct gtcacgtgtgggcaatgttccccc 246 210139_s_at tgtgaagctttacgcgcacacggacaaaatgcccaaactggagcccttgcaaaaacacggcttgtggcattggcatacttgcccttacaggtggagtatcttcgtc acacatctaaatgagaaatcagtgacaacaagtctttgaaatggtgctatggatttaccattccttattatcactaatcatctaaacaactcactggaaatccaattaa caattttacaacataagatagaatggagacctgaataattctgtgtaatataaatggtttataactgcttttgtacctagctaggctgctattattactataatgagtaaat cataaagccttcatcactcccacatttttcttacggtcggagcatcagaacaagcgtctagactccttgggaccgtgagttcctagagcttggctgggtctaggctgtt ctgtgcctccaaggactgtctggcaatgacttgtattggccaccaactgtagatgtatatatggtgcccttctgatgctaagactccagaccttttgt 247 210298_x_at tctactgcgtgacttgccatgagaccaagtttgccaagcattgcgtgaagtgcaacaaggccatcacatctggaggaatcacttaccaggatcagccctggcatg ccgattgctttgtgtgtgttacctgctctaagaagctggctgggcagcgtttcaccgctgtggaggaccagtattactgcgtggattgctacaagaactttgtggccaa gaagtgtgctggatgcaagaaccccatcactgggaaaaggactgtgtcaagagtgagccgcccagtctctaaagctaggaagcccccagtgtgccacggga aacgcttgcctctcaccctgtttcccagcgccaacctccggggcaggcatccgggtggagagaggacttgtccctcgtgggtggtggttctttatagaaaaaatcg aagcttagcagctcctcgtggcccgggtttggtaaaggctccagtgtggtggcctatgaaggacaatcctggcacgactactgcttccactgcaaaaaatgctcc gtgaatctggccaacaagcgctttgttttccacc 248 210299_s_at gcataggagataaaacccccactgagatgctctcatgcctcagctggacccaccgtgtagacacacgacatgcaagagttgcagcggctgctccaactcactg ctcaccctctctgtgagcagaaagaaccctactgacatgcatggttaacttcctcatcagaactctgcccttcccttctgttcttttgtgctttcaaataactaacacgaa cttccagaaaattaacatttgaacttagctgtaattctaaactgacctttccccgtactaacgtttggtttccccgtgtggcatgcttttctgagccttcctactttaaagcat ggaacatgcaggtgatttgggaagtgtagaaagacctgagaaaacgagcctgtttcagaggaacatcgtcacaacgaatacttctggaagcttaacaaaacta accctgctgtcctt 249 210302_s_at atttcgttttgcttttggttgcctgaatgttgtcaccaagtgaaaaaattatttaactatatgtaaaatttctcttttaaaaaaaagttttactgatgttaaacgttctcagtgcc aatgtcagactgtgctcctccctctcctgaacctctaccctcaccctgagctgtcttgttgaaaacagt 250 210495_x_at agccctttgctctggaggaagttctccagcttcagctcaactcacagcttctccaagcatcaccctgggagtttcctgagggttttctcataaatgagggctgcacatt gcctgttctgcttcgaagtattcaataccgctcagtattttaaatgaagtgattctaagatttggtttgggatcaataggaaagcatatgcagccaaccaagatgcaa atgttttgaaatgatatgaccaaaattttaagtaggaaagtcacccaaacacttctgctttcacttaagtgtctggcccgcaatactgtaggaacaagcatgatcttgtt actgtgatattttaaatatccacagtactcactttttccaaatgatcctagtaattgcctagaaatatctttctcttacctgttatttatcaatttttcccagtatttttatacggaa aaaattgtattgaaaacacttagtatgcagttgataagaggaatttggtataattatggtgggtgattattttttatactgtatgtgccaaagctttactactgtg 251 210517_s_at gtgccatagtgcaggcttggggagctttaagcctcagttatataacccacgaaaaacagagcctcctagatgtaacattcctgatcaaggtacaattctttaaaatt cactaatgattgaggtccatatttagtggtactctgaaattggtcactttcctattacacggagtgtgctaaaactaaaaagcattttgaaacatacagaatgttctattg tcattgggaaatttttctttctaacccagtggaggttagaaagaagttatattctggtagcaaattaactttacatcctttttcctacttgttatggttgtttggaccgataagt gtgcttaatcctgaggcaaagtagtgaatatgttttatatgttatgaagaaaagaattgttgtaagtttttgattctactcttatatgctggactgcattcacacatggcatg aaataagtcaggttctttacaaatggtattttgatagatactggattgtgtttgtgccatatttgtgccatt 252 210524_x_at gtcaggactgttatggccctgttgtgctgagttagttggaacagaattcaagctccctgcactagtccacctgccccactgcttcttcgcttctctcttggaaagtccagt ctctcctcggcttgcaatggaccccaactgctcctgcgccgctggtgtctcctgcacctgcgctggttcctgcaagtgcaaagagtgcaaatgcacctcctgcaag aagagctgctgctcctgctgccccgtgggctgtagcaagtgtgcccagggctgtgtttgcaaaggggcgtcagagaagtgcagctgctgcgactgatgccagga caacctttctcccagatgtaaacagagagacatgtacaaacctggattttttttttataccaccttgacccatttgctacattccttttcctgtgaaa 253 210735_s_at caggaaggaccttgctttggaccctacacacttcggctctctggacacttgcgacacctcaaggtgttctctgtagctcaatctgcaaacatgccaggcctcaggg atcctctgctgggtgcctccttgccttgggaccatggccaccccagagccatccgatcgatggatgggatgcactctcagaccaagcagcaggaattcaaagct gcttgctgtaactgtgtgagattgtgaagtggtctgaattctggaatcacaaaccaagccatgctggtgggccattaatggttggaaaacactttcatccggggctttg ccagagcgtgctttcaagtgtcctggaaagtctgctgcttctccaagctttcagacaagaatgtgcactctctgcttaggttttgcttgggaaactcaacttctttcctctg gagacggggcatctccctctgatttccttctgctatgacaaaacctttaatctgcaccttacaactcggggacaa 254 210764_s_at ttaccaatgacaaccctgagtgccgccttgtgaaagaaacccggatttgtgaggtgcggccttgtggacagccagtgtacagcagcctgaaaaagggcaaga aatgcagcaagaccaagaaatcccccgaaccagtcaggtttacttacgctggatgtttgagtgtgaagaaataccggcccaagtactgcggttcctgcgtggac ggccgatgctgcacgccccagctgaccaggacatgtgaagatgcggttccgctgcgaagatggggagacattttccaagaacgtcatgatgatccagtcctca aatgcaactacaactgcccgcatgccaatgaagcagcgtttcccttctacaggctgttcaatgacattcacaaatttagggactaaatgctacctgggtttccaggg cacacctagacaaacaagggagaagagtgtcagaatcagaatcatggagaaaatgggcgggggtggtgtgggtgatgggactcattgtagaaaggaagcc ttgctcattcttgaggagcattaaggtatttcgaaactgccaagggtgc 255 210809_s_at aaattgtggagttagcctcctgtggagttagcctcctgtggtaaaggaattgaagaaaatataacaccttacaccctttttcatcttgacattaaaagttctggctaactt tggaatccattagagaaaaatccttgtcaccagattcattacaattcaaatcgaagagttgtgaactgttatcccattgaaaagaccgagccttgtatgtatgttatgg atacataaaatgcacgcaagccattatctctccatgggaagctaagttataaaaataggtgcttggtgtacaaaactttttatatcaaaaggctttgcacatttctatat gagtgggtttactggtaaattatgttattttttacaactaattttgtactctcagaatgtttgtcatatgcttcttgcaatgc 256 210946_at aaggcaagaggatgcatctttcttcctggtgtacaagcctttaaagacttctgctgctgatatgcctcttggatgcacactttgtgtgtacatagttacctttaactcagtg gttatctaatagctctaaactcattaaaaaaactccaagccttccaccaaaacagtgccccacctgtatacatttttattaaaaaaatgtaatgcttatgtataaacat gtatgtaatatgctttctatgaatgatgtttg 257 210982_s_at gaaggagacggtctggcggcttgaagaatttggacgatttgccagctttgaggctcaaggtgcattggccaacatagctgtggacaaagccaacttggaaatcat gacaaagcgctccaactatactccgatcaccaatgacaagttcaccccaccagtggtcaatgtcacgtggcttcgaaatggaaaacctgtcaccacaggagtgt cagagacagtcttcctgcccagggaagaccaccttttccgcaagttccactatctccccttcctgccctcaactgaggacgtttacgactgcagggtggagcactg gggcttggatgagcctcttctcaagcactgggagtttgatgctccaagccctctcccagagactacagagaacgtggtgtgtgccctgggcctgactgtgggtctg gtgggcatcattattgggaccatc 258 211161_s_at aatattggatatcaactgcttgtaaaggtgctcctcctttttcttgtcattgctggtcaagattactaatatttgggaaggctttaaagacgcatgttatggtgctaatgtact ttcacttttaaactctagatcagaattgttgacttgcattcagaacataaatgcacaaaatctgtacatgtctcccatcagaaagattcattggcatgccacaggggat tctcctccttcatcctgtaaaggtcaacaataaaaaccaaattatggggctgcttttgtcacactagcatagagaatgtgttgaaatttaactttgtaagcttgtatgtggt tgttgatcttttttttccttacagacacccataat 259 211372_s_at atctcatacccgcaaattttaaccttgtcaacctctggggtattagtatgccctgacctgagtgaattcacccgtgacaaaactgacgtgaagattcaatggtacaag gattctcttcttttggataaagacaatgagaaatttctaagtgtgagggggaccactcacttactcgtacacgatgtggccctggaagatgctggctattaccgctgtg tcctgacatttgcccatgaaggccagcaatacaacatcactaggagtattgagctacgcatcaagaaaaaaaaagaagagaccattcctgtgatcatttccccc ctcaagaccatatcagcttctctggggtcaagactgacaatcccgtgtaaggtgtttctgggaaccggcacacccttaaccaccatgctgtggtggacggccaatg acacccacatagagagcgccta 260 211538_s_at agctcgaaagagtttgcaaccccatcatcagcaaactttaccaaggtggtcctggcggcggcagcggcggcggcggttcaggagcctccgggggacccacc atcgaagaagtggactaagcttgcactcaagtcagcgtaaacctctttgcctttctctctctctctttttttttgtttgtttctttgaaatgtccttgtgccaagtacgagatctat tgttggaagtctttggtatatgcaaatgaaaggagaggtgcaacaacttagtttaattataaaagttccaaagtttgttttttaaaaacattattcgaggtttctctttaatg cattttgcgtgtttgctgacttgagcatttttgattagttcgtgcatggagatttgtttgagatgagaaaccttaagtttgcacacctgttctgtagaagcttg 261 211548_s_at gctttttttgttgtcagctatcttaagaatcattaaatacacctgctttgggtaaaactctttgcaagcagtaattaacactagtaacagtgaaagcacaagatttccaaa tcagtcgttttctcaaaaaaatatcgtataagtgactcatcctgtctgctaactccagacctcccagcttgaagccaaatctttccatgtgagattgatatggatttccta gaagtactggaatgttgtcatatcttgccctattttaattctgctatagaaaacaattgccttcacttttaaggagtaatttgaatattaataactctggtctagattttcatat aatgtattaaagacaaagtagtgaacatcaatgaacatctgatagagataaactgtaatcaggcataagcttgtttgtatgttctggcagtgactaatcagtaaatg atgtcggtttgcccagtatcacttatcttctg 262 211549_s_at cgtgaacggcaaagtggcgctggtgaccggcgcggctcagggcataggcagagcctttgcagaggcgctgctgcttaagggcgccaaggtagcgctggtgg attggaatcttgaagcaggtgtacagtgtaaagctgccctggatgagcaatttgaacctcagaagactctgttcatccagtgcgatgtggctgaccagcaacaact gagagacacttttagaaaagttgtagaccactttggaagactggacattttggtcaataatgctggagtgaataatgagaaaaactgggaaaaaactctgcaaat taatttggtttctgttatcagtggaacctatcttggtttggattacatgagtaagcaaaatggaggtgaaggcggcatcattatcaatatgtcatctttagcagcccacc attgattgccaatggattgataacactcattgaagatgatgctttaaatggtgctattatgaagatcacaacttctaagggaattcattttcaagactatgatacaactc catttcaag 263 211596_s_at gagtattacattggccttgggggacagaaaggaggaagttctgacttttcagggctaccttatttctactaaggacccagagcaggcctgtccatgccattccttcgc acagatgaaactgagctgggactggaaaggacagcccttgacctgggttctgggtataatttgcacttttgagactggtagctaaccatcttatgagtgccaatgtgt catttagtaaaacttaaatagaaacaaggtccttcaaatgttcctttggccaaaagctgaagggagttactgagaaaatagttaacaattactgtcaggtgtcatca ctgttcaaaaggtaagcacatttagaattttgttcttgacagttaactgactaatcttacttccacaaaatatgtgaatttgctgcttctgagaggca 264 211637_x_at ggactggtgaagccttcggagaccctgtccctcacctgcagtgtctctggtggctccatcagtagttactactggagctggatccggcagcccccagggaaggga ctggagtggattgggtatatcaattacagtgggagcaccaactataacccctccctcaagagtcgagtcaccatatcagtagacacgtccaagaaccagttctcc ctgaagctgagctctgtgaccgctgcggacacggccgtgtattactgtgcgagaacgatttcggggggtcg 265 211643_x_at aatagtgatgacgcagcttccagccaccctgtctgtgtctccaggggaaagagccaccctctcctgcagggccagtcagagtgttcgcagcaacttagcctggta ccagcaaaaacctggccaggctcccaggctcctcatctacggtgcatccaccagggccaatggtatcccagccaggttcagtggcagtgggtctgggacaga gttcactctcaccatcagcggcctgcagtctgacgattttgcagtttattactgtcaacactataataactggcctccgtggacgt 266 211644_x_at aattgtgttgacgcagtctccaggcaccctgtctttgtctccaggggaaagagccaccctctcctgcagggccagtcagagtattagcagcagtttcttagcctggta ccagcagaaagttggccaggctcccaggctcctcatctatggtgcatccagcagggccactggcatcccagacaggttcagtggcagtgggtctgggacagac ttcactctcaccatcagcagactggagcctgaagattttgcagtgtattactgtcagcaatatggtagctcgc 267 211645_x_at tcctccctgtctgcatctgtaggagacagagtcaccatcacttgccgggcaagtcagggcattagaaatgatttagcctggtatcagcagaaaccagggaaagc ccctaagcgcctgatctatgctgcatccagtttgcaaagtggggtcccatcaaggttcagcggcagtggatctgggacagaattcactctcacaatcagcagcctg cagcctgaagattttgcaacttattactgtctacagcataatagttacccttg 268 211671_s_at gcagttgagtcgtcatcacttttcagtgatgggagagtagatggtgaaatttattagttaatatatcccagaaattagaaaccttaatatgtggacgtaatctccacagt caaagaaggatggcacctaaaccaccagtgcccaaagtctgtgtgatgaactttctcttcatactttttttcacagttggctggatgaaattttctagactttctgttggtg tatcccccccctgtatagttaggatagcatttttgatttatgcatggaaacctgaaaaaaagtttacaagtgtatatcagaaaagggaagttgtgccttttatagctatta ctgtctggttttaacaatttcctttatatttagtgaactacgcttgctcattttttcttacataattttttattcaagttattgtacagctgtttaagatgggcagctagttcgtagctt tccca 269 211696_x_at tgaggagaagtctgccgttactgccctgtggggcaaggtgaacgtggatgaagttggtggtgaggccctgggcaggctgctggtggtctacccttggacccaga ggttctttgagtcctttggggatctgtccactcctgatgctgttatgggcaaccctaaggtgaaggctcatggcaagaaagtgctcggtgcctttagtgatggcctggc tcacctggacaacctcaagggcacctttgccacactgagtgagctgcactgtgacaagctgcacgtggatcctgagaacttcaggctcctgggcaacgtgctggt ctgtgtgccggcccatcactttggcaaagaattcacccaaccagtgcaggctgcctatcagaaagtggtggctggtgtggctaatgccctggcccacaagtatca ctaagctcgctttcttgctgtccaatttctattaaaggttcctttgttccctaagtccaactactaaactg 270 211699_x_at agagaacccaccatggtgctgtctcctgacgacaagaccaacgtcaaggccgcctggggtaaggtcggcgcgcacgctggcgagtatggtgcggaggccct ggagaggatgttcctgtccttccccaccaccaagacctacttcccgcacttcgacctgagccacggctctgcccaggttaagggccacggcaagaaggtggcc gacgcgctgaccaacgccgtggcgcacgtggacgacatgcccaacgcgctgtccgccctgagcgacctgcacgcgcacaagcttcgggtggacccggtca acttcaagctcctaagccactgcctgctggtgaccctggccgcccacctccccgccgagttcacccctgcggtgcacgcctccctggacaagttcctggcttctgtg agcaccgtgctgacctccaaataccgttaagctg 271 211719_x_at gggagtttcctgagggttttctcataaatgagggctgcacattgcctgttctgcttcgaagtattcaataccgctcagtattttaaatgaagtgattctaagatttggtttgg gatcaataggaaagcatatgcagccaaccaagatgcaaatgttttgaaatgatatgaccaaaattttaagtaggaaagtcacccaaacacttctgctttcacttaa gtgtctggcccgcaatactgtaggaacaagcatgatcttgttactgtgatattttaaatatccacagtactcactttttccaaatgatcctagtaattgcctagaaatatct ttctcttacctgttatttatcaatttttcccagtatttttatacggaaaaaattgtattgaaaacacttagtatgcagttgataagaggaatttggtataattatggtgggtgatt attttttatactgtatgtgccaaagctttactactgtg 272 211745_x_at tcctgccgacaagaccaacgtcaaggccgcctggggtaaggtcggcgcgcacgctggcgagtatggtgcggaggccctggagaggatgttcctgtccttcccc accaccaagacctacttcccgcacttcgacctgagccacggctctgcccaggttaagggccacggcaagaaggtggccgacgcgctgaccaacgccgtggc gcacgtggacgacatgcccaacgcgctgtccgccctgagcgacctgcacgcgcacaagcttcgggtggacccggtcaacttcaagctcctaagccactgcct gctggtgaccctggccgcccacctccccgccgagttcacccctgcggtgcacgcctccctggacaagttcctggcttctgtgagcaccgtgctgacctccaaata ccgttaagctggagcctcggtggc 273 211798_x_at tacgcagactccgtgaagggccgattcaccatctccagagacaattccaagaacacgctgtatcttcaaatgaacagcctgagagccgaggacacggccgtat tactgtgcaagagagacttgtgtgattggggccaaggtaccctggtcaccgtgtcgagaggtggcggtggctcgggcggtggtgggtcgggtggcggcggatctt ctgagctgactcaggaccctgctgtgtctgtggccttgggacagacagtcaggatcacatgccaaggagacagcctcagaagctattatgcaagctggtaccag cagaagccaggacaggcccctgtacttgtcatctatggtaaaaacaaccggccctcagggatcccagaccgattctctggctccagctcaggaaacacagctt ccttgaccatcactggggctcaggcggaagatgaggctgactattactgtaactcccgggacagcagtggtaaccatgtggtattcggcggagggaccaagctg accgtcctaggtgcggccgcagaacaaaaactcatctcagaagaggatctgaatggggccgcat 274 211813_x_at ttgcacaagtttcctgggctggaccgtttcaacagagaggcttatttgactttatgctagaagatgaggcttctgggataggcccagaagttcctgatgaccgcgact tcgagccctccctaggcccagtgtgccccttccgctgtcaatgccatcttcgagtggtccagtgttctgatttgggtctggacaaagtgccaaaggatcttccccctga cacaactctgctagacctgcaaaacaacaaaataaccgaaatcaaagatggagactttaagaacctgaagaaccttcacgttgtctaccttcataacaacaata tctctgtagttggatcaagtgacttctgcccacctggacacaacaccaaaaaggcttcttattcgggtgtgagtcttttcagcaacccggtccagtactgggagatac agccatccaccttcagatgtgtctacgtgcgctctgccattcaactcggaaacta 275 211848_s_at tgtccatacagagtgtgcattccctggcaggggctcctgctcacagcctcgcttttaaccttctggaacctgccaaacagtgcccagaccaatattgatggtgtgcc gttcaatgtcgcagaagggaaggaggtccttctagtagtccataatgagtcccagaatctttatggctacaactggtacaaagggcaaagggtgcatgccaacta tcgaattataggatatgtaaaaaatataagtcaagaaaatgccccagggcccgcacacaacggtcgagagacaatataccccaatggaaccctgctgatcca gaacgtcacccacaatgacgcaggaatctataccctacacgttataaaagaaaatcttgtgaatgaagaagtaaccagacaattctacgtattctatgagtcagt acaagcaagttcacctgacctctcagctgggaccgctgtcagcatcatgattggagtactggctgggatggctctgatatagc 276 211889_x_at tgcacagtactcctggcttatcaatggaacattccagcaaagcacacaagagctctttatccctaacatcactgtgaataatagtggatcctatacctgccacgcca ataactcagtcactggctgcaacaggaccacagtcaagacgatcatagtcactgagagacagaatctcaccatgttgcccgggctggactcgaactcctgggct caagcaatcctcccatctgtttcccaaagtgctgagattacagataatgctctaccacaagaaaatggcctctcacctggggccattgctggcattgtgattggagt agtggccctggttgctctgatagcagtagccctggcatgttttctgcatttcgggaagaccggcagggcaagcgaccagcgtgatctcacagagcacaaaccctc agtgtccaaccacactcaggaccactccaatgacccacctaacaagatgaatgaagttacttattctaccctgaactttgaagccca 277 211896_s_at tcctccttcccttacggaattacatcttgatggcaacaaaatcagcagagttgatgcagctagcctgaaaggactgaataatttggctaagttgggattgagtttcaa cagcatctctgctgttgacaatggctctctggccaacacgcctcatctgagggagcttcacttggacaacaacaagcttaccagagtacctggtgggctggcaga gcataagtacatccaggttgtctaccttcat 278 211959_at tcacaccgtagcccacatggatagcacagttgtcagacaagattccttcagattccgagttgcctaccggttgttttcgttgttgttgttgttgtttttctttttctttttttttga agacagcaataaccacagtacatattactgtagttctctatagttttacatacattcataccataactctgttctctcc 279 211964_at cactttccaatgccacagacaactcacattgttcaactcccnttctcggggtgggacagacgagacaacagcacacaggcagccagccgtggnnccagagg ctcganggggctcaggggcntcanggcacccgtccccacacgnagggccccgtngggtgggncctnggccctngctttctacngccnaatgnttatgnccag ctccatgttctcccaaataccgttgatgtgaattattttaaaggcaaaacngtgctctttattttanaaaacactgataatcacactgcggtaggtcattcttttgccacat ccctatagaccactgggtttggcaaaactcaggcagaagtggaganccnttctagacatcantgtcagccttgctacttgaaggtacaccccatagggtcggag gtgctgtcccc 280 211985_s_at gaggcaaatggatctcgatatttcagatgggcttttgatgcactgttgccaaggaaggctttttctgattttttgacaaatgaatttttgcacactttcattggtgtctttcgg caacttacacacattgaaaat 281 211990_at gaggacttaggagagatctgaactccagctgccctacaaactccntcncagcttttcttctcacttcatgtgaaaactactccagtggctgactgaattgctgaccctt caagctctgtccttatccattacctcaaagcagtcattccttagtaaagtttccaacaaatagaaattaatgacactttggtagcactaatatggagattatcctttcatt gagccttttatcctctgttctcctttgaagaacccctcac 282 211991_s_at gcactgggaggcccaagagccaatccagatgcctgagacaacggagactgtgctctgtgccctgggcctggtgctgggcctagtnggcatcatcgtgggcacc gtcctcatcataaagtctctgcgttctg 283 212077_at tgcagaagtcaaaccctcatgacaaagtaggcacaagtctacaataagctaaatcagaatttacaaatacaagtgtcccaggtagcattgactcccgtcattgg agtgaaatggatcaaagtttgaattaaggcctatggtaaggtaacattgctttgttgtacttttgaacaagagctcctcctgatcactattacatatttttctagaaaatct aaagttcagaagagaatgtatcactgctgacttttattccaatatttggatggagtaagttttagggtagaattttgttcagtttggatttaatcttttgaaaagtaaattcctt gtttactggtttgactataattctctgttatctttacgaggtaaaactgcaagctgactagcatgttctgtgaatctgccattcctaaaaattttataaacacttgatacttttc actgataatggatcgctcca 284 212091_s_at tcacagcgggcaggacggaccccgcccacgacgtgcgggtggcggtggtgcagtacagcggcacgggccagcagcgcccagagcgggcgtcgctgcag ttcctgcagaactacacggccctggccagtgccgtcgatgccatggactttatcaacgacgccaccgacgtcaacgatgccctgggctatgtgacccgcttctac cgcgaggcctcgtccggcgctgccaagaagaggctgctgctcttctcagatggcaactcgcagggcgccacgcccgctgccatcgagaaggccgtgcaggn agnccagcgggcaggcatcgagatcttcgtggtggtcgtgggccgccaggtgaatgagccccacatccgcgtcctggtcaccggcaagacggccgagtacg acgtggcctacggcgagagccacctgttccgtgtccccagctaccaggccctgctccgcggtgtcttccaccagacagtctccaggaaggt 285 212097_at gaatttcacctgtaaacctgagtcgtacagaaagctgcctggtatatccaaaangctttttattcctcctgctcatattgtgattctgccntttggggnacttttncttnaa accttcagttatgatttttttttncatacacttattggnaactctgcttgatttttgcctcttccagtcttcctgacactttaattaccaacctgttactttgactttttgcattta aaacagacactggcatggatatagttttacttttaaactgtgtacataactgaaaatgtgctatactgcatactttttaaatgtaaagatatttttatctttatatgaagaaa atcacttaggaaatggctttgtgattcaatctgtaaactgtgtattccaagacatgtctgttctacatagatgcttagtccctcatgcaaatcaattactggtccaaaaga ttgctgaaattttatatgcttactgatatattttacaattttttatcatgcatgtcctgtaaaggttacaagcctgcacaataa 286 212136_at tcttccccttgagcttcagagaggagagttggcatggttaaatctgaatggttacctcactgctgaaaacccagaggggcgtggcacactcgcttgtgtggaaaag cctctaaatgcatcccttcctttctttcctgcttcctttgccttacaattgaagcagcccgtggtaccatcacagtatgcagagacttcctcacctttcatatctagggacc acccccgatgcattggtgagggtgggcacttataaatgcctgctattgttaagccattccagcctcttcctctgaatagaccagacgccctttcacttagttcagtgcc agtccttttgccttcccaaccctgctgttaggcctgctgttccctttgctcttgattaggagagatggaaggagatgagctcccataactgaattggcctttggttcatgttt tctccccatatgtatatatgccatatgtgaatatgccatatatatgtgccaacaaatctatctacgttgttcttttcaaattagcacgcagataggaattttgagtttctcttc tt 287 212158_at tatgtaaactttaacttccactttgtataaatttttaagtgtcagactatccattttacacttgctttatttttcattacctgtagctttgggcagatttgcaacagcaaattaatgt gtaaaattggattattactacaaaaccgtttagtcatatctatctaatcagatcttcttttgggaggatttgatgtaagttactgacaagcctcagcaaacccaaagatg ttaacagtattttaagaagttgctgcagattcctttggccactgtatttgttaatttcttgcaatttgaaggtacgagtagaggtttaaagaaaaatcagtttttgttcttaaa aatgcatttaagttgtaaacgtctttttaagcctttgaagtgcctctgattctatgtaacttgttgcagactggtg 288 212185_x_at cgccggctcctgcaaatgcaaagagtgcaaatgcacctcctgcaagaaaagctgctgctcctgctgccctgtgggctgtgccaagtgtgcccagggctgcatct gcaaaggggcgtcggacaagtgcagctgctgcgcctgatgctgggacagccccgctcccagatgtaaagaacgcgacttccacaaacctggattt 289 212192_at caactgtttttgcgactttataggcaggtaaattttgctattactattgaatacaaatgacaattcatttatgaccactcaaacagcgttagtaaccatttagtgacaaag gattaaaacatccatctggatgttaattttgaagatgtaaattatatgttgtttaaatttttccaggcatctgaaaaccttatctgctagacaatgtaagattcacacagag ttatctgggattctgattttttaaatagtacatatcattaaaccattttctctaaatgtaagaagagcagaaaaaatcttataagattatcagatttttctaatgacacaga aatgtaagaaaaaaatccctttatattgaaaaaagatgcagtcaaagtcttttcagacatgcccaaactttgaagaatttcttcaaccatctaatgctataaagatttttg ttcttcctgttcacaaccagttgtataacagaaatactagctactgttttccttc 290 212195_at gatgggtcgtgtgatgagatgcatttaaggccgatagtgatagatgttttttttatttcttgaacacaggctttgtctgaatgatgttcttttatctcttgaacacaagctttga atgataactacaggttttaagtgctgttacattaataccataatgtgatgtgttagaaacaaagggatatttcaaaggtagatatttgaaaattctctagtctcaatatgt atgtgtattgaatatactctaaaaataaatgtgcaatttgctagtaggacaatgcagtgactgactagcattaggtatgtttcttttatatcctagctatgtcccactttcttc taagtgcaatcctttcatgttcacttgctgttttaccccatctactctaacttcatttggaaggcttgtctagagtatagcatgtatttttacctttgcagtgaattgcatgtgct aattgtaaccacagctatttttatgttgacataactccaaatgttatattaaatgttctattatatattagctctaatcccttaagtaaa 291 212224_at acagtgttctctaatgttacagatgagatgcgcattgccaaagaggagatttttggaccagtgcagcaaatcatgaagtttaaatctttagatgacgtgatcaaaag agcaaacaatactttctatggcttatcagcaggagtgtttaccaaagacattgataaagccataacaatctcctctgctctgcaggcaggaacagtgtgggtgaatt gctatggcgtggtaagtgcccagtgcccctttggntgggattcaagatgtctggaaatggaagagaactgggagagtacggtttccatgaatatacagaggtcaa aacagtcacagtgaaaatctctcagaagaactcataaagaaaatacaagagtggagagaagctcttcaatagctaagcatctccttacagtcactaatat 292 212230_at caaggtcccactctaggtgatagacagggaccccttctactgaacctttgaggaaaggaggaaggaagaaatgcgtttagatcttggatgcagacctttcaaag ggttaaatgtaaccatatggatcaaccacatgcacatccttactacagaatccgtcctttcatttcaacttatagcaagctatgatttttatatataaatattatataaata atgtataaaacattaaaagttaactatgtaagatattatttctgaaacaatttagctatatccactatgattataaactgtgtctcgacctgtgttatttacattagctgctta aaaaagcattgagttaatttttttaaatatcaactaaaatatcatagttctgtggtagacattgttttataatgaaataactgcaactagagaaaactgtataaaaacatt aaattgtcagtatttttgtaaggttccattttgtaaagagaataatattcaaagacttttgtagcatacaaagtgaaaacttgtatctgcgaaacta 293 212233_at aagcagcctagggatgagcatttctttgaaagcaattaggttattcacctggtattaaaactatttactgttaaaaaatctgtgacttcatgaagttgatttttaaaggca gcatcaaaaactgaaaaggnaagggaaaaaataggcagcttctctgcacttgtttggagctccccaaaacaggagccatggagaagtggcatcaagaccgg gctgccctttcgagaacaccctgtggcagttcagagacacgcttttcctacactgcatgcagcccctctttccagcactggaaagaagtggtcttgagcccagctg agaagcacttcacactcctctctcttgttctgaatggtgtttgtgtcagtctgcagctgtgtatggtattatgtcttataatcctgcatcacttctatcctatccagtcatat 294 212265_at gggtagatgggagtgtcgcttgtatgttatcgtacagctgacatgtatttttgtctattctttattatcttagtttcatgctatgtatgtaccataaccaacctattgcctatgag aaacatgtaagataatgtatttacagccattgttacaagtttataatgtatttttctatcttgttttatatgtatgttatataacattcaaaaagaatttttttcttgattgagaaaa ggatacaaaatgcaaaatccacaattttgataactgaaaattgccaattgttttgcagtactttattatattgggtgtcttgtcttttttgggcttttagttagctaatgaatga atacattagacacttttgggttttagttgggattttacatagcttgcattttaattctttggttctttgctgtttctattaacccacagcattatt 295 212288_at gaaggttgtcatgggctgttccttgggggtttttatcctgctcaccgtggagataagcctgcggcttgtctaaccagcgcagcgcaaaggtctcaatgccttttggtaa catccgtcattgcagaagaaagtttacacgacgtcaaaaagtgacgttcatgctaagtgtttttccagaaatattggtttcatgtttcttattggctctgcctcctgtgctta tatcatccaaaaactttttaaaaaggtccagaattctattttaacctgatgttgagcacctttaaaacgttcgtatgtgtgttgcactaattctaaactttggaggcattttgc tgtgtgaggccgatcgccactgtaaaggtcctagagttgcctgtttgtctctggagat 296 212386_at gagatttaccatgtatcagtgcctggctttttgttataaagctttgtttgtctagtgctcttttgctataaaatagactgtagtacaccctagtaggaaaaaaaaaaaacta aatttaaaaataaaaaatatatttggcttatttttcgcaggagcaatccttttataccatgaatatt 297 212387_at gtttatacaactgtcagtccacccagtggtgcaactggttctgattcagtcttccgatncctttttatttttcactttttcctatttctgaattttttttttnatttgtgatcttgattttga tgaggggttggggagtggggagggagtcgaaccaagacttggagttaagaggattttcatcttttgcatccaacaggcagaatatgatctgtgtccaaaagtgaa cttgagtcaggaatgaatcaatttcagcataaacaagcacaaaaatttagtctgctggctgactggaagcaaaaaagtcaagatggaatatgatgaattccaac acaatggggcaccaaggcctttaggcctctctttttattttgctttggttttgtttgtttttctttagagacatgctctttctcatgggacttgaagtggactcatctttgtgcagtg ctggttttgccatactcatttcaagtattatagacatatgtaatggtgaaaatatatgaactgtggcctttttcattcttgttacttgtg 298 212397_at gaagtgactgttgtaccatggttgtgcacatgcttcagaatcctatggaagagaatattcctacttgcagtacatcaaaggaatggatggtggaccctactattcatgt tttgagacataaatgttcactttaaagcaattgcataatagataaaaacctgaactttcattggatttttgttaattttcctcattttgaattatgtgcactaccatagctacat cagtttgatacagtattgaaaaattatcagttatattttgctgtttatgatctatttgtagattaggattaaaatggatttaatccatttttaaggctgtgtgaatttttctaaaca agaaccatttgcaatatggatttcttagagattaaaccaattataacttattagcagtcgcgagcacatgttcatatagtcaatgtaaaaatacactaatgagtatttgg taaatcccagtaggcttttaccattagca 299 212414_s_at tccctcacttctcttaagccaagaagtttgctttccctagctgcagtgtagatggctcttgtttttgtttttttgttttaatcatttggcattcacatgtggctgttaatatgtgcttgt tttt 300 212419_at tggtgggagggctctcaatcagcagggccccaggagggaagaagaagtggggcaaagcntggcctcgccgctcgggagctttgccatctgagccacgcctc ctccaggccatgctccttgaacttggaaatgtcaaccggagcccttacaccagccctccagcatctaatagacttgaatctactctaaacgaatatttaatccaacc tcactacattgtagctcagtccaacgactaaccctgaaatgggggtgttccagccttcagcgagatggccaagcggtcccctgggggctgtggcagcggncttat ccttctctgttgccaaccttgccgtccgacctcctccgcccccatgcggtgaccccgtccgtgtctgtgtctgtccatacgtgtgagtccagctaaaaagacaaaaca gaacccgtgggcccagctcggaaggtgcgtggagaaggctccgacgtctccgaagtgcagcccttgggatggcattccgttgtgtgccttattcctggagaatct gtatacggctcgcctatagaa 301 212464_s_at cttctccaagcatcaccctgggagtttcctgagggttttctcataaatgagggctgcacattgcctgttctgcttcgaagtattcaatanccgctcagtattttaaatgaa gtgattctaagantttggtttgggatcaatanggaaagncatatgnncagnnccaanccaagatgcaaatgttttgaaatgatatgaccaaaattttaagtaggaa agtcancccaaacacttctgctttcacttaagtgtctggcccgcaatactgtaggaacaagcatgatcttgttactgtgatattttaaatatccacagtactcactttttcc aaatgatcctagtaattgcct 302 212592_at gtatcaaaatcttccaattatcatgctcacctgaaagaggtatgctctcttaggaatacagtttctagcattaaacaaataaacaaggggagaaaataaaactcaa ggagtgaaaatcaggaggtgtaataaaatgttcctcgcattcccccccgcntttttttttttttttgactttgccttggagagccagagcttccgcattttctttactattcttttt aaaaaaagtttcactgtgtagagaacatatatgcataaacataggtcaattatatgtctccattagaaaaataataattggaaaacatgttctagaactagttacaa aaataatttaaggtgaaatctctaatatttataaaagtagcaaaataaatgcataattaaaatatatttggacataacagactt 303 212667_at caggaggacacagcattattctagtgctgtactgttccgtacggcagccactacccacatgtaactttttaagatttaaatttaaattagttaacattcaaaacgcagc tccccaatcacactagcaacatttcaagtgcttgagagccatgcatgattagtggttaccctattgaataggtcagaagtagaatcttttcatcatcacagaaagttct attggacagtgctcttctagatcatcataagactacagagcacttttcaaagctcatgcatgttcatcatgttagtgtcgtattttgagctggggttttgagactnccctta gagatagagaaacagacccaagaaatgtgctcaattgcaatgggccacatacctagatctccagatgtcatttcccctctcttattttaagttatg 304 212671_s_at accaatgaggttcctgaggtcacagtgttttccaagtctcccgtgacactgggtcagcccaacaccctcatctgtcttgtggacaacatctttcctcctgtggtcaaca tcacntggctgagcaatgggcactcagtcacagaaggtgtttctgagaccagcttcctctccaaagagtgatcattccttcttcaagatcagttacctcaccttcctccc ttctgntgatgagatttatgactgcaaggtggagcactggggcctggatgagcctcttctgaaacactgggagcctg 305 212713_at cacatggttctagcctggacctggctgggctccatgagaatgagttgcctccaccctgtcccaacagctgacagccaggagccactctcccagctgcaggccttt gtggtccatcttgtcctgcttcctcactgtggacccctgtctgggccaccctagtgtgctaagctgagcagtgcagtgtgaacagggcccatggtgtattctaggcca cagcccagcactcctctgggctgctctcaaaccatgtcccatcttcagcatccctcccaccaacttactcccctgtggtgagtaccgtggaaccccagcccacctc actatcatactcagcttcccctgatggcccatcccagcccctgaagctntatgccaagaacacagctaccgcacaccaccctgaaacagccacagccaaggta ggcatgcatatgaggtcttccccataccctctgggtgttgagaggtttagccacatgagggagcagaggacaatctctgcagggctgggagtgggtagggactg aaggtctcaat 306 212730_at tcagtgtctgggctcatgacttgtaaatggaagctgatgtgaacaggtaattaatattatgacccacttctatttactttgggaaatatcttggatcttaattatcatctgca agtttcaagaagtattctgccaaaagtatttacaagtatggactcatgagctattgttggttgctaaatgtgaatcacgcgggagtgagtgtgcccttcacactgtgac attgtgacattgtgacaagctccatgtcctttaaaatcagtcactctgcacacaagagaaatcaacttcgtggttggatggggccggaacacaaccagtctttttgta tttattgttactgagacaaaacagtactcactgagtgtttttcagtttcctactggtggttttgatattgtttgtttaagatgtatatttagaatgacatcatctaagaagctgat tttgctaaactcctgttccc 307 212741_at gaactcatgtgatttacccttttcaactttttggaaaacgatttaatttattctaattagattaaccctattaatctatggattgggtatcaaaatgaatgccagtccagatgt gcctagacacgaaattggagctgaggactctcacgatatgcaagttcatccaacgtgaagataccataagctttttctctgaaccagagaaatgaaagtcagttta agaggctgatagatcttggccctgttaaggcatccacttcacagttctgaaggctgagtcagccccactccacagttaggccaagaattagattttaaaacttcatct gtctgtcccagttaactgttaaataaggcctcatcctccactgaagagtatggattgaaggattgtgaactatgtttagtgtgattgtgaacttggtgcctaatgttccat gtctgaagtttgccccagtgctacacgttggagta 308 212764_at gatgcaattggttctcctgcattgagatttgatttaacagtgttatgttaacatttatacttgccttggactgtagaacagaacttaaatgggaatgtattagttttacaacta caatcaagtcattttacctttacccagtttttaatataaaacttaaattttgaaattcactgtgtgactaatagcatgatgctctgcagttttattaagaaatnagcctaacc atacaactctcatttccttagtaagccaaattaggattaacttctataaacagtgttgggaacaatgtttaacattttgtgccaatttgttcctgtattcatgtatgtaagtta cagatctgactcttcatttttaagttccttgttacatcatggtcatt 309 212814_at cctatcctacttgcccatatgagcacggctccccatggccacatactcctgcaaagcttttatgctgcttcgcttttctctaaacagatctgatattgctgctcctgtggtttt ctcaaaattaactttgccgtggtttttaaaaaggaatcaaaatgcattgttgcattaagctttttcaataaaggaaaattacggaaggaaaataggcaacaccagca aattatatgtggacaggttctaaactctatatatacatatatatatatatatctatatatctatatacgtaatcatctagttctgtcatcttactgaaaggaataacacttcta aagatcaccatttctgagaagttcttggaaatctttatgtctaa 310 212859_x_at caccgcgcagagctcagggggtggtgcgcccggcccttctgcggcgcacagcccagcccaggaacgcgggcggtgcggactcagcgggccgggtgcagg cgcggagctgggcctctgcgcccggcccganctccgtctataaanagagcagccagttgcagggctcnantctgctttccaactgcctgactgcttgttcgtctca ctggtgtgagctccagcatcccctttgctcgaaatggaccccaactgctcttgcgccactggntggctcctgcacgtgcgccggctcctgcaagtgcaaagagtgc aaatgcacctcctgcaagaagagctgctgttcctgctnccccgtggnctgtgccaagtgtgcccagggctgcgtctgcaaaggggcatcggagaagtgcagct gctgtgcctgatgtgggaacagctcttctcccagatgtaaatagaacaacctgcacaacctggnatttttttaaaaatacaacactgagccatttgctgcatttc 311 212956_at tactgatgcttctgatactggatgtttagcttcttactgcaaaaacataagtaaaacagtcaactttaccatttccgtattctccatagattgaagaaatttataccacata tcgcatatgaccatctttccatcaaatcaatgtagagataatgtaaactgaaaaaaaatctgcaagataatgtaactgaatgttttaaaaacagaacttgtcactttat ataaaagaatagtatgctctatttcctgaatggatgtggaaatgaaagctagcgcacctgcactttgaattcttgcttcttttttattactgttatgattttgctttttacagatg ttggacgattttttcttctgattgttgaattcataatcatggtctcatttcctttgcttctttggaatatttctttcaacacattcctttattttattatacattgtgtcctttttttagctattg ctgct 312 213068_at gacaggagggtgtccacatatgttaacatcagttggatctcctatagaagtttctgctgctctttccttctccctgagctggtaactgcaatgccaacttcctgggcctt tctgactagtatcacacttctaataaaatccacaa 313 213071_at gctccacatgagccatgcatgcttagcaatccaagtgcagagctctttgctccaggagtgaggagactgggaggtgaaatggggaaatggaagggtttggagg cagagctgaaaacagggttggaaggatttcctgaattagaagacaaacgttagcatacccagtaaggaaaannngnnnaggggccanggggaacccgtg aggatcactctcaaatgagattaaaaacaaggaagcagagaatggtcagagaatgggattcagattgggaacttgtggggatgagagtgaccaggttgaact gggaagtggaaaaaggagtttgagtcactggcacctagaagcctgcccacgattcctaggaaggctggcagacaccctggaaccctggggagctactggca aactctcctggattggncctnatnnttttggtgggaaaggctgccctggggatcaactttccttctgtgtgtggctcaggagttcttctgcagagatggcgctatctttcct cctcctgtgatgtcctgctcccaaccatttgtactcttcatta 314 213317_at aagtgtgcataatttcatttaacgttaaagaaatagatccaattcctttcttgcaaccaaaaataaataaaatacgttgcctcaatataaggtttgggctattctgtgtttc tatagaagcaatctgtttttggtaaaatgtacttttaaggatccagtcatctgaagtattttatgtagagttagagatttcacaatattgactatacatatatttaaaatataa attatccagctgatgtttgaatttgtcttactttcctggccacctcgttgtcctattttataagctggggagttaactagcttaacaaaagatgcttagcttttgtaaaagaac aagtgtttcattttacaaagacactccaaatgatagttacttgattttctcgagacctttaactatggtgatgaataacaggacttgctttcaagccttaataaatgtaaa atgccttttaatgaagatacagctgagtgttttcctcatgaatctgaaccaattaccaatttgtgttccagtcttgatt 315 213428_s_at gaaaccaaggtcaggaggccgttgcagacataaatctcggcgactcggccccgtctcctgagggtcctgctggtgaccggcctggaccttggccctacagccct ggaggccgctgctgaccagcactgaccccgacctcagagagtactcgcaggggcgctggctgcactcaagaccctcgagattaacggtgctaaccccgtctg ctcctccctcccgcagagactggggcctggactggacatgagagccccttggtgccacagagggctgtgtcttactagaaacaacgcaaacctctccttcctcag aatagtgatgtgttcgacgttttatcaaaggccccctttctatgttcatgttagttttgctccttctgtgtttttttctgaaccatatccatgttgctgacttttc 316 213451_x_at cacaggcaggtgactactccatgcgcgtggacctgcgggctggggacgaggctgtgttcgcccagtacgactccttccacgtagactcggctgcggagtactac cgcctccacttggagggctaccacggcaccgcaggggactccatgagctaccacagcggcagtgtcttctctgcccgtgatcgggaccccaacagcttgctcat ctcctgcgctgtctcctaccgaggggcctggtggtacaggaactgccactacgccaacctcaacgggctctacgggagcacagtggaccatcagggagtgag ctggtaccactggaagggcttcgagttctcggtgcccttcacggaaatgaagctgagaccaagaaactttcgctccccagcggggggaggctgagctgctgccc acctctctcgcaccccagtatgactgccgagcactgaggggtcgccccgagagaagagccagggtccttcaccacccagccgctggaggaagccttctctgc cagcgatctcgcagcactgtgtttacag 317 213509_x_at ccaatggcgagggtctgccacactggccgctgttcgaccaggaggagcaatacctgcagctgaacctacagcctgcggtgggccgggctctgaaggcccac aggctccagttctggaagaaggcgctgccccaaaagatccaggagctcgaggagcctgaagagagacacacagagctgtagctccctgtgccggggagga gggggtgggttcgctgacaggcgagggtcagcctgctgtgcccacacacacccactaaggagaaagaagttgattccttcattcacttcgccattcattcatacttc cgtccatccattcagaaagcatttattaagaatttactcaggcatgatggcccatacttgtaatcccagctattgggaaggatgagatgggaggatggcttgaggcc agaggtttgagaccgaccagcc 318 213624_at gggagagtccatctggaagctggagtatatcctgacccagacctacgacattgaagatttgcagccggaaagtttatatggattagctaaacaatttacaatccta gacagtaagcagtttataaaatactacaattacttctttgtgagttatgacagcagtgtaacatgtgataagacatgtaaggcctttcagatttgtgcaattatgaatctt gataatatttcctatgcagattgcctcaaacagctttatataaagcacaattactagtatttcacagtttttgctaatagaaaatgctgattctgattctgagatcaatttgt gggaattttacataaatctttgttaattactgagtgggcaagtagacttcctgtctttgctttctttttttttttctttttgatgccttaatgtagatatctttatcattctgaattgtatta tatatttaaantgctcattaatagaatgatggatgtaaattggatgtaaatattcagtttatataattatatctaatttgtacccttgttgaaattgtcattta 319 213629_x_at cttcgcttctctcttggaaagtccagtctctcctcggcttgcaatggaccccaactgctcctgcgccgctggtgtctcctgcacctgcgctggttcctgcaagtgcaaa gagtgcaaatgcacctcctgcaagaagagctgctgctcctngctnccccgtgggctgtagcaagtgtgcccagggctgtgtttgcaaaggggcgtcagagaagt gcagctgctgcgactgatgccaggacaacctttctcccagatgtaaacagagagacatgtacaaacctggattttttttttataccaccttgacccatttgctacattcc ttttcctgtgaaa 320 213746_s_at cctggggctgagcaaggcctacgtaggccagaagagcagcttcacagtagactgcagcaaagcaggcaacaacatgctgctggtnggggttcatggcccna ngaccccctgcgaggagnnnnngnngnagcacgtgggcagccggctntacagcgtgtcctacctgctcaaggacaagggggagtacacactggtggtcaa atggggg 321 213891_s_at gaaactgtatgggtagcttttttgtttgttttttgttttgtttttgtttttgtttttgtttttagttgtaggtcgcagcggggaaattttttgcgactgtacacatagctgcagcattaaa aacttaaaaaaattgttaaaaaaanaaaaaaagggaaaacatttcaaaaaaaaaaaaanngataaacagttacaccttgttttcaatgtgtggctgagtgcctc gattttttcatgtttttggtgtatttctgatttgtagaagtgtccaaacaggttgtgtgctggagttccttcaagacaaaaacaaacccagcttggtcaaggccattacctgt ttcccatctgtagttattcg 322 213921_at gctgctgccgcggggaagcaggaactggccaagtacttcttggcagagctgctgtctgaacccaaccagacggagaatgatgccctggaacctgaagatctgt cccaggctgctgagcaggatgaaatgaggcttgagctgcagagatctgctaactcaaacccggctatggcaccccgagaacgcaaagctggctgcaagaatt tcttctggaagactttcacatcctgttagctttcttaactagtattgtccatatcagacctctgatccctcgcccccacaccccatctctcttccctaatcctccaagtcttca gcgagacccttgcattagaaactga 323 213953_at acaggaaattgctacttaccgccgccttctggaaggagaagacgtaaaaactacagaatatcagttaagcaccctggaagagagagatataaagaaaacca gnaagattaagacagtcgtgcaagaagtagtggatggcaaggtcgtgtcatctgaagtcaaagaggtggaagaaaatatctaaatagctaccagaaggagat gctgctgaggttttgaaagaaatttggctataatcttatctttgctccctgcaagaaatcagccataagaaagcactattaatactctgcagtgattagaaggggtgg ggtggcgggaatcctatttatcagactctgtaattgaatataaatgttttactcagaggagctgcaaattgcctgcaaaaatgaaatccagtgagcactagaatattt aaaacatcattactgccatctttatcatgaagcacatcaattacaagctgtagaccacctaatatca 324 214027_x_at gagaaagccaggcaggtagccagggggactagcccctgtggagactggggggcttgaaattgtccccgtggtctcttactttcctttccccagcccagggtgga cttagaaagcaggggctacaagagggaatccccgaaggtgctggaggtgggagcaggagattgagaaggagagaaagtgggtgagatgctggagaaga gaggagaggagagaggcagagagcggtctcaggctggtgggaggggcgcccacctccccacgccctcccctcccctgctgcaggggctctggagaga 325 214038_at atgagccttcatacatggactgagagtcagagcttgaagaaaagcttatttattttccccaacctcccccaggtgcagtgtgacattattttattataacatccacaaa gagattatttttaaataatttaaagcataatatttcttaaaaagtatttaattatatttaagttgttgatgttttaactctatctgtcatacatcctagtgaatgtaaaatgcaaa atcctggtgatgtgttttttgtttttgttttcctgtgagctcaactaagttcacggcaaaatgtcattgttctccctcctacctgtctgtagtgttgtggggtcctcccatggatca tcaaggtgaaacactttggtattctttggcaatcagtgctcctgtaagtcaaatgtgtgctttgtactgctgttgtt 326 214091_s_at atgcctacaggtatgcgtgattgtgtgtgtgtgcatgggtgnacagccacntgtctacctatgtgtctttctgggaatgtgtaccatctgtgtgcctgcagctgtgtagtg ctggacagtgacaaccctttctccagttctccactccaatgataatagttcacttacacctaaacccaaaggaaaaaccagctntaggtccaattgttntgctcta nactgatacctcaaccttggggccagcatctcccactgcctccaaatattagtaantatgactgacgtncccanaagtttntgggtnnnaccacactccccaacc ccccactcctanttcctgaagggccctcccaaggntacatccccaccccacagttctccctgagagagatcaacctccctgagatcaaccaaggcagatgtgac agcaagggccacggacc 327 214142_at gcctctggcaatgccattcaggccaggtcttcctcctatngtgnagannatnnnnntggnggtggaaagcgattctctcattctggcaaccagttggnacggccc catcaccgccctccgggtccgagtcaacacatactacatcgtaggtcttcaggtgcgctatggcaaggtgtggagcgactatgtgggtggtcgcaacggagacc tggaggagatctttctgcaccctggggaatcagtgatccaggtttctgggaagtacaagtggtacctgaagaagctggtatttgtgacagacaagggccgctatct gtcttttgggaaagacagtggcacaagtttcaatgccgtccccttgcaccccaacaccgtgctccgcttcatcagtggccggtctggttctctcatcgatgccattggc ctgcactgggatgtttaccccactagctgcagcagatgctgagcctcctctccttggcaggggcactgtgatgaggagtaagaactcccttatcactaac 328 214164_x_at acaaggcccaggctggggccagggccagaggggaaggccctggattctcactcatgtgagatcttgaatctctttctttgttctgtttgtttagttagtatcatctggta aaatagttaaaaaacaacaaaaaactctgtatctgtttctagcatgtgctgcattgactctattaatcacatttcaaattcaccctacattcctctcctcttcactagcctct ctgaaggtgtcctggccagccctggagaagcactggtgtctgcagcacccctcagttcctgtgcctcagcccacaggccactgtgataatggtctgtttagcacttc tgtat 329 214414_x_at tcaacttcaagctcctaagccactgcctgctggtgaccctggccgcccacctccccgccgagttcaacccctgnggtgcacgcctccctgganaagttcctggctt ctgtgagcaccgtgctgacctccaaataccgttaagctggagcctcggtagccgttcnnnnnncnngctnggcnntccaacgggccctcctcccctccttgcac cggcccttcctggtctttgaataaagtctgagtg 330 214433_s_at cttcctcggaggcagcattgttaagggaggccctgtgcaagtgctggaggacgaggaactaaagtcccagccagagcccctagtggtcaagggaaaacggg tggctggaggccctcagatgatccagctcagcctggatgggaagcgcctctacatcaccacgtcgctgtacagtgcctgggacaagcagttttaccctgatctcat cagggaaggctctgtgatgctgcaggttgatgtagacacagtaaaaggagggctgaagttgaaccccaacttcctggtggacttcgggaaggagccccttggc ccagcccttgcccnatgagctccgctaccctgggggcgattgtagctctgacatctggatttgaaggctccaccctcatcacccacactccctattttgggccctcac ttccttggggacctggcttcattctgctctctcttggcacccgacccttggcagcatgtaccacacagccaagctgagactgtggcaatgtgttgagtcatatacattta ctgaccactgttgct 331 214505_s_at ccatcggtgcggactccaaggaggtgcactataagaaccgcttctggcatgacacctgcttccgctgtgccaagtgccttcaccccttggccaatgagacctttgt ggccaaggacaacaagatcctgtgcaacaagtgcaccactcgggaggactcccccaagtgcaaggggtgcttcaaggccattgtggcaggagatcaaaac gtggagtacaaggggaccgtctggcacaaagactgcttcacctgtagtaactgcaagcaagtcatcgggactggaagcttcttccctaaaggggaggacttcta ctgcgtgacttgccatgagaccaagtttgccaagcattgcgtgaagtgcaacaagggtttggtaaaggctccagtgtggtggcctatgaaggacaatcctggcac gactactgcttccactgcaaaaaatgctccgtgaatctggccaacaagcgctttgttttccaccaggagcaagtgtattgtcccgactgtgc 332 214598_at ttgtcaaggggctttgcattcaaactgcttttccagggctatactcagaagaaagataaaagtgtgatctaagaaaaagtgatggttttaggaaagtgaaaatattttt gtttttgtatttgaagaagaatgatgcattttgacaagaaatcatatatgtatggatatattttaataagtatttgagtacagactttgaggtttcatcaatataaataaaag agcagaaaaatatgtcttggttttcatttgcttaccaaaaaaacaacaacaaaaaaagttgtcctttgagaacttcacctgctcctatgtgggtacctgagtcaaaatt gtcatttttgttctgtgaaaaataaatttccttcttgtaccatttctgtttagttttactaaaatctgtaaatactgtatttttctgtttattccaaatttgatgaaactgacaatcca atttgaaagtttgtgtcgacgtctgtctagcttaaatgaatg 333 214677_x_at tcataagtgacttctacccgggagccgtgacagtggcctggaaggcagatagcagccccgtcaaggcgggagtggagaccaccacaccctccaaacaaag caacaacaagtacgcggccagcagctatctgagcctgacgcctgagcagtggaagtcccacagaagctacagctgccaggtcacgcatgaagggagcacc gtggagaagacagtggcccctacagaatgttcataggttctcaaccctcac 334 214696_at gagtatacatcggtgcaggcttcctggatgacagttgggtgatatgtgtcatgtggcctaaaagcctccatgtcatttgacctacgaattctatctttgggaatttatcct aagaaantacttanggatttanttngtgataagatgttcatcccagcattgcaatggagaaaaatgggaagcaatggtttggttgggaatttattccttttctgctgtaa cgaaagtttgcaataggggattgcttaagtaaattattgtatctccatccagatggtggagtaccgcgcagacattaaaagtcatgtaaaagaacatctgactgaa agaaaaatgctccttgaatattaaaaggttgtaaaaatagtgcatgttatgtgatttcaattttgttttttaaaatatgggtgtatgcttgtatacgtagagcagataaaaa agacggaaggcatactaaaaaatgttgagtggttatctttgtatggtggaacaaagtcactgtaattttcatctttggtt 335 214752_x_at tggggctgagcaaggcctacgtaggccagaagagcagcttcacagtagactgcagcaaagcaggcaacaacatgctgctggtgggggttcatggcccaag gaccccctgcgaggagatcctggtgaagcacgtgggcagccggctctacagcgtgtcctacctgctcaaggacaagggggagtacacactggtggtcaaatg gggggacgagcacatcccaggcagcccctaccgcgttgtggtgccctgagtntggggcccgtgccagccggcagcccccaagcctgccccgctacccaagc agccccgccctnttcccctcaaccccggcccaggccgccctggccgcccgcctgtcactgcagccgcccctgccctgtgccgtgntgcgctcacctgcctcccc agccagccgctgacctctcggctttcacttgggcagagggagccatttggtggcgctgcttgtcttctttggttctgggaggggt 336 214768_x_at aatgctctgggtctctggatccagtggggnatattgtgatgactcagtctccactctccctgcccgtcacccctggagagccggcctccatctcctgcaggtctagtc agagcctcntgcatnntaatggatacaactatttggattggtacctgcagaagccagggcagtctccacagctcctgatctatttgggttctaatcgggcctccggg gtcccngacaggttcagtggcagtggatcaggcacagattttacactgaaaatcagcagagtggaggctgaggatgttggggtttattactgcatgcaagctctac aaactcctcngacnttnggccangggaccaagntgganatcaaacgaactgtggctgcaccatct 337 214777_at gcaagatggtgttgcagacccaggtcttcatttctctgttgctctggatctctggtgcctacggggacatcgtgatgacccagtctccagactccctggctgtgtctctg ggcgagagggccaccatcaactgcangtccagccagagtgttttatacagctccaacaataagaactacttagcttggtaccagcagaaaccaggacagcct cctaagctnctcatttactgggcatctacccgggaatccggggtccctgaccgattcagtggcagcgggtctgggacagattt 338 214916_x_at gaggtgcagctgttggagtctgggggaggcttggtacagcctggggggtccctgagactctcctgtgcagcctctggattcacctttagcanctatgccatgagctg ggtccgccaggctccaggnaaggggctggagtgggtctcanntattagtggtagtggtnntancacatactacgnagactccgtgaagggccggttcaccatct ccagagacaattccaagaacacgctgtntctgcaaatgaacagcctgagagccgaggncacggccgtatattactgtncnnnagaaaatggtgtcagcagtt gganntnccaaganannaccccaacctatgttgactactggggccaggaaccctggtcaccgtctcctcagggagtgcatccgccccaacccttttccccctcg tctcctgtgagaattccccgtcggatacgaagcagcgtggccgttggctgctc 339 215049_x_at cgtcagtcatcctttattgcagtcgggatccttggggttgttctgttggccattttcgtcgcattattcttcttgactaaaaagcgaagacagagacagcggcttgcagttt cctcaagaggagagaacttagtccaccaaattcaataccgggagatgaattcttgcctgaatgcagatgatctggacctaatgaattcctcagaaaattcccatg agtcagctgatttcagtgctgctgaactaatttctgtgtctaaatttcttcctatttctggaatggaaaaggaggccattctgagccacactgaaaaggaaaatggga atttataacccagtgagttcagcctttaagataccttgatgaagacctggactattgaatggagcagaaattcacctctctcactgactattacagttgcatttttatgga gttcttcttctcctaggattcctaagactgctgctga 340 215076_s_at ggggaatggagcaaaacagtctttgaatatcgaacacgcaaggctgtgagactacctattgtagatattgcaccctatgacattggtggtcctgatcaagaatttg gtgtggacgttggccct 341 215118_s_at cttgctctgttgcagattggcagatgccgcctccctatgtggtgctggacttgccgcaggagaccctggaggaggagacccccggcgccaacctgtggcccacc accatcaccttcctcaccctcttcctgctgagcctgttctatagcacagcactgaccgtgaccagcgtccggggcccatctggcaacagggagggcccccagtac tgagcgggagccggcaaggcacagggaggaagtgtggaggaacctcttggagaagccagctatgcttgccagaactcagcc 342 215125_s_at gcataaattaatcagccccagagtgctttaannnnttctcttaaataccggtgtctttgatcaggatgacatgtgccatttttcagaggacgtgcagacaggctggca ttctagattacttttcttactctgaaacatggcctgtttgggagtgcgggattcaaaggtggtcccaccgctgcccctactgcaaatggcagttntaatcttatcttttggct tctgcagatggttgcaatngatccttaaccaataatggtcagtcctcatctctgt 343 215176_x_at ctactctggctccgaggtgccagatgtgacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcaccatcacttgccgggcaagtc agagcattagcagctatttaaattggtatcagcagaaaccaggnaaagcccctangctcctgatctatgctgcatccantttgcaaagtggggtcccatcaaggtt cagtggcagtggatctgggacagatttcactctcaccatcagcagtctgcaacctgaagattttgcaacttactactgtcaacagagttacagtacccctca 344 215193_x_at gccgagtactggaacagccagaaggacntcctggaagacnagcgggccnnggtggacacctactgcagacacaactacggggttgnngagagcttcacn gtgcagcggcgagtccatcctnaggtgactgtgtatcctncaaagacccagcccctgcagcaccacaanctcctggtctgntctgtgagtggtttctatccaggca gcattgnaagtcaggtggttncggaanggcnaggaagagaagnctggggntggtgtccacnggcctgatccagaatggagactggaccttccagaccctggt gatgctngaaacagttcctcggagtggagaggtttacacctgccaagtggagcacccaagcntnacgagccctctcacagtggaatggagngcacggtctga atctgcacagagcaagatgctgagtggagtcgggggctt 345 215299_x_at aagatcctggagtttgtggggcgctccctnccagaggagacngtggacntcatggttnagcacacgtcgttcaaggagatgaagaagaaccctatgaccaact acaccaccgtccnccnggagttcatggaccacagcatctcccccttcatgaggaaaggcatggctggggacnngngnngnccacnttcaccgtggcgcaga atgagcgcttcgatgcggacntatgcggagaagatggcaggncngcagcctcangcttccgctntgagcngtgagaggggnnncntggagtcacngcaga gggagtgtgcgaatcaaacctgaccaagcggntcaagaataaaatatgaattgagggccngggacggtaggtcatgtctgtaatcccagcaatttggaggctg aggtgggaggatcatttgagcccaggagttcgagaccaacctgggcaacatagtgagattctgttaaaaaaataaaataaaataaaaccaatttttaaaaaga gaataaaatatgattgtgggccaggcagagtggctcatgc 346 215382_x_at ccggtcagcaggatcatcgtgcacccacagttctacatcatccagactggagcggatatcgccctgctggagctggaggagcccgtgaacatctccagccgcg tccacacggtcatgctgccccctgcctcggagaccttccccccgggnntgccgtgctgggtcactggctggggcgatgtggacaatgatgagcccctcccaccg ccatttcccctgaagcaggtgaaggtccccataatggaaaaccacatttgtgacgcaaaataccaccttggcgcctacacgggagacgacgtccgcatcatcc gtgacgacatgctgtgtgccgggaacacccggagngnntcatgccagggcgactcnggagggcccctggtgtgcaaggtgaatggcacctggctncaggcg ggcgtggtcagctgggncgagggctgtgcccagcccaaccggcctggcatctacacccgtgtcacctactacttggactggatcc 347 215388_s_at gaaccacctcaatgcaaagattctacgggaaaatgtgggccccctccacctattgacaatggggacattacttcattcccgttgtcagtatatgctccagcttcatca gttgagtaccaatgccagaacttgtatcaacttgagggtaacaagcgaataacatgtagaaatggacaatggtcagaaccaccaaaatgcttacatccgtgtgta atatcccgagaaattatggaaaattataacatagcattaaggtggacagccaaacagaagctttatttgagaacaggtgaatcagctgaatttgtgtgtaaacgg ggatatcngtctttcatcacgttctcacacattgcgaacaacatgttgggatgggnnnctggagtatccaacttgtgcannnngatagaatcaatcataaaatgca cacctttattcagaactttagtattaaatcagttcttaatttcatttttaagtattgttttactcctttttattcatacgtaaaattttggatta 348 215657_at tcttccaatttattatctgcaccaattattttgggcacttctcctgtgtatgtaaactttggagtttaggtctacgtcatttatataagagcctgtagacctgagtggatggac actgcctcttagaactagaacttagaactttatcttgaaaatgtacnncnnnngcngaannnccncacagagtatgtgtcaggtaggaaccaaatttatgattgtt atattcaaactggttttctgttccttgaaaatggtnttttttctgatcaaagcctatttaggagttattatgttcttgagtttattccatgtgtgtgaatattttgaatgaatccacta ataagatatgcatgtatgtctggannnnnnncnnnnnagaataaatatttaagtagactttaacaagtaaatggttgtaggcatcattaagtcttaaatagccttttc aaagatattagtgttctngttttaattattcagataattcctttaattctccactcaaatctgacttta 349 215867_x_at gattcctgtgggtccagctttggaactgggaaacctttcttcggatccgcactcattccactgatgccagctgcccctgaaggatgccagtactgtggtgtgtgagtct cagcagccgcccacacgctcctaactctgctgcatggcagatgcctaggtggaaatagcaaaaacaaggcccgggctggggccagggccagaggggaag gccctggattctcactcatgtgagatcttgaatctctttctttgttctgtttgtttagttagtatcatctggtaaaatagttaaaaaacaacaaaaaactctgtatctgtttctag catgtgctgcattgactctattaatcacatttcaaattcaccctacattcctctcctcttcactagcctctctgaaggtgtcctggccagccctggagaagcactggtgtct gcagcacccctcagttcctgtgcctcagcccacaggccactgtgataatggtctgtttagcacttctgtat 350 216207_x_at ctctggctcccaggtgccagatgtgccatccagttgacccagtctccatcctccctgtctgcatctgtaggagacagagtcaccatcacttgccgggcaagtcagg gcattagcagtgctttagcctgntatcagcagaaaccagggaaagctcctaagctcctgatctatgatgcctccagtttgnaaantggggtcccatcaaggttcag cggcagtggatctgggacagatttcactctcaccatcagcagcctgcagcctgaagattttgc 351 216336_x_at ccaactgcctgactgcttgttggcctcaccggtgggagctccagcatctcctttgctcgaaatggaccccaactgctcctgtgccactggtggctcctgcatgtgcgc cggctcctgcaagtgcaaagagtgcaaatgcacctcctgcaagaagagctgctgctcctgctgccccgtgggctgtgccaagtgtgcccagggctgcatctgca aaggggcgttggagaagtgcaactgctatgcctgacgtggggacagctctgctcccagatgtaaatagagtaacctgcacaaacctggattttttaaaaaataca acactgagccatttgcttcatt 352 216401_x_at tcctccctgtctgcatctgtaggagacagagtcaccatcacttgccgggtgagtcagggcattagcagttatttaaattggtatcggcagaaaccagggaaagttcc taagctcctgatctatagtgcatccaatttgcaatctggagtcccatctcggttcagtggcagtggatctgggacagatttcactctcactatcagcagcctgcagcct gaagatgttgcaacttattacggtcaacggacttacaatgccc 353 216442_x_at tggaggaagttctccagcttcagctcaactcacagcttctccaagcatcaccctgggagtttcctgagggttttctcataaatgagggctgcacattgcctgttctgctt cgaagtattcaataccgctcagtattttaaatgaagtgattctaagatttggtttgggatcaataggaaagcatatgcagccaaccaagatgcaaatgttttgaaatg atatgaccaaaattttaagtaggaaagtcacccaaacacttctgctttcacttaagtgtctggcccgcaatactgtaggaacaagcatgatcttgttactgtgatatttt aaatatccacagtactcactttttccaaatgatcctagtaattgcctagaaatatctttctcttacctgttatttatcaatttttcccagtatttttatacggaaaaaattgtattg aaaacacttagtatgcagttgataagaggaatttggtataattatggtgggtgattattttttatactgtatgtgccaaagctttactactgtg 354 216474_x_at ccgccatttcctctgaagcaggtgaaggtccccataatggaaaaccacatttgtgacgcaaaataccaccttggcgcctacacgggagacgacgtccgcatcgt ccgtgacgacatgctgtgtgccgggaacacccggagggactcatgccagggcgactccggagggcccctggtgtgcaaggtgaatggcacctggctgcagg cgggcgtggtcagctggggcgagggctgtgcccagcccaaccggcctggcatctacacccgtgtcacctactacttggactggatccaccactatgtccccaaa aagccgtgagtcaggcctgggttggccacctgggtcactggaggaccaa 355 216491_x_at agtcgggcccaggactggtgaagccttcggagaccctgtccctcacctgcactgtctctggtggctccatcagtagttactactggagctggatccggcagcccgc cgggaagggactggagtggattgggcgtatctataccagtgggagcaccaactacaacccctccctcaagagtcgagtcaccatgtcagtagacacgtccaa gaaccagttctccctgaagctgagctctgtgaccgccgcggacacggccgtgtattactgtgcga 356 216510_x_at agtgggtctcagctattagtgggagtgcaggtaccacatactacgcagactccgtgaagggccggttcaccacctccagagacaattccaagaacacgctgtat ctgcaaatgnacagnctgagagccgaggacacggccgtatattactgtgcgaaatccc 357 216576_x_at tcctccctgtctgcatctgtaggagacagagtcaccatcacttgccaggcgagtcaggacattagtaattttttaacttggtatcagaagaagccagggaaagccc ctaaagtcctgatctacgatgcatccaatttggaaacaggggtcccatcaaggttcagtggaagtggttctgggacagattttactttcaccatcgccagcctgcag cctgacgattttgcaacatattactgtcaacaatataatgatcaccccctcactttcggccctgggaccaaagtg 358 216834_at atgaaactgattacaacaggctgtaagaatcaaagtcaactgacatctatgctacatattattatatagtttgtactgagctattgaagtcccattaacttaaagtatat gttttcaaattgccattgctactattgcttgtcggtgtattttattttattgtttttgactttggaagagatgaactgtgtatttaacttaagctattgctcttaaaaccagggatca gaatatatttgtaagttaaatcattggtgctaataataaatgtggattttgtattaaaatatatagaagcaatttctgtttacatgtccttgctacttttaaaaacttgcatttatt cctcagatttt 359 216984_x_at catctcctgcactggaaccagcagtgacgttggtgcttataactatgtctcctggtaccaacagcacccaggcaaagcccccaaactcatgatttatgaggtcagt aatcggccctcaggggtttctaatcgcttctctggctccaagtctggcaacacggcctccctgaccatctctgggctccaggctgacgacgagggtgattactactg catctcatatacaagtagcaaccctctcgtggtt 360 217022_s_at tcaagtgggaagagcgctgttcaaggaccacctgagcgtgacctctgtggctgctacagcgtgttccagtgtcctgccgggctgtgccgagccatggaaccatg gggagaccttcacttgcactgctgcccaccccgagttgaagaccccactaaccgccaacatcacaaaatccggaaacacattccggcccgaggtccacctgct gccgccgccgtcggaggagctggccctgaacgagctggtgacgctgacgtgcctggcacgtggcttcagcccaaggatgtgctggttcgctggctgcaggggt cacaggagctgccccgcgagaagtacctgacttgggcatcccggcaggagcccagccagggcaccaccaccttcgctgtgaccagcatactgcgcgtggca gccgaggactggaagaagggggacaccttctcctgcatggtgggccacgaggccctgccgctggccttcacacagaagaccatcgaccgcttggcgggtaa acccacccatgtcaatgtgtctgttgtcatggcgga 361 217109_at gctgtcaggattcttcaaggagaatgaatactgggaatcaagacaggactataccttatccataggcgcaggtgcacagggggaggccataaagatcaaacat gcatggatgggtcctcacgcagacacacccacagaaggacactagcctggcgcgcgtgcacacacacacacacacacacgagttcataatgtggtgatggc cctaagttaagcaaaatgcttctgcacacaaaactctctggtttacttcaaat 362 217110_s_at gcacctgagcatgaaactcgacgcgttcttcggcatcttctttggggccctgggcggcctcttgctgctgggggtcgggacgttcgtggtcctgcgcttctggggttgc tccggggccaggttctcctatttcctgaactcagctgaggccttgccttgaaggggcagctgtggcctaggctacctcaagactcacctcatccttaccgcacattta aggcgccattgcttttgggagactggaaaagggaaggtgactgaaggctgtcaggattct 363 217148_x_at catctcctgcactggaaccagcagtgacgttgntggttataacnatgtctcctggtaccaacannacccaggcaaagcccccaaactcatgatttatgnngtcag taatcggccctcaggggtttctaatcgcttctctg 364 217165_x_at gcgctggttcctgcaagtgcaaagagtgcaaatgcacctcctgcaagaagagctgctgctcctgctgccccgtgggctgtagcaagtgtgcccagggctgtgttt gcaaaggg 365 217179_x_at aggacagagggtcaccatctcttgctctggaagcagctccaacattgggaagaattatgtatcctggtaccagcaactcccaggaacagcccccaaactcctca tctataaaaataataagcgaccctcagggattcctgaccgattctctggctccaagtctggcacgtcagccaccctgggcatcaccagactccagactggggac gaggccgattattactgcggaacatgggatagcagcctgagtggtggccgggggatat 366 217232_x_at tgaggagaagtctgccgttactgccctgtggggcaaggtgaacgtggatgaagttggtggtgaggccctgggcaggctgctggtggtctacccttggacccaga ggttctttgagtcctttggggatctgtccactcctgatgctgttatgggcaaccctaaggtgaaggctcatggcaagaaagtgctcggttctttgagtcctttggggatct gtccactcctgatgctgttatgggcaaccctaaggtgaaggctcatggcaagaaagtgctcggtgcctttagtgatggcctggctcacctggacaacctcaaggg cacctttgccacactgagtgagctgcactgtgacaagctgcacgtggatcctgagaacttcaggctcctgggcaacgtgctggtctgtgtgctggcccatcactttg gcaaaga 367 217235_x_at cagtgtccggatctcctggacagtcagtcaccatctcctgcaccggaaccagcagtgatgttggtggttataactatgtctcctggtaccaacagcacccaggcaa agcccccacactcatgatttatgatgtcattaagcggccctcaggggtccctgatcgcttctctggctccaaatctggcaacacggcctccctgaccatctctgggct ccaggctgaggatgaggctgattattattgcagctcaaatgcaggcagtttttatgtct 368 217258_x_at tcctgcactgggagcagctcctacatcggggcaggttatgatgtacactggtaccggcaacttcccggcacagcccccaaactcctcatctatggtaacaccgat cggccctcaggggtccctgaccgattctctggctccaagtctggcatctcagcctccctggccatcactgggctccaggctgaggatgaggctgattattactgcaa gtcctatgacagcagcctgag 369 217378_x_at gatgtgacatccaggtgacccagtctccatcttccctgtctgcgtctgtaggagacagagtcaccatcacctgccgggcaagtcagggcattagcaatgggttatc ctggtatcagcagaaaccagggcaagcccctacgctcctgatctatgctgcatccagtttgcagtcgggggtcccatctcggttcagtggcagtggatctgggaca gatttcactctcaccatcagcagcctgcagcctgaagatgttgc 370 217414_x_at ggtccccacagactcagagagaacccaccatggtgctgtctcctgccgacaagaccaacgtcaaggccgcctggggtaaggtcggcgcgcacgctggcga gtatggtgcggaggccctggagaggcacttcgacctgagccacggctctgcccaagttaagggccacggcaagaaggtggccgacgcgctgaccaacgcc gtggcgcacgtggacgacatgcccaacgcgctgtccgccctgagcgacctgcacgcgcacaagcttcgggtggacccggtcaacttcaagctaagccactgc ctgctggtgaccctggccgcccacctccccgccgagttcacccctgcggtgcacgcttccctggacaagttcctggcttctgtgagcaccgtgctgacctccaaat accgttaagctggagcctcggtagcc 371 217480_x_at gctgccaggtgccagatgtgacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcaccatcacttgccgggcgagtcagggcat tagcaataatttaaattggtatcagcagaaaccagggaaaactcctaagctcctgatctatgctgcacccagtctgcaaagtgggattccctctcggttcagtgaca gtggatctggggcagattacactctcaccatccgcagcctgcagcctgaagattttgc 372 217546_at agtcgctccatttatcgcttgagatctccagccttaccgcggctcgaaatggaccccaactgctcctgcaccactggtgtctcctgcgcctgcaccggctcctgcaa gtgcaaagagtgcaaatgcacctcctgcaagaagagctgctgctcctgctgccccgtgggctgtgccaagtgtgcccacggctgtgtctgcaaagggacgttgg agaactgcagctgctgtgcctgatgtgggaacagctcttctcccagatgttaatagaacaagctgcacaacctggattttttttcaatacgatactgagccatttgct 373 217757_at cctccagacctccttgaaatacaatattctcccagaaaaggaagagttcccctttgctttaggagtgcagactctgcctcaaacttgtgatgaacccaaagcccac accagcttccaaatctccctaagtgtcagttacacagggagccgctctgcctccaacatggcgatcgttgatgtgaagatggtctctggcttcattcccctgaagcc aacagtgaaaatgcttgaaagatctaaccatgtgagccggacagaagtcagcagcaaccatgtcttgatttaccttgataaggtgtcaaatcagacactgagctt gttcttcacggttctgcaagatgtcccagtaagagatctcaaaccagccatagtgaaagtctatgattactacgagacggatgagtttgcaatcgctgagtacaatg ctccttgca 374 217762_s_at ctattaccattctaactttcataaaaagttgggatcaagaagcagctgatttcctgccagggcttatattagggggntgattcttaaaggacattaggattggtgctca gaaatggttaatcatgctgtgtgctagccagggccagctggtaccttctttgccatgagcattcaagggacngctaacctttattgacaatctatatngcaaaagtca ggaaagaggttgtgagctgattggattaaagacctggcacttcagtaactcagcacgcttccacttcactcaacttaagagagttcattgacagtgttaggatgtga aggctgggaaacacttattttgcttcaagagttccacttggctctcccaaataggtacctcaaaaactgttagcaagcggcatttggatgtcttgacaggggctttgc agggatttttagggttttttccacattgtccacattaatggttggcatgattgtgcttgcaggccaag 375 217764_s_at gaatatgacgttaccttgcagactaaaaggttgaaggcccgaaactaacttttagctaacaataagggctgtgccccaatggaaactgagttcattttctgagaaa ggtttggatgactgaaatatttcctctacagtcaaggactttggcatgcggtggctgaaactgagcttttttgtgtgggctccagttctcactgttctgcaatgctcatggc aagttgaatggtgagctagcttataaattaaagagctctgaactgtattcagaccgactgggtatctagcttactgttttaacatcattgttgaaaccagaccctgtagt ccagtggtgctgccctgttgtgcaaactgctcctttttctcgtgtttttgtaaagagcttccatctgggctggacccagttcttgcacatacaagacaccgctgcagtcag ctaggacctttccgccatgtattctattctgtagtaaagcatttccatcaacaatgcctaattgtatctgttatttttggtttaacacacactgattcatact 376 217767_at ggtctacgcctattacaacctggaggaaagctgtacccggttctaccatccggaaaaggaggatggaaagctgaacaagctctgccgtgatgaactgtgccgct gtgctgaggagaattgcttcatacaaaagtcggatgacaaggtcaccctggaagaacggctggacaaggcctgtgagccaggagtggactatgtgtacaaga cccgactggtcaaggttcagctgtccaatgactttgacgagtacatcatggccattgagcagaccatcaagtcaggctcggatgaggtgcaggttggacagcag cgcacgttcatcagccccatcaagtgcagagaagccctgaagctggaggagaagaaacactacctcatgtggggtctctcctccgatttctggggagagaagc ccaacctcagctacatcatcgggaaggacacttgggtggagcactggcctgaggaggacgaatgccaagacgaagagaaccagaaacaatgccaggacc tcggcgccttcaccgagagcatggttgtc 377 217897_at cccctgcatatcttctcagcaataactccatgggctctgggacctacccttccaaccttccctgcttctgagacttcaatctacagcccagctcatccagatgcag actacagtccctgcaattgggtctctggcaggcaatagttgaaggactcctgttccgttggggccagcacaccgggatggatggagggagagcagaggcctttg cttctctgcctacgtccccttagatgggcagcagaggcaactcccgcatcctttgctctgcctgtcggtggtcagagcggtgagcgaggtgggttggagactcagc aggctccgtgcagcccttgggaacagtgagaggttgaaggtcataacgagagtgggaactcaacccagatcccgcccctcctgtcctctgtgttcccgcggaaa ccaaccaaaccgtgcgctgtgacccattgctgttctctgtatcgtgatctatcctcaacaaca 378 217967_s_at ctcttttactactgacctttcacagagaaaaaatatttcccttgaaaaaaactgggcttgtcattttttcccttgtagctttaagcagagacataagtgccttgcattacac atagtaaactttctttaaaaaaaaaaaaaaaagattttggagactaccagggtaagattccaacttgtccaaaagctttctggccttacatattttattataaaaattct caagtctggtaatcttctatgtcagagctagtgatttcaaaaggtttcacaattccccaagacaaaagtgattttcgttcattataataaggttaagtgatatgtgattcat aacaattttgatgtgaagaagggaaggacatcattgacttaataatagtatcagtcggtgcaacagttggcaacatgtgccttcacactttaccataaagagacgg gtttgagggtttgccttctaaagtctgcaacttcaagaaaaaaaatcgacactgtggattgactttcccggt 379 218087_s_at aactttgtatagcccatgtacctaccttgtatagaaaaataattttaaaaatttgaatggaagggggtaaaggaagtcatgaagtttttttgcatttttatttaaatgaagg aattccaaataactcacctacagatttttagcacaaaaatagccattgtaaagtgttaaaatttacgataagtattctattggggaggaaaggtaactctgatctcagt tacagtttttttttcctttttaatttcattattttgggtttttggtttttgcagtcctatttatctgcagtcgtattaagtcctattgctagaataggttactacaaaaaaggttatattct gaaagaaaaataactgacattatatataaccaattaatttaaagtattgccatttaaattacacactgagagcatgtcctatgcagacatagatttttctgttcatttatttt tcttcattgcagtggattgatttgataaatagatgtgttgaattactacatttgctgtacatat 380 218162_at ggagctagccttgttttttgcatctttctcactcccatacatttatattatatccccactaaatttcttgttcctcattcttcaaatttgggccagttgtggctcaaatcctctatat ttttagccaatggcaatcaaattctttcagctcctttgtttcatacggaactccagatcctgagtaatccttttagagcccgaagagtcaaaaccctcaatgttccctcct gctctcctgccccatgtcaacaaatttcaggctaaggatgccccagacccagggctctaaccttgtatgcgggcaggcccagggagcaggcagcagtgttcttc ccctcagagtgacttggggagggagaaataggaggagacgtccagctctgtcctctcttcctcactcctcccttcagtgtcctgaggaacaggactttctccacatt gttttgta 381 218224_at gcgggtcttgctggctaaaatgcccaggtaaagggttggttggacacagcgcttagtgcacgctgtcatcatggacatcataatcagttgtgaaaaacacgcgaa cctatgacacttcttattccacactgaatgtgaaattgcatgttcagatgtttnactacgaggcctggctcacaggaagtgttcagtaaaagtatgcactgttagattac tgataacgcggatagatttttgttnaccataaattgttccagatttatattaatggaaggaagtgtgcatttattagctattantcaactttacaangcaaacatcttatttct catctttaaacatgtcgaccagtttaattgaaaagtattctgagactgcaaaatggggtgttaaaaaatactgcagttacggagctgtgtaaaccagtttctcattgca taagatacagatgtaaattgcatggagaggttgatatgcacctgtacagtaattcactcccccatttcacttctttgtcagagaatagttcttgttcatactgagtgtt 382 218312_s_at gcatccgaggggagccgccggatgtggaagaagactcggctttcctgcagccatttagtgccgccccatgctaggttatttgacattgtgcagtgtagagttgcctt aaagtgcgtgatctgccagtgctttcttcaagtcacccttgccccgattcctcatgtttgcgctccccagggttgctcaagtggaaattttgtcagctgtttagccttttcgt acttggcgtgatgtcaacttcacttctaatctgcaaaagcagaagctgtttcctagtttacctcgcgtgtgtttacctatatggagtagctcgcagagatcacagaaat gcttgcagcctaaggcagggttttcagaccgtgggtcccagcccatttagtaaaatgggaaatcaattagcaagtggtcaccagcattacacagca 383 218353_at tatacagtttaataagcctcttgcaagttacttgttctctcacctgaggtatttttttcctccccaccttgcccctgttcctcccttcctcttctccctttgcaagaggaaatattt aacatatttgggtccaacttcaataatgtaataattaatacattaaaagcatttaacttcctttctagaaaaatgcacaggctaaggcatagacaaaacaaagaga aatgctgagaaatttgccactggagacaagcaatctgaataaatatttgccaaaagttctttttatgtcatatagtgtcaggatttgaaggagctattttttttaatgttgc aactagcaactcatcttcggaagacacagccaggagaatgaagtagaagtgaaaggtttataaatccatttgtaagcatttatcccatatattttaaattcaagaaa aattgtgtttatctttagaattttgtattcaatactttatgtactatgtgactcatgcttctggataaataaagcaccaaatatgtatctgtaaccacaatcacacata 384 218418_s_at ggcttgatgtagactggcttgctttgatttttagtgaagggaatgtacgtaaaacaaaatagggcttggctggtcaaaggagacaagcaggatggatggatggatg gatgaatagatagatggtgtttgcatgtaaattgcagagaaaacaaaaccaaagctgattggaaacaattaattgtgggtgtctgagggggaaggtcgcagcttt gggcagctttgagaagcggtacaagagctctgtgcctgtgtgtccagccctggagccagccagtgcatttattttaagctcttagaagcaactccttggcccagga atgcgtgacccctgagatgggtccacgcatctctctacacgtccttctctccgtgggatactggactcgtgcctctgcgcccattctcttctcacgcatatccatgagct ttaatttcactttctgatcacggtacgtccataaagccagt 385 218468_s_at ggagatgacttaagttggcagcagtaatcttcttttaggagcttgtaccacagtcttgcacataagtgcagatttgccccaagtaaagagaatttcctcaacactaac ttcacggggataatcaccacgtaactacccttaaagcatatcactagccaaagaggggaatatctgttcttcttactgtgcctatattaagactagtacaaatgtggt gtgtcttccaactttcattgaaaatgccatatctataccatattttattcgagtcactgatgatgtaatgatatattttttcattattatagtagaatatttttatggcaagagattt gtggtcttgatcatacctatt 386 218469_at gaagctgacacaccgtatgttgttagagtcttttatctggtcaggggaaacaaaatcttgacccagctgaacatgtcttcctgagtcagtgcctgaatctttattttttaa attgaatgttccttaaaggttaacatttctaaagcaatattaagaaagactttaaatgttattttggaagacttacgatgcatgtatacaaacgaatagcagataatgat gactagttcacacataaagtccttttaaggagaaaatctaaaatgaaaagtggataaacagaacatttataagtgatcagttaatgcctaagagtgaaagtagttc tattgacattcctcaagatatttaatatcaactgcattatgtattatgtctgcttaaatcatttaaaaacggcaaagaattatatagactatgaggtaccttgctgtgtagg aggatgaaaggggagttgatagtctcataaaactaatttggcttcaagtttcatgaatctgtaactagaatttaattttcaccccaataatgttctatatagcctttgctaa 387 218541_s_at gttcaaaatatttccaagcctgagtattgtctattggtatagatttttagaaatcaataattgattatttatttgcacttattacaatgcctgaaaaagtgcaccacatggat gttaagtagaaattcaagaaagtaagatgtcttcagcaactcagtaaaaccttacgccaccttttggtttgtaagaggttttttatacatttcaaacaggttgcacaaa agttaaaataatggggtcttttataaatccaaagtactgtgaaaacattttacatattttttaaatcttctgactaatgctaaaacgtaatctaattaaatttcatacagttac tgcagtaagcattaggaagtgaatatgatatacaaaatagtttataaagactctatagtttctataatttattttactggcaaatgtcatgcaacaa 388 218546_at ggcagcccacaagtttctcgtggggagatggaggcagagcccagggtaggggacagagctgctggggcctttccttgcctgggaatctgtcccaggaagagct tccccactcccatcccccaaattggaaaaaccgtacattcaagcctgtttggccctgaaattcttaagaatctggttaagaattaactcactaatgtcaaaagtcaa aacctcctaggggttgtcctgggagtcaggttcacgggtacagaagatgaatctcagatgtcactcaacctgagccgtcattctctgtggcagggctgccctgggtt tctcttactcaatccctggagtgtaagcatttggattgtgtcacagattacctttttaccttttctttctttttttttctttttttcaatatcagtgcccacaccttactgagtattgagtt ttagagctttcgcttgatgtgcttgaccaagagacttcttttgtatccttttct 389 218559_s_at tcaagtgcgttctttagaccaatgcattgcgtttctttccctgcttttgagatagtaggaagagttcttggtggtgtccccccccttcaattcttcagttgtatagtagttatag ggaagatatgggtgtttttctttattattacttttttttttctgcaggtcagtaaaaggatttaagttgcactgacaaaaataccaaaataaaagtgtatttttaagttcccattt gaaattgctggcgctgctggccggatgcatttttgagtttgtattagttgataaattaacagtaataacaagattgtatgaaccgcatggtgcttgcagttttaaatattgt ggatatttgtcctgcatcagaaacgagctttggtttttacagattcaactgtgttgaaatcaaacctgccgcaacagaaattgtttttatttcatgtaaaataagggatca atttcaaaccctgcttatg 390 218756_s_at cctcctgcctctggattttaggtgttgatttctggatcacgggataccacttcctgtccacaccccgaccaggggctagaaaatttgtttgagatttttatatcatcttgtca aattgcttcagttgtaaatgtgaaaaatgggctggggaaaggaggtggtgtccctaattgttttacttgttaacttgttcttgtgcccctgggcacttggcctttgtctgctct cagtgtcttccctttgacatgggaaaggagttgtggccaaaatccccatcttcttgcacctcaacgtctgtggctcagggctggggtggcagagggaggccttcac cttatatctgtgttgttatccagggctccagacttcctcctctgcctgccccactgcaccctctcccccttatctatctccttctcggctccccagcccagtcttggcttcttgt cccctcctggggtcatccctccactctgactctgactatggcagcag 391 219014_at ggcatgtgtgactgtttcagcgactgcggagtctgtctctgtggcacattttgtttcccgtgccttgggtgtcaagttgcagctgatatgaatgaatgctgtctgtgtggaa caagcgtcgcaatgaggactctctacaggacccgatatggcatccctggatctatttgtgatgactatatggcaactctttgctgtcctcattgtactctttgccaaatc aagagagatatcaacagaaggagagccatgcgtactttctaaaaactgatggtgaaaagctcttaccgaagcaacaaaattcagcagacacctcttcagcttg agttcttcaccatcttttgcaactgaaatatgatggatatgcttaagtacaactgatggcatgaaaaaaatcaaatttttgatttattataaatgaatgttgtccctgaactt agctaaatggtgcaacttagtttctccttgctttcatattatcg 392 219059_s_at agagaatgcccttctccttattgtaaccctgtctggatcctatcctcctacctccaaagcttcccacggcctttctagcctggctatgtcctaataatatcccactgggag aaaggagttttgncaaagtgcaaggacctaaaacatctcatcagtatccagtggtaaaaaggcctcctggctgtctgaggctaggtgggttgaaagccaagga gtcactgagaccaaggctttctctactgattccgcagctcagaccctttcttcagctctgaaagagaaacacgtatcccacctgacatgtccttctgagcccggtaa gagcaaaagaatggcagaaaagtttagcccctgaaagccatggagattctcataacttgagacctaatctctgtaaagctaaaataaagaaatagaacaagg ctgaggatacgacagtacactgtcagcagggactgtaaacacagacagggtcaaagtgttttctctgaacacattgagttggaatcactgtttagaacacacaca cttactttttctggtctctaccactgctgatattttct 393 219087_at attaccttatcatgtcttagagcccgtctttatgtttaaaactaatttcttaaaataaagccttcagtaaatgttcattaccaacttgataaatgctactcataagagctggtt tggggctatagcatatgcttttttttttttaattattacctgatttaaaaatctctgtaaaaacgtgtagtgtttcataaaatctgtaactcgcattttaatgatccgctattataa gcttttaatagcatgaaaattgttaggctatataacattgccacttcaactctaaggaatatttttgagatatccctttggaagaccttgcttggaagagcctggacacta acaattctacaccaaattgtctcttcaaatacgtatggactggataactctgagaaacacatctagtataactgaataagcagagcatcaaattaaacagacaga aaccgaaagctctatataaatgctcagagttctttatgtatt 394 219508_at atggggctggggacttgaattggatgcttcaaaaccatcacctgttggccaacaagtttgacccaaaggtagatgataatgctcttcagtgcttagaagaataccta cgttataaggccatctatgggactgaactttgagacacactatgagagcgttgctacctgtggggcaagagcatgtacaaacatgctcagaacttgctgggacag tgtgggtgggagaccagggctttgcaattcgtggcatcctttaggataagagggctgctattagattgtgggtaagtagatcttttgccttgcaaattgctgcctgggtg aatgctgcttgttctctcacccctaaccctagtagttcctccactaactttctcactaagtgagaatgagaactgctgtgatagggagagtgaaggagggatatgtgg tagagcacttgatttcagttgaatgcctgctggtagcttttccattctgtggagctgccgttcctaataattccag 395 219543_at ggaattcttctcttacttcaataaaatgggttttaacataactttaaattcagttaaatatacaatattgaatacctatagttgactttgggatggggactttttcaagtcatta agagtgtttgtttaaggtgatctcattgatggtagttctcagccgtctcaaaaactgcaagctaatcagtcagacattctttaatgaccccaattttttcactttaattgttac catgttttctatttttactgatttttgctaaagcatgtaagagtgaatttattatagcagtaatcttgtgtttctcctgatgtgca 396 219607_s_at atcaacacatttagcttggcgttttattcattccatcacccttactgtaactactatggcaactcaaataattgtcatgggactatgtccatcttaatgggtctggatggcat ggtgctcctcttaagtgtgctggaattctgcattgctgtgtccctctctgcctttggatgtaaagtgctctgttgtacccctggtggggttgtgttaattctgccatcacattct cacatggcagaaacagcatctcccacaccacttaatgaggtttgaggccacccaaagatcaacagacaaatgctccagaaatctatgctgactgtgacacaag 397 219669_at catctctcaggaggtgggctgtccaccaaaatgagcattcagggctgcgtggcccaaccttccagcttcttgttgaaccacaccagacaaatcgggatcttctctg cgcgtgagaagcgtgatgtgcagcctcctgcctctcagcatgagggaggtggggctgagggcctggagtctctcacttggggggtggggctggcactggcccc agcgctgtggtggggagtggtttgcccttcctgctaactctattacccccacgattcttcaccgctgctgaccacccacactcaacctccctctgacctcataacctaa tggccttggacaccagattctttcccattctgtccatgaatcatcttccccacacacaatcattcatatctactcacctaacagcaacactggggagagcctggagca tccggacttgccctatgggagag 398 219796_s_at tccttgtccacaagcactatggcccccggctcaagtgctgctctggcaaagctccggagccccagccccaaggctttgacaaccaggcgttcctccctgaccac aaggccaactgggcgcccgtccccagccccacgcacgaccccaagcccgcggaggcaccgatgcccgcagagcccgcaccccccggccctgcctcccc aggcggtgcccctgagccccccgcagcggcccgagctggcggaagccccacggcggtgaggtccatcctgaccaaggagcggcggccagagggcgggt acaaggctgtctggtttggcgaggacatcgggacggaggcagacgtggtcgttctcaacgcgcccaccctggacgtggatggcgccagtgactccggcagcg gcgatgagggcgagggcgcggggaggggtgggggtccctacgatgcgcccggtggtgatgactcctacatctaagtggccc 399 219799_s_at accatcgctggtggtatcccagggtccctgctcaagttttctttgaaaaggagggctggaatggtacatcacataggcaagtcctgccctgtatttaggctttgcctgc ttggtgtgatgtaagggaaattgaaagacttgcccattcaaaatgatctttaccgtggcctgccccatgcttatggtccccagcatttacagtaacttgtgaatgttaag tatcatctcttatctaaatatt 400 219948_x_at gaatactcataattcttatctctataatcaaaagtataatttactgtagaaaaataaagagatgcttgttctgaaagtaagatcagtgaactgcttttcagtctcaatcttt gagaattgtaaattcatcaaataattgcttacatagtaaaaatttaaggtattagaaaacctgcataacaaatagtattatatattaaatattttgatatgtaaagctcta cacaaagctaaatatagtgtaataatgtttacactaataagcaaatatgttaatcttctcatttttttactgtcatataatcttagtgatatgcctattaatagttttaaataaa taaattggctcatctggctttttgaaaattttgaaattcttacagatgttgattaggtatatctacaaattaatttcaattttaaaatgatgatataaaaataaatataagtatt tttcttgtgtatgtata 401 220026_at agtaactttgtttatccctcaagcaaatcctgatgacattgatcctactcctactcctactcctactcctgataaaagtcataattctggagttaatatttctacgctggtatt gtctgtgattgggtctgttgtaattgttaactttattttaagtaccaccatttgaaccttaacgaagaaaaaaatcttcaagtagacctagaagagagttttaaaaaaca aaacaatgtaagtaaaggatatttctgaatcttaaaattcatcccatgtgtgatcataaactcataaaaataattttaagatgtcggaaaaggatactttgattaaata aaaacactcatggatatgtaaaaactgtcaagattaaaatttaatagtttcatttatttgttattttatttgtaagaaatagtgatgaacaaagatcctttttcatactgatac ctggttgtatattatttgatgcaacagttttctgaaatgat 402 220037_s_at ttccacttctattccacggagaaaaaaattgatttgtgtcacagaagtttttatggaaactagcaccatgtctacagaaactgaaccatttgttgaaaataaagcagc attcaagaatgaagctgctgggtttggaggtgtccccacggctctgctagtgcttgctctcctcttctttggtgctgcagctggtcttggattttgctatgtcaaaaggtat gtgaaggccttcccttttacaaacaagaatcagcagaaggaaatgatcgaaaccaaagtagtaaaggaggagaaggccaatgatagcaaccctaatgagg aatcaaagaaaactgataaaaacccagaagagtccaagagtccaagcaaaactaccgtgcgatgcctggaagctgaagtttagatga 403 220075_s_at ctcaactcggccatcacatatcgaattaccaaccactcacacttccggatggagggagaggttgtgctgaccaccaccacactggcacaggcgggagccttct acgcagaggttgaggcc 404 220266_s_at tccattaccaagagctcatgccacccggttcctgcatgccagaggagcccaagccaaagaggggaagacgatcgtggccccggaaaaggaccgccaccc acacttgtgattacgcgggctgcggcaaaacctacacaaagagttcccatctcaaggcacacctgcgaacccacacaggtgagaaaccttaccactgtgactg ggacggctgtggatggaaattcgcccgctcagatgaactgaccaggcactaccgtaaacacacggggcaccgcccgttccagtgccaaaaatgcgaccgag cattttccaggtcggacc 405 220376_at aaaacccattctttcagttacatctactaagagctcgtagttcaataacattccaaagaacgtagtttggaaaacactggcctatcggctgtaataggaagggtcta aagaaaattatttgctgagtcctcataatcaattggctataatcacaatttaataatttatcaatgcaaacagtacattaaaaactgtagcacaatctataatttttacctt catatgcagagaaattaagaatttacatcttttacaaatatgtgtatctctgaaataatgaaatatattgatgggtgaaataatatttctggtattttcttcattataacacgt ggaatgggacagtggctagaggtatggatggagcaaggtcaaatatgagctgatggagctgggcgctaaataagggtataatatgctacttctgtgtatgttgtgt atggtatagtatgctatttctgtgtatgttcaaattgtttatgtatataataaagttttaaaaatttgtatgtacttgacaattccttagaa 406 220468_at agaggagacactttggcgttcttcaagcagaactgaggctgcgaaaaatccaagtctctacagagacactgatgaagttgaaagggtaattgtttttccatgccaa atgaggaaatcaaattaatgagttgacaaacttttcctgagatgttatttcatctacatttagttaaacaacttagaatgatatctagaaaatatttattttcagccagga actttagcaaactgtggcaatgatcactgggaatgaaaacgtataatgttctacaatttttgttatcacattggatgactttgaatatagtagtgacacttgggaccaaa taaattattttatatgactactagaacaaagttttagtaagctgtctgctaatagagtcagaattcttccagattgtttccagctgtaacaggtattgaatttccaccgtgct cctatgtaacagctgggtggtgtaaaaaatgaacttcaaattatggagtggaagaagcgtaatgttaatatcttgtaaattcgtattccctat 407 220645_at cattttccaggatctcagtgtgagtatcattgatgcctgggatataacaattgcatatggcacaaataatgtacacccacctcaacatgtagtcggaaatcagattaa tatattattaaactatatttgttaaataacacaaaagtctgaaattcattcacttaagtaaaaaaatttattgactgtctactagcaggccagatgctgtgtttggctctga attcccaactagcaagagcagagaatctacattatggctgatccataagccaccaattcagctaaatgagatgtttctaatctgggcttccacttaaaaataaaact aaaaatactcatgaaaagagcctacccttcttgatcagagccatacccctcttcaccaatgggaagt 408 220812_s_at ggtattttagtctagttttatatgaacggttgtatcagggtaaccaactcgatttgggatgaatcttagggcaccaaagactaagacagtatctttaagattgctaggga aaagggccctatgtgtcaggcctctgagcccaagccaagcatcgcatcccctgtgatttgcacgtatacatccagatggcctaaagtaactgaagatccacaaa agaagtaaaaatagccttaactgatgacattccaccattgtgatttgttcctgccccaccctaactgatcaatgtactttgtaatctcccccacccttaagaaggtacttt gtaatcttccccacccttaagaaggttctttgtaattctccccacccttgagaatgtactttgtgagatccaccctgcccacaaaacattgctcttaacttcaccgcctaa cccaaaacctataagaactaatgataatccatcacccttcgc 409 220834_at gctggccaagactactgggccgtgctttctggaaaaggcatttcagccacgctgatgatcttctccctcttggagttcttcgtagcttgtgccacagcccattttgccaa ccaagcaaacaccacaaccaatatgtctgtcctggttattccaaatatgtatgaaagcaaccctgtgacaccagcgtcttcttcagctcctcccagatgcaacaac tactcagctaatgcccctaaatagtaaaagaaaaaggggtatcagtctaatctcatggagaaaaactacttgcaaaaacttcttaagaagatgtcttttattgtctac aatgatttctagtctttaaaaactgtgtttgagatttgtttttaggttggtcgctaatgatggctgtatctcccttcactgtctcttcctacattaccactactacatgctggcaa aggtgaaggatcagaggactgaaaaatgattctgcaactctcttaaa 410 221004_s_at agcccaccagcaggagcttggagtttggggagtggggatgagtccgtcaagcacaactgttctctgagtggaaccaaagaagcaaggagctaggaccccca gtcctgccccccaggagcacaagcagggtcccctcagtcaaggcagtgggatgggcggctgaggaacggggcaggcaaggtcactgctcagtcacgtcca cgggggacgagccgtgggttctgctgagtaggtggagctcattgctttctccaagcttggaactgttttgaaagataacacagagggaaagggagagccacctg gtacttgt 411 221305_s_at gccactatcttgaagaaggtgcacagtgccctgctcctctttcctatgtccccagaattctcttagggttctcagatgccatgactttcaaggagagagtacggaacc acatcatgcacttggaggaacatttattttgccagtatttttccaaaaatgccctagaaatagcctctgaaattctccaaacacctgtcacagcatatgatctctacag ccacacatcaatttggttgttgcgaacagactttgttttggactatcccaaacccgtgatgcccaatatgatcttcattggtggtatcaactgccatcagggaaagcc 412 221541_at ctttatcatccccacaaacattttgaaactggaatatttgtcttcagaaaatggaaacaagactataaatgataagccctgtccctagcaccacctctcctgtgtgtgg aatagaggcccctcgtgctaccaacacttaccctgtgtttaaaaagatcttgtaccaagccaacggcgttcctggctctcctgcccacaggatgaacattttcggctt ccttaggagttttgccctaccgtattccaaagcgtgtgctggtttctcatattgtctgtaggctcac 413 221584_s_at gtgaggctcagtcagaacctccaccctcccccacaccaaagacaggggcagcgtagtattcaaaccagtattgtggtggggaataattgtatacatgtaaattat caagccctatgagtggaagaattttttcaaattatttttgtctctctatatattgatttatattatgtataactatctctttatataaactatatataattatatatatataactatat aattatatatatataactatatatataactatatatatgtatcccctagtattggatcatgaagagctcttcatgcattctttgcaaaggaggttataaagttacgccctca gaacatttataactataagaatgtgccagttaaagtgctcaacaggaaatatgacagtttaaaagcattgtaaaactcacatagcttacttctctctctaaagtgcaa caaggatgaatagaatgggccaaggtatgacaattaatggttctgcatgacctagccactgctgggggttttcttctataacgttgtccttgtga 414 221667_s_at gggacttaacatttcacgttgtatcttacttgcagtgaatgcaagggttacttttctctggggacctcccccatcacccaggttcctactctgggctcccgattcccatgg ctcccaaaccatgccgcatggtttggttaatgaaacccagtagctaaccccactgtgcttccacatgcctggcctaaaatgggtgatatacaggtcttatatccccat atggaatttatccatcaaccacataaaaacaaacagtgccttctgccctctgcccagatgtgtccagcacgttctcaaagtttccacattagcactccctaaggacg ctgggagcctgtcagtttatgatctgacctaggtcccccctttcttctgtcccctgtttttaagtccggatttttacagaaggaactgtctccagacagctcatcaaggaa ccaagcaaaggccagatagcctgacagataggctagtggtaattgtgtatatgggcgggacgtgtgtgtcatta 415 221747_at cctctgtcctcaaatgtccaaaatgttggaggacctctgttcatatcccacgcctgggctcttgccagcagtggagttactgtagagggatgtcccaagcttgttttacca atcagtgttaagctgtttgaaactctcctgtgtctgtgttttgtttgtgcgtgtgtgtgagagcacatcagtgtgtgcaggctgtgtttccccatttctctcctcccttcagacc catcattgagaacaaatgtaagaaatcccttcccaccaccctccctgcctcccaggccctctgcgggggaaacaagatcacccagcatcct 416 221748_s_at atattttgtatcatcgtgcctatagccgctgccaccgtgtataaatcctggtgtntgctccttatcctggacatgaatgtattgtacactgacgcgtccccactcctgtaca gctgctttgtttctttgcaatgcattgtatggcttta 417 221841_s_at atccgacttgaatattcctggacttacanaatgccaagggggtgactggaagttgtggatatcagggtataaattatatccgtgagttgggggagggaagaccag aattcccttgaattgtgtattgatgcaatataagcataaaagatcaccttgtattctctttaccttctaaaagccattattatgatgttagaagaagaggaagaaattcag gtacagaaaacatgtttaaatagcctaaatgatggtgcttggtgagtcttggttctaaaggtaccaaacaaggaagccaaagttttcaaactgctgcatactttgac aaggaaaatctatatttgtcttccgatcaacatttatgacctaagtcaggtaatatacctggtttacttctttagcatttttatgcagacagtctgttatgcactgtggtttcag atgtgcaataatttgtacaatggtttattcccaagtatgccttaagcagaacaaatgtgtttttctatatagttccttgccttaa 418 221896_s_at ccaatcctgaaggtactccctgtttgctgcagaatgtcagatattttggatgttgcataagagtcctatttgccccagttaattcaacttttgtctgcctgttttgtggactgg ctggctctgttagaactctgtccaaaaagtgcatggaatataacttgtaaagcttcccacaattgacaatatatatgcatgtgtttaaaccaaatccagaaagcttaa acaatagagctgcataatagtatttattaaagaatcacaactgtaaacatgagaataacttaaggattctagtttagttttttgtaattgcaaattatatttttgctgctgat atattagaataatttttaaatgtcatcttgaaatagaaatatgtattttaagcactcacgcaaaggtaaatgaacacgttttaaatgtgtgtgttgctaattttttccataag aattgtaaacattgaactgaacaaattacctataatggatttggttaatgacttatgagcaagctggtttggccagacagtatacccaaacttttatataatatacaga aggctatcacacttgtgaa 419 222043_at tcgactctgctgctcatgggaagaacagaattgctcctgcatgcaactaattcaataaaactgtcttgtgagctgatcgcttggagggtcctctttttatgttgagttgct gcttcccggcatgccttcattttgctatggggggcaggcaggggggatggaaaataagtagaaacaaaaaagcagtggctaagatggtatagggactgtcata ccagtgaagaataaaagggtgaagaataaaagggatatgatgacaaggttgatccacttcaagaattgcttgctttcaggaagagagatgtgtttcaacaagcc aacta 420 222162_s_at aataacgcaaatggcttcctctttcctttttttggaccatctcagtctttatttgtgtaattcattttgaggaaaaaacaactccatgtatttattcaagtgcattaaagtctac aatggaaaaaaagcagtgaagcattagatgctggtaaaagctagaggagacacaatgagcttagtacctccaatttcctttctttcctaccatgtaaccctgctttg ggaatatggatgtaaagaagtaacttgtgtctcatgaaaatcagtacaatcacacaaggaggatgaaacgccggaacaaaaatgaggtgtgtagaacagggt cccacaggtttggggacattgagatcacttgtcttgtggtggggaggctgctgaggggtagcaggtccatctccagcagctggtccaacagtcgtatcctggtgaa tgtctgttcagctcttct 421 222453_at tcaaatggaacctgccctctaaagcactttctttcctttacttgcgtggtttcatgtaagctgtgctgtttagaaacaacatctcagactttacaaagaaatgacaaaga aggcaattgcactttttaagggatatcgacaagcagtttctgttttctaaaggacaaaatacagagtgtgtgtcatttttaattagattctttcccctgctgagttggaaatt ccagtgcagcactgattgaccacagttgccaatctaaaagcacaaagacagaagtaaagctttatgctaattttatttcaatatgatagaaaatttatcttggtatgtc cttttttagataactccagcaggaaactgtaactgctatgtctttaggaaaacgtagaagaaagaacattattattctttaattcctacaaggtacttgaaaaccttaag tgaaaaagatttctatctttttatcttggcgcatt 422 222513_s_at tgccactaattcattcacactaaggtgtaaatgattgataataggaatgagttacctcttcccacagacatttgtttttaagtatgacagagcagggccttaatcccaa gggaaaaggttatggaactggagggggtgagctttctgggtagaaggagacttcctgaatttccttaaaacccagtaagagtaagacctgttgttttggaaggtct gctccaccatctaagagcactgtttttttttttttgttgttgttgttgttttacggtctctgagggaatatagtaaaaatgcatatgcacgtgcaatttgcacggcagcatttca ccgattgtggactgtattggctaatgtgtttcctggtctttagatgcaaaccattaataacactatcttatctcatagttttttcaggggtgcttcttgattagtagggaattttg aacacctctttaaatacagctagaaaataaaaccaatttgtaaagccacatttgcatatgatgccagcctcacgcatttgtatatctccagaaattcaggtatgcctc accaatttgcccgtctttaataa 423 222717_at taaactaacccttacattccatgtgatgtgatgtaggcttataagntgctaaaatctataggtntnggaagtgaaagattctattttttcttttttngtacataatgggaattt cattccagattatattttatttacatattaatttcacagaatattaatatttcttaacttcttaaagcatgctagcgttttatgtatatgtacacatatattcagacagggtaatttt atctgctgcctaacattgtactaaaatattgctttatctgtttttaattacaaaatgctaatgatttcttaaattatagtttaaagacaattggcccaggaagcaaatcccct gcctttagtatgaaccactataagtaaccttacaaatagagttaatccaagacaatattaacaaactgtgctttgtctttaataaaagggataggattaacaaacata ttgatggcataacctattcagctatgtccttatttttgcaataatgtaacctcaaatattggattgttgaaccaacaatggctgtgttaaa 424 222722_at tttatgatgactcagtggtgccagagtaaagtttctaaaataacattcctctcacttgtaccccactaaaagtattagnctacacattacattgaagttaaacacaaaa ttatcagtgttttagaaacatgagtccggactgtgtaagtaaaagtacaaacattatttccaccataaagtatgtattgaaatcaagttgtctctgtgtacagaatacat acttattcccatttttaagcatttgcttctgttttccctacctagaatgtcagatgtttttcagttatctccccatttgtcaaagttgacctcaagataacatttttcattaaagcat ctgagatctaagaacacaattattattctaacaatgattattagctcattcacttattttgataactaatgatcacagctattatactactttctcgttattttgtgtgcatgcct catttccctgacttaaacctcactgagagcgcaaaatgcagctttatactttttacttt 425 223121_s_at gataacctacatcaaccgagataccaaaatcatcctggagaccaagagcaagaccatttacaagctgaacggtgtgtccgaaagggacctgaagaaatcgg tgctgtggctcaaagacagcttgcagtgcacctgtgaggagatgaacgacatcaacgcgccctatctggtcatgggacagaaacagggtggggagctggtgat cacctcggtgaagcggtggcagaaggggcagagagagttcaagcgcatctcccgcagcatccgcaagctgcagtgctagtcccggcatcctgatggctccga caggcctgctccagagcacggctgaccatttctgctccgggatctcagctcccgttccccaagcacactcctagctgctccagtctcagcctgggcagcttccccct gccttttgcacgtttgcatccccagcatttcctgagttataaggccacaggagtggatagctgttttcacctaaaggaaaagcccacccgaatcttgtagaaat 426 223122_s_at ggtgcaactgtgacttgggtctggttggttgttgtttgttgttttgagtcagctgattttcacttcccactgaggttgtcataacatgcaaattgcttcaattttctctgtggccc aaacttgtgggtcacaaaccctgttgagataaagctggctgttatctcaacatcttcatcagctccagactgagactcagtgtctaagtcttacaacaattcatcatttt ataccttcaatgggaacttaaactgttacatgtatcacattccagctacaatacttccatttattagaagcacattaaccatttctatagcatgatttcttcaagtaaaag gcaaaagatataaattttataattgacttgagtactttaagccttgtttaaaacatttcttacttaacttttgcaaattaaacccattgtagcttacctgtaat 427 223235_s_at agggtacgagaacttgccaatgggaaattcatccgagtggcactggcagagaaggataggagtggaatgcccacacagtgaccaacagaactggtctgcgt gcataaccagctgccaccctcaggcctgggccccagagctcagggcacccagtgtcttaaggaaccatttggaggacagtctgagagcaggaacttcaagct gtgattctatctcggctcagacttttggttggaaaaagatcttcatggccccaaatcccctgagacatgccttgtagaatgattttgtgatgttgtgatgcttgtggagcat cgcgtaaggcttcttgcttatttaaactgtgcaaggtaaaaatcaagcctttggagccacag 428 223343_at gagtccaaatgtcatcagtgctcattttgagataccctgctatcgatggtcgctacaaaccaggaaatactcaagttattatgtgtatacattggntttagntttatgaa acaatttaccttcatgatctcatagttaaaattgtaataaatttaggaatataaaggatcaatatgggaagcaaaatttctaaaggcagtttctgttgttttaattagtattt gtgtagttcaaaccaggaaggatttgactatcattagattttgcttaactttatgaaagctaaaatattctctgttataaaggggcaactccatctggtcctatagcatctt tactactgatttttttttngtttaatttgaaaatgcaaagaattgttaaatgttcttaaatgttctcactacaaaaaaagaaaaaagataactacgtgaggtgatggatatg ttaattagctggattgtggtaatcattttggaatgtatatgtatatcaaaacatgtagtacaccctaaatatat 429 223395_at agatacatttttacccaccataaatgttacaatatctgaatatgctttgtcaaactatccctttatgcaatcgtcttcatattgtttttatgattctaatcaagctgtatgtagag actgaatgtgaagtcaagtctgagcacaaaaagataatgcacgatgagattgcctaccattttataggatatttactatgtatttatacgttaagacctctatgaatga atgtatcagagaatgtctttgtaactgtttaattcaatctgtaataaaaatctaactaactaactcatttatttctattaaaaaggtattgtcctttaggcggggaatggga atccttgctgcactgttgcagtcattctgaaaggacctttccctgtacttacctttcaacatgcttcaatcttatcaacgctacat 430 223484_at gaaaaccgatgtgatccttgatcgaaaaaaaaatccagaaccttgggaaactgtggaccctactgtacctcaaaagcttataacaatcaaccaacaatggaaa cccattgaagagttgcaaaatgtccaaagggtgaccaaatgacgagccctcgcctctttcttctgaagagtactctataaatctagtggaaacatttctgcacaaac tagattctggacaccagtgtgcggaaatgcttctgctacatttttagggtttgtctacattttttgggctctggataaggaattaaaggagtgcagcaataactgcactgt ctaaaagtttgtgcttattttcttgtaaatttgaatattgcatattgaaatttttgtttgatctatgaatgtttttcttaaaatttacaaagctttgtaaattagattttctttaataa aatgccatttgtgcaagatttct 431 223551_at aattgtgttgtgatgctactcactttgattgcaatgatgatgtccaaggtaagctattaaaaggcaggttacttccaaatcgcactgaaggaaaaggttaagaataat acatgatcacagaaatgcataccactgtctgtaaacccaacaaaattcactgttctcttttggatttatttagcctgatgtatttttaattcaatttttatggtgatgggcaaa tcattcttggtaaatgtaaatcaaacatgattgatttaaaacttcatggaatttgtagaaaattatggacatttttggtgagaaagaacaatagtcaaaactcacatgg atagagtgtgtttgttttttgccaaaaatgccccagaccttttcccaaacctcaaaaacgtcttggaaaaattgtaaaagtttgataacagaaacatctttaggatatttt tgtctgacgtattttgcttctagtatgtgcctactgtgatttttttcatgtggaaaatgcaaaatttgtaacaaaatggttatatggaacatgcctattaaacgaa 432 223597_at ggcatctggcacgtgcccaataagtcccccatgcagcactggagaaacagctccctgctgaggtaccgcacggacactggcttcctccagacactgggacata atctgtttggcatctaccagaaatatccagtgaaatatggagaaggaaagtgttggactgacaacggcccggtgatccctgtggtctatgattttggcgacgccca gaaaacagcatcttattactcaccctatggccagcgggaattcactgcgggatttgttcagttcagggtatttaataacgagagagcagccaacgccttgtgtgctg gaatgagggtcaccggatgtaacactgagcaccactgcattggtggaggaggatactttccagaggccagtccccagcagtgtggagatttttctggttttgattgg agtggatatggaactcatgttggttacagcagcagccgtgagataactgaggcagctgtgcttctattcta 433 223623_at gagaagcacctgttccaactaagactaaagtggccgttgatgagaataaagccaaagaattccttggcagcctgaagcgccagaagcggcagctgtgggac cggactcggcccgaggtgcagcagtggtaccagcagtttctctacatgggctttgacgaagcgaaatttgaagatgacatcacctattggcttaacagagatcga aatggacatgaatactatggcgattactaccaacgtcactatgatgaagactctgcaattggtccccggagcccctacggctttaggcatggagccagcgtcaac tacgatgactactaaccatgacttgccacacgctgtacaagaagcaaatagcgattctcttcatgtatctcctaatgccttacactacttggtttctgatttgctctatttc agcagatctttctacctact 434 223754_at agctgccgggcaacgtgttgtgtaagtgaacatctgggaggtaaacactacacgtgaagagtggtgaaagggaacattgattactgaagtgccctggagaggg aaagcactggtcaacatcacatggacaaatttcattgttttctaaagatggcctggaagtagtctttgccactgcttcctccacaaacagctcttcataacatgggctg catgaaatcaaagcaaactttcccatttcctaccatatatgaaggtgagaagcagcatgagagtgaagaaccctttatgccagaagagagatgtctacctaggat ggcttctccagttaatgtcaaagaggaagtgaaggaacctccagggaccaatattgtgatcttggaatatgcacaccgcctgtctcaggatatcttgtgtgatgcctt gcagcaatgggcatgcaataacatcaagtaccatgacattccatacattgagagtgaggggccttgaggctgtaggatgaca 435 223952_x_at ggggctatactccatccaaatatgcagtggaaggtttcaatgacagcttaagacgggacatgaaagcttttggtgtgcacgtctcatgcattgaacgtctagacaa actgaaaggcaataaatcctatgtgaacatggacctctctccggtggtagagtgcatggaccacgctctaacaagtctcttccctaagactcattatgccgctgga aaagatgccaaaattttctggatacctctgtctcacatgccagcagctttgcaagactttttattgttgaaacagaaagcagagctggctaatcccaaggcagtgtg actcagctaaccacaaatgtctcctccaggctatgaaattggccgatttcaagaacacatctccttttcaacc 436 224009_x_at ggggctatactccatccaaatatgcagtggaaggtttcaatgacagcttaagacgggacctgaaagcttttggtgtgcacgtctcatgcattgaaccaggattgttc aaaacaaacttggcagatccagtaaaggtaattgaaaaaaaactcgccatttgggagcagctgtctccagacatcaaacaacaatatggagaaggttacattg aaaaaagtctagacaaactgaaaggcaataaatcctatgtgaacatggacctctctccggtggtagagtgcatggaccacgctctaacaagtctcttccctaaga ctcattatgccgctggaaaagatgccaaaattttctggatacctctgtctcacatgccagcagctttgcaagactttttattgttgaaacagaaagcagagctggcta atcccaaggcagtgtgactcagctaaccacaaatgtctcctccaggctatgaaattggccgatttcaagaacacatctccttttcaacc 437 224342_x_at tatctgcggccccaggacagaaggtcgccatctcctgctctggaagcagctccaacattgggaataattatgtatcctggtaccaacaactcccaggaacagcc cccaaactcctcatttatgacaataataagcgaccctcagggattcctggccgattctctggctccaagtctggcacgtcagccaccctgggcatcaccggactcc agactggggacgaggccgattattactgcggaacatgggatagcagcctgag 438 224352_s_at ttttatttcaggcttccagctgtccctgtgagttatcctggacatttcgatggtttttggtaaggccaaactctgataagcaaaacagagaatactgacggtatacttaac catatgtgtaactgatacttggcaccatggaatttttcattgagttatttcctcattcttttaaaaaataagggactataaatcagttatttagtatcttttgtttttgtagctgatt ccttaactttcttgtatgcctctagtaatttcagagattaaatattgctttaaactgtgatactttgatttgctagattgacaaaactgatactaatataattaagttcatctttg aaatacatctttgtgcgtagagccaaaaaaagagataaaattaataatagttcacttgttatttgagattaatttggcatttgaaatgatcattttattttacaatcatttata atgaatcaatgttccagttagctttaaaaggtatacggtgctaattagtaaaatattgaaggcaatattttactgctagcttgca 439 224412_s_at taatcctgacattagctgacttgctagtgagcttgctttaaaaatctacactcttgcattcttaggcatacaggggaaatgttgaaaaggaaggtggaaaaccaaga atttagtttgccaatgattgcctctgattcttgtaagtttgagttccacaagggctaatttattccccttttacttgggttttggggtggtggaaagcgggaaatttgggtgatt tgttgattggcaatgaggataaaatgttaatacttttttggggacttaacaactttatcctattctacaagtcagtaaaggaacaattggtactcacctcagtgctgcact caactatggaaagaggcagagtttgcttgcccaattgccaaactaaa 440 224480_s_at attagtgtcattagtgtgttggaagagaaatactattcagtaagcttcgccaaagaaaagtgagtcaaagttaatgtgtgtgtgcatttatatgtaggcagctcgtaga ccacattttagccagcaactggtaacaaagagcttagttttccttgtttgaatgctgtagatctgtacctagtacccctcccatctactgatttgtttgtttttgtaaccaaac acattttcagatagaaggagccttaaaaaaaaaaaaatcacattgagtaacttcagtatgaatgaatgagagtgtgtggagctacccctcaccctccacccctttg tgctttttattcccgaattttcccagtctcttaaacagaaaaatgactgatataattatcttttggaaactgagccttaattttttttagagggggaaataagttttccccaact cacacagcataagcaatgtttgacagcaatataatgccgttgtaaactactgagagtattgtatctgttctggtaaccatgtaca 441 224560_at ttgtttttgacatcagctgtaatcattcctgtgctgtgttttttattacccttggtaggtattagacttgcacnttttttaaaaaaaggtttctgcatcgtggaagcatttgaccca gagtggaacgcgtggcctatgcaggtggattccttcaggtctttcctttggttctttgagcatnctttgctttcattcgtctcccgtctttggttctccagttcaaattattgcaa agtaaaggatctttgagtaggttcggtctgaaaggtgtggcctttatatttgatccacacacgttggtcttttaaccgtgctgagcagaaaacaaaacaggttaagaa gagccgggtggcagctgacagaggaagccgctcaaataccttcacaat 442 224663_s_at ggtcagatggtcaacttttttcagtattatttatagttggcacttgattgcagttctgtgaggcttgagcattcatacacctcacctgccttggcaagcctattttagtgatat ggcagcacggatataacactatgcattaaaagcactttttgtaataagtttaatatcctaaaaggaatgccaattaagttttgttaactgtgtcatcaacttatcctagta cctcagtgttcattcctgttacctgcatatcttcttaaaagaaatagctgttattaatgcctttttgttttccattgagtgtacactactgaataagtgtaggagttttatgtttac catgtgagtcctgcaacactaaagatattttgaatatcagtcatgatggcaatttctgtataaaagagccttaaatggaacattgttttgagatcaaactccccaccc 443 224694_at gatatctggccatgggtaacctcattgtaactatcatcagaatgggcagagatgatcttgaagtgtcacatacactaaagtccaaacactatgtcagatgggggta aaatccattaaagaacaggaaaaaataattataagatgataagcaaatgtttcagcccaatgtcaacccagttaaaaaaaaaattaatgctgtgtaaaatggttg aattagtttgcaaactatataaagacatatgcagtaaaaagtctgttaatgcacatcctgtgggaatggagtgttctaaccaattgccttttcttgttatctgagctctcct atattatcatactcagataaccaaattaaaagaattagaatatgatttttaatacacttaacattaaactcttctaactttcttctttctgtgataattcagaagatagttatg gatcttcaatgcctctgagtcattgttataaaaaatcagttatcactataccatgctat 444 224823_at gacctaatacatttcctctgtgtgtgtgtgtaacattccaaatactttttttttcttttccactgtttgtaaggtgcaacaatttaatatttttaagggactttttaagagttccttaa gaaccaatttaaaattacttcagtgcaatcctacacagtatcaacattagaattttgatattagtcttatgttatcttccattctatttttatctgctttttgctgctagtttcaaac tgccagtatttttccttttgcttttaaaatagttacaatatttttcatgatagccacagtattgccacagtttattataataaagggtttttatttgatttagcgcattcaaagctttt ttctatcacttttgtgttcagaatataacctttgtgtgcgtgtatgttgtgtgtgtgcatgtgtggcgtatatgtgtgttacaggttaatgccttcttggaattgtgttaatgttctctt ggtttattatgccatcagaatggtaaatgagaacactacaactgtagtcagctcacaatttt 445 224836_at gagtgagtcccagttacatcaaacagtgacttccagttattccccagtaagtctgagtggttccttcaagctgggtgtctttccagcctttgccagtctagccccagca gggcaccgtgtatgaatgcagtttggtgctgttttagagtatgcctgctccccagccccctgcctggaaccctctgagcaacttgctctgacctataatgtcttaggtgc aacacggaccccaccagagctcttggatacccccctagatccatgtggctttatgtgaggggactgaatgcagacacaccatagcccccttctactactttccctct cgccctgccacctagttccacatggaaccaacaagttgagtgcatccctgttgggtgttttgtgttgagactggctgaaatgaggagactttgaccatgtgacgtgtc aacagactcaaggagacaaccacctcaactgggtcatgtg 446 224840_at ccccagtctcacctacgaaatatgaagagcaaaagctgattttgcttacttgctaaactgttgggaaagctctgtagagcatggttccagtgaggccaagattgaa atttgatactaaaaaggccacctagctttttgcagataacaaacaagaaagctattccaagactcagatgatgccagctgtctcccacgtgtgtattatggttcacca gggggaactggcaaaagtgtgtgtggggaggggaagggtgtgtgagtggttctgagcaaataactacagggtgcccattaccactcaagaagacacttcacgt attcttgtatcaaattcaataatcttaaacaatttgtgtagaagtccacagacatctttcaaccaccttttaggctgcatatggattgccaagtcag 447 224959_at tcatgcgtcatccctaaaataataagatacatgggatcaaatagcccttgccttttcaacacaaatcagttggaaaattatggtttgagtcctgttgctgccatggcttc tgtttctcagaaatgagtgtgtatgaacataccaatctatgtaataggctacctttttttgtcttctttggaactttgtacacaaaccaagacaatatcagggtgacaggt gaatgaacttaaattctcagtcttgtctattcaccaaaaaagtatactgcctgttttttctttaattattcaaggttgatgacttttaggaacatgttttatactgtattttttaatta aagcaagtgccttgatgtaattccatgtaaatcattgcttaaccctcttatgggatgaggatgagttattaatgtattgcagcctactggaaaggagggggagttggtt aatagcagatacttttcttctagaagcttatgttttatgctgtttattatgtaagatcctgtatgtgtgttgaga 448 224963_at ataatgatccattcgagttctgtgatccttattgttcttaattgtgtttctctacgtattgttacagatgagccatacgtttctttgtatcaatgtagacatgacttcagatacctc tgaggacctacccagcagtctaggaccctgggccaagtgctgggactatggtactaaatccagtagatgggctgtgtagcaactctcccagggaacacactag ggtacttagggaggtgctttgtggagcatgttgaagctttgagatctgagcaggaggcagtgatgtccctggtctattcagggaaagatttcagtgtgaaatggtaa acatccaattgacaggatttagattttgcttagtttttctgctttttaatgtttctatcccccatctcagtgttttctttatccatcccagtgatgcct 449 224964_s_at ataattttacatgatcctcaatatcaactccagtttaaaaagtgttatttttaaaacatttgaaaccaagtactgtttaatttcaatcagaagatgcaaatacatactttgat ctatgtttgattttgctaataatatttgaaggagattgcctaccaaggacaaaacaataaatttaaaaatcaaacgatttctccatacgctcatagtcacatatggaatt ttgagaaaataaagcatgctgtctttaggaatttttatacttctttgtctttcttccttaatatttgcttctagctgctcttggcaatgatgaattgttatgtatgcattaatgttttgc agcccaaaagttgttcacatttttcctatataagatctgtggagtgtgtgtttcaaagagagaactacagaaatgttaaagcaggaaaacctgaatgtgatgtgcac attttcatcccacatggaca 450 224989_at catttctgtcacatgcacttagttgacattacatctacatatattagctttttcctacatgagccatctatttacttagtaaccagtgttcttaatgaagtatttagtcttgggttt cttgtaaaatttctctgcattccttagacagtgtactatacatgaaatattcttgttgacctagtaatttatattattccatttaattcttaaacctatggcctttttattgagcaca ctcttaaatcattatttggcttgtaaacattcatctgaattgtggctacaatcctctttaaataatctaggaaaaaagaaagataaagcttacattttcacagttttggctct taaacacattccacaaatgccattaagaatttattttgttttaggccagtcatggt 451 224990_at gagcttctagaaatttcacttgcaagtttatttttgcttcctgtgttactgccattcctatttacagtatatttgagtgaatgattatatttttaaaaagttacatggggcttttttgg ttgtcctaaacttacaaacattccactcattctgtttgtaactgtgattataatttttgtgataatttctggcctgattgaaggaaatttgagaggtctgcatttatatattttaaa tagatttgataggtttttaaattgctttttttcataaggtatttataaagttatttggggttgtctgggattgtgtgaaagaaaattagaaccacgctgtatttacatttaccttgg tagtttatttgtggatggcagttttctgtagtttnggggactgtggtagctcttggattgttttgcaaattacagctgaaatctgtgtcatggattaaactggcttatgtggcta gaataggaagagagaaaaaatgaaatggttgtttactaattttatactcccatt 452 225207_at ttgtgtgtaatttcatggtggcctagtgttgtggtgcttctggtaatggtaatagaagctcaactatttttttgtggatttcagtttttatcatcagaagtcctagacagtgacat ttcttaatggtgggagtccagctcatgcatttctgattatacaaaacagtttgcagtaggttatttgtcatttcagttttttactgaaatttgagctaaacatttttacatgtaaa tacttgtatttaccaaagatttaaatcagttgattaattaattaactcaaatactgtgaactatctntaaaacactagaaaaaagaaatgttagtatctcaattacacca actgtgcaaatgaactttgataaaatagaaataatctacattggcctttgtgaaatctggggaagagctttaggattctagtagatggatactgaatactcaggccca cttaanttattaatgtatacattgtgtttttgtctttatgctatgtacag 453 225242_s_at ggcgtgcaattttggtctgcgccacataaccattctgaagcttttaggcgttggagaggaagttgggggagtgttagaactgttcccaattaatgggagctctgttgtt gagcgagaagacgtaccagcccatttggtgaaagacattcgtaactattttcaagtgagcccggagtacttctccatgcttctagtcggaaaagacggaaatgtc aaatcctggtatccttccccaatgtggtccatggtgattgtgtacgatttaattgattcgatgcaacttcggagacaggaaatggcgattcagcagtcactggggatg cgctgcccagaagatgagtatgcaggctatggttaccatagttaccaccaaggataccaggatggttaccaggatgactaccgtcatcatgagagttatcaccat ggatacccttactgagcagnnannnnnnaccttagactcagccagtttcctctgcagctgctaaaactacatgtggccagctcca 454 225269_s_at aactgtgtacttgtctggtcagctgtgtatgatcagttatctacctcagagtctattttcttttgtgctgggacaggttgctggccctccctgtttccacagaccaaatcctcc tagctcaggagctagggctaagcagttatttctttcaagtattttttagttcttaaattttatgcttgtatttgatgatagatgtcagtgacatttcatagtttcaaaagtccttgc tgctctgagaagtgtagattctagtgaaaattacatagtcataagagaaatgtgtttttgtttttgtttttgtttcatttttttaaagttgtggtattattggttctatgctccctgga atattactgctttgtgaaagtccagactgaacgcagcaccctctgtgtacctagtacagttataaacctgggtctctcactacttgatatttttgcattagttaagacaga aatttgatagctcggttagaggggaggggaaatctgctgctagaaatgtctgaactaagtgccatactcgtctgggtaagatttgggaaacataacctctgtac 455 225275_at gatgagagcaaaggggtcgcaccatatggaaatgttgaaaactattgtaaagtagtattatgaagtagcttttgtgtcattcatgtcgatgacatgaaagtgaagta aatttattctatgtaaattcacactaaaaccagtacagtaccataagtagaatacatgtaagaatcacctagtcttcactatattgagtaaatataacatgctaatttta caattaatgaaactaaacttttaaacatctccattatatctacatccttttgaaggtatttatcatagttgccaattttaattttaggattgactttctctttctgaatgacttcata aagtttggtgtgaattttgaagacttgggttactaatgattgtatctttgctagtcaacaacttatgaaatatactcaatgcgtctgatgtgtcattaagtgcagaaataac taagacacaaataacctttgcaaaccttcaagctgtgtaatattccaatgttgtttttttctttgtatatatacttatatcacgtaggatgtaaaaccagtatgaccttgtcta gtctccaaacttaa 456 225353_s_at gccacacgtccaaaaccaatcaggtcaactcgggcggtgtgctgctgaggttgcaggtgggcgaggaggtgtggctggctgtcaatgactactacgacatggt gggcatccagggctctgacagcgtcttctccggcttcctgctcttccccgactagggcgggcagatgcgctcgagncccacgggccttccacctccctcagcttcc tgcatggacccaccttactggccagtctgcatccttgcctagaccattctccccaccagatggacttctcctccagggagcccaccctgacccacccccactgcac cccctccccatgggttctctccttcctntgaacttctttaggagtcactgcttgtgtggttcctgggacacttaaccaatgccttctggtactgcc 457 225381_at gtatgtttgtaagtgcttctgcacgaatgtttatacatgactgtttccatagtacttatgtttttaaaaatattcagtcatttcctactataatcctcatgtatccatgtaactgac tcaaaaatacttcagccacagaaagctaaaactgagcaaatctcattcttcttttccatcccctttgcatgtggctggcatttagtaatgattaataatatggccagctg aataacagaggtttgagacacaattctttctcaaaggagtcagctaagctgggtctacttatggacaaacatctaaatgtgtggaagtatctgatatttgacaatggt aaatttccacttagctagctagcattgtcagacttcaatctcctcatggctctggccgtcctgttttaagcatgataattgttggccacatctcacatagttctcattgagtg agttcataaataaacagggtttttttttttttttaaagagcagccaagcacaaagtgtgactttgttgacattttatgtgactttgtcatatgttcctaacc 458 225442_at agtgtcaggtgccttgcaggaaaataatctgagtcccaagctagcctgtgctcatccacaatcacaatgaacatgtcaaggaagaatttgcagagactcaaggg aagcacaatgggataaggtaatcactttcagtgaaaaactgttttcttgaaaacaggcttggacacaattgaaagctggcttcctgcaaacacaccaagagtctgt aatctagcctatccattatatgtcctttattattcatgatatcctattcttctaccttgttgcctggtaactttttctgaggactgagtttctgcagcgatgtggtgcactcttcctg tgatgaggaaacatctgggccccct 459 225458_at ctggacacccggttaccaaagtcagcaaagaagatgcggtaatcgccgcctgatctccacatggtgaacacaacactcccaccaacacctccttgactggtcg gtcttcagcaccgggggtgggcaggcaggtgttctgtgttgacgagaattgcacaggctaaacacaaacacggaaccagagtgagaacacctcactcacggc agcccaggctgctccctaccaggtgacggagcgcgccggggctgtgggtgccaggggctgagtgctagggactcgtcatgagtggggatccccacgttcctgt cactgctgtcaaacagaaggtaaacagtcttatgaatgtatttccttaggaaaacttgtaaaaacttttattaggatatctatttaatactgaactttggcctactttgtgat agactataaacaaattgaggaaatcactatttctcacttctgtattttctcaaaaataattttgttacagagttcaatatactgtgtaccattgatcttctattgtg 460 225575_at gaaactgcggatcccaaactgttccctttttcatttcttgaaatgttaccactacagacatttttttaaggtgaataaacagttgtgatgtgctgtacntaaaatcatgttta atcgtataaggaaacatttcaatacacttatacaggaagaaaactatagatgaagtacatgtgtgtgattcagtctgattcacagaattctgagagtaatatggaat aaaacaactccacttagatgataactgaagcatttcctgccttgtgaaaatttggattttaaattgctgttagaatgggaaatttggacactttatatcattgtataatttca gaatttagtttctgtatcttttggaaaacatgattatagcaaaaacatagaaaataatctattactaaaacaccataaatgtaaaactagtatgcttggctgttaactcta aagatgttacttatgtctgttttta 461 225602_at tgagggtgagcttactcagggcccccagaggaagccctcagcctctgccctccccccacacagggcgggagcccaggcctgttcctggcagctgtggctgca gctgtgctcctgctccctcctggaatgtgcgacaagcccaaatgttccngggnaggcggccggggcagggggcttagaagtgctaatatggttctgtgttttgcctg aaacgataccaggttcccctgaatagcaactttacaaggtccatgtgggagggaccaacccagatgccctgctgagtgtccctgaaaccatggcagctccatct gtcaagatggcaggggccggagtgagggggctgctggcttaacagcaggcatctgggcaggccagtcctcaaagcagctcctgaaggtctgtgttgcactgtc accagtctcaagctatgcctctaatttcaccagggatattg 462 225604_s_at gtgtgatgcatgtgagcgtctctggcacacacacttggacatacagttctgtgtgcgctcattcttattacaggagtgagcaaaggaagcatttaccccgatggttac ctagaccacgattatttggattggggggagg 463 225626_at atccctgtattcatggcttgactttgtgactgctctacactgcatgtctgacattgcagagtgagctatgttgaggtaaactggttggttgtcattattttgcaatcagcctg gtctctcccatgaagatgtcgtgtgcataagcacaatcatcactgattagaagatcacagcagaatacccttggattagagagaagttcgtaccttgcatttctctga attctagtctctcataagcactgctttgctggatgattttcactgctttgtgttaatgactttgagcgatctctcacatgatggggttctttagtacatggtaacagccatgtc atcttacacacctagcattgtgaatgctgtagtgacatcctttataggcaccttacagctcaaaacttttgtttcatttcatgccttacttatca 464 225688_s_at agtgccatttattctagtttatcatgttttgcatgtttgaaagtatgaatgtgctctttcctaaaacatggcaaatgaatagatgtagagaataacaatattacttacaaga tgaaatgattagattagaagtgtccctttattaaactttgtcagcctgactgggtacaattcttttgttaatttgcagtgtggtttgtatacacgtatacgtgttatcaataata agattttgcaactggatgacacaagattttacttgaacagtgaaggacaaaaatcatgattgtggaagatatttttaaaatctgattttgcagcgatcacttttaaaccc tgtagtgatgtaagactaaaatataattgctaagattttgttggttaatgtaaagatatgacttttctgcactgtactctcttcataggattgtaaaggtgttctaatccaatt gcatgatgtagtaagcctcttaaatatgtgtgtta 465 225710_at tcctatgtcttctttcttaaatccagttgctgattttgtaaaatacagttgtgataaagcagcattacgggggggaaaaagctatattccaactggtgttaaatgtattcaa caaaatcttacatcatacagtatttatttcttaattaatagaacttcagtgatatacttggtagatatctcaagccttttgtcttttacacaatggtgctctatcctattgttttcttt tcaaagaagcatctgaacacttgcatttctattttcctatccaaaggcatccacatctaagtgtgtttttaaagttgattaaaattatttttctgttaaagcattctgaaagtg tttgtctttacctagaatgatttgtacacactcgtggtcaactgaacatgaatgtcagtagtagtctaattatgggaagggtaaacgtgttagattaaggctcttaaagct ctaaaccatataaactatggacttgtatcatgatttaactgttcttagatctttcttacacagtgattcattcctctatttgtacagtggcttt 466 225720_at tatcaaaggtttgccagccaataaagtgcatcccaagtatacaggggagaaagctagactcctacagggtcctagagtttaagtaatttttttgttattaatataggta ataatttttctaatttttattttttggttccaaatgtaaagctccttgtgtttacctctgtttatgtcattcttgacatgtttatctaaattatgtgtgctctgtgacaggtgaaatgtaa atctgggatccatagtcaagatatcataaggacctacttcccagcctacctttcttcctctacctgataatgataatactcaaaataacaacattcaaaggaaacac aaagaaatcctgctttcacatctcctatttcttgggctccttaataactactgatggtttgttcatgaaaaaaaatttttaaatcaaaagattgtacttggccctgagttgaa aaaatttcaaaaatcaaaagtttgtacttggccctgagttgaa 467 225721_at cagaaacatgaccctcgctggtcttgggtccacatatcattggactctgggggacacaaagatgcctgtgacactttggtgttgccgagttagtcaacaattattctg ggaaaaagcagaattgaattcttctctagatgtcctaccagggttggccaagggccacaaagcaggctaataaattcccacaggatccagacaccaggcaaa attgctctaagaagccagttactgtcatccctctatggttctagaaaaaatagtacaaaaatgacaggtcatcctatgagcgtcatgccaatgaaaccccatcttctg gagaagcccttgaatcagaattatcttttttcttgatgtcgtcagatgcagccagtttcttaatttttttaaaaactgtatgtttctgtggtatgtatatttgtacacctaactacc tggcacttggaaatcacagcactact 468 225728_at ttatcctgcgacaacactttcagcagantagcctctccttatctcacagatcacaagcacccctagatagtgtgattctgtcagatagcatttatgcaaaaatctatga agttaaaagatcgtagaagccaaatgaaatgtacatatctactgactgatgacaagggaatttcattaggaagaaggtaaagaaacatcgttgagtagcctacct tgatttctgtcaagttcataaccagcttcatattttaaaggcttcaggtttgaaattaagtcaactgcatgcagctttgctgataaatgaataattctctttgatgccatttat gagaaaagacttcaatatctgttgcctgtcatatttaagaaaaattactgtttctactctctgtatctgattttaaaagaaaaaactattcatacctggcttccaggtaatt gactttga 469 225782_at gaactgagtcaatatggcaaggtgtatgtgatctgtgggagttatgccatttaacataggaagtgcatgggactttccctctctgcactccagctcttactgtaccatta gaagatgcagaattctgttggtgtgcaaaaagtatagccttacattcaagcagaatggatctgaagaaagcagcaatatctgttactagagaacattcccatgtgtt taaactcttcacttcttagatgcatttaaattcttaatgcaaatgacgtagcaatttgaaaacttctccgtattacttgtgtttaaaatgtcttgctttaaatacaaaacaaat ggtaaaggggattatcttttgtttagatggttaaatattatttttgccttagatagctttgtaataatttttctccagacagttcaacacttttga 470 225894_at tactgactgactacaggggctgattgtgaagcacgaggaaccccatgtgtgtggagactgtagggtgagagcacacaattattagcatcatttctgagtgatctca cagattttttttcttgtgtttgttttgctttttgacaactgcttctcccacgttccttgcaattctattctctcaccttcactttactatttgtattcgatggaccaggataattcaggc aaggttaccttgtaaacttnaattggccacacaccatgttgtcacccagctggctatgaagtgaataatggtactgaaagtaaacctgaagacctttctcagatctat tttaagtctgagtctgaccaaccatggaaaatattcgacatgaattaatgtagagaactataaagcatttatgacagctccaagaaaaatcatctactctatgcagg agatatgtttagagacctctcagaaaaacttgcctggtttgagggtacacagtaccattttaatcttctgaaaatatctgtattcctgctctttttctgctgtcactgtcaatc tgctatattttt 471 225895_at ttcctgacgggaatgttgtgctataatgaatctgcataacgcttgggattctaggaggaaggaaggttccatggacatgtaagtacagcatattcccctcagtcttcta ggagggcagagtgaatcccagaactggtaagattgggaatctgagcattgccactttaatcttagaatatttatcattttgacacatcctgttttttagagaggaaaac aaacacagtttctgcattggtagtgtaaagcataccttgttaggaacgtgttttgtaagacacatttgggttgtcattctagagcatgtcaaactttgtacttcaaaatata tttagtatgattgttagtggtaacatatatcaaggctttgaattaactgttttatttaattttcacaagaagcacttattttagccataggaaaaccaatctgagctacaaat agttctttaaaataagcccaggttatttagctattctagaaagtgccgacttctttcaagaag 472 226001_at ttaaatattcattccattacatctagactcaccaagaactacatgttatgatgttaagttgaagttgaaacatgatgttttgcattaaatttaagatatgcaaatttatgtag agaaaataaatgttatataccctataatctttcacctaattagtatttaattatatggatttgttttatattataaaagatgttttgattttgtcttttgatattgacaaaattgtttg gatatccttatgttctcaagtctgtatctgcctcccctgccttatttcttatgttttgccacagttaacccattgtgcttctttgtaatcaaacagtttgtgggagaatgggcttat tgaatgtctaaaaaataagtttaaagtgtttgttaccctaagttttttacatttttaaactctaattacatatgtgaatgttattactctcagtgaattgttattgtttgcaaaaat gcactgggcagtaacattttgt 473 226051_at gccggactggaaccgtctgagcggcctaacccgcgcccgggtagagacctgcgggggatgacagctgaaccgcctaaaggaggtgaaggctttcgtcacgc aggacattccattctatcacaacctggtgatgaaacacctccctggggccgaccctgagctcgtgctgctgggccgccgctacgaggaactagagcgcatccca ctcagtgaaatgacccgcgaagagatcaatgcgctagtgcaggagctcggcttctancgcaaggcngcgcccgacgcgcaggtgccccccgagtacgtgtg ggcgcccgcgaagcccccagaggaaacttcggaccacgctgacctgtaggtccgggggcgcggcggagctgggacctacctgcctgagtcctggagacag aatgaagcgctcagcatccc $474.00 226084_at aatggcttctatgatcagaactgggaaaacagtgnatcttatggtggaagaggtnctcagcaagtgtacagtatttaccttcctttgtcttacatnggctttttaaattttc cattaatttcaacataattatgggaacaagtgtacagaagaattttttttttaagatatgtgagaacttttcatagatgaactttttaacaaatgttttcatttacaggaaatt gcaaagaaaattctcaagtgatagtctttttttttaagtgtttcgtaagacaaaaattgaataatgttttttgaagttctggcaagattgaagtctgatattgcagtaatgat atttattaaaaacccataactaccaggaataatgatacctcccaccccttgattcccataacataaaagtgctacttgagagtgggggagaatggcatggtaggct acttttcagggccttgacaagtacatcacccagtggtatcctacatacttctttcaagatcttcaaccatgaggtaaaagagccaagttcaaagaaccctagcaca aatttgctttgg 475 226103_at ggaacctatcaatttgagtggactttttctttagtagtacaccatttnggttgtngtagtttcaaagtctttctgaagcagatatattgggattggagcggggtggggaaa actgtcactcctttcagaggaaaaggggaggagcatggagaaaaacaaaaattaaaggacttaaagaatggctatacagtgttgagtgttgaggatattaaac atgttatttttcaaacgtatgtaatatatattaaatttataaagcaaatttatgttgtgatcttgcctgaacaaattatattttaatgaaaaaactttctattaatagttcacgca agagaaaacactttcaacatagtcgaaggcttcaagatctaagtgtatcagacttagggaaaaagtggcacaaccttcgatttaaaattctagtctttaaaatgagt ttgtaaataattagctattacgttctattaagttgtt 476 226147_s_at agggatctctctacaagagcccctgcccctctgttggaggcacagttttagaataaggaggaggagggagaagagaaaatgtaaaggagggagatctttccc aggccgcaccatttctgtcactcacatggacccaagataaaagaatggccaaaccctcacaacccctgatgtttgaagagttccaagttgaagggaaacaaag aagtgtttgatggtgccagagaggggctgctctccagaaagctaaaatttaatttcttttttcctctgagttctgtacttcaaccagcctacaagctggcacttgctaaca aatcag 477 226302_at ggtaattatggaaactcctcaaagaggagaaagtaatttttttccagacatttttctcattctgtgtctttcacacactagtttccatagttcgagaattctgttttttaccattg ggctgtgaatgttcacaatatcagtcctgttgaattcctatgaggtaatcacaatgtgtatatgttcattttctaggtatgataaaagaatgtatggctttttattctgtggaa gtaaaatcctgaacgtttacaacttttccttaacttgtaaataaaaaattgtaagttttttctttttttacagaaaacttagcttgtgtaattctgttagtttcagatttctctcctgt ttttgcaaattgtgggaaagattgacaatgcaaatgtgtcaaagacatactgttgggtgc 478 226303_at acatgggtttatacaagttcctcttgagaaggcaaaaagaccaccatgtgtgagagctctttgacttggccaataggggcctatcttaatgcacttgtttggacacatt tctgatcttatttgtaaaggctgcaaaaggagaggatgaaatgctgtaaaagtaggaaatgaagtggaagctggaagaaaatgtaattggtggtacagctatgg gccagatggtggaggggagggtggggacccctgccggcaagcagagtgtcacagctggctttcctcacttgggaaaagggtactgccggtctagcagcctcct ctgtactcagccaggacacccagcgcgtgggacctgtttgtgtctgttttgcttccttgggaacggcacagtcactcaccctgccatttgcggaaatgacctggtgca ctttgactgttaagcaatgcgttattgctgtagtcaaggttagtgcaagcaaggaaacattcccagtaaggtatttgtttccattttctgtctgtgcttctgtcagaaacttg ctaggac 479 226304_at caaacgtcctggactgcacagacctcccactccagaccatccaggcctggttcccaagacccgatccttcccctgcaaccagacagtctacaactgccccctcc agcccattttctgccgtgaaaccccagccagccacaccagactctggaaccctttttcgactgccccaactcttggacaccaggccaactagaacacccaacac caaactgtacagactctcccaccccaacctccccagactctgcacggatgtcctaggccccctccccaactctaaccagaccccatccccctaagtccctttgtctt gacccccaagtcttcaaccagatatcctcggcaacccacctcccaccctcctcctcttctccttcaagacccaactgagcacccgctctgattccccacagcctttct ccctgccaccactcccttagtctttcccaggcttactctcccaataaatgtgctag 480 226333_at ggtggagttggtggtcttaatttggagatgcaggggcaacctgtgaccctttgaggcaagagccctgcacccagctgtcccgtgcagccgtgggcaggggctgc acacggaggggcaggcgggccagttcagggtccgtgccaggccctcctcagtgccctgtgaaggcctcctgtcctccgtgcggctgggcaccagcaccaggg agtttctatggcaaccttagtgattattaaggaacactgtcagttttatgaacatatgctcaaatgaaattctactttaggaggaaaggattggaacagcatgtcacaa ggctgttaattaacagagagaccttattggatggagatcacatctgttaaatagaatacctcaactctacgttgttttcttggagataaataatagtttcaagtttttgtttgt ttgttttacctaattacctgaaagcaaataccaaaggctgatgtctgtatatggggcaaagggt 481 226430_at atttttccatcttattcaagtcagagcacttttttttaaatagcaatacaacaggcaagagaatactcaaaaatatttaaaactgtattgataccaagagtatgttttaaat attttctaataaatacttgagcggtttttgtctggcaggcttccaaatttgccaaaattaagcgttcagtattttcaacacatacgctttttactggtttatactgaactatctg atgagaattcctgtgttcccaaagcaactgatgtttacaggtcttgtgtttctcctcctcctttctaaggatgagggaatccacaacagactttctctagaaaacactaat gatggacaactttttggtgtcatcaatgagttggctactaccttgatgtaaaaatttgtaaggaaaattttcaccatttcgagtgtcaagtgtatttttaactgtctggtttgta cttttatgacttttgtactaccaaagcgga 482 226492_at agtgatctctggaagcgctaaagctaaaatttctgttcttgaaacacttcagctttgcaactaaaatattacagattaataataaattaaaccaaccaatgataaaca ctactcagtccaccaacaacaaacgtgtttgaattcaccttaccaatattaatcccagcgtgtgtaaaacagaacagtaactctatgtgaccccagataacattttgt aacattgtgcttccttgtagtttgtaatgtgagttcaatcagtatttatgttgaaatttctaacattaaatctagtctctatcctgttaatttaatttttaaatgctttatccatttgtg caaaggtaaacgcagattgtatcttttttaatggtacggcataaaaagtaaccctcaagtgaagtgtctcta 483 226594_at tgacgagacctcttcaaaaacccacagtaaaactcccctccctccagttggccaccagtctgccaccaaacatgaacaaattctgctgctaatcggtttcccttgtg atctggttcctgaggtcttcggatctgtgcaatgaattatttattgttttattaaaccgacagtggtgtcccagagaggaaccataaataaaatggaaatctggtgctgt gataaagtaataactagcattaatgagacctggttttcctttcagaaagtccagtatacctgtaacaaaggttaaagcaatttatatttaatttgcattctgatgttaacat ttaaacagcaattctaacaaaaatgcatcgagtctaattcttacctctatcaaaaaacaactgtataaatttatgaccaacattaaaacaaaaacaaaatgtaaatt ttctctttagaaatgattaactggaaatgagtgagacagcaccttgtgggttt 484 226654_at tgctcgcattgatcatcctaatcatcttattcagcctatcccagagaaaacggcacagggaacagtatgatgtgcctcaagagtggcgaaaggaaggcacncct ggcatcttccagaagacggccatcngnnnagaccagaatctgagggagagcagattcggccttgagaacgcctacaacaacttccggcccaccctggagac tgttgactctggcacagagctccacatccagaggccggagatggtagcatccactgtgtgagccaacgggggcctcccaccctcatctagctctgttcaggaga gctgcaaacacagagcccaccacaagcctccggggcgggtcaagaggagaccgaagtcaggccctgaagccggtcctgctctgagctgacagacttggcc agtcccctgcctgtgctcctgctggggaaggctgggggctgtaagcctctc 485 226682_at gctgattctaattgtgtgtaggtcttgaggattaagcacacaaatttcacaaacttctgtttgagtaaacaaactcagccttctgtaaatatacatgcaagtttggaaac agtaatactgtacctataaatatatgctgtctgntttgtgtacagtatgtaaaaactccttttctgccacactaaaaatgcaagccatttatgggaatcctaaaactagta ttgaactaaaactttgctaatgatctttattagaggatcgtccaacttttcacttaccttgggttttcttttcaattcactcttacactagtctgcttatttccagctgtttattttatt gagtcctgaatttaaaaaaaaaatattttgattcattttgtaaatacaagctgtacaaaaaagagagatttaatgttgtcttttaaatactccaattttcattctaatatgaa tgttgttatattgtacttagaaactgtacctttaatattacattacctttattaaaagtgcattgaacacatcaattttagatgtgctttatgtactgttatccta 486 226694_at taagcattcagtgagctgccaattttgattttgtgttgctctttacccaaattattttttctttgtttttctttttttgggggaggaggggaaaaaagcagcaatactgtgtttgga aattatactctgtatctggttttcctgtgtatgttaaccacttaaatgttattatcctgctttggttttagagtgattgtgaggcattcaatgca 487 226811_at agtgcctaaatcttgtttacctatcactttaaaaaaataattgaagtgtaagctaaataaaatgcttggagtttngcctgggctagtgagagttggtgcaaattcttgtgt gtgtttgcataggaaggtgagatgaccatctactaaagaggaagtagctaaatacagatctgtgggtgtttttaaaaaaactcaacctatctggtgttttattttaatgg ataaaaatgtaatttttctaaggtagcaacttatttccaaattaatatagatgaaaaatagataccaattagactaaattgaaagctttttgttctatatttgcatagccttt gaaatatttcttagtgcctaggaggtctggggattcctctttcgtggtggtcactaaccttacttgatgcaga 488 226818_at aacaccaattatgcaaactacttttttttccagcagaaagggagctgacatgatcaaatccatgttttcaaatgaactgaaaaaggcatccagcaccacttatanc acatttatttcagttccaggctgacagccntggggnatctagcaggatnnataattgtcatctggtgagagttgggactttgctcaattttaataccaatctctcctgatt gtaattacctccactactttcatgatccccctacaatatttttttaaatgatatatttattcactgaatcaaatgtcattaatgagttatcttctgtggaggatgactgttctcttt gttaatgttcacaatcaagatcttgggctgagaagaggcccttcacccaaggagtttgaagtatcacagcgtgtgggaaggtgggaaccaggatacccattcattt ccaaccgagacacagagaagtgagtcacagaatttgagccngctctcttgactgcccagccagagacactgatttctgtaacctcttcacttgatcctgcctcttaa gcatta 489 226834_at tcatttctagagtacctgagccaaacaaatacacaacggaagctgcagctgtatcatcactagcaatttgctcatcattatttactacctttgaacctaaggtttcctgc ctatgcttttgaaagcaaaaatcagtctcctttgcatgaaaaagagccttagatttttaaacatgttagttaccagaatgctaaaataccagttgattacccaaattattt tggaaatctatccataatggaagtctacaacaaacacataaaacagattacactaagagctgagaaattcaaaggaactgaagattctgagagataaactgttc aagtcttagcaatgatactgcacttctctttgacaggttctgggcttaagttagaggccctactggttccaaaccatattccactgactttgcaag 490 226841_at cctctgagtgttttgtgggttctgggtgttttgtacattttagccaagctaaccacttgtctgcaagtactgactttcctatgaattctttgaagattattgagtcagaaagga aaaatatagccccaaattcccaggcttttaatgcattacattaactgcctattgaaatgagaagttcttcacaaacttgtatacccactaacaagattgcacataaac atgcattaaagtatatactaagaaaccctctgtccaacggctcatgcatatgaagtccgaacatgggagtttgccaattgcattcatcaagtcgttttgcggagtcag atccctgatggaagagctcacaggctctgccttccaagtcctgggttcctaactggtgaccttagcctggggtctgtggggagaccaaccctggcttccaagaaa ccacattccatggactatcagaaatagacacagatttgggtgacaaagctggctctgtatttgcatttt 491 227006_at gcaagcgcgtgctgagcaagctgcagtctccatcgcgggcccgcgggncagggggcagtcccggggggctgcagaagcggcacncnngcgtcaccgtca agtatgaccggcggganctgcagcggcggctggacgtggagaagtggatcgacgggcgcctggaggagctgtaccgcggcatggaggcagacatgcccg atgagatcaacattgatgaattgttggagttagagagtgaagaggagagaagccggaaaatccagggactcctgaagtcatgtgggaaacctgtcgaggactt catccaggagctgctggcaaagcttcaaggcctccacaggcagcccngcctccgccagccaagcccctcccacgacggcagcctcagccccctccaggac cgggcccggactgctcacccctgaccctcttgcactctccctgccccccggacgccgcccagcttgcttgtgtataagttgtatttaatggttctg 492 227052_at cactgttccatggtcagcaagtcatatttcataatgtggattttccaaaataattattgaatacagctattctatggctacttttagtgtttttgtggtatgtggtgtgggagtgt ttatggaattaccagtatcttaaattttcaaaggaaccttggaagtctatcactctaaatgaaagtctgtcactctacatgaattatgtgctcaaatttgaccaactcagtt taagacacaaaacagtaatttgaagaaggaaaaatgaagagagtttctagtttaatgggttaaatttttgttgttgcaatagtaagtttagtcttcttataatatttctaaa tgaaaaatcataggtatttgttaccatgtgtgaagattantttgttaaaagcaaaagtggtcgtgtgatatgctaaatgttaattactgattttatatgtttaaatcacgcca aacaaattatgtctgtgccatccagggtctgttgttaatctttttctgagtacttggattgggataaagggcttgtactatgcactt 493 227061_at acacttatagtctactgcccatgtaaggatcagctccggctaagaggccaaagatgggtgacatcgttatgctctgccntttattttttctttcttacccacttagcttcct aattggaggaaggaggcgtggtaaaggtatatgaagactatggtttaattagaccagaaaacactgtcataatctctggggtcatcagaatgtccagttttgtctttg ggccaagataagggcagtgggatttatgatgtgttgtttatagtctgaaactactctggtgatcanccagggtcagtttctttaatgatggtttccaactggcctaatac attaagtaagactggctgataacatgaccagacagacataaagaccctgttgggaatgacattgaactctcaaagtcaagatttcttacacaaatctatcagctgg agaaaatgaaggcagtgtggtatatgtgtgcaaataaggacattatgaagcttaaatatggaatgtctcttggacccccgatgtcatctgtattctctttttcttcttgtac tatatcctttgcctgtaaata 494 227099_s_at tcccagtgcgaactctgctgtgagtgtgtgcggggaggcgcgcccgcgctgagtcggcggcgggtagccactccatgcccttgtccgatggtttgcaactccgatt ttgcacaccgctccaccgtgccccccagcgcacacccattcacactcacgccaacactctcgctgaacacttttataattgttaggcgtggccgttgggactttggg cgcagcgcggctgctactgcgtctggaggattgatatttatttttgcattgcgatggctgaaggcatttatttaacgatctttttacctggatatgtctgtgaggctcctgaa 495 227235_at gtgaagtaccatagaccatattgtctagatgggacaaaataataaattttgactaagaacttactgtttagagagaaaaaatagtaaataatgttcaaaatgagaa gacaataactgacaagtctgtgatttttgggttagatgagaccacttttgatttttgaggaataaaaggagttagttttttggtcctgatgtgtaaaatgattcatggggttt cacatacagacaagtagttttcttttcagcaaatatttaacatatctctcaatatatttttcaccagtttttggtaaatatgcattgctataggtataccaagttttttttgttatgt ttagtaactaatttcattttttctgtatatgtaaatatagctattggaccctgcattgaaaaccttcttagtactaacaacactccttttattattaccttcatagttactttaaatg acatatttatttcgagttttacttctggctgagttgcaaagtctatgagaatgttacctcctgtctcagaagcttgttagttattgtgccacc 496 227265_at acatctgctagaaccttttgccttaactattcaccaatatatgctaatattcataaatatggattgactgtttacaaacattagaatcttgtcttggttccattttgatggctaa tatttgttatcttaattaagactatttctgaggtcatgattacttgaaaatattgactaaaactgggtccttagaaattccaggtggagctgatttacctatgactgagggg aaaaaaaaatcaaattttactgataatagtaatgctccaaatgaattaatgacacatctgttcaataaataaagagcttaaatatacaaaacataagaaatctggg caacaaaacttgtggtctttacttttgaatagctacccaagaaaaggttttaaaggtaaaagttatgagtaatgtcatcacaataagctcttgtttaaaattcttttcttttat gtataattaggtttatgtttcatgtcttt 497 227404_s_at atcccatgggcaataaagcgcattcaatgtgtttataagccaaacagtcactttgtttaagcaaacacaagtacaaagtaaaatagaaccacaaaataatgaact gcatgttcataacatacaaaaatcgccgcctactcagtaggtaactacaacattccaactcctgaatatatttataaatttacattttcagttaaaaaaatagacttttg agagttcagattttgttttagattttgttttcttacattctggagaaccgaagctcagctcagccctcttccttattttgctcccaaagcctcccccaaatcatcactccctgc cccccttaaggctagaggtgagcatgtccctcacaattgcacatgtcaagccatcagcaaggcgcatcacacaaaaggcaccaag 498 227522_at cagtgagtcgaggttgcgctactgcactccagcctggacaacagagggagactctgtctcnaaaaaaaaaaaaacctacagctgttcaaggaccagctgaca ggtcaagtgtggccttttctggtctttgaacacatcatagaaagtgacaaatgctgcaaagccatgaagaacatgaactataaacgggtagactaactgcccagc ttagacacttatctatgccacaaaacagctgaatttgtcacatttatatattgcaatatgggaagtattgagatcaaaacaggattccattgacctaattat 499 227529_s_at gccatcacagttgcgattccatgagtagctgctttatgactgctttttgtactatctggatgtgcccagagttacttctgtacaagctctgtatctatgtccgttgagaacatt attttaacaagaagaacaccaacagtagcatgaaatataatactgttttataattctaaagctgctgttaatttatgaagtacataataatctaatgtaaactgcagaa gtcagagcaa 500 227561_at gcaaccattggggaatgaccttttcatttcagaagtggatgaggaaggtggtgtgagcatcaggtatattnctggaccatttcaagtgctggtgagaagaaagga actctttgcctgaactgggcttggttttccaagtgctgctttggaaatgaagacccagagatgcagagcttatggtagttcataaatcttcatgttctattatctttcatctg ccaataaagttcattttcaataatgtccaccattgctgtgcccagaataaccacaggcaaacatcaaaacaatacgcataagttagacaagattaaatcttgtctg atatctgcacaaacagatatgcaccatgttggaaacatgtgttttcctagtcccatccaggcttcccacaagaaagccatgatgtgggtctaaacc 501 227623_at attgtttcccatagcagaatgtcaatattcacagtacatttctgtaaagagcaaaccaatataatgttttgagtgttgaaaaaaattccagatttntgaagaattagaca actcttcatctaccttatttctagttcacacagttatctcaaattccactgaaactaatgggatactgtcttgtgtagatgccagttgagtttataatgtgacctagtaaagc tgtcttttttgttgtgttgtatgagtgtcggatcatgcttttaggaatacttttattaaaatggtgtgcattcatgcaaaaggccaactggcttttgtgaacaatagatcttttctc ccctttattttgttctcttgacacttttgtgaaaattacctagcctgata 502 227662_at aaagccttccctaaaaagagagcatgccagtcatagagacactaatttggcacttttcctccttcttaggtttaaatgttataccaatgcatgtgtttgaaatatccatta agatgatttaaaatttgtcttgtattttgagtttcttaaatgcgtggattcttgttcatttatctctgaatatgtctcttttatattttggcacaattatacacattggaaagggcca acctattagggctcaagtatgtatatgcnaaaaaaaaaagttatatcaaacaggcacagttattacaactagagagaaattccagaaatatttgtttttttaagaga aagtaaattttcacattagatttctattcaaagtactaatatctacatggtccacacttttctattttaaaaaattgtgttctcttgttaaatagattaacatttccacttctgttta tcacaa 503 227682_at atctttccatattgaggacagcctctgcatataaaaatgttcattgggagaaaaattatttttaaaactaaatttttatagtagtcctccattactggcaattaaggagca acccacaaaatgtcattatgtggttctttgattaggcataaaaagtattgcaaacagcttttctattcctttggaatatgaatctttttaatgtctaaagttaacctgcaaca ttttctagtaggacaagtcaatgtaaattaggtaatttttgcctgttttataccttctgtngcattttgttcaaatgaaaacattttttaaaacatgattgaattttttacttctcaga taattggtttgagtgtggaatttcttttttaacactttgatatgtaagttagtgtaaattaatacttttataacactactaggctttatatttttatggaatgttttaaaatttgaaatt tttgaantgttaatttagcagtactttatcattatgtgccaatactgacaag 504 227705_at tttactccagtcattcgatgttgctgagatttacatatgactcttgtcaacatctcatcttttgacccaatcttattcatttaataagaggtctcattcatttgcatggaaaaat gctcattgtatattgcaaagtgaaaataacgagttgcaaaacagtgtatacatatatgtgtgtatatatgtacactttatttgtacatttctatgtgacataatgcaaagg aaagtgtctgattttattatacaccaaaggttaacagtgaatctctgtgtgatctctttttttttctttttgcctatctgcatcttcacttgccaaaaaatgaatatatgtttatgt gtgtatattacttgtgtcacaaaaaaccctaaagtagacagtaaaagaacttgtcaatcgcctttggaaggcaatgaaacacttaataaactctcaataa 505 227725_at agccaagaactgaccggggccagggnctgccatggtctccttgcctgctccaaggcacaggatacagtgggaatcttgagactctttggccatttcccatggctc agactaagctccaagcccttcangagttccaagggaacacttgaaccatggacaagactctctcaagatggcaaatggctaattgaggttctgaagttcttcagt acattgctgtaggtcctgaggccagggatttttaattaaatggggtgatgggtggccaataccacaattcctgctgaaaaacactcttccagtccaaaagcttcttga tacagaaaaaagagcctggatttacagaaacatatagatctggtttgaattccagatcgagtttacagttgtgaaatcttgaaggtattacttaacttcactacagatt gtctagaagacctttctaggagttatctgattctagaagggtctatacttgtccttgtctttaagctatttgacaactctacgtgtt 506 227727_at gggctgttccagagattcgatcctcttaaggcattatcagtgagcaaatgtgaaggaaatggtgtctggaagaaagttctggttcacatgccttgtagctaagtctttc tgcaaacaacctcccttccccccgtcgagtcatttggtgactttgatggggggatttctggttatgtcaaggctctggagacaggaanggcctttggccgccttggt agttgacctgccttttctgactccgggacgagccagtcctaggctgcctcngggagcacttgaggtatcccgcaggccatgaggacccactgggcagctcctgg acagcctcttggctccagcccccacccgaaagtggnacactgnntccgccctggccacctggggactggcactgtggtgcacagtggcccaatgtggccaac ggaagtttt 507 227735_s_at cacaggtgtagcactcccaaagcaagactccaganngnnnnnnacctcatgcctggcacctgaggtacccagcagcctcctgtctcccctttcagccttcaca gcagtgagctgcaatgttggagggcttcatctcgggctgcaaggaccctgggaaagttccagaactccacgtccttgtctcaattgtgccatcaactttcagagcta tcatgagccaacctc 508 227736_at caccatgaccggtcacagctacaaatccagagaccatcaatcctgctagagtgcagggnggcaagcacccaagggtggctgaccaagactgcagagtctcc tccatcttcaggtccattcagcctcctggcatttaactaccagcatccagtggtccccaaggaatcccttcctagcctcctgacatgagtctgctggaaagagcatcc aaacaaacaagtaat 509 227826_s_at ggttagattccgttttgactgcttggtatctcattgtaagcatttcccagggacactacacagtctttataattatgatcactacatcttttggataacttaggcttttgcacta ttttgtcacgatgcctcaaacttttctatcattgtctgtaattactcctataatcttttatt 510 227827_at aatatctcaagatttctaggcattttcctatgtctaatagtaggatgttctctctgaatttatttattacaaaaataacattacaacaataaagcaaaataatatttaaaag aaagaaaaaacaaacagtcgcaataccagaacaccattgtagtcgtttgtgtatgtgtgacttctttactgtgttcatgcagagacaagctttgtaatacctttgtaact actgtacaggtgcgtggttagattccgttttgactgcttggtatctcattgtaagcatttcccagggacactacacagtctttataattatgatcactacatcttttggataa cttaggcttttgcactattttgtcacgatgcctcaaacttttctatcattgtctgtaattactcctataatcttttattataaaatattgaaacaaagtcacatcactaaaaaca ctgtgagtataatttattagtaagtgtagactgtgtatcattagcaaa 511 228133_s_at ggagctgcttcaagaagaaacccggcagaagctcaacgtgtctacgaagctgcgccagctggaggaggagcggaacagcctgcaagaccagctggacga ggagatggaggccaagcagaacctggagcgccacatctccactctcaacatccaggtgcctgccccgtgtccttgcttccttcatgggtcctctcaacttctctgcg ctgagatcccccgcaggcagatcgcggtggagtgttggtgcgatggtgcttgaccccccagcttcccctgctattgggtttctccaacgaggagacatggtcttcgc ttctcagagtctgtggggccagggacaggggccantcatggtccccctctcaccctaccctggacgctgtccttgtagctctccgactcgaagaagaagctgcag gactttgccagcaccgtggaagctctggaagaggg 512 228195_at tgttacctttcagttacatgcctttgatcctaaaattctctacttttgntgccttatcagttctttgcaatctgcctgtggttatcagcacttaaagcacaattttgaaggggaa aaaaatgataatcaccttagtcccaaagaaataatttntgtcaaactgccttattagtattnaaaacagacacactgaatgaagtagcatgatacgcatatatccta ctcagtatcattggccttttatcaaatggggaaactatacttttgtattacatagttttagaaatcgaaagttagagactctttataagtaatgtcaaggaacagtaattta aaaacaaagttctaacaaatatattgtttgcttaatcacaatgccctcaacttgtatttgaataactaaataggacatgtcttccttggagctgtgggcattagttcaga agc 513 228202_at gtttacacctatactgcataatccaacaattttaatttcagttgaagacatgttactaatataactattattaaaagagtagaggatgtgtaattaaccatatcttctaaaa catggttactaaaagaatatgtaacatcaatattgaccttggtttcttacacaagtgttgctaactcaatagtgaaggagacactattaaattttctgaacccatgaga gatactagagatggggagtggaaagtgtttggttcagggatatctgaagaacagaagggcagagatttcttaagtgacgcctcatctacaagctggaaattccta aaaacaagtagaaagcttataaacaacaggtgatacactcacctcactggttttagtaaattaccaatacagaaagtatccctagtcttaaaaacaagtggaaa atttgaactgattagtcatattcctttgattacactgtt 514 228232_s_at cagtcagagtggacaaacctctgtgggaggctctactgcactgagatgcagctcttccgagggggctcctaagccagtgtacaactgggtgcgtcttggaactttt cctacaccttctcctggcagcatggttcnagatgaggtgtctggccagctcattctcaccaacctctccctgacctcctcgggcacctaccgctgtgtggcca ccagatgggcagtgcatcctgtg 515 228241_at gcctcctcagacactctcaagaggatggggagatgacatcacttgggtacaaacttatgaagaaggtctcttttatgctcaaaaaagtaagaagccattaatggtt attcatcacctggaggattgtcaatactctcaagcactaaagaaagtatttgcccaaaatgaagaaatacaagaaatggctcagaataagttcatcatgctaaac cttatgcatgaaaccactgataagaatttatcacctgatgggcaatatgtgcctagaatcatgtttgtagacccttctttaacagttagagctgacatagctggaagat actctaacagattgtacacatatgagcctcgggatttacccctattgatagaaaacatgaagaaagcattaagacttattcagtcagagctataagagatgataga aaaaagccttcacttcaaagaagtcaaatttcatgaagaaaacctctggcacattgacaaat 516 228469_at aaggttatagccacattcaacttgaatggtcccnaatgttaaatttaccatgaatactgtgtcttacaatgctgagctctcgactagactaaccagaataggaacac agtctcaaaggataccataagacaaacagtatttagacatataaaaaactacagagatgataacttgaagaataaataacgtgaaaaactactatattcttgaat gggagtagaatgtaagctctttgagggcagggactttgactgtcttgttcattgctatatgataatgcctggcccaacagcaggcattctgtagtgtctgttgaacaaa catctaaaatctggcaaagtgaacaatggttcctgaggataagtatttaaataacaaaattaactttcactacaaaagctgccaacttacctttatcttctggtgctatc ccctgagctttcttaagatca 517 228504_at gaatgcatgatctcaagccttaactactataatctttttctgcccctcagaaattgaataacctaaccaagatgcctttaggggatgccctaagtaaatgtaatttcag atttcagggnttttttttttttcctctctaagtgttccttccctttcttctcctgctctccatcatgttatggagaccagtgaggaaccagtgttaacttggtgacaatgtgacag ctggtgctttatctaagctccgttttctatttcttgggaatgctttattgtggaaactgcttcagatacttaaattgaatcataacttgcttctgtaaattgcgtaaagacaaca aactgattttagtttgaaaagtttatcttttacttgtaaaccttgtttgccagttacct 518 228507_at agccccaggtgtatttctgagtgtcaacagtgttaatttcaagcatgctaataaaatgtnnnnncggnnnatannnnnnnnnnaannanncnttnaaantnnn ggtttccnntgntaaaancanccncntttgcttttgttagctgtaatattttttgtcatttagataagacctggtttggctctcaataaaagatgaagacagtagctctgta cagggatatatctatattagtcttcatctgatgaatgaagaaattttctcatattatgttcaagaaagtatttacttcctaaaaatagaattcccgattctgtctattttggttg aataccagaacaaatctttccgttgcaatcccagtaaaacgaaagaaaaggaatatcttacagactgttcatattagatgtatgtagactgttaatttgcantttcccc atatttcctgcctatcttacccagataactttctttgaaggtaaaagctgtgcaaaaggcatgagactcaggcctactctttgtttaaat 519 228640_at aatcttgtgagttgtgacctaggtgaaggtntaatgataacatctggaggaagcatcatttgttcagctacctagggtttactttcagacttttcctacagtttaaagcac ttgcgttcagtgtggtacgatctgtttgtaatgttaatcattgactattgttctgctacttggatgttgatagtgaagcagagaacaatttatcatcgtttattatgagtcactat gcacgcaactatgcttaacatggcgaaatgtattaaacactcgtccaactattt 520 228706_s_at aaagggtggcatttgcgtcacgtggaccagggacagtgctgaaatcagcagtgctcagaaacaatttaacatgttgaaacgacaatattctaaaatactgatga atcttgcatcaatataattattgggttttttttctttttcctgctgtataactccttgccatgcaaactctcaagaggccaatatattcctggccatgtttgaatgagcctcttaa aataaacttagagccatgcaaatgccagcagcttaatggatttcatggaatgaaataccgtgattaactcatagctacatatcattgcataaatgggatttatctttttt ctcacttatttttgcggtgaaa 521 228707_at agagccatgcaaatgccagcagcttaatggatttcatggaatgaaataccgtgattaactcatagctacatatcattgcataaatgggatttatcttttttctcacttatttt tgcggtgaaagtcgagggcatgcaagagtttctcttccagaagccaagaggagaacaaaggtcctaatgctgtactattccaccctttggacgcctcatccagga cgcagaggactctaggtttaacatttt 522 228750_at gacccagagtcacctaagagaactcttccaacttaaatgactagggtgtgtaatcagttgcttcttattctgtgtctcagatttcctagtccatgacatttaatagtgagt atagagtaggatattctatacattttagtatttggcccttggaaacaaagttaaataccatgtcactcagaagactctcaaagtttgtgtataaatggcgaagtatgca ctatgagagattctaatccattcacatcattcttgagttgtgcaaatacacttggctttgatttcacttggtgatctaaatttgtttatttaagctgcaagaaagttacattaat ttggaatgtgtcatcacttggacccagtatatcagatttttattgagtaaaatgttaaaaataataagtgtaactcagattctggatgttcgagtttacaatacattgcctgt aataaaagctgattctgaagtgcatttttcttgacttactttggcag 523 228766_at atgcacgtacaaatttcttaacctgttatcaatgtctgagctacataattatctttctagttggagtttgttttaggtgtgtaccaactgacatttcagtttttctgtttgaagtcc aatgtattagtgactctgtggctgctctcttcacctgccccttgtggcctgtctacaattctaaatggattttgaactcaatgtcgtcgcttctggtttcctgcatataccaat agcattacctatgactttttttttcctgagctattttcactgagctgagctaatgaactaaaactgagttatgtttaatatttgtatcaaatacataaaaggaatactgcttttt ccttttgtggctcaaaggtagctgcatt 524 228846_at ggaatcttttccaataaccagctaaagatttgcactgaaatacaacttgtatgccttttgcatttttaaagcctgcttcctggatttaagcagagtgatagtgttcaaaga gccagttcagcctgtaacatatttgaaaaagatatgtctgcactttgaggtcccttttgaatgccattcactagacctctcaagcattttgtttcattgctacatccaagcg cctcacaagtccacaatgcgggacagcatcaaaagctcaagactttgnaaaaagcttgtgggcttgcactgggggagggaagggaacaaaatttgtgtacttct ttgtttaatttagaaataaggcatccaagagatgccattattttctgtgtttcaattgttgtgcctttgagttaaactgcatttttgtcttttggttgaaatctgaaatgtactgtcc caatat 525 228854_at ctccttatctgttctagttccgaagcagtttcactcgaagttgtgcagtcctggttgcagctttccgcatctgccttcgtttcgtgtagattgacgcgtttctttgtaatttcagt gtttctgacaagatttaaaaaaaaaaaaaaggaaaaaaaaagaaaaaatgaatttactgctgcaggtttttttctctctccatgtgtcactaagtgaagtttgtgcctt ctatagcaaagagaatattttttacatcctactaacagtagatttttttgtagtgaacattttttgtatttttatttataagtctcataagaaaaatagcaatgttcagttgtata ccttgaatctgcagttaga 526 228885_at aataggtcttgcaggtttccttttgaattttaagtatcataaatattttttaagtaaataatacggggtgtcagtaatatctgcagaatgaatgcagtctttcatgctaatga gttagtctggaaaaataaagtcttattttctatgttttattcatagaaatggagtattaatttttaatattttcaccatatgtgataacaaaggatctttcatgaatgtccaagg gtaagtcagtattaattaatgctgtattacaaggcaatgctaccttctttattccccctttgaactacctttgaagtcactatgagcacatggatagaaatttaacttttttttg taaagcaagcttaaaatgtttatgtatacatacccagcaacttttataaatgtgttaaacaattttactgatttttataataaatattttggtaagattttgaataatatgaatt caggcagatatactaaactgcttttatttacttgtttagaaaattgtatatatatgtttgtgtatcctaacagctgctatgaa 527 228961_at gagaacatcagatctaatagagcatagtgatactatttaatttaaccaaagtctctagtgaatatttcanctttgaatgtaaactaacaaataaacctgaccaccaa ggagattgtttgcccagagtttcaaagcacattgtctacaaatggaaattgaaataatttataaaatattgacgttactatgttttttaaaaagttcctaattttttcactaa atggaggaaactattagttttattgttaaatatggtagatattaatattcctcttagatgaccagtgattccaattgtcccagtttgaaataagtaccctgtgagtatgaga taaattagtgacaatcagaacaagtttcagtatcagatgttcaagaggaagttgctattgcattgattttaatatttgtacataaacactgatttttttgagcattattttgtat ttgttgtactttaatacctggtgtacagttccagaaa 528 229070_at gaaggatgctgaggacctagatgagaagttacctgcaaaaggcaaaagggttacttagtgtcagaaccaaggcaatgacttctctctcccagatctcctagcta ctggtcctgggccanntttttttttttaaataatcccaacntttctttaaaagacaagcatttcagtaagctagttattttcatgggttgctcatccatttttttcagtgatctaaa aatgtagggagatggctactactgaagttgtctgtctacttgggataatagcaaattaattgaagacaatgggaaagtaagttataaaaaatactgggaaatctgttt ctcttctgagcaagcattcagggcaggtataaacatcaaacatagtgacattgtcaaaacctcttccatt 529 229254_at ggaaagagaaacgtggctcaagtgctggctcaccttctagctgtgtggccctgggcaggttactgaggctcttccaanctcacttttcacatgtaaaatggcatttct aaaagtacctaccctacctcaaaggaattctgaaaaaagtaagtgaatttgtnannnaagcaaagcactcacaatatgcctgacacacaaactgcttaataaat gttagtaatttttaaaacctcctcataagcggcttagaaattattcatgtttggtacatatttattgcaagtcaagcagatccaacttttttgaaagctggtggtctaggagt atagttttaattatatttgtaaatactcaaaagtattagatgccagtctaatttaaatgcagtctgactgtagcgagtaactgacctgggcaatg 530 229530_at gggactcagttcttagagaagtcttttggtcttagagttcatcaagcagagaaggggaaggacatggtccaggaaaataaatcagcacacaaagagatggggt cttgagggtgcatagtacattctggacagccagttacctgggatgagttgggagggaggagaataaggacaaaagaccatctgggcaaaaatcacgaaggg gtatgtgtgtcatgtaaaggtgtgccatgatagttattcatattgctattgtaatattaatatatagtaattaactacacatgacacagctttacatgaccttaagtagttatc aacattaccataatagtaatattaataactacaataagagccattattattcacttgagg 531 229659_s_at gttagcaagtgccagcttgtaggctggttgaagtacagaactcagaggaaaaaagaaattaaattttagctttctggagagcagcccctctctggcaccatcaaa cacttctttgtttcccttcaacttggaactcttcaaacatcaggggttgtgagggtttggccattcttttatcttgggtccatgtgagtgacagaaatggtgcggcctggga aagatctccctcctttacattttctcttctccctcctcctccttattctaaaactgtgcctccaacagaggggcaggggctcttgtagagagagatccctggcccaggacag gagatgccaaatctaatttatctcactgagggc 532 229831_at tttcctaccaatttcacattttgcagaaacttgttcacatttccaacaatatcagaattagaaaacagttcagataacaagaaagattaaaaattagggaaattctgat atcaccataaagcactattttacatttagagattacatttaagataaagtcatcatacacaaaaacaataaatatttataactttctctataaggtccgcatatactgtat atattgaaacaatctgaatgactagtagatttcatatgaccattgttatttccactttctccaatacttgtattttatgctacatgtaatgaagttggacctttttattatttagta attcctatatgttcctatacttttcattttcaanatgattgctctattgtttcatgttgtttctagcaatatatctccatgagatatgcactttgtttcatattgaaaagtataaaattt atctttcaattcctgtgtgtgtatcctatggttatctgtatgtat 533 229839_at tcccaacccggttctggcaaagaatccagttatcccttccatgaagacgcacataactctcttacttggtctttccattagggacaacataagtcttgttttacatcaaat aaaaacaatgttaaaaagtgtgtgaaccttaaaaatggaagtctactagtttacatacctacttcagaggacatggaaatgaccatgggcctgcatttcagggac caaagcaaattaggcctggcctaaaatacatcagaccttttg 534 230087_at gttgaccccaactttggaactcagatcataggatctcccagaggtttcaggtgttcctaagaagcttctaaaggaagttttggaagaaagactaataggtgtaaac atataaacatatatattatatatagctatatatatttaaagagatctctacatatatatatatataaatacaactactgtactctctgcatctgtacaaagtatgagttaaac tgcccaggtagtgtgagatacgtaatgcatgaatgtgaatatcctgaaatctgccttcttagcaacgtgccgcgtgtactggagagaggacagttgctcctgggagt tctctcaatgggcaaatgtacaagttgatgccgtcttatccaccaacaagccattaaggttggtttcctgctgagacttttgtaccggaagcgagaccggcagcact gggggtgtccatatgccacttatgagg 535 230264_s_at ggccaaggcacatttgactcctgagatgaattttttgtggtcataatcaaatacttagttgtttttgatgccccaaaataaagtgagaatggtaatttgccaggaattctt cataacagtatcttacaaaaaacgtgttgctctcttcacagtattatgtgtaaagtcattgtttaaagcacgaatgttccctctggggtacttgttaaagctaaatttatttt gcttccctccacttagaagtgctgcacactttacagcagcttcctttctttccatngcactgcctagttaacagaagtcttataaaaatttaaaaagacacatttcttaca aaaaagagttgaatgaggtaaaatggcattagatggctctatattttttaaagctatgtaattgttcagcgtcacttttctaagtacttatacatatctaaacatgtcttcat ggtttatattttcacttatatatgctgggctggattaagctttgt 536 230595_at ggggcagagggactatgttgtgagcctngcnaaagaagnttgtgtggggactgtgggcagtgaatgcgttgggaacaatatggaaaactgggagctgccttgg aatctacagggccgnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnggctgaagaaaagaagaatggtattcatgcagttcccattttacagatgaaaa caagaggactttttctgtgaagtcaagaaagtggttacaatggtactttcagcctgtccgaattatgtattgcccctcccctttttattaataacattgaagtgtgatggga caaccactgaagccgtctgttgaaacctgctgggactttttagccattctcttcaacataaagaatgggtgtttttggagggggtgagaggaatggggaaatgttgtc aaagagtacaatgttttagttgagacaggaggaatatattttgttgagatctacagcacagcat 537 230788_at gatagcgaatgcactcagggtcagcagtggagtttaaaaattgtctcttttcaacttatttaaatgacagcacctgagaagaggaaccgttttacactggatgtttctc atgtagaacaagaaatctttctggaattgatgtttacatgtctgttgttggtcatctctcctgtgtcttaaatactttaatgttggaagagcatagtgtttgggctagtgggttt ctgacagcccatgggaatgccctgaaactactgtatctgatgtttgttttcgatgaggttccatgttttgttttc 538 230830_at gcagctgtggtggtcattataagcatngtccntcctgggaagaagcatccaggcaagcagaaaagaaaagatgcagccaccagaaaaagaaactccagaa gtcctgcatttggatgaggccaaggatcacaacagcctaaacaacctaagagaaactttgctctcagaaaagccaaacttggcccaggtggaacttgagttaa aagagagagatgtgctgtcagttttccttccggatgtaccagaaactgagagctagtgagggttcagagaagccccatcctaagccagacacatgatgtgggct cagctcagtggcctgaaacctctcaggttttagagtctctcccaagaagccgcttttttc 539 231120_x_at tactagttgttttacactctcttttcttattcttagggcttttgtgtatgtctnactnntntttnaannanntncncnnnnanncagaccttaanttttatatttttttaaagtngct aacatagcngnaggcacttaagcatttagtcaatgatattggtagaaatagtaaaatacatcctttaaatatatatctaagcatatattttaaaaggagcnaaaata aaaccaaagtgttagtaaattttgatttattagatattttagaaaaataatagaattctgaagttttaaaaatgtcagtaattaatttattttcattttcagaaatatatgcatg cagttatgttttatttgattgttgacttaggctatgtctgtatacagtaaccaa 540 231579_s_at gagtaggttcggtctgaaaggtgtgggcctttatatttgatccacacacgttggtcttttaaccgtgctgancagaaaacaaaacnggttaanaananccgggtgg nnagntgacagaggnaanccgctnaaataccttcacaataaatagtggcaatatatatatagtttaagaaggctccccatttggcatcgtttaatttaaatgttatgtt ataagcacagctctcttctccaattttcatcctgcaagcaactcaaaannnttnaaannaannttnnnntgtagttattttcaaatctttgcttgataagtattaagaaa tantggacttgctgccgtaatttaaagctctgttgantttgtttccgnttgganttttgggggaggggagcactgtgtttatgctggaatatgaagtctgagaccttccggt gctgggaacacacaa 541 231773_at ggaacctataaatgtagtttcatctgtcgtcaattactgcagaaaattatgtgtatccacaacctagttattttaaaaattatgttgactaaatacaaagtttgttttctaaa atgtaaatatttgccacaatgtaaagcaaatcttagctatattttaaatcataaataacatgttcaagatacttaacaatttatttaaaatctaagattgctctaacgtcta gtgaaaaaaatatttttaaaatttcagccaaataatgcattttatttataaaaatacagacagaaaattagggagaaacctctagttttgccaatagaaaatgcttctt ccattgaataaaagttatttcaaattgaannngtncctttcacangtnnatgattaaatctganttcttaatnatatatcctatgctgattttcccaaaacatgacccata gtattaaataca 542 231925_at tctttttgagtgatagtgccattgaatgagcagtatggaaacagtgttacttgatattttgagctttctcaggtttatctaaatcagtggtagcttaacaaaacccagacta attgtgtgtaattgtatttttaataaaaggaaagtacatttcctataatagcatagtactgtttgcatgtaagagtatgcaaaaccttgtgtgtgtgtgtgtgtgtgtgtgtgt gtgtgtgtcttagtgtgtgtaaggcatggcagccaactttgtatctgctatttttagtacgagcagagcttcataattgtggtcactagaactgtacttaccatggacagtt aaaact 543 231975_s_at tctctcagtttaaacatcttaacagagaatttgttactgtttattaaaagaattgcatttggaagcaagaaaacaaccggatttgcaatcatgtgaagaaacaataatg cctttattatcaagtgttaagcacaattcttataacaaactgtgataaattctttttgtttttttttcctttgccccattattttcttatgaacaaaccaaaaattcatggtgagca gttgcagtgttggctgatatatcttttatgtacagggaatttgaaaaggacagtggattcatttagaagtgtaactggtgctgtgattatagcaatacatttgttagttgtac ttcatctttttcatgctagctttttaaatgtttagttttcctcttgtcatggtcagctgctgaatttacttgaag 544 233565_s_at agattctggccacggctgggaacgttgtcaccctgaccatcatccccagtgtgatctacgagcacatggtcaaaaagttgcctccagtcctgctccaccacaccat ggaccactccatcccagatgcctgaagccactgcagggcagggcaggcagggggggcttcccgccctcctgcagcaaagggcaaccaccctcggatgatg ggttgcagccggcctgctgcttaaggtgggggctgccatgaggggggcgtgtccaggagggtgaccatgggatggcttatacacacaggcctccttggagcctc agactccaagctaggctgaggctcaggcagggcccacaggcagccgattctcttgtgctgatttaaatgctggacacggaggcaggctgtttaaacgctgcttaa agtcgcaactgggcccctttcaagaaattttgctctaccaggaaaacagttacacattttaagagaacagagctacgttctttgtgagagctttttccttgccttgacttg ctctttgtcacagactgca 545 234764_x_at gtcaccatctcttgttctggaagcagctccaacatcggaagtaattatgtatactggtaccagcagctcccaggaacggcccccaaactcctcatctataggaata atcagcggccctcaggggtccctgaccgattctctggctccaagtctggcacctcagcctccctggccatcagtgggctccggtccgaggatgaggctgattatta ctgtgcagcatgggatgacagattgagtggttttat 546 234987_at gtttactctgagattctgtagtcctaatattgtatcattgtgctgtctgcaaaacaacttgaatctattttgnttgcatcttttgttacatgtaacgcagctgtactttatgttctttg caactgtttccattatgagaacgctgtgctatttacaaggttacatttttcttggccaggcgaggtggtcatgcctgtaatcccagcactttgggaggccaaggtgggc ggatcacttgaggtaaagagttgagaccagcctggctagcatggcgaaacccagtctctactaaaaatancaaaaattagccgggtgaaattagccgggcg 547 235146_at ggtgttttaaggttagcacatgcacaaaggaacgagttggtttaaaaagataaatcactgcaaagaatgaaattggcttattcacatcaaaactagataagatgct aaaaaaaaaagatatgaaacagaactaacctatagtttcctgaaatcagtacagtttaatttataagaagctagaaagtaatgcaccttgattgttttaggaatgatt tatgtgttgcaattttaatttatttaaagcatgtctactgtgtttgtcctaagagaaatatttcaacaaaacgtgctctgtgtttaagatatgtttaggcagtagttagcaactc tgaaagtagaaactggaaatgtttattgtgaggcttgttgcagaatttccattttgtgagttactacttagtttcatgtcagcctaaaattgtaaattccctgtagatcttcac cccattgtggtgtcatcaatgaatccaaagcaggtgccattattt 548 235766_x_at gcagggtcataatcacacagcagtgccttatatagttgccataagacttcagtgcagtacaacatanttttacngctacatatcagggcatattctatatggtgtatttg tgttagaataacacattaaatgtctttaaacataaaaataagaatgtttgcatgtttcagttttcaagaaccaaatgagtaattagctatagattccactggccttaaac atacaattaagtgtatacatgatatagtgcacacacaaaagccacctttaattattgaaataacctgtattctttttggaaatcatttaagtttggtattgaagtactatattt tttgtgcatcaatgtatttttctatttacaagcctatgt 549 235849_at ggagatcgtgttctgctttttacatgaggagcagaactgggccatacacgtgttcaagaactaggggagctacctggtagcaagtgagtgcagacccacctcacc ttgggggaatctcaaactcataggcctcagatacacgatcacctgtcatatcaggtgagcactggcctgcttggggagagacctgggcccctccaggtgtagga acagcaacactcctggctgacaactaagccaatatggccctaggtcattcttgcttccaatatgcttgccactccttaaatgtcctaatgatgagaaactctctttctga ccaattgctatgtttacataacacgcatgtactcatgcatcccttgccagagcccatatatgtatgcatatataaacatagcactttttactacatagctcagcacattg caaggtttgcatttaagttaaaaaaaaaaagaaaaaaaacctaagggtgaaacgatgccactttgacgc 550 236300_at tgactttcatacacacccagtacatctcaaaggatgctaagggacattttctgccagtagagttctccccctttttnggtgacagcaatattattatgttcacatctaact ccagagcttacttcctgtggtgccaatgtatttgttgcaatttactacatttttatatgagcctatttataggtgccattaaactcaggtctttcaaatgaaagagtttctagc ccncttagggaaaaagataattgtttagaaaaccataaaatcaatggtaggaaaagttggaactggttacctggatgccatggttctctgttaaataaagtaagag accaggtgnannnnnaannnnnannanngntattttcagcatgctaataaatgtctttccggttatatatctatctaaaattaacctttaaaatattggtttccttgata aaagcaccactttggcttttgttagctgtaatattttgtcatttagattaagacctggttaggctctcaataaaagatgaagacagtagctctgtacagcggataatatc 551 236313_at gctagttgcattatactgggtcatgaaaaattatcccttgaaatagatatgaaacatgttacttcatttctggtttaaataacttgtggaatctttcctaatgacaacntgat attaagggaaactaaagaaaatgttattgtggatcccacagtactatattacactgtttttttttgtttgttttgttagtttttttttatttaaagcaaacctcaaacctcaaacattattgggt atcaattaccacctggttgtattaaaatagtaacttatcaatgccatgtaaaaattaattccattttcgaagccacctggcagacaggtttagctgtttcatcagcagcc taatatatactgttaaatttgttaaggatttcactttgaaggatacatgcaaaacatatagttactattttcatgagtcctgcttctagctccattgtggaatacagaaaatt aaatatacctgttaagttcgtatctaaacctaagacattaccaaggtttgtacaaattctactacctgacatttattccaaga 552 238143_at ctcccctgaagaacgtgtccagcaacgcagagtgccctgcttgttatgaatctaatggaacttcctgtngtgggaagccctggaaatgctatgaagaagaacagt gtgtctttctagttgcagaacttaanaatgacattgagtctaagagtctcgtgctgaaaggctgttccaacgtcagtaacgccacctgtcagttcctgtctggtgaaaa caagactcttggaggagtcatctttcgaaagtttgagtgtgcaaatgtaaacagcttaacccccacgtntgcaccaaccacttcccacaacgtgggctccaaagct tccctctacctcttggcccttgccagcctccttcttcggggactgctgccctgaggtcctggggctgcactttgcccagcaccccatttctncttctctgaggtccagag caccccctgcggtgctgacaccctctttccctgctctgccccgtttaactgcccagtaagtgggagtcacaggtctccaggcaatgccgacagctgccttgt 553 238750_at tttgtccatagaggcttcaagatagataggtaagagnccagtagtgttcataagaagccaatagagagcaggagccactttatcaggtggcaggtgtcctgggc ctccctgctggctagtcccaagcggtggtgttgccaggatgtcttggaggtgataatgggacacacagaggcactgagtctccataggttaaaatgccaccaaaa ctggcctttgcctaatatccctcattgactatttagcatttaatttatttattttcctgacatttctgcaagctttgtatttatatttccactttatagatgaggaaatttgaggctctt agaggtaaaatgacttgcccaggtcacacaggaagtggcagagacaagctttttaaataagaaaaaattaataaaatataatatgagagtaacttaaaatatta ataaaccacaattttaaattaattaaccgtgataaccaacattaataaaagttaagataccaaaacactggtgtctaattctttcaac 554 238751_at gttctgttgtttatccatgaagcctatatatttctagtgcaaaangcccagtgggtctcaaaacattcttggaggggtttgacacactgctattagtagtgactcataattc cacgattccctgggatacagagaaggcaggggggtagtactgtttgaacaaaaatcttcccaagaccctggcaaagagatcttccttaggaatcagtggcatat gcgtttatgttctttaacagggaaagtaaaagtgagcgcacttttttgaagctcataaatactcatgtgactgtaaatttagaaatgttaattaattgggcctaatgtttga tctggaaaagtacttagcagtcaccaggaatttgccttgaactgactcgaaccacaaatcagaaccgtatttccacaattta 555 239272_at gcactgttaaaatccggctaggccaagatttcccaatgtcttgaagccaatggctaggaaaacagctgagcctgggactggactttgtcagtaacctctcttcccta gggcacgggaggagtngggtgaataggacctcttggcttgaggaccatgattgtgaatacagacatttaattcagaatgacacctacattgatgaattttcattgta caagtgtttttccagatcaaacacaaaacccatgtaattccttgataaattttcaatgcagggcagataaactgttgctaac 556 241994_at gtgatcttggactgtcaattcccctncctgtgatccattttactgcaaacataagggttgcagtaaagggttgtctcacgtcttctgctttaaaagcctataaatatatga cctgaaaactccagttacataaaggatctgcagctatctaaggcttggttttcttactgtcatatgatacctgggtctaatgaactctgctgagatcacctcaagtttctg cggttggtaaagagaacaagggaagaacaaacatcccttttattgctccaaatggtgatttaatccctacatggtgctgggtggacaatgtgtcactgtcacatgcc ttnactgtataaatccaaccttctgccagagagaatctgtggttctggccatggagggaggatagtggaaatgatatagttggactggtgcttgatgtcacta 557 242317_at atgtgattatacttctctttgacttgtcagcttagctttagnngatacactctggtgcccaactattattgtatcagtgaacttnccactttncttttnctctcaatttttg ttgtatcattcctaccttgtgaggacatataatatttacattctgttgtcatcctcacatttcttagttccacagtttaaatgtatttgaaactcaaaacattcccattaatctctt ggtcagctgaaattaatgatttaatagtttccttaaaaaagactcatggaacaatttccctaaatttttgccatgtcaaatatgtttatctgtagcctttacacagtaaaaa caatttggctagataatacaattctcagttcatat 558 242447_at agggcacttctcaacattaattttggaattattcaccatttaaaaattgtcactgctctttttcattactgtagataactgagagttagctgttctaggaaaaggccatgtttc agttagtgctatgacttcttttttcgattaaggttgaagcagtgttctcttagtagcctgaacacttctcaaagcgacttatcactagcggctttaatattgagcttctatatc gttgtgtccacctcactttttaaggctgttcatacctggcaatattcacttactctgctatttttaaaaactattttaaagttttaagcacaatgttgactcttctgtaatttccta aaattatattgttttcctacagacagctcaactttccttgatatgt 559 242601_at ctcattattcctttacatgcagaatagaggcatttatgcaaattgaactgcagtttttcagcatatacacaatgtcttgtgcaacagaaaaacatgttggggaaatattc ctcagtggagagtcgttctcatgctgacggggagaacgaaagtgacaggggtttcctcataagttttgtatgaaatatctctacaaacctcaattagttctactctaca ctttcactatcatcaacactgagactatcctgtctcacctacaaatgtggaaactttacattgttcgatttttcagcagact 560 243278_at ataaatgaccagactttttctaagaaaaatgttgctttaatgcatttcatgaatttttactcttatatcattgcttgctagtaatagcaaatctgcttttctgcatctgctttgcgt agctattgtaaggctttgaactaatgtatgtatttattgcttgaacttctgtgcataccttataaagcataatgtctgacaatttaaatggctcatgtattcttgcttntatcata agctgattatggggactatgatcttttgtatacagcaaattttaaactgtagcacaaacatctgtttatgtattggtggaatatacctgttttatttatcttttttgaggtaaact aatttttgatacttttcattactgtgtactatgttcatactttgaattctctgacgttagaagtcatggttgagaattgtaacagctgttattcgttctgtattcatggctttc 561 200832_s_at aaaagcgaggtggccatgttatgctggtggttgccagggcctccaaccactgtgccactgacttgctgtgtgaccctgggcaagtcacttaactataaggtgcctc agttttccttctgttaaaatggggataataatactgacctacctcaaagggcagttttgaggcatgactaatgctttttagaaagcattttgggatccttcagcacagga attctcaagacctgagtattttttataataggaatgtccaccatgaacttgatacgtccgtgtgtcccagatgctgtcattagtctatatggttctccaagaaactgaatg aatccattggagaagcggtggataactagccagacaaaatttgagaatacataaacaacgcattgccacggaaacatacagaggatgccttttctgtgattggg tgggattttttccctttttatgtgggatatagtagttacttgtgacaagaataattttggaataatttctattaatatcaactctgaagctaattgtactaatctgagat 562 201147_s_at gagtcggagatgatgcagcacacacacaattccccagcccagtgatgcttgtgttgaccagatgttcctgagtctggagcaagcacccaggccagaataacag agctttcttagttggtgaagacttaaacatctgcctgaggtcaggaggcaatttgcctgccttgtacaaaagctcaggtgaaagactgagatgaatgtctttcctctcc ctgcctcccaccagacttcctcctggaaaacgctttggtagatttggccaggagctttcttttatgtaaattggataaatacacacaccatacactatccacagatata gccaagtagatttgggtagaggatactatttccagaatagtgtttagctcacctagggggatatgtttgtatacacatttgcatatacccacatgggg 563 201162_at ggaatgtcactggtgcccaggtgtacttgagctgtgaggtcatcggaatcccgacacctgtcctcatctggaacaaggtaaaaaggggtcactatggagttcaaa ggacagaactcctgcctggtgaccgggacaacctggccattcagacccggggtggcccagaaaagcatgaagtaactggctgggtgctggtatctcctctaag taaggaagatgctggagaatatgagtgccatgcatccaattcccaaggacaggcttcagcatcagcaaaaattacagtggttgatgccttacatg 564 201163_s_at aggtgaaggtgccgagctataaacctccagaatattattagtctgcatggttaaaagtagtcatggataactacattacctgttcttgcctaataagtttcttttaatcca atccactaacactttagttatattcactggttttacacagagaaatacaaaataaagatcacacatcaagactatctacaa 565 201185_at ctcaaagactctcccgtggatgacggatgaggactctgggctgctggaataggacactcaagacttttgactgccattttgtttgttcagtggagactccctggccaa cagaatccttcttgatagtttgcaggcaaaacaaatgtaatgttgcagatccgcaggcagaagctctgcccttctgtatcctatgtatgcagtgtgctttttcttgccagc ttgggccattcttgcttagacagtcagcatttgtctcctcctttaactgagtcatcatcttagtccaactaatgcagtcgatacaatgcgtagatagaagaagccccac gggagccaggatgggactggtcgtgtttgtgcttttctccaagtcagcacccaaaggtcaatgcacagagaccccgggtgggtgagcgctggcttctcaaacgg ccgaagttgcctctttt 566 201261_x_at tctctctttctgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtcttgtgcttcctcagacctttctcgcttctgagcttggtggcctgttccctccatctctccgaacctggc ttcgcctgtccctttcactccacaccctctggccttctgccttgagctgggactgctttctgtctgtccggcctgcacccagcccctgcccacaaaaccccagggaca gcggtctccccagcctgccctgctcaggccttgcccccaaacctgtactgtcccggaggaggttgggaggtggaggcccagcatcccgcgcagatgacaccat caaccgccagagtcccagacaccggttttcctagaagcccctcacccccactggcccactggtggctaggtctccccttatccttctggtccagcgcaaggaggg gctgcttctgaggtcggtggctgtctttccattaaagaaacacc 567 201792_at ccaccgctggctgggaggagtcggagactgagacctacacagaggtggtgacagagtttgggaccgaggtggagcccgagtttgggaccaaggtggagcc cgagtttgagacccagttggagcctgagttcgagacccagctggaacccgagtttgaggaagaggaggaggaggagaaagaggaggagatagccactgg ccaggcattccccttcacaacagtagagacctacacagtgaactttggggacttctgagatcagcgtcctaccaagaccccagcccaactcaagctacagcag cagcacttcccaagcctgctgaccacagtcacatcacccatcagcacatggaaggcccctggtatggacactgaaaggaagggctggtcctgcccctttgagg gggtgcaaacatgactgggacctaagagccagaggctgtgtagaggctcctgctccacctgccagtctcgtaagagatggggttgctgcagtgttggagtaggg gcagagggagggagccaaggtcactcca 568 202237_at ctactacatgattggtgagcagaagttctccagcctccccctgggccgggaggcagtagaggctgctgtgaaagaggctggctacacaatcgaatggtttgagg tgatctcgcaaagttattcttccaccatggccaacaacgaaggacttttctccctggtggcgaggaagctgagcag 569 202238_s_at tcgtcactgactactcagaccagaacctgcaggagctggagaagtggctgaagaaagagccagaggcctttgactggtccccagtggtgacctatgtgtgtgat cttgaagggaacagagtcaagggtccagagaaggaggagaagttgagacaggcggtcaagcaggtgctgaagtgtgatgtgactcagagccagccactgg gggccgtccccttacccccggctgactgcgtgctcagcacactgtgtctggatgccgcctgcccagacctccccacctactgcagggcgctcaggaacctcggc agcctactgaagccagggggcttcctggtgatcatggatgcgctcaagagcagctactac 570 202310_s_at tggcctacatggaccagcagactggcaacctcaagaaggccctgctcctccagggctccaacgagatcgagatccgcgccgagggcaacagccgcttcacc tacagcgtcactgtcgatggctgcacgagtcacaccggagcctggggcaagacagtgattgaatacaaaaccaccaagacctcccgcctgcccatcatcgat gtggcccccttggacgttggtgccccagaccaggaattcggcttcgacgttggccctgtctgcttcctgtaaactccctccatcccaacctggctccctcccaccca accaactttccccccaacccggaaacagacaagcaacccaaactgaaccccctcaaaagccaaaaaatgggagacaatttcacatggactttggaaaatatt tttttcctttgcattcatctctcaaacttagtttttatctttgaccaaccgaacatgacca 571 202311_s_at gctccccatttttataccaaaggtgctacatctatgtgatgggtggggtggggagggaatcactggtgctatagaaattgagatgcccccccaggccagcaaatgt tcctttttgttcaaagtctatttttattccttgatattttttntttntttttttttttttttgtggatggggacttgtgaatttttctaaaggtgctatttaacatgggaggagagcgtgtgc ggctccagcccagcccgctgctcactttccaccctctctccacctgcctctggcttctcaggcctctgctctccgacctctctcctctgaaaccctcctccacagctgc agcccatcctcccggctccctcctagtctgtcctgcgtcctctgtccccgggtttcagagacaacttcccaaagcacaaagcagtttttncccctaggggtgggagg aagcaaaagactctgtacctattttgt 572 202404_s_at actttcccatgagtgtgatccacattgttaggtgctgacctagacagagatgaactgaggtccttgttttgttttgttcataatacaaaggtgctaattaatagtatttcag atacttgaagaatgttgatggtgctagaagaatttgagaagaaatactcctgtattgagttgtatcgtgtggtgtattttttaaaaaatttgatttagcattcatattttccatc ttattcccaattaaaagtatgcagattatttgcccaaagttgtcctcttcttcagattcagcatttgttctttgccagtctcattttcatcttcttccatggttccacagaagcttt gtttcttgggca 573 202450_s_at gaacaacgcctgtggcattgccaacctggccagcttccccaagatgtgactccagccagccaaatccatcctgctcttccatttcttccacgatggtgcagtgtaac gatgcactttggaagggagttggtgtgctatttttgaagcagatgtggtgatactgagattgtctgttcagtttccccatttgtttgtgcttcaaatgatccttcctactttgctt ctctccacccatgacctttttcactgtggccatcaggactttccctgacagctgtgtactcttaggctaagagatgtgactacagcctgcccctgactgtgttgtcccag ggctgatgctgtacaggtacaggctggagattttcacataggttagattctcattcacgggactagttagctttaagcaccctagaggactagggtaatctgacttctc acttcctaagttcccttctatatcctcaaggtagaaatgtctatgttttctactccaattc 574 202859_x_at gtacccagttaaattttcatttcagataaacaacaaataattttttagtataagtacattattgtttatctgaaagttttaattgaactaacaatcctagtttgatactcccagt cttgtcattgccagctgtgttggtagtgctgtgttgaattacggaataatgagttagaactattaaaacagccaaaactccacagtcaatattagtaatttcttgctggtt gaaacttgtttattatgtacaaatagattcttataatattatttaaatgactgcatttttaaatacaaggctttatatttttaactttaagatgtttttatgtgctctccaaatttttttt actgtttctgattgtat 575 202878_s_at atccgaattctccatatattcactaatcaaagacactattttcatactagattcctgagacaaatactcactgaagggcttgtttaaaaataaattgtgttttggtctgttctt gtagataatgcccttctattttaggtagaagctctggaatccctttattgtgctgttgctcttatctgcaaggtggcaagcagttcttttcagcagattttgcccactattcctc tgagctgaagttctttgcatagatttggcttaagcttgaattagatccctgcaaaggcttgctctgtgatgtcagatgtaattgtaaatgtcagtaatcacttcatgaatgc taaatgagaatgtaagtatttttaaatgtgtgtatttcaaatttgtttgactaattctggaattacaagatttctatgcaggatttaccttcatcctgtgcatgtttcccaaactg tgaggagggaaggctcagagatcgagcttctcctctgagttctaacaaaatggtgctttgagggtcagcctttaggaaggtgcagctttgttgtcctttg 576 202917_s_at ggcatcatgttgaccgagctggagaaagccttgaactctatcatcgacgtctaccacaagtactccctgataaaggggaatttccatgccgtctacagggatgac ctgaagaaattgctagagaccgagtgtcctcagtatatcaggaaaaagggtgcagacgtctgg 577 202998_s_at gccagtcttgaccgggatgaggcccacagacaggttgtcatcagcttgtcccattcaagccaccgagctcaccacagacacagtggagccgcgctcttctccag tgacacgtggacaaatgcgggctcatcagcccccccagagagggtcaggccgaaccccatttctcctcctcttaggtcattttcagcaaacttgaatatctagacc tctcttccaatgaaaccctccagtctattatagtcacatagataatggtgccacgtgttttctgatttggtgagctcagacttggtgcttccctctccacaacccccaccc cttgtttttcaagatactattattatattttcacagacttttgaagcacaaatttattggcatttaatattggacatctgggcccttggaagtacaaatctaaggaaaaacc aacccactgtgtaagtgactcatcttcctgttgttccaattctgtgggtttttgattcaacggtgctataaccagggtcctgggtgacagggcgctcactgagcaccatg tgtcatcacagaca 578 203083_at caggaaatagtcactcatcccactccacataaggggtttagtaagagaagtctgtctgtctgatgatggatagggggcaaatctttttcccctttctgttaatagtcatc acatttctatgccaaacaggaacgatccataactttagtcttaatgtacacattgcattttgataaaattaattttgttgtttcctttgaggttgatcgttgtgttgttttgctgca ctttttacttttttgcgtgtggagctgtattcccgagacaacgaagcgttgggatacttcattaaatgtagcgactgtcaacagcgtgcaggttttctgtttctgtgttgtggg gtcaaccgtacaatggtgtgggaatgacgatgatgtgaatatttagaatgtaccatattttttgtaaattatttatgtttttctaaacaaatttatcgtataggttgatgaaac gtcatgtgttttgccaaagactgtaaatatttatttatgtgttcacatggtcaaaatttcaccactgaaaccctgcacttagctagaacct 579 203325_s_at cccacctggagctgaatcacatgacctagctgcaccccagcgcctgggcccgccccacgctctgtccacacccangcgccccgggagcggggccatgcctc cagccccccagctcgcccgacccatcctgttcgtgaataggtctcaggggttgggggagggactgccagatttggacactatatttttttctaaattcaacttgaaga tgtgtatttcccctgaccttcaaaaaatgttccaaggtaagcctcgtaaaggtcatcccaccatcaccaaagcctccgtttttaacaacctccaacacgatccattta gaggccaaatgtcattctgcaggtgccttcccgatggattaaag 580 203570_at ctggaggacagcacctgtgacttcggcaacctcaagcgctatgcatgcacctctcatacccagggcctgagcccaggctgctatgacacctacaatgcggacat cgactgccagtggatcgacataaccgacgtgcagcctgggaactacatcctcaaggtgcacgtgaacccaaagtatattgttttggagtctgacttcaccaacaa cgtggtgagatgcaacattcactacacaggtcgctacgtttctgcaacaaactgcaaaattgtccaatcctgatctccgggagggacagatggccaatctctcccc ttccaaagcaggccctgctccccgggcagcctcccgccgaggggcccagcccccaacccacaggcagggaggggcatccctccctgccggcctcaggga gcgaacgtggatgaaaaccacagggattccggatgccagaccccattttatacttcacttttctctacagtgttgttttgttgttgttggtttttattttttatactttggccata ccacagagctagattgccc 581 203878_s_at tgccagcgactgtctcagactgggcagggaggctttggcatgacttaagaggaagggcagtcttgggacccgctatgcaggtcctggcaaacctggctgccctg tctcatccctgtccctcagggtagcaccatggcaggactgggggaactggagtgtccttgctgtatccctgttgtgaggttccttccaggggctggcactgaagcaa gggtgctggggccccatggccttcagccctggctgagcaactgggctgtagggcagggccacttcctgaggtcaggtcttggtaggtgcctgcatctgtctgccttc tggctgacaatcctggaaatctgttctccagaatccaggccaaaaagttcacagtcaaatggggaggggtattcttcatgcaggagaccccaggccctggaggc tgcaacatacctcaatcctgtcccaggccggatcctcctgaagcccttttcgcagcactgctatcctccaaagccattgtaaatgtgtgtacagtgtgtataaaccttc ttcttctt 582 204006_s_at gagtacaggtgccagacaaacctctccaccctcagtgacccggtgcagctagaagtccatatcggctggctgttgctccaggcccctcggtgggtgttcaagga ggaagaccctattcacctgaggtgtcacagctggaagaacactgctctgcataaggtcacatatttacagaatggcaaagacaggaagtattttcatcataattct gacttccacattccaaaagccacactcaaagatagcggctcctacttctgcagggggcttgttgggagtaaaaatgtgtcttcagagactgtgaacatcaccatca ctcaaggtttggcagtgtcaaccatctcatcattctctccacctgggtaccaagtctctttctgcttggtgatggtactcctttttgcagtggacacaggactatatttctctg tgaagacaaacatttgaagctcaacaagagactggaaggaccataaacttaaatggagaaaggaccctcaagacaaatgacc 583 204051_s_at aaccagccagtcccaagaagaacattaaaactaggagtgcccagaagagaacaaacccgaaaagagtgtgagctaactagtttccaaagcggagacttcc gacttccttacaggatgaggctgggcattgcctgggacagcctatgtaaggccatgtgccccttgccctaacaactcactgcagtgctcttcatagacacatcttgc agcatttttcttaaggctatgcttcagtttttctttgtaagccatcacaagccatagtggtaggtttgccctttggtacagaag 584 204320_at gaaaatgtaccttggtgccaccaacccattttgtgccacatgcaagttttgaataaggatgtatggaaaacaacgctgcatatacaggtaccatttaggaaatacc gatgcctttgtgggggcagaatcacagacaaaagctttgaaaatcataaagatataagttggtgtggctaagatggaaacagggctgattcttgattcccaattctc aactctccttttcctatttgaatttctttggtgctgtagaaaacaaaaaaagaaaaatatatattcataaaaaatatggtgctcattctcatccatccaggatgtactaaa acagtgtgtttaataaattgtaattattttgtgtacagttctatactgttatctgtgtccatttccaaaacttgcacgtgtccctgaattccgctgactctaatttatgaggatgc cgaactctgatggcaataatatatgtattatgaaaatgaagttatgatttccgatgaccctaagtcc 585 204475_at gaagaactgtctattttctcagtcatttttaacctctagagtcactgatacacagaatataatcttatttatacctcagtttgcatatttttttactatttagaatgtagcccttttt gtactgatataatttagttccacaaatggtgggtacaaaaagtcaagtttgtggcttatggattcatataggccagagttgcaaagatcttttccagagtatgcaactct gacgttgatcccagagagcagcttcagtgacaaacatatcctttcaagacagaaagagacaggagacatgagtctttgccggaggaaaagcagctcaagaa cacatgtgcagtcactggtgtcaccctggataggcaagggataactcttctaacaca 586 204620_s_at tgccgtgctcccaaaacattttaaatgaaagtattggcattcaaaaagacagcagacaaaatgaaagaaaatgagagcagaaagtaagcatttccagcctatc taatttctttagttttctatttgcctccagtgcagtccatttcctaatgtataccagcctactgtactatttaaaatgctcaatttcagcaccgatggccatgtaaataagatg atttaatgttgattttaatcctgtatataaaataaaaagtcacaatgagtttgggcatatttaatgatgattatggagccttagaggtctttaatcattggttcggctgctttta tgtagtttaggctggaaatggtttcacttgctctttgactgtcagcaagactgaagatggcttttcctggacagctagaaaacacaaaatcttgtaggtcattgcaccta tctcagccataggtgcagtttgcttctacatgatgctaaaggctgcgaatgggatcctgatggaactaaggactccaatgtcgaactcttctttgctgc 587 204811_s_at ggggaactgagggcaaggggatatagtgatggggctcagatggactgggaggagggggagggtgatgcattaattaatggcttcgttaattaatgtcatgttgctt gtcgctttctcagtgtgtgtgtgtggtccatgcccactgctggtgccagggtgggtgtccatgtgcacccggcctggatgccagctgtgtccttcgggggcgtgcgtgt aactgtagtgtagtcaggtgctcaatggagaatataaacatatacagaaaaatatatattttaagtttaaaaaacagaaaaacagacaaaacaatccccatcag gtagctgtctaacccccagctgggtctaatccttctcattacccacccgacctggctgcccctcaccttgggctggggactggggggccatttccttttctctgcccttt ttttgttgttctattttgtacagacaagttggaaaaacaacagcgacaaaaaagtcaagaaactttgtaaaatatcgtgtgtgtgattccttgt 588 205479_s_at cccgaccggtgggcatttgtgaggcccatggttgagaaatgaataatttcccaattaggaagtgtaagcagctgaggtctcttgagggagcttagccaatgtggg agcagcggtttggggagcagagacactaacgacttcagggcagggctctgatattccatgaatgtatcaggaaatatatatgtgtgtgtatgtttgcacacttgttgt gtgggctgtgagtgtaagtgtgagtaagagctggtgtctgattgttaagtctaaatatttccttaaactgtgtggactgtgatgccacacagagtggtctttctggagag gttataggtcactcctggggcctcttgggtcccccacgtgacagtgcctgggaatgtacttattctgcagcatgacctgtgaccagcactgtctcagtttcactttcaca tagatgtccctttcttggccagttatcccttccttttagcctagttcatccaatcctcactgggtgggg 589 205765_at caccacctacctatgatgccgtggtacagatggagtaccttgacatggtggtgaatgaaacactcagattattcccagttgctattagacttgagaggacttgcaag aaagatgttgaaatcaatggggtattcattcccaaagggtcaatggtggtgattccaacttatgctcttcaccatgacccaaagtactggacagagcctgaggagtt ccgccctgaaaggttcagtaagaagaaggacagcatagatccttacatatacacaccctttggaactggacccagaaactgcattggcatgaggtttgctctcat gaacatgaaacttgctctaatcagagtccttcagaacttctccttcaaaccttgtaaagaaacacagatccccttgaaattagacacgcaaggacttcttcaacca gaaaaacccattgttctaaaggtggattcaagagatggaaccctaagtggagaatgagttattctaaggacttctactttggtcttcaagaaagctgtgccccaga acaccagagatttcaacttagtca 590 205828_at gaaaatcgatgcagccatttctgataaggaaaagaacaaaacatatttctttgtagaggacaaatactggagatttgatgagaagagaaattccatggagccag gctttcccaagcaaatagctgaagactttccagggattgactcaaagattgatgctgtttttgaagaatttgggttcttttatttctttactggatcttcacagttggagtttg acccaaatgcaaagaaagtgacacacactttgaagagtaacagctggcttaattgttgaaagagatatgtagaaggcacaatatgggcactttaaatgaagcta ataattcttcacctaagtctctgtgaattgaaatgttcgttttctcctgcctgtgctgtgactcgagtcacactcaagggaacttgagcgtgaatctgtatcttgccggtcat ttttatgttattacagggcattcaaatgggctgctgcttagcttgcaccttgtcacatagagtgatctttcccaagagaaggggaagcactcgtgtgcaacagac 591 205927_s_at tccacacacggccaggcctgtttatctacactgctgcccactcctctctccagctccacatgctgtacctggatcattctgaagcaaattccgagcattacatcattttg tccataaatatttctaacatccttaaatatacaatcggaattcaagcatctcccattgtcccacaaatgtttggctgtttttgtagttggattgtttgtattaggattcaagca aggcccatatattgcatttatttgaaatgtctgtaagtctctttccatctacagagtttagcacatttgaacgttgctggttgaaatcccgaggtgtcatttgacatggttctc tgaacttatctttcctataaaatggtagttagatctggaggtctgattttgtggcaaaaatacttcctaggtggtgctgggtacttcttgttgcatcctgtcaggaggcaga taatgctggtgcctctctattggtaatgttaagactgctgggtgggtttggagttcttggc 592 207173_x_at gaacatccaagtctttcttcttttttaagttgtcaaagaagcttccacaaaattagaaaggacaacagttctgagctgtaatttcgccttaaactctggacactctatatg tagtgcatttttaaacttgaaatatataatattcagccagcttaaacccatacaatgtatgtacaatacaatgtacaattatgtctcttgagcatcaatcttgttactgctga ttcttgtaaatctttttgcttctactttcatcttaaactaatacgtgccagatataactgtcttgtttcagtgagagacgccctatttctatgtcatttttaatgtatctatttgtaca attttaaagttcttattttagtatacatataaatatcagtattctgacatgtaagaaaatgttacggcatcacacttatatttta 593 207191_s_at aatctcttctagagcacctgctatccccaacttctagacctgctccaaactagtgactaggatagaatttgatcccctaactcactgtctgcggtgctcattgctgctaa cagcattgcctgtgctctcctctcaggggcagcatgctaacggggcgacgtcctaatccaactgggagaagcctcagtggtggaattccaggcactgtgactgtc aagctggcaagggccaggattgggggaatggagctggggcttagctgggaggtggtctgaagcagacagggaatgggagaggaggatgggaagtagaca gtggctggtatggctctgaggctccctggggcctgctcaagctcctcctgctccttgctgttttctgatgatttgggggcttgggagtccctttgtcctcatctgagactga aatgtggggatccaggatggcttccttcctcttacccttcctccctcagcctgcaacctctatcctggaacctgtcctccctttctccccaactatgcatctgttgtctgctc ct 594 208063_s_at aagaagctaagcctgatctcctgtaaaaacatcatttccctgatggacaccagcggcaatgggaagctggagtttgatgaattcaaagtgttctgggacaagctg aagcagtggattaaccttttccttcggtttgatgctgacaagtccggcaccatgtctacctatgaactacggactgcactgaaagctgcaggctttcagctgagcag ccacctcctgcagctgattgtgctcaggtatgcggatgaggagctccagctggacttcgatgacttcctcaactgcctggtccggctggagaatgcgagccgggtg ttccaggctctcagtacaaagaacaaggagttcattcatctcaatataaatgagttcatccatttgacaatgaacatctgaggctgccttgtagagatgcagcctgcc cagctgaatcttggcttctggaccttgaccttcagaacttctcttggtgtggaaccattacgcccagggttcactc 595 208782_at actcccaagagcaaatccacattcctcttgagttctgcagcttctgtgtaaatagggcagctgtcgtctatgccgtagaatcacatgatctgaggaccattcatggaa gctgctaaatagcctagtctggggagtcttccataaagttttgcatggagcaaacaaacaggattaaactaggtttggttccttcagccctctaaaagcatagggctt agcctgcaggcttccttgggctttctctgtgtgtgtagttttgtaaacactatagcatctgttaagatccagtgtccatggaaacattcccacatgccgtgactctggact atatcagtttttggaaagcagggttcctctgcctgctaacaagcccacgtggaccagtctgaatgtctttcctttacacctatgtttttaagtagtcaaacttcaagaaac aatctaaacaagtttctgttgcatatgtgtttgtgaacttgtatttgtatttagtaggcttctatattgcatttaacttgtttttgtaactcctgattcttcct 596 208850_s_at gaagcctcaagttccagtgcagagatcctacttctctgagtcagctgaccccctccccgcaatccctcaaaccttgaggagaagtggggaccccacccctcatc aggagttccagtgctgcatgcgattatctacccacgtccacgcggccacctcaccctctccgcacacctctggctgtctttttgtactttttgttccagagctgcttctgtc tggtttatttaggttttatccttccttttctttgagagttcgtgaagagggaagccaggattggggacctgatggagagtgagagcatgtgaggggtagtgggatggtg gggtaccagccactggaggggtcatccttgcccatcgggaccagaaacctgggagagacttggatgaggagtggttgggctgtgcctgggcctagcacggac atggtctgtcctgacagcactcctcggcaggcatggctggtgcctg 597 208851_s_at aaagcagcgctagtggagggttggagaaggaggtaaggatgagggttcatcatccctccctgcctaaggaagctaaaagcatggccctgctgcccctccctgc ctccacccacagtggagagggctacaaaggaggacaagaccctctcaggctgtcccaagctcccaagagcttccagagctctgacccacagcctccaagtc aggtggggtggagtcccagagctgcacagggtttggcccaagtttctaagggaggcacttcctcccctcgcccatcagtgccagcccctgctggctggtgcctga gcccctcagacagccccctgccccgcaggcctgccttctcagggacttctgcggggcctgaggcaagccatggagtgagacccaggagccggacacttctca ggaaatggcttttcccaacccccagcccccacccggtggttcttcctgttctgtgactgtgtatag 598 208937_s_at ttcagccagtcgccaagaatcatgaaagtcgccagtggcagcaccgccaccgccgccgcgggccccacgtgcgcgctgaaggccggcaagacagcgagc ggtgcgggcgaggtggtgcgctgtctgtctgagcagagcgtggccatctcgcgctgccggggcgccggggcgcgcctgcctgccctgctggacgagcagcag gtaaacgtgctgctctacgacatgaacggctgttactcacgcctcaaggagctggtgcccaccctgccccagaaccgcaaggtgagcaaggtggagattctcc agcacgtcatcgactacatcagggaccttcagttggagctgaactcggaatccgaagttggaacccccgggggccgagggctgccggtccgggctccgctca gcaccctcaacggcgagatcagcgcc 599 209218_at gattccctgcatcaactaagaaaagcctgttttctttatttcaaacttggtggcgaatgtgttgcgggtcctgttgggctgctttctgtattgtctcctaaccctctagttttaat tggacacttctttgctgttgcaatctatgccgtgtatttttgctttaagtcagaaccttggattacaaaacctcgagcccttctcagtagtggtgctgtattgtacaaagcgt gttctgtaatatttcctctaatttactcagaaatgaagtatatggttcattaagcttaaaggggaaccatttgtgaatgaatatttggaacttaccaagtcctaagagactt ttggaagaggatatatatagcatagtaccataccacttata 600 209395_at gctgtggggatagtgaggcatcgcaatgtaagactcgggattagtacacacttgttgatgattaatggaaatgtttacagatccccaagcctggcaagggaatttct tcaactccctgccccctagccctccttatcaaaggacaccattttggcaagctctatcaccaaggagccaaacatcctacaagacacagtgaccatactaattata ccccctgcaaagccagcttgaaaccttcacttaggaacgtaatcgtgtcccctatc 601 209396_s_at tcaccaatgccatcaaggatgcactcgctgcaacgtagccctctgttctgcacacagcacgggggccaaggatgccccgtccccctctggctccagctggccgg gagcctgatcacctgccctgctgagtcccaggctgagcctcagtctccctcccttggggcctatgcagaggtccacaacacacagatttgagctcagccctggtg ggcagagaggtagggatggggctgtggggatagtgaggcatcgcaatgtaagactcgggattagtacacacttgttgatgattaatggaaatgtttacagatccc caagcctggcaagggaatttcttcaactccctgccccctagccctccttatcaaaggacaccattttggcaagctctatcaccaaggagccaaacatcctacaag acacagtgaccatactaattataccccctgcaaagccagcttgaaaccttcact 602 209596_at tccaacctccttcaaattcagtcaccactgttatattaccttctccaggaaccctccagtggggaaggctgcgatattagatttccttgtatgcaaagtttttgttgaaag ctgtgctcagaggaggtgagaggagaggaaggagaaaactgcatcataactttacagaattgaatctagagtcttccccgaaaagcccagaaacttctctgca gtatctggcttgtccatctggtctaaggtggctgcttcttccccagccatgagtcagtttgtgcccatgaataatacacgacctgttatttccatgactgctttactgtattttt 603 209875_s_at gaatggtgcatacaaggccatccccgttgcccaggacctgaacgcgccttctgattgggacagccgtgggaaggacagttatgaaacgagtcagctggatgac cagagtgctgaaacccacagccacaagcagtccagattatataagcggaaagctaatgatgagagcaatgagcattccgatgtgattgatagtcaggaactttc caaagtcagccgtgaattccacagccatgaatttcacagccatgaagatatgctggttgtagaccccaaaagtaaggaagaagataaacacctgaaatttcgta tttctcatgaattagatagtgcatcttctgaggtcaattaaaaggagaaaaaatacaatttctcactttgcatttagtcaaaagaaaaaatgctttatagcaaaatgaa agagaacatgaaatgcttctttctcagtttattggttgaatgtgtatctatttgagtctggaaataactgatgtgtttgataattagtttagtttgtggcttcatggaa 604 209955_s_at acagctttccaaggtgacaaactcctctatgcagtgtatcgaaagctgggtgtttatgaagttgaagaccagattacagctgtcagaaaattcatagaaatgggttt cattgatgaaaaaagaatagccatatggggctggtcctatggaggatacgtttcatcactggcccttgcatctggaactggtcttttcaaatgtggtatagcagtggct ccagtctccagctgggaatattacgcgtctgtctacacagagagattcatgggtctcccaacaaaggatgataatcttgagcactataagaattcaactgtgatgg caagagcagaatatttcagaaatgtagactatcttctcatccacggaacagcagatgataatgtgcactttcagaactcagcacagattgctaaagctctggttaat gcacaagtggatttccaggcaatgtggtactctgaccagaaccacggcttatccggcctgtccacgaaccacttatacacccacatgacccacttcctaaagcag tg 605 210095_s_at tcttttgtcctccttagcacaatgtaaaaaagaatagtaatatcagaacaggaaggaggaatggcttgctggggagcccatccaggacactgggagcacataga gattcacccatgtttgttgaacttagagtcattctcatgcttttctttataattcacacatatatgcagagaagatatgttcttgttaacattgtatacaacatagccccaaat atagtaagatctatactagataatcctagatgaaatgttagagatgctatatgatacaactgtggccatgactgaggaaaggagctcacgcccagagactgggct gctctcccggaggccaaacccaagaaggtctggcaaagtcaggctcagggagactctgccctgctgcagacctcggtgtggacacacgctgcatagagctct ccttgaaaacagaggggtctcaagacattctgcctacctattagc 606 210511_s_at aaaggagcagtcgcacagacctttcctcatgctgcaggcccggcagtctgaagaccaccctcatcgccggcgtcggcggggcttggagtgtgatggcaaggtc aacatctgctgtaagaaacagttctttgtcagtttcaaggacatcggctggaatgactggatcattgctccctctggctatcatgccaactactgcgagggtgagtgc ccgagccatatagcaggcacgtccgggtcctcactgtccttccactcaacagtcatcaaccactaccgcatgcggggccatagcccctttgccaacctcaaatcg tgctgtgtgcccaccaagctgagacccatgtccatgttgtactatgatgatggtcaaaacatcatcaaaaaggacattcagaacatgatcgtggaggagtgtgggt gctcatagagttgcccagc 607 211571_s_at acaagcatcctgtctcacgaagaacaaatgtttgttaatcgtgtgggccatgattatcagtggataggcctcaatgacaagatgtttgagcatgacttccgttggact gatggcagcacactgcaatacgagaattggagacccaaccagccagacagcttcttttctgctggagaagactgtgttgtaatcatttggcatgagaatggccag tggaatgatgttccctgcaattaccatctcacctatacgtgcaagaaaggaacagttgcttgcggccagccccctgttgtagaaaatgccaagacctttggaaaga tgaaacctcgttatgaaatcaactccctgattagataccactgcaaagatggtttcattcaacgtcaccttccaactatccggtgcttaggaaatggaagatgggcta tacctaaaattacctgcatgaacccatctgcataccaaaggacttattctatgaaatactttaaaaattcctcatcagcaaaggacaattcaataaatacatccaaa catgatcatcgttggagccggaggtgg 608 211966_at tggtgatgtctgctactatgccagccggaacgacaagtcctactggctctctaccactgcgccgctgcccatgatgcccgtggccgaggacgagatcaagcccta catcagccgctgttctgtgtgtgaggccccggccatcgccatcgcggtccacagtcaggatgtctccatcccacactgcccagctgggtggcggagtttgtggatc ggatattccttcctcatgcacacggcggcgggagacgaaggcggtggccaatcactggtgtcaccgggcagctgtctagaggacttccgcgccacaccattcat cgaatgcaatggaggccgcggcacctgccactactacgccaacaagtacagcttctggctgaccaccattcccgagcagagcttccagggctcgccctccgcc gacacgctcaaggccggcctcatccgcacacacatcagccgctgccaggtgtgcatgaagaacctgtgagccggcgcgtgccaggaagggccattttggtgc ttattcttaacttattacctcaggtgccaacccaaaa 609 211980_at gaaagactgtgctgtcctttaacataggtttttaaagactaggatattgaatgtgaaacatccgttttcattgttcacttctaaaccaaaaattatgtgttgccaaaacca aacccaggttcatgaatatggtgtctattatagtgaaacatgtactttgagcttattgtttttattctgtattaaatattttcagggttttaaacactaatcacaaactgaatga cttgacttcaaaagcaacaaccttaaaggccgtcatttcattagtattcctcattctgcatcctggcttgaaaaacagctctgttgaatcacagtatcagtattttcacac gtaagcacattcgggccatttccgtggtttctcatgagctgtgttcacagacctcagcagggcatcgcatggaccgcaggagggcagattcggaccact 610 211981_at tcggctactcttttgtgatgcacaccagcgctggtgcagaaggctctggccaagccctggcgtcccccggctcctgcctggaggagtttagaagtgcgccattcat cgagtgtcacggccgtgggacctgcaattactacgcaaacgcttacagcttttggctcgccaccatagagaggagcgagatgttcaagaagcctacgccgtcca ccttgaaggcaggggagctgcgcacgcacgtcagccgctgccaagtctgtatgagaagaacataatgaagcctgactcagctaatgtcacaacatggtgctac ttcttcttctttttgttaacagcaacgaaccctagaaatatatcctgtgtacctcactgtccaatatgaaaaccgtaaagtgccttataggaatttgcgtaactaacacac cctgc 611 212344_at ggaaaacacctcatttgaccttgccagctgaccttcaaaccctgcatttgaaccgaccaacattaagtccagagagtaaacttgaatggaataacgacattccag aagttaatcatttgaattctgaacactggagaaaaaccgaaaaatggacggggcatgaagagactaatcatctggnaaaccgatttcagtggcgatggcatga cagagctagagctcgggcccagccccaggctgcagcccattcgcaggcacccgaaagaacttccccagtatggtggtcctggaaaggacatttttgaagatca actatatcttcctgtgcattccgatggaatttcagttcatcagatgttcaccatggccaccgcagaacaccgaagtaattccagcatagcggggaagatgttgacca aggtggagaagaatcacgaaaaggagaagtcacagcacctagaaggcagcgcctcctcttcactctcctctgattagatgaaactgttaccttacccta 612 212353_at aatatccttgttgtgtattaggtttttaaataccagctaaaggattacctcactgagtcatcagtaccctcctattcagctccccaagatgatgtgtttttgcttaccctaag agaggttttcttcttatttttagataattcaagtgcttagataaattatgttttctttaagtgtttatggtaaactcttttaaagaaaatttaatatgttatagctgaatctttttggta actttaaatctttatcatagactctgtacatatgttcaaattagctgcttgcctgatgtgtgtatcatcggtgggatgacagaacaaacatatttatgatcatgaataatgt gctttgtaaaaagatttcaagttattaggaagcatactctgttttttaatca 613 212354_at gtgtgcacacggagactcatcgttataatttactatctgccaagagtagaaagaaaggctggggatatttgggttggcttggttttgattttttgcttgtttgtttgttttgtac taaaacagtattatcttttgaatatcgtagggacataagtatatacatgttatccaatcaagatggctagaatggtgcctttctgagtgtctaaaacttgacacccctgg taaatctttcaacacacttccactgcctgcgtaatgaagttttgattcatttttaaccactggaatttttcaatgccgtcattttcagttagatgattttgcactttgagattaaa atgccatgtctatttgattagtcttatttttttatttttacaggcttatcagtctcactgttggctgtcattgtgacaaagtcaaataaacccccaaggacgacacacagtat ggatcacatattgtttgacattaagcttttgccagaaaatgttgcatgtgttttacctcgactt 614 212488_at gaaaggcgatctcttcactgtgaaaagttgcccgggtgcagcgccttttccttctaccatgggaaatgcaggctgggcccttggggtgagcctgcggggctctggt gctgtccccgacccccaccaccaccagaatgcagttccagcttaggaagccacaaacaagccacccaggaggaacaaaacaccgccagcgtggattttcc aaatttccctggaaagtaagtctcgctcttgccaaagaaaagtctggcttggagagtctctggagcccaggatgccagcatgtgccaatgactgtcaccttcatctc ttcaaaagaaaagccatagccgaggactgtcccgcgacccccgtggactgcgtctaggtcatgtgattctgttttcatttctcatcccatccaatttgtccttttctcctgt cattttcttcctctgtggtcccttcaaagttgttataatttgtactgaacttcaaaatgtgtcccgttctccccagaccactctagccacagtatatt 615 212489_at attgaaaagcaggtaccagtgccccttttcagacagtttttgattcgctctagacnttttttnttttttaatagggagggaaaaaatttgataattttcttntttctacatgcac ttaagactaaaacacaggtttggattaattttatttgcttcctttttccgcttttcttcccgcagagcctgatgggagaatgtccagggcagggaaaccacattttttgtag gtgataactcaatgaaaattggtgcttattttttacacttctctcttgtggctctcttgtggtgctatctgttttaaggtctccttgaaggcgcactggggtccctggccatgcc tcgttctccctgctttctttatcctgttattgcctccacagtctgttgccaaggactctaagatcaatgcacgtcactttcctttccactgggcaggatagccaagcacact ccctcctgcgctctcccgccccggtgcgtccactcccgagggctgttatgaggactgggttgtgcctacttgatttgaaaacacacac 616 213106_at acttctcagcaaataaatctcccttaagtaggaaanctagatttcatattngcttnctttgaattaacagcaactttccacaggtaaatctgttcttgcaaagatgtgag cagaatagttaaaaataatatttttatgtttcatggttctaaatggaagccataaatgcagtaaatactatctgttgtttaactactttaatcgtcattttttacattttcaagttt attaggttaagaaaaacagggcagccttggaaggcagctactacagaaaactgcagttttgcgttaaagataaagtagtattttcagctccctgaaaaaccattcc tgctgaaactgctgtagaaattgtgaagctgcatgagtggagagtattgaatctgtggttatagtagttttctcaggtttgtttatcttgatgtttgatgcactgtgttttatagt tattaaaattgagtaatattatttctatgcagtgttatgtgtcattggccttttgtgaatgtgcatgttttaaactgcaaattttaaacattttgtcctctaattgttat 617 213125_at gaatgagtattcctatacgacccagatagactacaaccccaaggaccgcctgctctatgcctgggacaatggccaccaggtcacttaccatgtcatctttgcctac tgacacccttgtccccacaagcagaagcacagaggggtcactagcaccttgtgtgtatgtgtgtgcgcgcacgtgtgtgtaggtgggtatgtgttgtttaaaaatata tattattttgtataatattgcaaatgtaaaatgacaatttgggtctatttttttatatggattgtagatcaatccatacgtgtatgtgctggtctcatcctccccagtttatatttttg tgcaaatgaacttctccttttgaccagtaaccaccttccttcaagccttcagcccctccagctccaagtctcagatctcgaccattgaaaaggtttcttcatctgggtctt gcaggaggcaggcaacac 618 213524_s_at gtgctcggcctgatggagactgtgtgcagccccttcacggccgccagacgtctgcgggaccaggaggcagccgtggcggagctgcaggccgccctggagcg acaggctctccagaagcaagccctgcaggagaaaggcaagcagcaggacacggtcctcggcggccgggccctgtccaaccggcagcacgcctcctagga actgtgggagaccagcggagtgggagggagacgcagtagacagagacagaccgagaaggaagggagagacagagggggcgcgcgcacaggagcct gactccgctgggagagtgcaggagcacgtgctgttttttatttggacttaacttcagagaaaccgctgacatctagaactgacctaccacaagcatccaccaaag gagtttgggattgagtttntgctgctgtgcagcactgcattgtcatgacatttccaacactgtgtgaattatctaaatgcgtctaccattttgcactagggag 619 213869_x_at cacagcctccaagtcaggtggggtggagtcccagagctgcacagggtttggcccaagtttctaagggaggcacttcctcccntcgcccatcagtgccagcccct gctggctggtgcctgagcccctcagacagccccctgccccgcaggcctgccttctcagggacttctgcggggcctgaggcaagccatggagtgagacccagg agccggacacttctcaggaaatggcttttcccaacccccagcccnccacccggtggttcttcctgttctgtgactgtgtatagtgccaccacagcttatggcatctcat tgaggacaaagaaaactgcacaataaaaccaagcctctggaatctgtcctcgtgtccacctggccttcgctcctccancagtgcctgcctgnccccncttcgctg gggtctccacgggtgaggctggggaacgccacctcttcctcttccctgacttctccccaaccacttagtagcaacgctaccccaggggctaatgactgcacactg ggcttcttttcagaatgaccctaacgagacacatttgcccaaa 620 213905_x_at cacaaaaccccagggacagcggtctccccagcctgccctgctcangccttgcccccaaacctgtactgtcccggaggaggttgggaggtggaggcccagcat cccgcgcagatgacaccggttttcctagaagcccctcacccccactggcccactggtggctaggtctccccttatccttctggtccagcgcaaggaggggctgctt ctgaggtcggtggctgtctttccattaaagaaacaccgtg 621 214234_s_at gaatgaagaaaagtcgcctcaacgacaaacaaaagcaccgactagatttccttcagctgatgattgactcccagaattcgaaagaaactgagtcccacaaag ctctgtctgatctggagctcgcagcccagtcaataatcttcatttttgctggctatgaaaccaccagcagtgttctttccttcactttatatgaactggccactcaccctga tgtccagcagaaactgcaaaaggagattgatgcagttttgcccaata 622 214235_at ggtgaggggatgacccctggagatgaagggaagaggtgaagccttagcaaaaatgcctcctcaccactccccaggagaatttttataaaaagcataatcactg attccttcactgacataatgtaggaagcctctgaggagaaaaacaaagggagaaacatagagaacggttgctactggcagaagcataagatctttgtacaatat tgctggccctggttcacctgtttactgttatcacaata 623 214247_s_at acttaggtaattgtagggcgaggattataaatgaaatttgcaaaatcacttagcagcaactgaagacaattatcaaccacgtggagaaaatcaaaccgagcag ggctgtgtgaaacatggttgtaatatgcgactgcgaacactgaactctacgccactccacaaatgatgttttcaggtgtcatggactgttgccaccatgtattcatcca gagttcttaaagtttaaagttgcacatgattgtataagcatgctttctttgagttttaaat 624 215646_s_at tctcacctatacgtgcaagaaaggaacagttgcttgcggccancccctgttgtagaaaatgccaagacctttggaaagatgaaacctcgttatgaaatcaactcc ctgattagataccacntgcaaagatggtttcattcaacgtcaccttccaactatccggtgcttaggaaatggaagatgggctatacctaaaattacctgcatgaacc 625 217430_x_at agggcctaagggtgacagaggtgatgctggtcccaaaggtgctgatggctctcctggcaaagatggcgtccgtggtctgaccggccccattggtcctcctggccc tgctggtgcccctggtgacaagggggaccccattcccgaggagctttatgag 626 217763_s_at aacattgtaatggccatcgctggaaacaagtgcgacctctcagatattagggaggttcccctgaaggatgctaaggaatacgctgaatccataggtgccatcgtg gttgagacaagtgcaaaaaatgctattaatatcgaagagctctttcaaggaatcagccgccagatcccacccttggacccccatgaaaatggaaacaatggaa caatcaaagttgagaagccaaccatgcaagccagccgccggtgctgttgacccaagggcgtggtccacggtacttgaagaagccagagcccacatcctgtgc actgctgaaggaccctacgctcggtggcctggcacctcactttgagaagagtgagcacactggctttgcatcctggaaggcctgcagggggcggggcaggaa atgtacctgaaaaggattttagaaaaccctgggaaacccaccacaccaccacaaaatggcctttagtgt 627 218211_s_at gccacaccttcgcgaaacctgtggtggcccaccagtcctaacgggacaggacagagagacagagcagccctgcactgttttccctccaccacagccatcctgt ccctcattggctctgtgctttccactatacacagtcaccgtcccaatgagaaacaagaaggagcaccctccacatggactcccacctgcaagtggacagcgaca ttcagtcctgcactgctcacctgggtttactgatgactcctggctgccccaccatcctctctgatctgtgagaaacagctaagctgctgtgacttccctttaggacaatg ttgtgtaaatctttgaaggacacaccgaagacctttatactgtgatcttttacccctttcactcttggctttcttatgttgc 628 218638_s_at ctgccccgagctcgaagaagaggctgagtgcgtccctgataactgcgtctaagaccagagccccgcagcccctggggcccccggagccatggggtgtcggg ggctcctgtgcaggctcatgctgcaggcggccgaggcacagggggtttcgcgctgctcctgaccgcggtgaggccgcgccgaccatctctgcactgaagggcc ctctggtggccggcacgggcattgggaaacagcctcctcctttcccaaccttgcttcttaggggcccccgtgtcccgtctgctctcagcctcctcctcctgcaggata aagtcatccccaaggctccagctactctaaattatggtctccttataagttattgctgctccaggagattgtccttcatcgtccaggggcctggctcccacgtggttgca gatacctcagacctggtgctctaggctgtgctgagcccactctcccgagggcgcatccaagcgggggccacttgagaagtgaataaatggggcggtttcggaa gcgtcagtgtttccatgttatgg 629 219955_at gaagttgcaacattcgtttgataggaattccagaaaaggagagttatgagaatagggcagaggacataattaaagaaataattgatgaaaactttgcagaacta aagaaaggttcaagtcttgagattgtcagtgcttgtcgagtacctagtaaaattgatgaaaagagactgactcctagacacatcttggtgaaattttggaattctagtg ataaagagaaaataataagggcttctagagagagaagagaaattacctaccaaggaacaagaatcaggttgacagcagacttatcactggacacactggat gctagaagtaaatggagcaatgtcttcaaagttctgctggaaaaaggctttaatcctagaatcctatatccagccaaaatggcatttgattttaggggcaaaacaa aggtatttcttagtattgaagaatttagagattatgttttgcatatgcccaccttgagagaattactggggaataatataccttagcacgccagggtgactaca 630 221011_s_at gagtggttcatccatactctcattccctcgcctccccttgtggacgggggtcttgccttttcaattcctgtgttttggtgtcttcccttatctgctaccctgaatcacctgtcctg gtcttgctgtgtgatgggaacatgcttgtaaactgcgtaacaaatctactttgtgtatgtgtctgtttatgggggtggtttattatttttgctggtccctagaccactttgtatga ccgtttgcagtctgagcaggccaggggctgacagctaatgtcaggaccctcagcggtggagcctgctggggggacccagctgctcttggacaagtggctgagc tcctatctggcctcctcttttttttttttttcaagtaatttgtgtgtatttctaactgattgtattgaaaaaattcctagtatttcagtaaaaatgcctgttgtgagatgaacctcctgt aacttctatctgttcttttttgaggctcaggga 631 221729_at tggaattagaccatttggcctttgaactttcataggaaaaatgacccaacatttcttagcatgagctacctcatctctagaagctgggatggacttactattcttgtttata ttttagatactgaaaggtgctatgcttctgttattattccaagactggagataggcagggctaaaaaggtattattatttttcctttaatgatggtgctaaaattcttcctata aaattccttaaaaataaagatggtttaatcactaccattgtgaaaacataactgttagacttcccgtttctgaaagaaagagcatcgttccaatgcttgttcactgttcct ctgtcatactgtatctggaatgctttgtaatacttgcatgcttcttagaccagaacatgtaggtccccttgtgtctcaatactttttttttcttaattgcatttgttggctctatttta attt 632 221730_at tagattccggtatatcgttcttcaagacacttgctctaagcggaatggaaatgtgggcaagactgtctttgaatatagaacacagaatgtggcacgcttgcccatcat agatcttgctcctgtggatgttggcggcacagaccaggaattcggcgttgaaattgggccagtttgttttgtgtaaagtaagccaagacacatcgacaatgagcac caccatcaatgaccaccgccattcacaagaactttgactgtttgaagttgatcctgagactcttgaagtaatggctgatcctgcatcagcattgtatatatggtcttaag tgcctggcctccttatccttcagaatatttattttacttacaatcctcaagttttaattgattttaaatatttttcaatacaacagtttaggtttaagatgaccaatgacaatgac cacctt 633 221731_x_at tttcagcaccgatggccatgtaaataagatgatttaatgttgattttaatcctgtatataaantaaaaagtncncaatgagtttngggcatatttaatgatgattatggag ccttagaggtctttaatcattggttcnggctgcttttatgtagtttaggctggaaatggtttcacttgctctttgactgtcagcaagactgaagatggcttttcctggacagct agaaaacacaaaatcttgtaggtcattgcacctatctcagccataggtgcagtttgcttctacatgatgctaaaggctgcgaatgggatcctgatggaactaagga ctccaatgtcgaactcttctttgctgcattcctttttcttcacttacaagaaaggcctgaatggaggacttttctgtaaccaggaacattttttaggggtcaaagtgctaat aattaactcaaccaggtctactttttaatggctttcataacactaactcataaggttaccgatcaatgcatttcatacggatatagacctagggctctggagggtgggg 634 221874_at ctggcctacgtgttcaattttctatgaacaaaggctttagtccttgacccagggctaaagtggtctgtccaagctgttgttggtagagggagtatgataaaatgtttaaa tctcatttggttaccttgagtcctggaacacgcagtaactgtcatgctatagtcntcatctgtatttggctgggaatacaaatgaagattgtggtgtattcaagcagtag ggtttttgcttttgtttttgttttagtgccaacaaaacttttttttgtctgactacattaaagataagactgactatatttatacaacagaaactttgtaatagattttttcagctttgt gaaatcgaattttttttcatcagggctggttggatttcctttttaccctgtaatccaagcgttaatagtttgttagaagatgggttattgcatgtcactt 635 223969_s_at gaagatcaaggatgttctcaacagtctagagtacagtccctctcctataagcaagaagctctcgtgtgctagtgtcaaaagccaaggcagaccgtcctcctgccct gctgggatggctgtcactggctgtgcttgtggctatggctgtggttcgtgggatgttcagctggaaaccacctgccactgccagtgcagtgtggtggactggaccact gcccgctgctgccacctgacctgacagggaggaggctgagaactcagttttgtgaccatgacagtaatgaaaccagggtcccaaccaagaaatctaactcaa acgtcccacttcatttgttccattcctgattcttgggtaataaa 636 223970_at ggagctcagagatctaagctgctttccatcttttctcccagccccaggacactgactctgtacaggatggggccgtcctcttgcctccttctcatcctaatcccccttctc cagctgatcaacccggggagtactcagtgttccttagactccgttatggataagaagatcaaggatgttctcaacagtctagagtacagtccctctcctataagcaa gaagctctcgtgtgctagtgtcaaaagccaaggcagaccgtcctcctgccctgctgggatggctgtcactggctgtgcttgtggctatggctgtggttcgtgggatgtt cagctggaaaccacctgccactgccagtgcagtgtggtggactggaccactgcccgctgctgccacctgacctgacagggaggaggctgagaactcagttttgt gaccatgacagtaatgaaaccagggtcccaaccaagaaatctaactcaaacgtcccact 637 224724_at gcctgagaaagcaagcacgcactctcagtcaacatgacagattctggaggataaccagcaggagcagagataacttcaggaagtccatttttgcccctgcttttg ctttggattatacctcaccagctgcacaaaatgcattttttcgtatcaaaaagtcaccactaaccctcccccagaagctcacaaaggaaaacggagagagcgag cgagagagatttccttggaaatttctcccaagggcgaaagtcattggaatttttaaatcataggggaaaagcagtcctgttctaaatcctcttattcttttggtttgtcaca aagaaggaactaagaagcaggacagaggcaacgtggagaggctgaaaacagtgcagagacgtttgacaatgagtcagtagcacaaaagagatgacattt acctagcactataaaccctggttgcctctgaagaaactgccttcattgtatatatgtgactatttacatgtaatcaacatgggaacttttaggggaacctaataagaaa tcccaattttcaggagtggtggtgtcaataaacgctctgtggccagtg 638 225664_at ggaacccagagctgctgtgtatttcgagcgggcagtttatcttttgctatacttattttcaattcaattacaccacgattcaaataattcccctcctaaaaccaaaaagg agggaaacgtcaactccattgcaattacttatcttcctcttctatctctgttatacgccggggcatagaatgctcgtatacatctctttaacaaccacaaaccttaagcc atgtagatgaagttagtgcatcaacgggatacagttccatattgccttaaacctccttgttttagacacactaacatttataccaaattgcagattattctgcagagagg gaattgcatgtttgtgttgta 639 225681_at aattaatattcatcgcacttcttctgtggaaggactttgtgaaggaattggtgctggattagtggatgttgctatctgggttggcacttgttcagattacccaaaaggaga tgcttctactggatggaattcagtttctcgcatcattattgaagaactaccaaaataaatgctttaattttcatttgctacctctttttttattatgccttggaatggttcacttaa atgacattttaaataagtttatgtatacatctgaatgaaaagcaaagctaaatatgtttacagaccaaagtgtgatttcacactgtttttaaatctagcattattcattttgct tcaatcaaaagtggtttcaatattttttttagttggttagaatactttcttcatagtcacattctctcaacctataatttggaatattgttgtggtcttttgttttttctcttagtatagc atttttaaaaaaatataaaagctaccaatctttgtacaatttg 640 225799_at aaatgactggatggtcgctgctttttaagtttcaaattgacattccagacaagcggtgcctgagcccgtgcctgtcttcagatcttcacagcacagttcctgggaaggt ggagccaccagcctctccntgaataactgggagatgaaacaggaagctctatgacacacttgatcgaatatgacagacacngaaaatcacgactcancccc ctccagcacctctacctgttgcccgccgatcacagccggaatgcagctgaaagattccctggggcctggttccaaccgcccactgtggactctgaggcctctgca tttgcgggtggtctgcctgtgatattttggtcatgggctggtctg 641 226237_at gaagaggagcaacatctatgccaaatactgtgcattctacaatggtgctaatctcagacctaaatgatactccatttaatttaaaaaagagttttaaataattatctat gtgcctgtatttcccttttgagtgctgcacaacatgttaacatattagtgtaaaagcagatgaaacaaccacgtgttctaaagtctagggattgtgctataatccctattt agttcaaaattaaccagaattcttccatgtgaaatggaccaaactcatattattgttatgtaaatacagagttttaatgcagtatgacatcccacaggggaaaagaat gtctgtagtgggtgactgttatcaaatattttatagaatacaatgaacggtgaacagactggtaacttgtttgagttcccatgacagatttgagacttg 642 226248_s_at tgaaagtgggcatctctgcaggcacctgtactgccatcctgctcaccgtcttgacctgctacttttggaaaaagaatcaaaanctagagtacangtactccangct ggtgatgaatgctactctcaaggactgnnnnntnncngnngctgacagctgcgccatcatggnanncnnnnangnanngnnnnnnnncancnnnnnnc anntgcgccatcatggaaggcgaggatgtagaggacgacctcatctttaccagcaagaagtcactctttgggaagatcaaatcatttacctccaagaggactcct gatggatttgactcagtgccgctgaagacatcctcaggaggcccagacatggacctgtgagaggcactgcctgcctcacctgcctcctcaccttgcatagcacctt tgcaagcctgcggcgatttgggtgccagcatcctgcaacacccactgctggaaatctcttcattgtggccttatcagatgtttgaatttcagatctttttttatagagtacc caaaccctcctttctgcttgcctcaaacctgccaaatatacccacac 643 226311_at aaacgacgcaaatctctgagctggggaccacttggagaaccggcttagtaacagtcctgatcttcgcaagccagcttcttctgcatctgaggggctcctggcgcc cagaggaggcagacagatgtcttctagctgagtttctaaccgcatgatgagactcagaccttccgctgcactagaaaatctgcaacagtgtccctgagtcacttct ccttagtgggcagactcgtgttagatttgtggaacccagctctctgatttactccttttggaaaacccatggaatttcatgtataaggctttcatttgtattttaaggtttttctg tttgttttgagtatatacatggtgctcaatagcaacatcttagcagatgaagcagtttatgattccactccctcctgtatgacaggtagccactatactgaatcaaggtg ctgaactcaaatcacaaaattctggcttaccgatacaacaaccaatac 644 226777_at tataaggtaactctttagtcctccatttagcacattttaaatcctccaaagaataagtatcatgtgattattttagctttacaaaaaaaaagttgaatggcgttttattttcat ggcctataagcaggtaccttagtagggcagatataggaaaaacaaattagagcaaaacaaatcctctacaaatccaaggcaggaaaagtggtggcagagtg actcattctcctgtccctcccatcaggtcaaatcaggaggctgcagtgaatgcctgttctttgaatgtgtagcagttgttncctgtaactctttaaaacttggctataggct gtttagcacagtacagattaaagatacagttacgtaaacagcaaagtaattttatagtgcttcatccatttatcatgctttggtttgctaattttttcacatacctttttctatca cagtctgttgcttttgtacacatttctcatattggggttcgaca 645 226930_at ggtgccaggaaggtcacagatggacactggccattctggtcatctcagtctggaactcagtcccacttcttggcctggacaatgaacaggattcagttttgctgttaa ctttgcttctctacttttttttgtttgtttgtaatagcacatcccagagacatcagaaaccagcaactgattcagtgtgatttccagactttttaggcatgaaattcggacact tcagtatttccaggaatagcatatgcacgctgttcttgcttcatggaatgctacatgctttctgtttttctcattttggatttctccaaaactaactgaatttaagcttcaggtcc ctttgtatgcagtagaaaggaattattaaaaacaccaccaaagaaaataaatatatcctacttgaaatttactctatggacttacccactgctagaataaatgtatca aatcttatttgtaaattctcaattttgatatatatatgtatatatgcatatacatatccacacttgtctgcaag 646 227140_at ttaccctctatttaaatgctttgaaaaacagtgcattgacaatgggttgatatttttctttaaaagaaaaatataattatgaaagccaagataatctgaagcctgttttattt taaaactttttatgttctgtggttgatgttgtttgtttgtttgtttctattttgttggttttttactttgttttttgttttgttttgttttgttttgcatactacatgcagttctttaa ccaatgtctgtttggctaatgtaattaaagttgttaatttatatgagtgcatttcaactatgtcaatggtttcttaatatttattgtgtagaagtactggtaatttttttatttacaat atgtttaaagagataacagtttgatatgttttcatgtgtttatagcagaagttatttatttctatggcattccagcggatattttggtgtttgcgaggcatgcagtcaatattttgtac agttagtggacagtattcagcaacgcctgatagcttctttggcctt 647 227566_at ccacacaccaggcactaatcacctggtgaggatttggcatatccaccaaaaaatgcatccgatttaaccaacatctccaccagcgctacggactcctcccaattc tgacatctcttgcagacaatactatgctctctacacactgtttagaaatggaaaggtgatctgcactgtatcttgggtttgttggctatgcttcctttgatgacatatattata cagtatatatatacatatattttttttgttagagttctagccattttatttctccgcagggtcctttctcagacattactgcatgctgtatatggcgttagctgtgtgttgatcttcta aaagatgatagagtttactggtaattgtgtaatcagctcctgcctttttatt 648 227676_at caggaaactcttctctgacttggggagttcctacgcganacaactgggcttccgggacagctgggtcttcataggagccaaagacctcaggggtaaaagcccct ttgagcagttcttaaagaacagcccagacacaaacaaatacgagggatggccagagctgctggagatggagggctgcatgcccccgaagccattttagggtg gctgtggctcttcctcagccaggggcctgaagaagctcctgcctgacttaggagtcagagcccggcaggggctgaggaggaggagcagggggtgctgcgtgg aaggtgctgcaggtccttgcacgctgtgtcgcgcctctcctcctcggaaacagaaccctcccacagcacatcctacccggaagaccagcctcagagggtccttct ggaaccagctgtctgtggagagaatggggtgctttcgtcagggactgctgacggctggtcctgaggaaggacaaactgcccagacttgagcc 649 227719_at cacttgatagactgtaagcacctgcttaactttgtgtcccaaatatttagtgtgtatatatatatatatatanncncacacacacacatatatattcaacaaataaagca aaatataacatgcatttcacattttgtctttccctgttacgattttaatagcagaactgtatgacaagtttaggtgatcctagcatatgttaaattcaaattaatgtaaaaca gattaacaacaacaaagaaactgtctatttgagtgaagtcatgctttctattataataacttggcttcggttatccatcaaatgcacacttatactgttatctgattg 650 229218_at gccaaaaggcctggcttctgataggaaactggtaagaaactcttcatgaaaacacatcactaatattcgctattactctcctggtctgaagtcagcttttctgaaccat taaggtatttcatcacaagttatattttataatatcagtttaagaggcttttattcatgtgaacaccagnnccctttcaggggcatggtctttttgaaaaaaaaaaaanaa aaaaannaacagttttagccacatatcagatatttctatatctaattatcctttatggctaacattctgcctccattgttaaggtataattgttcctgaatttaaaggtggttt ggcctctaatttaattctgattcagactctcctgtcaggactcaagaaaatttaattaattaccaaggattaagtcttctggttaaggtttctgggaaaaaaaaatagca aagatgttgatttcttggaatccttttacaggttcataacagaaaaatcttcattccctgtaggcatttaattaaacctagttgagaagtgtgtgggattcctcaattatga acaaaacacgtatattggctttcttt 651 229802_at gacatgattgtctataatctcgctagccttgtactgtgtgtgcatagcaattacagggaagtaatctagctcctgactattatgttgaactatgtcgctgctttttacaaact tgtcttgatccaaagcagtcacaatgataaccctgcatatctgggaatcataagtcaactatgtatctctgtgtgtgtatatatatgtatgtatgtatctattttcaaactgt gatttaatatttaaatattcctactgccatttttgtgactgaaaaactacacatgaggaaacgtcttagaattttccaatagaggaaaaataacacttgggcaatctgtc atgtttcacaacagttctcatttttctcatgatttgtgtagcgtggaatgtgtttgctcaatgtgaagggttttcattgctcaatttctctgtgtaa 652 231766_s_at ggttccggctaacacattttctaagtcgccagtgctgcttacagtttgaatacatgaaaatcctgtttctnagatgtttgcgcacgtgcttattaggaaatgagtctgtatg gaaatctcaccacagataatggttaacgaaccgggtcgacatcacaaaggagggtggagactctttttactaacttgaatgagacaaaagcagtggtgtcagttt ataatcctgatgcatttcagtaataatgtagaaaaacattattttaaaaaagttccaacacacagccatgaggagccnnnnnnnnnntcagttttgaaagaggtg cataataaaactactaaccagaggagtctatgccatttt 653 231832_at gagtttcaactttaaatgttcactatgtcatttagtgtccanctttacggataggttgactatctaaataggcatttttagtcattaaaaaaaantctagtcaccaggagg atccctataactcaaaataacttgtttgtaaaagaaaatttgtttacttacccattagtaagttcctgcatattcattataagatggcaaatcaaacttttctaggatgaag acagcttatttttaagttgtatagtcttagttggtttagggtctcaattttaattaataaaatacttggtttttatttgcttgtccttttgaattcctgttttaataattttaaaatgagc acaaagaangttgaagttcagattaatctcttctgaatgatgtttttttcctctgtgatgagttgtttctg 654 231879_at tgctgtagtcactggtgttcctcacccaccagctgtaactcagtttgtgtgaggtacagccacagaagatgtcatgtactgtatattacctggtgatagttgcttttcacc ccccgagttcagtttctaggagccaatgaaacttcccctcacctcctcatctttccaagttgttctttgaattgaggagtttgaaggcataaacagttacttggggatttg cgaaaatcctacttagttactgcgtttacagttctttggcccagtctctgacccttcccnagtatttgtgcnatgattgtgtttactgctggatttttgaaggttttttttttnna gaaagtgccatttcattatttgatt 655 232176_at gggatcactgggagaagccatggcattatcttcaggcaatttagtctgtcccaaataaaataaatccttgcatgtaaatcattcaagggttatagtaatatttcatata ctgaaaagtgtctcataggagtcctcttgcacatctaaaaaggctgaacatttaagtatcccgaattttcttgaattgctttccctatagattacaattggatttcatc atttaaaaaccatacttgtatatgtagttataatatgtaaggaatacattgtttataaccagtatgtacttcaaaaatgtgtattgtcaaacatacctaactttcttgcaata aatgcaaaagaaactggaacttgacaattataaatagtaatagtgaagaaaaaatagaaaggttgcaattatataggccatgggtggctcaaaactttgaa 656 232458_at gattcctggattgatgtcttatctacaggcttctttttaaaaatnnnnnnngattggctgtgagtttaccaggattatagttgaggctaaaggacagctcctcaggaaa gcccctgttctacatctacggtcacatgctggaccttgagttgtcactcagagaaaagagtgccatctaccgaaactccacagtttccattgtgaatggcttctttggt gcagagttccaaaaattatgtagcccagctctttaattttgtaacatctaatgatatcaccgccttgaagtgattaaagtagattgcttaaagaattaaagctttaaaga tgaaagatgttattgcttttgctggacatgaggaacagttgtaaagtttccaggtctacaataactttctgganccctctcagtgaactgtttcttgta 657 232481_s_at gaagtccatcctttggtccaaagcatctggaagaggaagaagagaggaatgagaaagaaggaagtgatgcaaaacatctccaaagaagtcttttggaacag gaaaatcattcaccactcacagggtcaaatatgaaatacaaaaccacgaaccaatcaacagaatttttatccttccaagatgccagctcattgtacagaaacattt tagaaaaagaaagggaacttcagcaactgggaatcacagaatacctaaggaaaaacattgctcagctccagcctgatatggaggcacattatcctggagccc acgaagagctgaagttaatggaaacattaatgtactcacgtccaaggaaggtattagtggaacagacaaaaaatgagtattttgaacttaaagctaatttacatg ctgaacctgactatttagaagtcctggagcagcaaacatagatggagagtttgagggctttcgcagaaatgctgtgattctgttttaagtccataccttgtaaataagt gccttacgtgagtgtgtcatcaatcagaacctaagc 658 233555_s_at gctgctcaagcgcctgcagaacaacgacacgtgcagcatgccaggcctcacgtgcttcacccacgacaaccagcactggcagacggcgcctttctggacact ggggcctttctgtgcctgcaccagcgccaacaataacacgtactggtgcatgaggaccatcaatgagactcacaatttcctcttctgtgaatttgcaactggcttcct agagtactttgatctcaacacagacccctaccagctgatgaatgcagtgaacacactggacagggatgtcctcaaccagctacacgtacagctcatggagctg aggagctgcaagggttacaagcagtgtaacccccggactcgaaacatggacctgg 659 234994_at acaatcggctaaccttgacatttctttttaccttcatatgccactatctcggtagttcaaaaaaatttagttcttgataaattgccttgaagtttaccttgtgctggagagcct tatgataactccaaagactttcttacggtataatacatgttgtttaggattgtgtttcttagtcactgaagataataaatattaaaatggatgttttcatcagaaaattttcat gttttcctttaaggtaacataattgtaagaattgtttaataaaatactcaggaaattctaaaggtttctccnaatacctaaacatttctgaacatcagtattgcagttgtgg aagagcagaaggaggatacatttgtttgtgttgctccccaaaattccaccttgcatttgcatcacaaacttccctcaattgaggcagttttctttg 660 235976_at cagtgctgctgtgaactaaagtatgtcatttatgctcaaagtttaattcttcttcttgggatattttaaaaatgctactgagattctgctgtaaatatgactagagaatatatt gggtttgctttatttcataggcttaattctttgtaaatctgaatgaccataatagaaatacatttcttgtggcaagtaattcacagttgtaaagtaaataggaaaaattatttt atttttattgatgtacattgatagatgccataaatcagtagcaaaaggcacttctaaaggtaagtggtttaagttgcctcaanagagggacaatgtagctttattttaca agaaggcatagttagatttctatgaaatatttattctgtacagttttatatanttttggttcacaaaagtaattattcttgggtgcctttcaa 661 236894_at aaagtatattgtgctagcttgtctaagaataaacttnnatactgttgggggagggctgcacctgtcaagataacctgtcaatgtagtaggaaaacaggaggggac agtaacagaaaagcacgggaaaagatggcaaggttagttaaaatagaaaagtgctcagttcctcatacctgtaatcccagcagtttagggggccaaggaagg tgggtcacttgagcccaagagttcaaggccatcctgggcaatgtggcgaaagtgtctacaaaaaaatacaaaaagaggaagaaatgatatttcacaagtttgta tcatttgtcat 662 237521_x_at cagtccaaaatccatagacacagacagtagaaaggtggttatncaagggnctggtaggagagggagttagtatttagtggtatagagttttagtgtttnccgggta aaaatgttnctagagatctgttgcaaccatgtgaatatacttaacactaccgtactgtacactgaaaaaatggttaagaggataaatttaaatggttaagaggaaa aatggttaagaggataatgttgttttgttaccacagtagtaacttttaaaaaccctcatgtatgttcttt 663 37892_at caacccattttgtgccacatgcaagttttgaataaggatggtatagaaaacaacgctgcatatacaggtaccatttaggnannancngatgcctttntgggggca gaatcacatggcaaaagctttgaaaatcataaagatataagttggtgtggctaagatggaaacagggctgattcttgattcccaattctcaactctccttttcctatttg aatttctttggtgctgtagaaaacaaaaaaagaaaaatatatattcataaaaaatatggtgctcattctcatccatccaggatgtactaaaacagtgtgtttaataaat tgtaattattttgtgtacagttctatactgttatctgtgtccatttccaaaacttgcacgtgtccctgaattcc

TABLE 7 MSP primers and PCR conditions Re-anneal Gene Probe set Gene Name Forward primer 5′-3′ Reverse primer 5′-3′ Temp CA4 206208_at Carbonic anhydrase TCGTTTTTCGCGTTTAGTT GCGCACCGAAAAAACCG 61.0° C. IV GTC (SEQ ID NO: 664) (SEQ ID NO: 665) CXCL12 209687_at Chemokine, CXC CGGTTACGGTTAGTATTCG AAAATACGACGATAAAAA 64.0° C. Motif, Ligand 12 GTTTC ACGCG (SEQ ID NO: 667) (SEQ ID NO: 666) DF 205382_s_at complement factor D CGAGGGTTTTTTAGCGATT AAACGAACCGCTCCCCG 64.0° C. TGTC (SEQ ID NO: 668) (SEQ ID NO: 669) MAMDC2 228885_at MAM domain- TTCGGCGTTTTCGTTTTTTA CCCCTTAACAACATAATCG 60.0° C. containing protein 2 C (SEQ ID NO: 670) CG (SEQ ID NO: 671) precursor MT1M 217546_at Metallothionein-1M GATGGTGCGTTCGGTATTT GCTTACACCCGCCCGACTA 62.0° C. ATGT (SEQ ID NO: 672) (SEQ ID NO: 673) CAGE Control unbiased GTTTTGTGATTGGTTAGGT CCRTCACCTTCTACACCAA 61.0° C. amplification assay TATTAAAGT (SEQ ID AAAATA (SEQ ID NO: 675) NO: 674)

TABLE 8 COBRA Primers and PCR conditions Re-anneal Temp, Gene Probe set Gene Name Forward primer 5′-3′ Reverse primer 5′-3′ Enzyme ADAMDECI 206134_at ADAM-like, TGTGGATTTATTTTTATAA ATAACTCATTAAAAACT 61.0° C. decysin 1 GGATATTGAAT (SEQ ID CACATCTAAACACTA BstU I NO: 676) (SEQ ID NO: 677) GPM6B 209170_s_at Neuronal membrane TTAAGAAAGAGAGTAAG AAAATCCCAATTAAAAA 60.0° C. glycoprotein M6-b GAGGAAGAGTT (SEQ ID ACAACCA (SEQ ID Hinf I NO: 678) NO: 679) P2RY14 206637_at Purinergic receptor CAAAATAATAAATCCCTC GGAGGAAAGGAATTAG 60.0° C. P2Y, G-protein TACTACTATTATCAA TTTAGAAGTTAGTT Acl I coupled, 14 (SEQ ID NO: 680) (SEQ ID NO: 681)

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1-35. (canceled)
 36. A method of screening for the onset or predisposition to the onset of a large intestine neoplasm or monitoring the progress of a neoplasm in an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from: (i) the gene, genes or transcripts detected by Affymetrix probeset IDs: 207502_at 207003_at 203000_at 204938_s_at 200600_at 201744_s_at 203001_s_at 204939_s_at 200621_at 201842_s_at 203066_at 204940_at 200795_at 201852_x_at 203131_at 204955_at 200799_at 201858_s_at 203305_at 205097_at 200845_s_at 201859_at 203382_s_at 205200_at 200859_x_at 201865_x_at 203477_at 205267_at 200897_s_at 201893_x_at 203645_s_at 205382_s_at 200974_at 201920_at 203680_at 205412_at 200986_at 201957_at 203729_at 205433_at 201041_s_at 202007_at 203748_x_at 205464_at 201058_s_at 202037_s_at 203766_s_at 205547_s_at 201061_s_at 202069_s_at 203881_s_at 205683_x_at 201069_at 202133_at 203908_at 205935_at 201105_at 202222_s_at 203913_s_at 205950_s_at 201137_s_at 202242_at 203914_x_at 206134_at 201141_at 202274_at 203951_at 206143_at 201150_s_at 202283_at 203980_at 206149_at 201289_at 202291_s_at 204069_at 206198_s_at 201300_s_at 202388_at 204083_s_at 206199_at 201324_at 202555_s_at 204122_at 206208_at 201348_at 202620_s_at 204135_at 206209_s_at 201426_s_at 202686_s_at 204326_x_at 206422_at 201427_s_at 202746_at 204438_at 206461_x_at 201438_at 202760_s_at 204457_s_at 206561_s_at 201496_x_at 202766_s_at 204570_at 206576_s_at 201539_s_at 202888_s_at 204688_at 206637_at 201540_at 202920_at 204697_s_at 206641_at 201616_s_at 202953_at 204719_at 206710_s_at 201645_at 202957_at 204745_x_at 206784_at 201667_at 202992_at 204834_at 207080_s_at 201739_at 202994_s_at 204894_s_at 207134_x_at 201743_at 202995_s_at 204931_at 207266_x_at 207961_x_at 210133_at 212764_at 218312_s_at 207977_s_at 210139_s_at 212859_x_at 218353_at 207980_s_at 210298_x_at 212956_at 218418_s_at 208131_s_at 210299_s_at 213068_at 218468_s_at 208370_s_at 210302_s_at 213071_at 218469_at 208383_s_at 210495_x_at 213428_s_at 218559_s_at 208399_s_at 210517_s_at 213509_x_at 218756_s_at 208450_at 210764_s_at 213624_at 219014_at 208581_x_at 210809_s_at 213746_s_at 219087_at 208747_s_at 210946_at 213891_s_at 219508_at 208763_s_at 210982_s_at 214027_x_at 219607_s_at 208788_at 211161_s_at 214038_at 219669_at 208789_at 211548_s_at 214091_s_at 219799_s_at 208791_at 211596_s_at 214142_at 220026_at 208792_s_at 211643_x_at 214414_x_at 220037_s_at 208894_at 211644_x_at 214505_s_at 220376_at 209047_at 211645_x_at 214677_x_at 220834_at 209074_s_at 211671_s_at 214696_at 221541_at 209101_at 211696_x_at 214752_x_at 221667_s_at 209116_x_at 211719_x_at 214768_x_at 221747_at 209138_x_at 211798_x_at 214777_at 221748_s_at 209147_s_at 211813_x_at 215049_x_at 222043_at 209156_s_at 211848_s_at 215076_s_at 222162_s_at 209167_at 211889_x_at 215118_s_at 222453_at 209170_s_at 211896_s_at 215176_x_at 222513_s_at 209191_at 211959_at 215193_x_at 222717_at 209209_s_at 211964_at 215382_x_at 222722_at 209210_s_at 211985_s_at 215388_s_at 223121_s_at 209283_at 211990_at 215657_at 223122_s_at 209301_at 211991_s_at 216207_x_at 223235_s_at 209312_x_at 212077_at 216401_x_at 223343_at 209335_at 212091_s_at 216442_x_at 223395_at 209357_at 212097_at 216474_x_at 223551_at 209373_at 212136_at 216576_x_at 223623_at 209436_at 212158_at 216834_at 223952_x_at 209457_at 212185_x_at 216984_x_at 224009_x_at 209496_at 212192_at 217148_x_at 224352_s_at 209498_at 212195_at 217179_x_at 224412_s_at 209612_s_at 212230_at 217235_x_at 224480_s_at 209613_s_at 212233_at 217258_x_at 224560_at 209621_s_at 212265_at 217378_x_at 224663_s_at 209651_at 212288_at 217480_x_at 224694_at 209656_s_at 212386_at 217546_at 224823_at 209667_at 212387_at 217757_at 224836_at 209668_x_at 212397_at 217762_s_at 224840_at 209687_at 212414_s_at 217764_s_at 224959_at 209735_at 212419_at 217767_at 224963_at 209763_at 212464_s_at 217897_at 224964_s_at 209868_s_at 212667_at 217967_s_at 225207_at 209948_at 212671_s_at 218087_s_at 225242_s_at 210084_x_at 212713_at 218162_at 225269_s_at 227099_s_at 212730_at 218224_at 225275_at 225353_s_at 229530_at 206000_at 218541_s_at 225381_at 229839_at 206094_x_at 218546_at 225442_at 230087_at 206262_at 219059_s_at 225575_at 230264_s_at 206377_at 219543_at 225602_at 230788_at 206385_s_at 219796_s_at 225604_s_at 230830_at 206664_at 219948_x_at 225626_at 231120_x_at 207126_x_at 220075_s_at 225688_s_at 231579_s_at 207245_at 220266_s_at 225710_at 231773_at 207390_s_at 220468_at 225720_at 234764_x_at 207392_x_at 220645_at 225721_at 234987_at 207432_at 220812_s_at 225782_at 236300_at 207761_s_at 221004_s_at 225894_at 236313_at 208596_s_at 221305_s_at 225895_at 242317_at 208920_at 221584_s_at 226001_at 200884_at 209114_at 221841_s_at 226051_at 201495_x_at 209374_s_at 221896_s_at 226084_at 202266_at 209458_x_at 223484_at 226103_at 202350_s_at 209791_at 223597_at 226303_at 202731_at 210107_at 223754_at 226304_at 202741_at 210524_x_at 224342_x_at 226333_at 202742_s_at 210735_s_at 224989_at 226430_at 202768_at 211372_s_at 224990_at 226492_at 202838_at 211538_s_at 225458_at 226682_at 203058_s_at 211549_s_at 225728_at 226694_at 203060_s_at 211637_x_at 226147_s_at 226818_at 203240_at 211699_x_at 226302_at 226834_at 203296_s_at 211745_x_at 226594_at 226841_at 203343_at 212224_at 226654_at 227006_at 203474_at 212592_at 226811_at 227061_at 203638_s_at 212741_at 227052_at 227235_at 203963_at 212814_at 227522_at 227265_at 204018_x_at 213317_at 227682_at 227404_s_at 204034_at 213451_x_at 227725_at 227529_s_at 204036_at 213629_x_at 227735_s_at 227561_at 204130_at 213921_at 227736_at 227623_at 204388_s_at 213953_at 228133_s_at 227662_at 204389_at 214164_x_at 228195_at 227705_at 204508_s_at 214433_s_at 228232_s_at 227727_at 204532_x_at 214598_at 228241_at 227826_s_at 204607_at 214916_x_at 228469_at 227827_at 204673_at 215125_s_at 228961_at 228202_at 204818_at 215299_x_at 229070_at 228504_at 204895_x_at 215867_x_at 229254_at 228507_at 204897_at 216336_x_at 229659_s_at 228640_at 205112_at 216491_x_at 229831_at 228706_s_at 205259_at 216510_x_at 230595_at 228707_at 205403_at 217022_s_at 231925_at 228750_at 205480_s_at 217109_at 231975_s_at 228766_at 205554_s_at 217110_s_at 233565_s_at 228846_at 205593_s_at 217165_x_at 235146_at 228854_at 205892_s_at 217232_x_at 235766_x_at 228885_at 205929_at 217414_x_at 235849_at 238143_at 239272_at 242601_at 238750_at 241994_at 243278_at; 238751_at 242447_at and/or

(ii) CLCA4 PCK1 LOC387763 ADAMTS1 ZG16 CNN1 TIMP3 ITM2A CA2 HSD17B2 MYLK POU2AF1 MS4A12 PLAC8 CLDN8 FAM55D AQP8 TMEM47 RDX C6orf204 SLC4A4 OGN TSPAN7 AKAP12 CEACAM7 CALD1 TNFRSF17 TUBB6 TAGLN ACTG2 SYNPO2 LGALS2 GCG MGC4172 VIM KIAA0828 ADH1B MAB21L2 SMPDL3A MGC14376 UGT2B17 RPL24 P2RY14 PPP1R14A ADAMDEC1 ABCG2 CHGA MUC4 MT1M CCDC80 C15orf48 PKIB AKR1B10 UGT1A1 COL3A1 PIGR FN1 MRC1 CYR61 ASPN MGP HSD11B2 TRPM6 A2M CXCL12 ANPEP OSTbeta LOC25845 PDK4 MATN2 IGLV1-44 LGALS1 CA4 PRNP VSIG2 BCHE PYY ABI3BP IGHM ST6GALNAC1 IGHA1 HLA-C LRRC19 GJA1 TPM2 NDE1 CD163 SCNN1B C6orf105 SRPX CEACAM1 FABP4 HPGD WWTR1 TIMP2 F13A1 ADH1C HMGCS2 ENTPD5 CD36 CLCA1 LOC646627 DDR2 SPARCL1 GUCA1B KRT20 CHRDL1 ZCWPW2 FABP1 KLF4 SRGN TNC ENAM FHL1 PDE9A MT1A CFD ARL14 PMP22 LOC652745 FBLN1 LUM FLNA MALL LOC63928 SORBS1 STMN2 GNG2 ABCA8 METTL7A MYL9 DNASE1L3 POSTN FAM129A SEMA6D EGR1 DCN SCARA5 PADI2 CMBL ITLN1 SI SEPP1 GCNT3 COL6A2 ACTA2 TGFB1I1 SERPING1 FCGBP CD177 SFRP2 MEIS1 SLC26A2 C10orf99 UGT1A3 EDN3 PGM5 COL15A1 MS4A7 MSN DMN NR3C2 ALDH1A1 MT1G GPNMB DHRS9 SGK TPSAB1 IGFBP5 LMOD1 CFL2 GPX3 CLEC3B EFEMP1 C1S CDKN2B LOC253012 GREM1 SELENBP1 FOSB DPT IL1R2 MT1E HSPA1A CYBRD1 RBMS1 IGLJ3 APOE PTGER4 PTRF QKI SERPINF1 MAG1 TSPAN1 LOC399959 PPP1R12B BEST2 UGT1A9 ANKRD25 HSPB6 HLA-DQA1 COX7A1 CRISPLD2 FNBP1 PRIMA1 MUC12 ANK2 C4orf34 MT1F PDCD4 LOC283666 SORBS2 MAFB CAV1 CRYAB GPA33 FAM107A FAM46C ACAT1 GALNAC4S- PRKACB LRIG1 IGL@ 6ST SELM HLA-DPA1 PBLD CFHR1 TYROBP C1orf115 CCL8 MGC13057 TNS1 HBA2 LIFR C10orf56 MYH11 EDIL3 HLA-DRB1 SULT1A1 ITM2C DES UGP2 TTRAP CES2 MT2A IGKV1D-13 CCL28 MS4A4A KCNMA1 AP1S2 IDH3A PDGFRA GAS1 EMP3 EDG2 CA12 TBC1D9 MMP28 UGT1A8 FKBP5 C7 UGT2A3 RAB27A HSPB8 P2RY1 RGS5 ANTXR1 TPSB2 NR3C1 PTGIS EMP1 FGL2 STOM DUSP5 CSRP1 C1QB CKB MFAP4 PLEKHC1 ANGPTL1 CLU UGT1A6 LOC572558 MEP1A SLC26A3 PRKAR2B FOXP2 GUCY1A3 SDC2 HHLA2 HSPA2 UGDH SST LOC652128 ATP1A2 DUSP1 HLA-DRA C3 TNXB C2orf40 TSC22D3 ATP2B4 FUCA1 PLN IL6ST HBA1 MRGPRF UGT2B15 C1QC TCF21 HIGD1A PDLIM3 MT1X PPID MFSD4 TP53INP2 AOC3 PPAP2B AXL ATP8B1 PPAP2A SPON1 AQP1 ANK3 ZSCAN18 PHLDB2 MAP1B CTGF IVD RARRES2 PALLD MUCDHL SFRP1 ETHE1 MPEG1 SDPR COL4A2 MMP2 KLHL5 COL14A1 GPM6B SRI TCEAL7 DSCR1 EPB41L3 CNTN3 FILIP1L CITED2 MAOA RGS2 IQGAP2 MT1H DMD COL6A1 PRDX6 NEXN MSRB3 FBN1 RAB31 MUC2 PLOD2 MXD1 LOC96610 NID1 C9orf19 PLCE1 FGFR2 HBB MIER3 KCNMB1 PAPSS2 GCNT2 XDH CALM1 XLKD1 C20orf118 CLDN23 HLA-DPB1 SMTN SLC20A1 SGCE SMOC2 C8orf4 CD14 FOXF2 LOC285382 SDCBP2 KCTD12 AGR3 CLIC5 CCL11 ELOVL5 PNMA1 PAG1 FXYD6 FOXF1 LOC339562 HCLS1 OLFML3 RELL1 PALM2-AKAP2 RGS1 COL6A3

in a biological sample from said individual wherein a lower level of expression of the genes or transcripts of group (i) and/or group (ii) relative to control levels is indicative of a neoplastic large intestine cell or a cell predisposed to the onset of a neoplastic state.
 37. The method according to claim 36 wherein said one or more genes or transcripts are selected from: (i) the gene, genes or transcripts detected by Affymetrix probeset IDs: 207502_at or 207003_at; and/or (ii) GUCA2B or GUCA1B.
 38. The method according to claim 36 wherein said one or more genes or transcripts are selected from: (i) the gene, genes or transcripts detected by Affymetrix probeset IDs: 220026_at; and/or CLCA4; (ii) the gene, genes or transcripts detected by Affymetrix probeset IDs: 214142_at; and/or ZG16; (iii) the gene, genes or transcripts detected by Affymetrix probeset IDs: 209301_at 205950_s_at; and/or CA2 CA1; (iv) the gene, genes or transcripts detected by Affymetrix probeset IDs: 220834_at; and/or MS4A12; (v) the gene, genes or transcripts detected by Affymetrix probeset IDs: 206784 at; and/or AQP8. (vi) the gene, genes or transcripts detected by Affymetrix probeset IDs: 203908_at, 206198_s_at, 205547_s_at, 207003_at, 206422_at, 209613_s_at, 207245_at; and/or SLC4A4, CEACAM7, TAGLN, GUCA1B, GCG, ADH1B, UGT2B17; (vii) the gene, genes or transcripts detected by Affymetrix probeset IDs: 206134_at, 217546_at, 206561_s_at, 211719_x_at, 202291_s_at 209687_at; and/or ADAMDEC1, MT1M, AKR1B10, FN1, MGP, CXCL12; (viii) the gene, genes or transcripts detected by Affymetrix probeset IDs: 225207_at 211548_s_at 205382_s_at 206208_at 206262_at 207502_at 207080_s_at 210107_at 202995_s_at 215118_s_at 205892_s_at 206149_at 204083_s_at 212592_at 204719_at 229070_at; and/or PDK4 HPGD CFD CA4 ADH1C GUCA2B PYY CLCA1 FBLN1 IGHA1 FABP1 LOC63928 TPM2 ENAM ABCA8 C6orf105;

(ix) the gene, genes or transcripts detected by Affymetrix probeset IDs: 210809_s_at 201617_x_at 202133_at 201893_x_at 202274_at 204607_at 223597_at 218756_s_at 238143_at 209156_s_at 210302_s_at 213953_at 203240_at 228885_at 220266_s_at 224963_at 209735_at 210299_s_at 226303_at 228504_at 220468_at 212730_at 225242_s_at 201744_s_at 201141_at 215125_s_at 218087_s_at 211959_at 204438_at 207761_s_at 205200_at 204130_at 217967_s_at 242601_at 202888_s_at 229839_at 213068_at 202350_s_at 206664_at 208383_s_at 201300_s_at 200974_at 203951_at 223395_at 219669_at 204818_at 214768_x_at 227736_at 219014_at 228133_s_at 203477_at 209656_s_at 204955_at 205259_at 222722_at; and/or POSTN OGN WWTR1 DCN CALD1 HMGCS2 ITLN1 ACTG2 LOC646627 COL6A2 MGC4172 KRT20 FCGBP MAB21L2 KLF4 SLC26A2 RPL24 FHL1 PGM5 ABCG2 ARL14 DMN CCDC80 LUM GPNMB UGT1A1 SORBS1 IGFBP5 MRC1 METTL7A CLEC3B HSD11B2 FAM129A LOC253012 ANPEP SCARA5 DPT MATN2 SI PCK1 PRNP ACTA2 CNN1 ABI3BP CD177 HSD17B2 HLA-C C10orf99 PLAC8 NDE1 COL15A1 TMEM47 SRPX NR3C2.


39. The method according to claim 36 wherein said neoplastic cell is an adenoma or an adenocarcinoma.
 40. The method according to claim 36 wherein said neoplasm is an adenoma and said one or more genes or transcripts are selected from: (i) the gene, genes or transcripts detected by Affymetrix probeset IDs: 200600_at 200986_at 201150_s_at 201645_at 200665_s_at 201041_s_at 201289_at 201667_at 200799_at 201061_s_at 201300_s_at 201743_at 200845_s_at 201069_at 201426_s_at 201744_s_at 200859_x_at 201105_at 201438_at 201842_s_at 200897_s_at 201137_s_at 201616_s_at 201852_x_at 200974_at 201141_at 201617_x_at 201858_s_at 201859_at 209101_at 212397_at 223235_s_at 201865_x_at 209138_x_at 212414_s_at 223343_at 201893_x_at 209147_s_at 212419_at 224560_at 201920_at 209156_s_at 212464_s_at 224694_at 202007_at 209191_at 212667_at 224840_at 202069_s_at 209209_s_at 212671_s_at 224964_s_at 202133_at 209210_s_at 212713_at 225242_s_at 202283_at 209312_x_at 212764_at 225269_s_at 202291_s_at 209335_at 212956_at 225353_s_at 202403_s_at 209436_at 213428_s_at 225381_at 202620_s_at 209457_at 213509_x_at 225442_at 202686_s_at 209496_at 213746_s_at 225602_at 202760_s_at 209621_s_at 213891_s_at 225604_s_at 202766_s_at 209651_at 214038_at 225626_at 202953_at 209656_s_at 214677_x_at 225688_s_at 202957_at 209868_s_at 214752_x_at 225710_at 202994_s_at 210084_x_at 215049_x_at 226001_at 202995_s_at 210133_at 215076_s_at 226051_at 203066_at 210139_s_at 215193_x_at 226084_at 203131_at 210495_x_at 215382_x_at 226103_at 203305_at 210517_s_at 215388_s_at 226430_at 203382_s_at 210764_s_at 216442_x_at 226682_at 203477_at 210809_s_at 216474_x_at 226694_at 203645_s_at 210982_s_at 216834_at 226818_at 203680_at 211161_s_at 217480_x_at 226834_at 203729_at 211596_s_at 217757_at 226841_at 203748_x_at 211671_s_at 217762_s_at 227061_at 204069_at 211719_x_at 217764_s_at 227099_s_at 204122_at 211813_x_at 217767_at 227235_at 204135_at 211896_s_at 217897_at 227404_s_at 204438_at 211959_at 218162_at 227529_s_at 204457_s_at 211964_at 218224_at 227561_at 204570_at 211985_s_at 218312_s_at 227623_at 204688_at 211990_at 218353_at 227705_at 205412_at 211991_s_at 218418_s_at 227727_at 205683_x_at 212077_at 218468_s_at 228507_at 205935_at 212091_s_at 218469_at 228750_at 207134_x_at 212136_at 218559_s_at 228846_at 207266_x_at 212158_at 219087_at 229530_at 208131_s_at 212185_x_at 219607_s_at 230264_s_at 208370_s_at 212195_at 221541_at 231579_s_at 208747_s_at 212230_at 222043_at 234987_at; 208788_at 212233_at 222453_at and/or 208789_at 212265_at 222513_s_at 208894_at 212386_at 223121_s_at 209047_at 212387_at 223122_s_at

A2M CYBRD1 KLHL5 PRKAR2B ACAT1 CYR61 LGALS1 PRNP ACTA2 DCN LOC283666 PTGIS AKAP12 DDR2 LOC339562 PTRF ANKRD25 DSCR1 LOC387763 QKI ANTXR1 DUSP1 LOC399959 RAB31 AP1S2 DUSP5 LRIG1 RARRES2 APOE EFEMP1 LUM RBMS1 AQP1 EGR1 MAFB RDX ASPN ELOVL5 MAP1B RELL1 ATP2B4 EMP3 MEIS1 RGS1 AXL F13A1 MFAP4 RGS5 C10orf56 FBLN1 MGP SDC2 C1QB FBN1 MMP2 SELM C1QC FILIP1L MPEG1 Sep-06 C1S FKBP5 MRC1 SERPINF1 C20orf118 FLNA MRGPRF SERPING1 C3 FN1 MS4A4A SFRP2 C9orf19 FOXF1 MS4A7 SGCE CALD1 FXYD6 MSN SLC20A1 CALM1 GALNAC4S- MT2A SMOC2 CCDC80 6ST MXD1 SORBS1 CCL11 GAS1 NEXN SPARC CCL8 GJA1 NID1 SPON1 CD14 GNG2 NR3C1 SRGN CD163 GPNMB OLFML3 STOM CES2 GREM1 PAG1 TBC1D9 CFHR1 GUCY1A3 PALLD TCEAL7 CLU HCLS1 PALM2-AKAP2 TGFB1I1 COL14A1 HLA-DPA1 PDGFRA TIMP2 COL15A1 HLA-DPB1 PDLIM3 TIMP3 COL1A2 HLA-DQA1 PHLDB2 TMEM47 COL3A1 HLA-DRA PLEKHC1 TNC COL4A2 HLA-DRB1 PLOD2 TPSAB1 COL6A1 HSPA1A PMP22 TPSB2 COL6A2 IDH3A PNMA1 TUBB6 COL6A3 IGFBP5 POSTN TYROBP COX7A1 IGL@ PPAP2A VIM CRISPLD2 IGLJ3 PPAP2B WWTR1 CTGF IL6ST PRDX6 ZSCAN18.


41. The method according to claim 36 wherein said neoplasm is a cancer and said one or more genes or transcripts are selected from: (i) the gene or genes detected by Affymetrix probeset IDs: 200884_at 206000_at 214598_at 226147_s_at 201495_x_at 206094_x_at 214916_x_at 226302_at 202266_at 206262_at 215125_s_at 226594_at 202350_s_at 206377_at 215299_x_at 226654_at 202731_at 206385_s_at 215867_x_at 226811_at 202741_at 206664_at 216336_x_at 227052_at 202742_s_at 207126_x_at 216491_x_at 227522_at 202768_at 207245_at 216510_x_at 227682_at 202838_at 207390_s_at 217022_s_at 227725_at 203058_s_at 207392_x_at 217109_at 227735_s_at 203060_s_at 207432_at 217110_s_at 227736_at 203240_at 207761_s_at 217165_x_at 228133_s_at 203296_s_at 208596_s_at 217232_x_at 228195_at 203343_at 208920_at 217414_x_at 228232_s_at 203474_at 209114_at 218541_s_at 228241_at 203638_s_at 209374_s_at 218546_at 228469_at 203963_at 209458_x_at 219059_s_at 228961_at 204018_x_at 209791_at 219543_at 229070_at 204034_at 210107_at 219796_s_at 229254_at 204036_at 210524_x_at 219948_x_at 229659_s_at 204130_at 210735_s_at 220075_s_at 229831_at 204388_s_at 211372_s_at 220266_s_at 230595_at 204389_at 211538_s_at 220468_at 231925_at 204508_s_at 211549_s_at 220645_at 231975_s_at 204532_x_at 211637_x_at 220812_s_at 233565_s_at 204607_at 211699_x_at 221004_s_at 235146_at 204673_at 211745_x_at 221305_s_at 235766_x_at 204818_at 212224_at 221584_s_at 235849_at 204895_x_at 212592_at 221841_s_at 238143_at 204897_at 212741_at 221896_s_at 238750_at 205112_at 212814_at 223484_at 238751_at 205259_at 213317_at 223597_at 239272_at 205403_at 213451_x_at 223754_at 241994_at 205480_s_at 213629_x_at 224342_x_at 242447_at 205554_s_at 213921_at 224989_at 242601_at 205593_s_at 213953_at 224990_at 243278_at; and/or 205892_s_at 214164_x_at 225458_at 205929_at 214433_s_at 225728_at

(ii) ADH1C FGFR2 LOC646627 PTGER4 AGR3 FOSB LOC652128 RAB27A ALDH1A1 FOXF2 LOC96610 SCARA5 ANK3 FOXP2 MAOA SDCBP2 ARL14 FUCA1 MATN2 SELENBP1 ATP1A2 GPA33 MEP1A SI ATP8B1 HBA1 METTL7A SMTN BEST2 HBA2 MFSD4 SORBS2 C10orf99 HBB MGC13057 SRI C15orf48 HHLA2 MIER3 SST C1orf115 HIGD1A MMP28 ST6GALNAC1 C4orf34 HMGCS2 MT1A SULT1A1 C6orf105 HPGD MT1F TNXB C8orf4 HSD11B2 MT1M TSPAN1 CA12 HSD17B2 MUC12 TTRAP CCL28 HSPA2 MUC2 UGDH CKB IGHA1 MUC4 UGP2 CLCA1 IGHM MUCDHL UGT1A1 CLDN8 IL1R2 MYH11 UGT1A3 CLIC5 IL8 NDE1 UGT1A6 CMBL IQGAP2 NR3C2 UGT1A8 CNTN3 ITLN1 P2RY1 UGT1A9 DNASE1L3 ITM2C PADI2 UGT2A3 EDG2 KCNMA1 PAPSS2 UGT2B15 ENAM KIAA0828 PBLD UGT2B17 ENTPD5 KLF4 PDCD4 VSIG2 ETHE1 KRT20 PDE9A XDH FABP1 LOC253012 PIGR XLKD1 FAM46C LOC25845 PLCE1 ZCWPW2. FAM55D LOC285382 PPID FCGBP LOC572558 PRKACB


42. The method according to claim 36 wherein said control level is a non-neoplastic level.
 43. A method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising screening the level of expression of one or more genes or transcripts selected from: (i) the gene, genes or transcripts detected by Affymetrix probeset IDs: 202920_at 222717_at 231120_x_at 203881_s_at 224412_s_at 231773_at 204719_at 225381_at 203296_s_at 204931_at 225575_at 206664_at 204940_at 227529_s_at 211549_s_at 205433_at 227623_at 214598_at 206637_at 227705_at 219948_x_at 207080_s_at 227827_at 220812_s_at 207980_s_at 228504_at 221305_s_at 209170_s_at 228706_s_at 229831_at 209209_s_at 228766_at 231925_at 209613_s_at 228854_at 235146_at 220037_s_at 228885_at 238751_at 220376_at 230788_at 243278_at; and/or

(ii) ADH1B ANGPTL1 HHLA2 SORBS2 DMD SORBS2 PYY GCNT2 CLDN23 ABCA8 SDPR CNTN3 RPL24 PKIB PLEKHC1 SI CITED2 LRRC19 CLDN8 TCF21 LIFR P2RY14 P2RY1 ATP1A2 PLN ANK2 HPGD TRPM6 XLKD1 GPM6B CD36 LOC399959 UGT1A8 BCHE AKAP12 FOXP2 TCEAL7 UGT2A3

in a biological sample from said individual wherein a level of expression of the genes or transcripts of group (i) and/or group (ii) which is not substantially above background levels is indicative of a neoplastic cell or a cell predisposed to the onset of a neoplastic state.
 44. The method according to claim 43 wherein said neoplastic cell is an adenoma or adenocarcinoma.
 45. The method according to claim 44 wherein said neoplasm is an adenoma and said one or more genes or transcripts are selected from: (i) the gene, genes or transcripts detected by Affymetrix probeset IDs: 209209_s_at, 225381_at, 227529_s_at, 227623_at, 227705_at; and/or (ii) AKAP12, LOC399959, PLEKHC1, TCEAL7.
 46. The method according to claim 44 wherein said neoplasm is a cancer and said one or more genes or transcripts are selected from: (i) the gene, genes or transcripts detected by Affymetrix probeset IDs: 203296_s_at 219948_x_at 231925_at 206664_at 220812_s_at 235146_at 211549_s_at 221305_s_at 238751_at 214598_at 229831_at 243278_at; and/or

(ii) ATP1A2 HHLA2 SORBS2 CLDN8 HPGD UGT1A8 CNTN3 P2RY1 UGT2A3 FOXP2 SI.


47. A method of characterising a neoplastic cell or cellular population, which cell or cellular population is derived from the large intestine of an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from: (i) the gene, genes or transcripts detected by Affymetrix probeset IDs: 200600_at 202766_s_at 210495_x_at 218469_at 200665_s_at 202859_x_at 210511_s_at 218559_s_at 200832_s_at 202878_s_at 210764_s_at 218638_s_at 200974_at 202917_s_at 210809_s_at 219087_at 200986_at 202998_s_at 211161_s_at 221011_s_at 201058_s_at 203083_at 211571_s_at 221729_at 201069_at 203325_s_at 211719_x_at 221730_at 201105_at 203382_s_at 211813_x_at 221731_x_at 201141_at 203477_at 211896_s_at 37892_at 201147_s_at 203570_at 211959_at 223122_s_at 201150_s_at 203645_s_at 211964_at 223235_s_at 201162_at 203878_s_at 211966_at 224560_at 201163_s_at 204006_s_at 211980_at 224694_at 201185_at 204051_s_at 211981_at 224724_at 201261_x_at 204122_at 212077_at 225664_at 201289_at 204320_at 212344_at 225681_at 201426_s_at 204475_at 212353_at 225710_at 201438_at 204620_s_at 212354_at 225799_at 201616_s_at 205479_s_at 212464_s_at 226237_at 201645_at 205547_s_at 212488_at 226311_at 201667_at 205828_at 212489_at 226694_at 201744_s_at 207173_x_at 212667_at 226777_at 201792_at 207191_s_at 213125_at 226930_at 201842_s_at 208747_s_at 213428_s_at 227099_s_at 201852_x_at 208782_at 213524_s_at 227140_at 201859_at 208788_at 213869_x_at 227566_at 201893_x_at 208850_s_at 213905_x_at 229218_at 202237_at 208851_s_at 214247_s_at 229802_at 202238_s_at 209101_at 215049_x_at 231579_s_at 202283_at 209156_s_at 215076_s_at 231766_s_at 202291_s_at 209218_at 215646_s_at 231879_at 202310_s_at 209395_at 216442_x_at 232458_at 202311_s_at 209396_s_at 217430_x_at 233555_s_at 202403_s_at 209596_at 217762_s_at 234994_at; and/or 202404_s_at 209875_s_at 217763_s_at 202450_s_at 209955_s_at 217764_s_at 202620_s_at 210095_s_at 218468_s_at

(ii) COL1A2 INHBA FAP IGFBP3 CTHRC1 COL6A2 VIM SERPINF1 FN1 ANTXR1 TIMP2 ISLR POSTN GPNMB SCD HNT SPP1 BGN TIMP3 COL5A1 MMP1 TAGLN AEBP1 OLFML2B SPARC COL4A1 GJA1 KIAA1913 LUM RAB31 NNMT PALM2- GREM1 LGALS1 COL1A1 AKAP2 IL8 ELOVL5 SULF2 SERPING1 IGFBP5 MGP COL6A1 TYROBP SFRP2 MMP2 SPON2 ACTA2 SULF1 LOXL2 CTSK COL3A1 ASPN MYL9 MXRA5 PLOD2 COL6A3 DCN C1S MMP11 COL8A1 CALD1 DKK3 CD163 COL12A1 FBN1 SRGN FCGR3B COL5A2 MMP3 LBH PLAU CDH11 IGFBP7 CTGF MAFB THBS2 FSTL1 TNC LOC541471 COL15A1 COL4A2 G0S2 LOC387763 COL11A1 VCAN SQLE CHI3L1 S100A8 SMOC2 EFEMP1 THY1 FNDC1 HTRA1 APOE LOXL1 SFRP4 CYR61 MSN CD93

in said cell or cellular population wherein a lower level of expression of the genes of group (i) and/or group (ii) relative to a gastrointestinal cancer control level is indicative of an adenoma cell or a cell predisposed to the onset of an adenoma state.
 48. A method of characterising a neoplastic cell or cellular population, which cell or cellular population is derived from the large intestine of an individual, said method comprising assessing the level of expression of one or more genes or transcripts selected from: (i) the gene, genes or transcripts detected by Affymetrix probeset IDs: 200884_at 214234_s_at 226248_s_at 203240_at 214235_at 226302_at 203963_at 214433_s_at 227676_at 204508_s_at 215125_s_at 227719_at 204607_at 215867_x_at 227725_at 204811_s_at 217109_at 228232_s_at 204895_x_at 217110_s_at 229070_at 204897_at 218211_s_at 231832_at 205259_at 219543_at 232176_at 205765_at 219955_at 232481_s_at 205927_s_at 221841_s_at 235976_at 208063_s_at 221874_at 236894_at 208937_s_at 223969_s_at 237521_x_at 210107_at 223970_at 242601_at; and/or 213106_at

(ii) CLCA1 CTSE ATP8B1 FCGBP C6orf105 CACNA2D2 HMGCS2 CKB KLF4 RETNLB ATP8A1 CYP3A5P2 L1TD1 MUC4 CAPN9 SLITRK6 UGT1A1 NR3C2 VSIG2 SELENBP1 PBLD LOC253012 PTGER4 CA12 ST6GALNAC1 MLPH WDR51B ID1 KIAA1324 FAM3D CYP3A5

in a biological sample from said individual wherein a lower level of expression of the genes or transcripts of group (i) and/or group (ii) relative to a gastrointestinal adenoma control level is indicative of a cancer or a cell predisposed to the onset of a cancerous state.
 49. The method according to claim 47 wherein said one or more genes or transcripts are selected from: (i) the gene or genes detected by Affymetrix probeset IDs: 202404_s_at, 212464_s_at, 210809_s_at, 225681_at; and/or COL1A2, CTHRC1, FN1, POSTN; (ii) the gene, genes or transcripts detected by Affymetrix probeset IDs: 209875_s_at 227140_at 204475_at; and/or SPP1 MMP1; (iii) the gene, genes or transcripts detected by Affymetrix probeset IDs: 200665_s_at 226237_at 226930_at 201744_s_at 225664_at 204051_s_at 218468_s_at 221730_at 210511_s_at 202859_x_at 207173_x_at 209156_s_at 211959_at 203083_at 224694_at 223122_s_at 203477_at 201141_at 212353_at 37892_at 213905_x_at 219087_at 202917_s_at 205547_s_at 201438_at; and/or SPARC COL8A1 SFRP4 LUM COL12A1 INHBA GREM1 COL5A2 COL6A2 IL8 CDH11 ANTXR1 IGFBP5 THBS2 GPNMB SFRP2 COL15A1 BGN SULF1 COL11A1 TAGLN ASPN S100A8 COL6A3 FNDC1;


50. The method according to claim 48 wherein said one or more genes or transcripts are selected from: (i) the gene, genes or transcripts detected by Affymetrix probeset IDs: 210107 at; and/or CLCA1; (ii) the gene, genes or transcripts detected by Affymetrix probeset IDs: 203240_at 219955_at 242601_at 204607_at 232481_s_at 227725_at 223969_s_at 228232_s_at; and/or FCGBP L1TD1 LOC253012 HMGCS2 SLITRK6 ST6GALNAC1 RETNLB VSIG2;

(iii) the gene or genes detected by Affymetrix probeset IDs: 235976_at 236894_at 237521; and/or SLITRK6 L1TD1.
 51. The method according to any one of claim 36, 43, 47 or 48 wherein said cell is a colorectal cell.
 52. The method according to any one of claim 36, 43, 47 or 48 wherein said biological sample is a faecal sample, enema wash, surgical resection, tissue biopsy or blood sample.
 53. The method according to any one of claim 36, 43, 47 or 48 wherein said level of expression is assessed by screening for changes to mRNA expression, protein expression genomic DNA or the chromatin protein with which said gene is associated.
 54. The method according to claim 53 wherein said changes to genomic DNA are changes to DNA methylation.
 55. The method according to any one of claim 36, 43, 47 or 48 wherein said individual is a human.
 56. A molecular array, which array comprises a plurality of: (i) nucleic acid molecules comprising a nucleotide sequence corresponding to any one or more of the neoplastic marker genes listed in claim 36 or a sequence exhibiting at least 80% identity thereto or a functional derivative, fragment, variant or homologue of said nucleic acid molecule; or (ii) nucleic acid molecules comprising a nucleotide sequence capable of hybridising to any one or more of the sequences of (i) under medium stringency conditions or a functional derivative, fragment, variant or homologue of said nucleic acid molecule; or (iii) nucleic acid probes or oligonucleotides comprising a nucleotide sequence capable of hybridising to any one or more of the sequences of (i) under medium stringency conditions or a functional derivative, fragment, variant or homologue of said nucleic acid molecule; or (iv) probes capable of binding to any one or more of the proteins encoded by the nucleic acid molecules of (i) or a derivative, fragment or, homologue thereof wherein the level of expression of said marker genes of (i) or proteins of (iv) is indicative of the neoplastic state of a cell or cellular subpopulation derived from the large intestine. 